Sydnexis Announces Three Abstracts Accepted for Poster Presentations at Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting
DEL MAR, Calif., May 01, 2025--(BUSINESS WIRE)--Sydnexis, Inc., (www.sydnexis.com) a pre-commercial stage biopharmaceutical company, announces that three abstracts have been accepted for poster presentations at the upcoming Association for Research in Vision and Ophthalmology (ARVO) 2025 Meeting taking place from May 4 to 8 in Salt Lake City, UT.
These posters present clinical data related to the STAR Study, Sydnexis' groundbreaking pivotal phase 3 clinical trial evaluating SYD-101, a novel and proprietary low-dose atropine formulation to slow the progression of pediatric myopia. Two of the posters feature baseline methodologies and a 36-month analysis of myopia progression in a globally diverse population of 282 patients. The third poster highlights the benefits of SYD-101.
"We are pleased to share what makes SYD-101's proprietary formulation novel in our landmark STAR Study, which is the largest ever clinical trial completed for the treatment of slowing the progression of pediatric myopia," said Patrick Johnson, Ph.D., President at Sydnexis. "We look forward to this first of many opportunities to engage with the broader ophthalmology community about how the landmark study may impact future treatment paradigms for the growing pediatric myopia epidemic."
Sydnexis recently announced the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for SYD-101 and assigned a PDUFA target action date of October 23, 2025. If approved, SYD-101 would be the first and only pharmaceutical option available in the United States for the treatment of the progression of pediatric myopia.
Abstract and Poster Details
Title: The natural history of myopia progression in a large diverse pediatric population.Lead Author: Janet K. Cheetham, Pharm.D., Sydnexis Inc. et alDate: Tuesday, May 6, 2025Location: Calvin L. Rampton Salt Palace Convention Center Poster HallPoster: A0117
Title: Methods and baseline of a large, multi-center, phase 3 study with low-dose atropine (SYD-101) for the treatment of myopia progression in over 800 children (STAR Study).Lead Author: Patrick Johnson, Ph.D., Sydnexis Inc. et alDate: Tuesday, May 6, 2025Location: Calvin L. Rampton Salt Palace Convention Center Poster HallPoster: A0118
Title: Effect of pH and BAK in low-dose atropine on pupil dilation in dutch belted rabbits.Lead Author: Tim Murphy, M.S., Sydnexis Inc. et alDate: Tuesday, May 6, 2025Location: Calvin L. Rampton Salt Palace Convention Center Poster HallPoster: A0132
About Pediatric Myopia:
Myopia is the most common eye disease in children, impacting approximately one-third of children and adolescents worldwide. By 2050, global prevalence is projected to increase and affect more than 740 million children and adolescents and 5 billion people in total. Once considered a benign refractive condition, even at low levels, myopia is now associated with many serious irreversible sight-threatening comorbidities later in life.
About Sydnexis, Inc.:
Founded in 2014, Sydnexis, Inc. (www.sydnexis.com) is a privately held, pre-commercial stage biopharmaceutical company based in San Diego, California. Sydnexis recently completed its three-year primary endpoint in the pivotal Phase 3 clinical trial evaluating its proprietary low-dose atropine formulation to slow progression of pediatric myopia and the risk of associated co-morbidities. The Phase 3 clinical trial is now completing the fourth-year randomized withdrawal for exploratory endpoints and third year results will be announced upon completion of the fourth year of the study. The company is venture-backed by four major investors: Visionary Ventures, RA Capital, Longitude Capital, and Bluestem Capital.
