Eli Lilly and Co (LLY): Expands Genetic Hearing Loss Pipeline with $1.3B RNA Therapy Partnership
On May 16, Eli Lilly and Company (NYSE:LLY) announced a partnership with Rznomics to develop RNA-based gene therapies for sensorineural hearing loss, with milestone payments exceeding $1.3 billion. Rznomics will lead early-stage research, while Lilly handles clinical development and commercialization using RNA editing, a reversible alternative to CRISPR.
A healthcare professional working on a computer terminal with a patient in the background.
The collaboration complements Lilly's existing genetic hearing loss pipeline, including AK-OTOF, a Phase I/II AAV gene therapy targeting OTOF gene mutations. Early data showed hearing restoration in a trial participant within 30 days. Eli Lilly and Company (NYSE:LLY) also signed a $1.4 billion deal with Sangamo Therapeutics for CNS gene therapy in April 2025.
Industry focus on genetic hearing loss treatments is growing, with Regeneron's DB-OTO showing measurable hearing improvements in 10 of 11 pediatric patients. Rznomics, which raised $58 million in funding, sees the partnership as a step toward global biotech expansion. CEO Seong-Wook Lee emphasized the potential of precision RNA therapeutics in treating previously untreatable diseases.
While we acknowledge the potential of LLY as an investment, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than LLY and that has 100x upside potential, check out our report about the .
READ NEXT: 20 Best AI Stocks To Buy Now and 30 Best Stocks to Buy Now According to Billionaires.
Disclosure: None.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
CNET
39 minutes ago
- CNET
These 6 Attitudes Are Secretly Wrecking Your Weight Loss Goals
The official start to summer is fast approaching, so you might be doubling down on your health goals -- whether it's feeling better in your body, boosting your energy or simply making smarter choices day to day. But if you've been working hard and the scale isn't budging, you're not alone. Despite what Instagram influencers might suggest, weight loss isn't instant, and progress doesn't always follow a straight line. Real results take time, consistency and some serious patience. Still, it's easy to feel stuck or discouraged when your efforts don't seem to pay off. The truth is, a few everyday habits might be quietly sabotaging your progress without you realizing it. The good news? Once you know what to watch for, you can course-correct fast. From overlooked snacking to underestimating your stress, these sneaky pitfalls could be standing between you and your goals-and fixing them might be simpler than you think. It's totally normal to hit a wall or feel like your progress has stalled. But that doesn't mean you're doing anything wrong. Whether you're focusing on nutrition, getting more movement in or taking care of your mental health, you're still moving forward. To help you stay on track, here are a few common habits that might be holding you back -- and how to fix them. Read more: 6 Wellness and Fitness TikTok Trends Experts Want to 'De-Influence' 1. Thinking in the short term Everything on this list is somewhat of a hard truth, but this is often the hardest to accept (and change). If you approach weight loss with a short-term attitude, you may not make it anywhere except on the yo-yo diet train. Without a long-term approach to weight loss, you may lose 10 or more pounds in two weeks and then suffer a rebound when you discover that regimen wasn't working for you. This is all too common when people embark on strict diets such as keto or paleo, or fad diets that promise rapid weight loss. In reality, for most people, a well-balanced diet that includes all food groups and even some treats works best in the long run. Part of successful, sustainable weight loss — losing the weight and keeping it off for good — is understanding that fad diets, excessive exercise and "detoxes" don't usually work. They last only as long as your willpower lasts, and I'm willing to bet that's not more than two weeks to a couple of months. Despite what the wellness industry might have you believe, there are no quick fixes, miracle cures or magic pills when it comes to weight loss. Losing weight requires dedication to a plan that supports long-term healthy habits. The general recommendation for weight loss is a rate of 1 to 2 pounds per week, although initial weight loss might surpass that for people who are very overweight and then slow down to the suggested 1 to 2 pounds per week. Studies have shown this to be an effective way to lose weight without losing too much water or lean tissue and to avoid a rebound. Overcoming an all-or-nothing mindset promotes long-term weight loss.2. The all-or-nothing mindset Many people who struggle with a short-term attitude also struggle with an all-or-nothing mindset. I began my health and fitness journey with this mindset. I cut out all processed foods: no bread, no pasta, no milk, no cheese and no individually wrapped snacks. I basically existed on chicken, vegetables and berries. This was great until it wasn't, and I ended up on a CVS run for all the chocolate and Goldfish I could hold in two hands. Then, because I'd "ruined" my diet, I would eat as much as I could physically handle, because, "Why not? I already ruined it." Then I'd feel bad about the snacks I ate and return to my overly restrictive regimen the next day. This is a destructive cycle to be in, but it's something I see all the time with personal training clients. An all-or-nothing mindset can keep you in a perpetual cycle of lose-gain-lose, not to mention shame and guilt around food. This all-or-nothing concept applies to fitness too: If you've been doing the most effective workouts to get in shape in the least amount of time left and right but don't feel fitter or stronger, you might be doing too much. Toning it down could, counterintuitively, be the answer to improving your fitness (and playing the long game). A supportive community, in real life or online, can keep you motivated to lose weight and stay fit.3. Believing you can do it all on your own Supportive friends, family members and significant others are critical to successful weight loss. If I were asked to cite the most common reason for not sticking to a healthy diet from my past personal training clients, I would say stigma. That's right. As silly as it sounds, people really do get made fun of for eating healthy, especially in regions where food is an integral part of the culture. Growing up in southern Louisiana near New Orleans, I experienced