Superbug That Can Feed on Plastic Is Spreading in Hospitals
Researchers from the Brunel University of London have found, per a new study in the journal Cell, that the bacterial Pseudomonas aeruginosa appears to "digest" medical plastic.
Associated with more than 559,000 deaths globally per year, this drug-resistant bug is, according to the Center for Disease Control and Prevention, believed to cause other illnesses like pneumonia or urinary tract infections. People often seem to develop it after surgery, but until this study, researchers weren't aware that it might be living or feeding on medical plastics.
By analyzing a strain of the bacteria taken from a patient's wound swab, the microbial researchers found that P. aeruginosa seems specifically to survive longer on polycaprolactone, a plastic used in all kinds of medical interventions ranging from sutures, stints, and surgical mesh to wound dressings, drug-delivery patches, and implants.
In Brunel University's press release about the "world-first" research, study leader Ronan McCarthy said this finding suggests that medical professionals should rethink how bugs spread throughout hospitals and other healthcare settings.
"Plastics, including plastic surfaces, could potentially be food for these bacteria," McCarthy said. "Pathogens with this ability could survive for longer in the hospital environment."
The study also, as the professor noted, "means that any medical device or treatment that contains plastic" — including the ventilators some pneumonia patients need and catheters necessary for UTIs — "could be susceptible to degradation by bacteria."
Beyond its ability to break down such important medical tools, the researchers also found that the enzyme they isolated appears to grow stronger biofilms, or outer layers that help bacteria resist antibiotics and make them harder to treat, after digesting plastic.
Though there will obviously need to be more study to figure out how best to head off this plastic-eating menace, there's a 200-year history of pathogenic adaptation behind P. aeruginosa that suggests it may eventually circumvent any such measures.
Still, McCarthy pointed out that scientists "need to understand the impact this has on patient safety."
"Plastic is everywhere in modern medicine," he said, "and it turns out some pathogens have adapted to degrade it."
More on bacteria: Mysterious Bacteria Not Found on Earth Are Growing on China's Space Station
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NBC News
2 days ago
- NBC News
Watch out for this new invasive tick. It could saddle you with a little-known, debilitating infection
An invasive tick species is creeping its way into more parts of the country, as warming temperatures help it spread a little-known infection that can leave people with debilitating symptoms, and in rare cases, dead. In May, scientists at the Connecticut Agricultural Experiment Station in New Haven discovered for the first time that the longhorned tick had become a carrier for the bacteria that causes the Ehrlichiosis infection. With cases already on the rise, that was a big cause of concern. 'I am afraid to say that it is a storm brewing,' said Goudarz Molaei, the director of the lab's tick-testing program. 'Climate change eventually will almost eliminate winter in our region. And this tick, like other tick species, will be active year round.' Warming temperatures, which have already translated into shorter winters, allow the longhorned tick and other tick species to wake up early from hibernation, increasing the risk of getting bitten. The longhorned tick, which is native to East Asia, first invaded places like Australia, New Zealand and the Pacific Islands. It has nowbeen detected in at least 21 states in the U.S. with Michigan reporting its first sighting at the end of June. Researchers aren't sure how the tick made it to the U.S., but it's likely it arrived on the backs of imported livestock or other animals. In 2017, scientists identified the country's first longhorned tick in New Jersey, though it's likely the species has been in the U.S. since at least 2010. 