View source version on businesswire.com: https://www.businesswire.com/news/home/20250501030361/en/
Contacts
For media inquiries, please contact: media@launchlabpartners.com
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
35 minutes ago
- Yahoo
Lineage Announces Pricing of $500 million of Senior Notes due 2030
NOVI, Mich., June 10, 2025--(BUSINESS WIRE)--Lineage, Inc. (NASDAQ: LINE) (the "Company"), today announced that Lineage OP, LP (the "Operating Partnership"), a direct subsidiary of the Company, priced an offering of $500 million aggregate principal amount of 5.250% Senior Notes due 2030 (the "Notes") at a price of 98.991% of the principal amount. The Notes will be senior unsecured obligations of the Operating Partnership and will be fully and unconditionally guaranteed by the Company, Lineage Logistics Holdings, LLC and each other subsidiary of the Company (other than the Operating Partnership and certain excluded subsidiaries) that guarantees or is otherwise obligated in respect of the Company's revolving credit and term loan agreement. Interest on the Notes will accrue at a rate of 5.250% per annum and be payable semi-annually on January 15 and July 15 of each year. The Notes will mature on July 15, 2030. Closing of the offering is expected to occur on June 17, 2025, subject to the satisfaction of customary closing conditions. The Company intends to use the net proceeds from the Notes to repay amounts outstanding from time to time under its revolving credit facility and for other general corporate and working capital purposes. The Notes have not been and will not be registered under the Securities Act of 1933, as amended (the "Securities Act"), or any state securities laws, and may not be offered or sold in the United States absent registration or an applicable exemption from the Securities Act. The Notes will be offered only to "qualified institutional buyers" under Rule 144A of the Securities Act or, outside the United States, to persons other than "U.S. persons" in compliance with Regulation S under the Securities Act. This communication is not an offer to sell or a solicitation of an offer to buy securities of Linage, Inc. or its subsidiaries, nor shall it constitute an offer, solicitation or sale of any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction. There can be no assurances that the offering of the Notes will be completed as described herein or at all. Safe Harbor Statement This press release contains forward-looking statements which are based on current expectations, forecasts and assumptions that involve risks and uncertainties that could cause actual outcomes and results to differ materially, including statements related to the timing and consummation of the offering of the Notes and the expected use of the net proceeds. Forward-looking statements can generally be identified by the use of words such as words "estimate," "anticipate," "expect," "believe," "intend," "may," "will," "could," "should," "would," "seek," "position," "support," "drive," "enable," "optimistic," "target," "opportunity," "approximately" or "plan," or the negative of these words and phrases or similar words or phrases that are predictions of or indicate future events or trends and that do not relate solely to historical matters are intended to identify forward-looking statements. You can also identify forward-looking statements by discussions of strategy, plans or intentions of management. The Company can provide no assurances that it will be able to complete the offering on the anticipated terms, or at all. For a further list and description of such risks and uncertainties, see the Company's reports and other filings with the U.S. Securities and Exchange Commission, including the Annual Report on Form 10-K for the year ended December 31, 2024. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. View source version on Contacts Investor Relations ContactEvan BarbosaVP, Investor Relationsir@ Media Contact Megan HendricksenVP, Global Marketing & Communicationspr@
Business Wire
an hour ago
- Business Wire
Lineage Announces Pricing of $500 million of Senior Notes due 2030
NOVI, Mich.--(BUSINESS WIRE)--Lineage, Inc. (NASDAQ: LINE) (the 'Company'), today announced that Lineage OP, LP (the 'Operating Partnership'), a direct subsidiary of the Company, priced an offering of $500 million aggregate principal amount of 5.250% Senior Notes due 2030 (the 'Notes') at a price of 98.991% of the principal amount. The Notes will be senior unsecured obligations of the Operating Partnership and will be fully and unconditionally guaranteed by the Company, Lineage Logistics Holdings, LLC and each other subsidiary of the Company (other than the Operating Partnership and certain excluded subsidiaries) that guarantees or is otherwise obligated in respect of the Company's revolving credit and term loan agreement. Interest on the Notes will accrue at a rate of 5.250% per annum and be payable semi-annually on January 15 and July 15 of each year. The Notes will mature on July 15, 2030. Closing of the offering is expected to occur on June 17, 2025, subject to the satisfaction of customary closing conditions. The Company intends to use the net proceeds from the Notes to repay amounts outstanding from time to time under its revolving credit facility and for other general corporate and working capital purposes. The Notes have not been and will not be registered under the Securities Act of 1933, as amended (the 'Securities Act'), or any state securities laws, and may not be offered or sold in the United States absent registration or an applicable exemption from the Securities Act. The Notes will be offered only to 'qualified institutional buyers' under Rule 144A of the Securities Act or, outside the United States, to persons other than 'U.S. persons' in compliance with Regulation S under the Securities Act. This communication is not an offer to sell or a solicitation of an offer to buy securities of Linage, Inc. or its subsidiaries, nor shall it constitute an offer, solicitation or sale of any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction. There