Genesee & Wyoming - The Little Rail that Does: Talking Transports
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2 days ago
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Lilly stock falls as Mounjaro fails to show superiority over Trulicity
-- Eli Lilly and Company (NYSE:LLY) stock fell on Thursday morning after the pharmaceutical giant's diabetes drug Mounjaro failed to demonstrate superiority over its older GLP-1 drug Trulicity in a cardiovascular outcomes trial. Lilly's shares declined as much as 4.5% before paring the drop to 2.25% following the release of topline results from the SURPASS-CVOT trial, which compared the two incretin therapies in adults with type 2 diabetes and established atherosclerotic cardiovascular disease. While Mounjaro met its primary objective of non-inferiority with an 8% lower rate of major adverse cardiovascular events (MACE-3) compared to Trulicity, the results fell short of proving superiority. The trial showed a hazard ratio of 0.92 with a 95.3% confidence interval of 0.83 to 1.01, missing the threshold for statistical superiority. The study did show some positive secondary outcomes, including a 16% lower rate of all-cause mortality for Mounjaro versus Trulicity. Mounjaro also demonstrated greater improvements in A1C, weight reduction, and kidney function measures. However, these secondary endpoints were not controlled for multiplicity-adjusted type 1 error. Bloomberg Intelligence analyst Michael Shah called outcomes of the trial positive but underwhelming. "Eli Lilly's Mounjaro met the primary endpoint in the SURPASS-CVOT trial, demonstrating a non-inferior rate of major adverse cardiovascular events vs. Trulicity. Yet this is undermined by the fact that the trial also tested for superiority, but that was not achieved (or at least not disclosed in the initial release). The commercial implications could be limited, as prescribers generally view Mounjaro as a more effective GLP-1 than Trulicity." Lilly plans to present detailed results at the European Association for the Study of Diabetes Annual Meeting in September and submit the data to global regulatory authorities by year-end. Related articles Lilly stock falls as Mounjaro fails to show superiority over Trulicity If Powell goes, does Fed trust go with him? 7 Undervalued Stocks on the Rise With 50%+ Upside Potential Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
3 days ago
- Yahoo
Cynthia Lummis' new bill could change mortgage rules forever
Cynthia Lummis' new bill could change mortgage rules forever originally appeared on TheStreet. Senator Cynthia Lummis (R-WY) introduced a new bill related to mortgages on July 29. Titled the "21st Century Mortgage Act," the legislation requires government-sponsored enterprises, Fannie Mae and Freddie Mac, to consider cryptocurrency assets when assessing single-family mortgage eligibility. Lummis said: 'This legislation embraces an innovative path to wealth-building keeping in mind the growing number of young Americans who possess digital assets.' The bill aims to codify the Federal Housing Finance Agency Director William Pulte's June 25 directive to the enterprises to consider cryptocurrency as an asset for single-family loans. The bill also prohibits the conversion of crypto assets into U.S. dollars during the mortgage Mae and Freddie Mac don't issue mortgages themselves, but they are responsible for setting mortgage-related guidelines. They purchase mortgages on the secondary market, bundle them into mortgage-backed securities (MBSs), and guarantee payments to investors. Housing crisis in U.S. Data suggests that the U.S. is facing a severe housing crisis due to high house prices and mortgage rates. Lummis cited the U.S. Census Bureau data to underline how homeownership among young Americans under 35 is 36.6% during Q1 2025. 