'The fact it was here for so long without us actually knowing about it was really a wakeup call,' said Dana Price, an associate research professor in the department of entomology at Rutgers University. Modeling indicates areas from southern Canada throughout the continental U.S. are environmentally suitable to the longhorned tick. That means the threat is two-fold: The longhorned's geographic range is expanding and so is the time that they're active and able to transmit disease, scientists said. Ehrlichiosis is becoming so prevalent that there is a region of the country unofficially named after it: The 'Ehrlichiosis Belt' stretches from as far north as Connecticut and New York to as far west as Arkansas. The lone star and blacklegged ticks have long carried Ehrlichia chaffeensis, the bacteria that causes Ehrlichiosis. The infection sends about 60% of patients to the hospital and claims the lives of about 1 in 100 patients, according to the Center for Disease Control and Prevention. Infected individuals will typically experience fever, chills, muscle aches, headaches and fatigue one to two weeks after being bitten. But if people aren't treated quickly, the infection can sometimes lead to brain and nervous system damage, respiratory failure, uncontrolled bleeding and organ failure. The number of Ehrlichiosis cases has risen steadily since 2000 when the CDC reported 200 cases of Ehrlichiosis compared with 2,093 in 2019. Studies suggest that the number of annual Ehrlichiosis cases are grossly underreported with one study from Rutgers University researchers saying 99% of cases go undetected. The CDC reported earlier this month that there have been more emergency room visits in July for tick bites than the past eight Julys. In early July, officials closed Pleasure Beach, a popular swim spot in Bridgeport, Connecticut, for the summer after discovering an infestation of several tick species including the longhorned tick. Manisha Juthani, the commissioner of the Connecticut Department of Public Health, said that as climate change makes 'tick season' less predictable, Connecticut residents should take precautions like wearing long pants, tucking them into their socks and conducting tick checks on family members and pets after being outdoors for extended periods of time. 'The reality is that with the changes we're seeing in climate, we have to be more prepared and more aware of the infections and the pathogens that we can be exposed to by being outside and potentially being aware of the things that can really cause the most harm to people,' Juthani said. While longhorned ticks often prefer the blood of livestock to humans, entomologists say their unique biology makes them a formidable public health hazard. They can establish populations of thousands from a single female because, like bees, they have the ability to reproduce without a mate. They can also ingest and become carriers for pathogens typically carried by other tick species if they happen to feed on the same host. The process, known as co-feeding transmission, is common among most tick species. Molaei said his recent discovery of the Ehrlichiosis-causing bacteria in the longhorned tick raises concerns about what other pathogens the tick may be able to contract and transmit to humans. The longhorned tick and the lone star tick, one of the original carriers of ehrlichia, both feed on similar hosts, like white-tailed deer. 'We live in this part of the world with several important tick species, and we have to learn how to live with this many ticks,' Molaei said. 'And the key is to protect ourselves.' The World Health Organization reports that more than 17% of infectious diseases globally are transmitted through vectors, intermediary animals that ferry viruses, bacteria and other pathogens from one animal to the next. Tick-borne diseases in the U.S. accounted for 77% of vector-borne disease reports from 2004 to 2016, with cases more than doubling in the last 13 years, according to data collected by the CDC. Jennifer Platt was bitten by a tick during that time. She contracted Ehrlichiosis from a tick bite in North Carolina in the summer of 2011. When she couldn't pick up and carry her 2-year-old son, her friend, who is a nurse, suggested she go to the hospital immediately. The friend suspected Platt might have a tick-borne infection. Platt was sick and on antibiotics for months after her diagnosis. Her shoulder locked due to the infection — a rare but contractable chronic symptom of tick-borne disease — leading to months of physical therapy and putting her out of work for three months. It took her more than a year to fully recover from the lasting impacts of the infection. 'The best way I'd describe it,' she said, 'is I felt like death.' A few years after she started feeling better, she was diagnosed with Lyme and Babesiosis diseases — which she attributes to the same tick bite. Platt, who co-founded the advocacy nonprofit Tick-Borne Conditions United, said she hopes the recent discovery of the Ehrlichia bacteria in the longhorned tick will help raise awareness among doctors and the general public about the threat of tick-borne diseases, especially little-known ones like Ehrlichiosis. 'My mission in life is to support people in being who they are,' Platt said. 'And if you're sick from a tick-borne disease, you can't be who you are.'


