ERA 2025
Semaglutide Significantly Improves Chronic Kidney Disease The landmark FLOW study shows the benefits extend to kidney, cardiovascular, and mortality outcomes in high-risk patients with type 2 diabetes and CKD. Medscape Medical News , May 24, 2024
Semaglutide Significantly Improves Chronic Kidney Disease Antinephrin Autoantibodies: Biomarker for Kidney Disease? Using an innovative analysis technique, researchers identified antinephrin autoantibodies as markers of difficult to diagnose kidney diseases. Medscape Medical News , May 26, 2024
Antinephrin Autoantibodies: Biomarker for Kidney Disease? SGLT2 Inhibitors Add to GLP-1s' Cardio, Kidney Benefits The largest analysis to date details added effects of SGLT2 inhibitors among those with type 2 diabetes when combined with GLP-1 receptor agonists.
Medscape Medical News, Jun 03, 2024
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Trump-Musk row fuels 'biggest crisis ever' at Nasa
The row between Donald Trump and Elon Musk over a major spending bill has exacerbated uncertainty over the future of Nasa's budget, which is facing deep cuts. The space agency has published its budget request to Congress, which would see funding for science projects cut by nearly a half. Forty science missions, which are in development or in space already, are in line to be stood down. The president has threatened to withdraw federal contracts with Musk's company, Space X. Nasa relies on the firm's Falcon 9 rocket fleet to resupply the International Space Station with crew and supplies. The space agency also expects to use its Starship rocket to send astronauts to the Moon and eventually to Mars once it has been developed. Dr Simeon Barber, a space scientist at the Open University said that the uncertainty was having a "chilling impact" on the human space programme. "The astonishing exchanges, snap decisions and U turns we've witnessed in the last week undermine the very foundations that we build our ambitions on. "Space science and exploration relies upon long term planning and cooperation between government, companies and academic institutions." Aside from the feud between the President and Mr Musk, there is also concern about deep cuts requested by the White House to Nasa's budget. All sectors have been earmarked for savings, apart from an effort to send astronauts to Mars, which has received a $100m (£736,000) boost. According to Casey Dreier, chief of space policy for the Pasadena-based Planetary Society, which promotes space exploration, the potential cuts represent "the biggest crisis ever to face the US space programme". Nasa has said that its request to reduce its overall budget by nearly a quarter "aligns (its) science and technology portfolios to missions essential for the exploration of the Moon and Mars". Dr Adam Baker, a space analyst at Cranfield University told BBC News that if these proposals are approved by Congress, it would fundamentally shift the agency's focus. "President Trump is repurposing Nasa for two things: to land astronauts on the Moon before the Chinese and to have astronauts plant a US flag on Mars. Everything else is secondary." Those who back the proposals say the White House's budget has given Nasa a clear purpose, for the first time since the days of the Apollo Moon landings of the 1960s and 70s, when the aim was to beat the Soviet Union to the Moon. Nasa's critics say that since then the space agency has become a bloated, unfocussed bureaucracy which routinely goes massively over budget in its space missions and wastes taxpayer's money. One of the most egregious examples of this is Nasa's new rocket for its plans to return American astronauts to the Moon, the Space Launch System (SLS). Its development has been delayed, and costs have spiralled such that it costs $4.1bn (£3.3bn) for each and every launch. By contrast, SpaceX's equivalent rocket system, Starship, is estimated to cost around $100m (£80m) per launch because it is designed to be reusable. Jeff Bezos's Blue Origin space company promises similar savings for its proposed New Glenn rocket. To no one's surprise, SLS will be phased out under the White House proposals, in the hope that Starship and New Glenn can take its place. But the past three development launches of Starship have been unsuccessful, and Blue Origin has only recently begun to test its Moon rocket. "The worry is that Nasa may be jumping out of the frying pan, into the fire," says Dr Barber. "The development of these alternatives to SLS is being bankrolled by Elon Musk and Jeff Bezos. "If they lose their appetite for this endeavor and SpaceX or Blue Origin say they need more money to develop their systems, Congress will have to give it to them," says Dr Barber. Nasa needs saving from itself – but is this billionaire right for that job? Of greater concern, says