'The American dream of homeownership is not a reality for many young people,' she said. As per the Federal Reserve Economic Data (FRED), the median sales price of houses in the U.S. has soared to $410,800 during Q2 2025. The steep rise in home prices that began around 2020 doesn't seem to be slowing down. As per Freddie Mac, the average interest rate on a 30-year mortgage is 6.74% and that on a 15-year mortgage is 5.87% as of now — within the highest range in the last two decades. The current mortgage rates rival even those during the 2007-09 financial crisis. Similar bill already introduced If Fannie Mae and Freddie Mac begin to consider crypto during mortgage eligibility assessment, it would alter the housing market however, isn't the only one to introduce the first such legislation. Rep. Nancy Mace (R-NC) already introduced a similar bill titled the 'American Homeowner Crypto Modernization Act of 2025' on July 14 that urges agencies to consider crypto holdings during the mortgage credit evaluation process. Such moves are reflective of the broader shift toward a pro-crypto agenda of the Donald Trump administration that recently made astonishing progress on three key crypto bills. Cynthia Lummis' new bill could change mortgage rules forever first appeared on TheStreet on Jul 29, 2025 This story was originally reported by TheStreet on Jul 29, 2025, where it first appeared. 擷取數據時發生錯誤 登入存取你的投資組合 擷取數據時發生錯誤 擷取數據時發生錯誤 擷取數據時發生錯誤 擷取數據時發生錯誤
Yahoo
3 days ago
- Yahoo
ExiScale Earns 4.7-Star Trustpilot Rating, Strengthening Its Position as a Reliable Meta Ad Account Provider
Marketers turn to ExiScale for long-term stability, lifetime guarantees, and real human support amid rising Meta ad account bansExiScale Logo SHERIDAN, Wyo., July 31, 2025 (GLOBE NEWSWIRE) -- ExiScale, a company founded by marketers for marketers, is proud to announce it has achieved a 4.7-star rating on Trustpilot, underscoring its growing reputation as a trusted partner for advertisers seeking reliable access to Meta (Facebook) ad accounts. With the rise in account bans, spending restrictions, and compliance challenges across Meta's advertising ecosystem, many digital marketers are finding it increasingly difficult to maintain campaign stability. ExiScale steps in to solve this issue by offering infrastructure that enables uninterrupted ad performance and scalability for affiliates, agencies, and eCommerce brands alike. 'Our mission from the start was simple: help advertisers get back online and stay there,' said Kyron Hellmrich, CEO of ExiScale. 'We experienced firsthand the frustrations of account bans and wasted ad spend, so we built ExiScale to eliminate those roadblocks for others. The 4.7-star rating on Trustpilot reflects the consistent results and support we've been able to deliver.' ExiScale's Distinct Advantages Unlike traditional account sellers, ExiScale offers a full-service solution focused on long-term reliability and advertiser success. Its services are built around transparency, security, and customer support. Clients gain access to: Aged, high-trust Facebook profiles ready to run ads immediately Business Managers and ad accounts with no spending limits Lifetime replacement guarantees with no hidden terms 24/7 customer support from real people, not bots Clean, US-based IP infrastructure for safer and more consistent ad delivery Straightforward setup and onboarding within hours This infrastructure is designed to help advertisers scale confidently without the constant fear of account shutdowns or technical complications. 'Before ExiScale, we were stuck in a cycle of buying weak accounts that failed within days,' said one client review. 'Now, we've been running campaigns for months without disruption.' With a focus on transparency and real-time support, ExiScale has quickly become a preferred partner for marketers serious about maintaining stable advertising operations on Meta platforms. The company continues to expand its services, with plans to introduce new tools and account configurations tailored to the evolving needs of performance marketers. From affiliate marketers to agencies and eCommerce brands, more businesses are turning to ExiScale for high-trust Meta ad accounts they can depend on. The platform is designed for advertisers seeking a stable, long-term alternative to unreliable account providers. To learn more about ExiScale or to explore its Meta ad account solutions, visit About ExiScale ExiScale is a digital advertising provider specializing in high-trust Meta (Facebook) ad accounts for marketers, agencies, and eCommerce brands. Built by marketers, ExiScale delivers aged accounts, unlimited-spend Business Managers, and 24/7 live support to help clients run stable, scalable campaigns. Media Contact:Kyron HellmrichExiScale+1 (307) 461-9524support@ A photo accompanying this announcement is available at in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