Scientific American
2 days ago
- Scientific American
New Brain Device Is First to Read Out Inner Speech
After a brain stem stroke left him almost entirely paralyzed in the 1990s, French journalist Jean-Dominique Bauby wrote a book about his experiences—letter by letter, blinking his left eye in response to a helper who repeatedly recited the alphabet. Today people with similar conditions often have far more communication options. Some devices, for example, track eye movements or other small muscle twitches to let users select words from a screen. And on the cutting edge of this field, neuroscientists have more recently developed brain implants that can turn neural signals directly into whole words. These brain-computer interfaces (BCIs) largely require users to physically attempt to speak, however—and that can be a slow and tiring process. But now a new development in neural prosthetics changes that, allowing users to communicate by simply thinking what they want to say. The new system relies on much of the same technology as the more common 'attempted speech' devices. Both use sensors implanted in a part of the brain called the motor cortex, which sends motion commands to the vocal tract. The brain activation detected by these sensors is then fed into a machine-learning model to interpret which brain signals correspond to which sounds for an individual user. It then uses those data to predict which word the user is attempting to say. On supporting science journalism If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today. But the motor cortex doesn't only light up when we attempt to speak; it's also involved, to a lesser extent, in imagined speech. The researchers took advantage of this to develop their 'inner speech' decoding device and published the results on Thursday in Cell. The team studied three people with amyotrophic lateral sclerosis (ALS) and one with a brain stem stroke, all of whom had previously had the sensors implanted. Using this new 'inner speech' system, the participants needed only to think a sentence they wanted to say and it would appear on a screen in real time. While previous inner speech decoders were limited to only a handful of words, the new device allowed participants to draw from a dictionary of 125,000 words. 'As researchers, our goal is to find a system that is comfortable [for the user] and ideally reaches a naturalistic ability,' says lead author Erin Kunz, a postdoctoral researcher who is developing neural prostheses at Stanford University. Previous research found that 'physically attempting to speak was tiring and that there were inherent speed limitations with it, too,' she says. Attempted speech devices such as the one used in the study require users to inhale as if they are actually saying the words. But because of impaired breathing, many users need multiple breaths to complete a single word with that method. Attempting to speak can also produce distracting noises and facial expressions that users find undesirable. With the new technology, the study's participants could communicate at a comfortable conversational rate of about 120 to 150 words per minute, with no more effort than it took to think of what they wanted to say. Like most BCIs that translate brain activation into speech, the new technology only works if people are able to convert the general idea of what they want to say into a plan for how to say it. Alexander Huth, who researches BCIs at the University of California, Berkeley, and wasn't involved in the new study, explains that in typical speech, 'you start with an idea of what you want to say. That idea gets translated into a plan for how to move your [vocal] articulators. That plan gets sent to the actual muscles, and then they carry it out.' But in many cases, people with impaired speech aren't able to complete that first step. 'This technology only works in cases where the 'idea to plan' part is functional but the 'plan to movement' part is broken'—a collection of conditions called dysarthria—Huth says. According to Kunz, the four research participants are eager about the new technology. 'Largely, [there was] a lot of excitement about potentially being able to communicate fast again,' she says—adding that one participant was particularly thrilled by his newfound potential to interrupt a conversation—something he couldn't do with the slower pace of an attempted speech device. To ensure private thoughts remained private, the researchers implemented a code phrase: 'chitty chitty bang bang.' When internally spoken by participants, this would prompt the BCI to start or stop transcribing. Brain-reading implants inevitably raise concerns about mental privacy. For now, Huth isn't concerned about the technology being misused or developed recklessly, speaking to the integrity of the research groups involved in neural prosthetics research. 'I think they're doing great work; they're led by doctors; they're very patient-focused. A lot of what they do is really trying to solve problems for the patients,' he says, 'even when those problems aren't necessarily things that we might think of,' such as being able to interrupt a conversation or 'making a voice that sounds more like them.' For Kunz, this research is particularly close to home. 'My father actually had ALS and lost the ability to speak,' she says, adding that this is why she got into her field of research. 'I kind of became his own personal speech translator toward the end of his life since I was kind of the only one that could understand him. That's why I personally know the importance and the impact this sort of research can have.' The contribution and willingness of the research participants are crucial in studies like this, Kunz notes. 'The participants that we have are truly incredible individuals who volunteered to be in the study not necessarily to get a benefit to themselves but to help develop this technology for people with paralysis down the line. And I think that they deserve all the credit in the world for that.'