Dr Barber, is the potential loss of 40 missions to explore other planets and to monitor the impact of climate change on Earth from space, many of which involve collaborations with international partners. "I think it is very sad that what has taken so long to build can be knocked down with a wrecking ball so quickly with no plan to rebuild it afterwards." The projects facing the axe include dozens of planetary missions already in space for which most of the development and launch costs have already been paid for, with relatively small savings proposed on their operating costs. Also under threat are two collaborations with the European Space Agency: An ambitious plan to bring martian rocks collected by Nasa's Perseverance Rover back to Earth and a mission to send Europe's Rosalind Franklin Rover to the red planet to search for signs of past life. Prof Sir Martin Sweeting, head of the UK space firm Surrey Satellite Technology Ltd, and co-author of a Royal Society report on the future of space says that while the development was "unwelcome", there may be an upside for Europe as it takes greater responsibility for its own space exploration programme. "Maybe we have been too reliant on Nasa the big player to carry a lot of the emphasis in space," he told BBC News. "It is an opportunity to think about how Europe wants to get a better balance in its space activities." But there is much more downside for Europe in the short term. As well as the return of Mars samples and its Rover, ESA risks reduced access to the International Space Station if it is wound down, and the budget cuts cancel Nasa's extensive contributions to its successor, the Lunar Gateway, a multinational space station planned for orbit around the Moon. In its recently published strategy ESA stated it "will be seeking to build a more autonomous space capability, and to continue being a reliable, strong and desirable partner with space agencies from around the globe," with the implication that it would do so with or without Nasa. Also facing cuts are numerous current and proposed Earth Observation programmes according to Dr Baker. "These Earth observation programmes are our canary in the coal mine," he told BBC News. "Our ability to predict the impact of climate change and mitigate against it could be drastically reduced. If we turn off this early warning system it is a frightening prospect". The budget proposals have yet to be approved by Congress. The planetary Society's Casey Dreier has told BBC News that many Republicans have told lobbyists privately that they are prepared to vote against the cuts. But, Mr Dreier worries that there is a strong possibility that political gridlock might mean that no budget will be agreed. It is likely that the reduced White House budget would be put in place as an interim measure, which could then not easily be reversed, because once space missions are turned off it is hard, if not impossible, to start them up again.
Yahoo
an hour ago
- Yahoo
Beloved NYC eatery Jacob's Pickles shuttered over roaches, rats and sewage
Upper West Side eatery Jacob's Pickles was abruptly shuttered this week following a slew of icky code violations. The Department of Health temporarily closed the Southern-style dining hotspot after the place showed evidence of rats and roaches. The restaurant was also cited for having an 'improper, inadequate, or unapproved' sewage disposal system. An inspection report revealed that the venue, located at 509 Amsterdam Ave. between 84th and 85th Streets, also allegedly failed to properly protect 'food, supplies, or equipment' from possible contamination sources. The shutdown took effect Wednesday with a statement from the restaurant claiming they'll be back open come Monday. 'While unexpected, we're genuinely grateful this issue was brought to our attention,' the statement read. 'With the guidance of the health department, we uncovered underlying structural issues that contributed to unforeseen facility maintenance challenges. 'The safety of our guests and staff is always our top priority, and we will not reopen until every concern is resolved in full compliance with NYC Health Code standards,' the statement concluded. The restaurant's website stated that Jacob's Pickles was closed for renovations and 'will open in a few days.' Jacob's Pickles has had a C rating with the Department of Health since December. Owner Jacob Hadjigeorgis said in May 2024 he would move the American restaurant to a new location at 688 Columbus Ave., between 93rd and 94th Streets, after which he planned to open a new bar, Velvet Cowboy, inside the space Jacob's Pickles had occupied. It's unclear if Hadjigeorgis' plans have changed.
Yahoo
an hour ago
- Yahoo
Young People Are Getting Colon Cancer At An Alarming Rate. Here's The One Thing Experts Say Can Lower Your Risk.
