Michigan State vs Ole Miss men's basketball predictions, picks, odds for 2025 men's Sweet 16
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The second night of the men's 2025 NCAA Tournament Sweet 16 is underway and there are four more juicy matchups Friday to devour as the March Madness bracket dwindles down to eight teams by the weekend.
No. 2 Michigan State and No. 6 Ole Miss will start things off with a South region matchup that will pit two coaches who last faced each other in the NCAA Tournament during the 2019 Final Four. Ole Miss coach Chris Beard got the better of Michigan State's Tom Izzo in that matchup when Beard was still coaching at Texas Tech.
This year, Beard has the Rebels in the Sweet 16 for the first time since 2001 after wins over the North Carolina Tar Heels and Iowa State Cyclones in the opening two rounds of March Madness. Izzo, meanwhile, has the Spartans in the Sweet 16 for the 16th time during his Hall of Fame career after winning the Big Ten regular-season title this season and beating the Bryant Bulldogs in the first round and the New Mexico Lobos in the round of 32.
Michigan State ranks as the seventh-best team in the KenPom rankings, sporting the 25th-best offense and fifth-best defense. Meanwhile, Ole Miss ranks 21st overall with the 24th-ranked offense and 21st-ranked defense.
Here's how our experts see Friday's Sweet 16 clash playing out. Be sure to check out the complete Sweet 16 schedule, times and TV info, as well as our power rankings.
Michigan State vs. Ole Miss Sweet 16 picks and predictions
Jeremy Cluff: Ole Miss 74, Michigan State 69
Craig Meyer: Ole Miss 71, Michigan State 67
Sportsbook Wire: Michigan State 76, Ole Miss 72
Sam Hutchens: Michigan State 79, Ole Miss 78
Our four experts are splits, with two backing the Ole Miss Rebels to pull off the upset. AZ Central's Jeremy Cluff and USA TODAY's Craig Meyer are taking them to win outright along with the under 143.5-point total, while Sportsbook Wire and Clarion Ledger's Sam Hutchens laying the 3.5-point spread with Michigan State and taking the over.
Michigan State vs. Ole Miss date, start time, where to watch
Game Day: Friday, March 28, 2025
Friday, March 28, 2025 Game Time: 7:09 p.m. ET
7:09 p.m. ET Location: State Farm Arena in Atlanta, Georgia
State Farm Arena in Atlanta, Georgia TV Channel: CBS
CBS Live Stream: Fubo - Watch Now!
Watch Michigan State vs. Ole Miss on Fubo
Michigan State vs. Ole Miss odds
Odds as of Monday, March 24 via BetMGM.
Spread: Michigan State (-3.5)
Michigan State (-3.5) Moneyline Favorite: Michigan State -175
Michigan State -175 Moneyline Underdog: Ole Miss +140
Ole Miss +140 Total: 144.5
March Madness Sweet 16 results, predictions
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