Forbes
2 days ago
- Forbes
Decoding The Molecular Benefits Of Exercise
There has always been a dream that there could be a pill to replace exercise. New research suggests a molecule called betaine, naturally produced by the kidneys, may do just that. According to a new study published in Cell, it may mimic many of the health-protective effects of exercise. This suggests that it could help protect against aging-related decline, even in individuals who are unable to maintain regular physical activity. Betaine is produced by the kidneys. Previous research has linked it to cardiovascular health and liver function, but its role in geroprotection has been underappreciated. This research shows the kidney acts as a command center in exercise-driven rejuvenation. Betaine directly inhibits key drivers of inflammation, silencing 'inflammaging'—chronic inflammation that accelerates cellular aging. This links movement at the gym to age-defying changes in cellular Molecular Language of Movement Decades of research have linked regular exercise to longer lifespans and reduced risk for inflammation-driven diseases. Therefore, we know exercise is beneficial, but the mechanisms—what actually changes at the microscopic level—are not well understood. For example, activities such as running, cycling or resistance training have a positive effect on metabolism and heart health. Recent advances now enable us to investigate the molecular changes underlying these improvements. This new study presents a systematic, cell-by-cell analysis. It looks at how both acute and sustained exercise drive rapid shifts in molecular signatures, redefining our understanding of 'exercise as medicine'. The study tracked 13 healthy human volunteers over periods of rest, a single 5-km run, and long-term training in the form of 25 days of running. During these periods, samples were collected. These examined how the body's cells and molecules responded. More specifically, the study went beyond general health markers. It used advanced techniques, such as single-cell sequencing, to determine which genes are activated in individual cells during exercise. It also measures proteins, small molecules related to metabolism and it studies the gut microbiome. To explain this in simpler terms, you might compare this to a car tune-up. Even short, regular sessions of exercise prompt the body to 'fix' and 'upgrade' its cellular machinery, leading to wide-ranging health improvements. The study's use of sophisticated technology is like opening the hood and not just checking the oil, but inspecting every engine part for improvement. These tests and samples provide an unprecedented, detailed insight into the body's inner workings in response to exercise. The findings show that a single workout triggers a short burst of inflammation, described as 'metabolic chaos,' that helps the body adjust to sudden physical stress. Sustained exercise, on the other hand, reprograms the body towards youthfulness, reshapes the gut microbiome, enhances antioxidant activity, promotes DNA stability in immune cells and elevates betaine Path Forward in Understanding the Molecular Benefits of Exercise These results build upon prior work linking exercise to reductions in cellular senescence, tissue inflammation, and metabolic disease—all key hallmarks of aging. What distinguishes this research is the identification of a single, kidney-derived metabolite that can orchestrate what is known as systemic geroprotection. Consider the case of elderly patients facing joint pain or disability. They are often unable to engage in adequate physical activity. Betaine supplementation, pending further clinical validation, could potentially offer a pharmacological lifeline to healthspan extension, helping these individuals maintain independence and quality of life without the barrier of vigorous exercise. That said, the study tested only a small, similar group of people, so we can't be sure the results apply to everyone. The limited sample size and lack of participant diversity mean that the findings may not be generalizable to broader populations. Still, the early results are promising. As research moves from bench to bedside, we approach an era where the secrets of exercise may be unlocked—and replicated—to benefit all.