Dense bean salads, which use beans as a salad base instead of lettuce, are all the rage on social media for good reason. The beans, along with the fresh veggies in the dish, help you reach your daily fiber goal, a number that experts say most Americans don't hit, which isn't good. Eating enough fiber is a crucial way to reduce your risk of colon cancer, a type of cancer that's on the rise in people 50 and younger in the US. (It's recommended that women eat roughly 25 grams of fiber each day while men consume about 38 grams, but most adults eat roughly 10 grams of fiber each day.) Decades ago, researchers found that people in Uganda had very low rates of colon cancer when compared to Americans because of their diet, which was high in fiber — veggies, fruits and grains — and low in meat, said Dr. Ron Quinton, the medical director of the Goldring Center for Culinary Medicine at Tulane University in New Orleans. Specifically, colon cancer occurred at a rate of 3.5 out of 100,000 in men in Uganda compared to 51.8 out of 100,000 in men in Connecticut. 'And I think that's the first time that it was really noticed that this was a prevention for colon cancer,' noted Quinton. Meaning, it's really important to prioritize your fiber consumption. There are multiple ways that fiber benefits colon health and even more ways to reach the daily recommended amount. Here's what experts say: Eating enough fiber helps move your stool through your digestive tract. 'Fiber plays an important role in the health of the colon, and when the colon gets unhealthy, then we're set up for development of cancer and other inflammatory diseases,' said Quinton. Overall, fiber adds bulk to the stool, which helps with proper colon function. '[Fiber] makes the stools more easy to move along, so the time that the stool spends in the colon is lessened, so less chance for constipation, more normal stools,' explained Quinton. This is also good for the removal of toxins: 'If there are any toxins in the stool that lead to cancer, they spend less time in the colon, and therefore lessen the chances of cancer exposure or other diseases,' he said. Fiber also benefits the microbiome, which is protective against colon cancer, too. Related: I'm Still Recovering From How Hard These 15 Women Made Me Laugh With Their Comedic Perfection This Week Fiber is also important for the microbiome, which has been the main focus of research in the past decade, said Mary Ellen Camire, a professor of food science and human nutrition at the University of Maine. Fiber is often prebiotic, meaning it's food for probiotic bacteria, Camire added. And probiotics help rebuild and balance your microbiome. 'When the bacteria get a nice fiber meal, they are very active, and they make compounds that help protect the colon' against colon cancer, along with other kinds of cancers, she explained. More, the cells that line the colon, which are called colonocytes, get their energy from the microbiome, added Quinton. 'And when the colonocytes are healthy, then they form an intact barrier along the colon, so that substances that may cause disease or cancer can't cross that barrier,' Quinton said. 'It also helps the colon produce mucus [and] thick mucus lining also protects the colon, so without enough fiber, our microbiome gets diseased and they don't produce the energy or nutrients that our colon needs to stay healthy,' he noted. Here's how you can eat more fiber: Related: 19 "Body Changes" That Clearly Indicate A Person Is Not Young Anymore, And I'm Not Ready For This Reality 'Fiber is a really critical part of our overall diet, and the typical American only gets 5 or 10% of the recommended amount of fiber in their diet on any given day,' said Quinton. As mentioned above, women need about 25 grams of fiber each day and men need about 38 grams, he said. Beans and legumes are very high in fiber and certain fruits and veggies are, too. Lentils have 18 grams of fiber per cup, black beans have about 15 grams in 1 can, chia seeds have 10 grams in 2 tablespoons, barley has 6 grams in 1 cup, raspberries have 8 grams in 1 cup and a pear has 6 grams, according to the Cleveland Clinic. This summer, you could make a bean and whole wheat pasta salad to up your fiber intake, or make some cold barley salads, said Camire. You can also lean into seasonal produce, she said. Camire added that it's important to spread your fiber intake out across the day and to consume different kinds of foods for fiber. 'The mistake a lot of people make when they decide 'I'm going to make fiber a priority' is they don't give their system time to adjust. If you're used to eating 15 grams of fiber a day, and you start eating 30 grams a day, the bacteria think they're having a party and so you may have some gas and cramping,' Camire said. You should start out gradually and slowly build up, she noted. 'Once you find the foods that you tolerate well and that you like, getting enough fiber won't be difficult or expensive,' Camire added. And fiber supplements don't cut it. It's tempting to turn to fiber supplements as a quick and easy way to reach your fiber goal, but experts say you shouldn't. 'None of the supplements ... are an adequate replacement for natural fiber,' Quinton said. Also, since you need so much fiber, fiber supplements end up being just a drop in the bucket, Camire added. While some of the supplements can increase your stool bulk and help constipation, 'they don't necessarily have the soluble fiber elements that feed the microbiome and keep it healthy, which keeps your gut healthy,' said Quinton. 'I don't think you can just replace the fiber with supplements. You need to be eating whole food,' Quinton added. Beyond fiber intake, there's more you can do to lower your colon cancer risk. It's important to also take other preventative steps to lower your risk of developing colon cancer. These include monitoring yourself for concerning symptoms such as ongoing stomach pain, blood in your stool or a change in your bowel movements. If you notice these symptoms, talk to your doctor. It's also important to let your doctor know if colon cancer runs in your family as you may be eligible for an early colonoscopy screening. Colonoscopy screenings start at 45 for those with no family history and without the symptoms mentioned above, but no matter when you're eligible, colonoscopies are the best way to screen for colon cancer and remove potentially precancerous polyps. 'During a colonoscopy, if we see a polyp, and we believe it to be the precancerous kind, which the vast majority are, we will remove those polyps at the colonoscopy,' Dr. Jeffrey Dueker, a gastroenterologist at UPMC and an associate professor of gastroenterology at the University of Pittsburgh School of Medicine, previously told HuffPost. 'And in doing so, we are reducing the colorectal cancer risk going forward,' Dueker added. With rising colon cancer rates in the U.S., it's important to do what you can to lessen your risk, which includes eating a high-fiber diet, going to necessary doctor's appointments and monitoring yourself for article originally appeared on HuffPost. 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