can be no assurances that the offering of the Notes will be completed as described herein or at all. Safe Harbor Statement This press release contains forward-looking statements which are based on current expectations, forecasts and assumptions that involve risks and uncertainties that could cause actual outcomes and results to differ materially, including statements related to the timing and consummation of the offering of the Notes and the expected use of the net proceeds. Forward-looking statements can generally be identified by the use of words such as words 'estimate,' 'anticipate,' 'expect,' 'believe,' 'intend,' 'may,' 'will,' 'could,' 'should,' 'would,' 'seek,' 'position,' 'support,' 'drive,' 'enable,' 'optimistic,' 'target,' 'opportunity,' 'approximately' or 'plan,' or the negative of these words and phrases or similar words or phrases that are predictions of or indicate future events or trends and that do not relate solely to historical matters are intended to identify forward-looking statements. You can also identify forward-looking statements by discussions of strategy, plans or intentions of management. The Company can provide no assurances that it will be able to complete the offering on the anticipated terms, or at all. For a further list and description of such risks and uncertainties, see the Company's reports and other filings with the U.S. Securities and Exchange Commission, including the Annual Report on Form 10-K for the year ended December 31, 2024. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
Yahoo
an hour ago
- Yahoo
Wolters Kluwer executive delivers keynote on the future of integrated tech stacks and agentic AI at AICPA Engage 2025
Cathy Rowe explores how unified tech stacks and agentic AI are transforming audits, tax workflows, and firm-wide decision-making. MINNEAPOLIS, June 10, 2025--(BUSINESS WIRE)--Wolters Kluwer Tax and Accounting (TAA) executive, Cathy Rowe, Senior Vice President and Segment Leader, U.S. Professional Market, delivered a compelling keynote address today at AICPA Engage 2025, held at the Aria Resort and Casino in Las Vegas. Her remarks focused on the accelerating pace of technological change and how integrated tech stacks and agentic AI are reshaping the accounting profession for audit and tax professionals. In her keynote, Rowe emphasized that the rate of technological change is now faster than ever, urging firms to embrace both sustaining and disruptive innovation. She shared insights from Wolters Kluwer's "Future Ready Accountant" study, which found that 77% of firms experienced growth last year, yet 40% cited keeping up with new technology as their top challenge. Rowe highlighted that firms using fully integrated solutions reported revenue increases of 10% or more, underscoring the ROI of strategic tech investments. She outlined four key pillars for leveraging AI in modern firms: Data-Driven Firm Management – Using AI to generate real-time insights and automate reporting. Increased Efficiencies and Capacity – Streamlining workflows and optimizing staff allocation. Proactive Risk Management – Monitoring tax and audit data to identify and mitigate risks. Enhanced Client Service – Shifting from compliance to advisory roles through AI-driven insights and automation. A central theme of Rowe's address was the emergence of agentic AI—a transformative evolution from traditional automation to intelligent agents that act autonomously with human oversight. She explained how agentic AI spans four key categories: Taskers, Automators, Collaborators, and Orchestrators. These agents can classify documents, manage workflows, guide professionals through complex tasks, and even orchestrate entire audit or tax preparation processes. Crucially, this next-generation AI is made possible through open integration platforms, enabling firms of all sizes to benefit from seamless automation, data interoperability, and intelligent decision-making. "Agentic AI is not just a buzzword—it's a strategic enabler," Rowe stated. "It empowers professionals to work at the top of their credentials, enhances client service, and creates competitive advantage. With open integration APIs, firms can build intelligent, responsive systems that adapt in real time." Wolters Kluwer is actively advancing the integration of agentic AI across its suite of tax and accounting solutions as part of its long-term innovation strategy centered on firm intelligence. Building on more than a decade of AI investment, these enhancements will empower professionals to automate complex workflows, enhance decision-making, and deliver greater value to clients. Customers can expect to begin experiencing these next-generation capabilities in the near future, reinforcing Wolters Kluwer's commitment to helping firms stay future-ready. Rowe concluded by encouraging firms to assess their current workflows, evaluate integration opportunities, and invest in talent and change management to become truly future-ready. Professionals interested in learning how Wolters Kluwer can help them prepare for the future are encouraged to contact their sales representative. Interview Opportunity Media interested in scheduling an interview with Cathy Rowe may reach out to Shannon Wherry, Associate Director, External Communications at About Wolters Kluwer Wolters Kluwer (EURONEXT: WKL) is a global leader in information, software solutions and services for professionals in healthcare; tax and accounting; financial and corporate compliance; legal and regulatory; corporate performance and ESG. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with technology and services. Wolters Kluwer reported 2024 annual revenues of €5.9 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries, and employs approximately 21,600 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands. For more information, visit and follow us on LinkedIn, Facebook, YouTube and Instagram. View source version on Contacts Media Contacts Shannon WherryAssociate Director, External CommunicationsWolters Kluwer Tax & AccountingOffice: +1