this very often when I decided I was making changes to my diet. At family gatherings and social outings, I'd get comments like, "That's all you're eating?" or, "You're really not going to eat any dessert?" or, laden with sarcasm, "Next time we'll have a salad potluck." It's not fun to be ridiculed or scoffed at, especially for things you care about (like your health!), so it can be very easy to fall into a trap of eating and drinking for the sake of your social life. This is why a solid support system is key to long-term weight loss. Without it, the journey can feel lonely and intimidating. If you currently feel you lack a support system, try having open conversations with your friends, family and partner about it. You can make it clear that they don't have to change their eating habits if they don't want to but that your health means a lot to you, and you'd appreciate it if they didn't mock or downplay your hard work. If an IRL support system isn't working out, turn to online communities that promote both health and body positivity. I really love Flex and Flow on Instagram, Health At Every Size and the Intuitive Eating Community. These communities emphasize health without emphasizing weight, which is helpful because when you focus on health outcomes, you'll reach your happy weight with ease. Reddit also has a great forum (/r/loseit) where you'll find lots of real-life stories about weight loss. Exercise is important for an overall healthy lifestyle, but it's hard to lose weight from exercise alone.4. Exercise conquers it all theory If you're at all attuned to the wellness industry, you'll know this saying: "Abs are made in the kitchen, not the gym." Even if your goals don't include a shredded stomach, the adage is still relevant. You just can't out-exercise a poor diet. Exercise should be part of your overall approach to weight loss because it's proven to aid weight loss (not to mention its long list of other health benefits), but it's difficult to lose weight from exercise alone. Many people overestimate the number of calories they can burn from their workouts. I's typically a lot less than you think and far less than the calories your body burns at rest during the day just maintaining your current physique. For example, a 154-pound man will burn fewer than 450 calories during an intense, hour-long weightlifting workout. You can easily cancel that effort out if you don't pay any attention to your diet. The exact number of calories you burn during exercise depends on many factors, including your current weight, the intensity of the activity, the length of the workout, your age and your body composition. Plus, focusing on only exercise can lead to a destructive cycle of exercising extra to burn off calories you feel you shouldn't have eaten. Or you may end up feeling like you need to "earn" your calories through exercise. Either way, taking this approach can lead to a strained relationship with food and exercise, as well as stalled weight loss. Some people, such as those who have spent years putting on muscle mass, can eat lots of calorie-dense food and not gain weight because muscle burns more calories at rest. Even if you can eat whatever you want and lose or maintain your weight, that doesn't mean it's healthy for you. A diet rich in fruit, vegetables, healthy fats, lean proteins and some whole grains will serve you best in terms of sustainable weight loss and health. Combined with a consistent exercise routine, you'll experience sustained weight loss and weight maintenance once you reach your goal weight. Chronic stress and sleep deprivation can hinder weight loss progress. Getty Images 5. Your sleep and stress levels don't matter Losing weight will be much harder if you're chronically stressed, sleep-deprived or overworked. This scenario may sound familiar to you: You wake up motivated interval run A few hours into the day, your lack of sleep catches up with you. You reach for the afternoon coffee By the time work is over, you're way too drained to go for that run. You decide to skip it. You're tired and maybe a little stressed or moody, so you nix the healthy dinner and hit a drive-through instead, because you want comfort food. This is fine if it happens occasionally (everyone deserves a lazy evening every once in a while), but weight loss will seem impossible if this happens all the time. The truth is that nutrition and exercise are only two components of a healthy life that can lead to weight loss. While important, too strong of a focus on nutrition and exercise can cause you to overlook other factors that are just as important: sleep and stress management. Supplements will not work unless you do. Basak6. Supplements will do all the heavy lifting I hate to be the bearer of bad news, but that fat burner supplement in your medicine cabinet isn't going to do the work for you. Certain supplements may help you reach your weight loss goals, but you have to work to make your supplements work. For example, incorporating a daily protein shake in the mornings can help you feel fuller throughout the day, which may help keep cravings at bay. Increased protein intake can also help you build muscle, which aids in body recomposition. Certain weight-loss supplements do have some evidence backing them, but no supplements are proven like the method that no one wants to take: eat fewer calories than you burn.
USA Today
an hour ago
- USA Today
How to clean your dog's, cat's teeth without a toothbrush: Video
Cats and dogs need dental care, too! While they don't need routine visits to the dentist like their human companions do, it is still just as important to keep their teeth clean as it is to keep yours clean. Like humans, pets can have bad breath and face the risk of plaque buildup, gum disease and tartar, which can cause oral health issues and could result in the loss of teeth, or the costly professional removal of teeth. However, since they lack opposable thumbs and the ability to use a toothbrush, they need some help from you. Watch this video for 4 easy ways to keep your pet's teeth clean. How often should you brush your dog's teeth You should aim to brush your dog's and cat's teeth at least 2-3 times per week, according to PetMD. Need a break? Play the USA TODAY Daily Crossword Puzzle. Many veterinarians perform a routine check of your pet's mouth during a routine visit, where they will see any oral issues developing in your pet's mouth. How to brush a dog's, cat's teeth The best way to familiarize your pet with having their teeth cleaned is to start getting them used to it as soon as you can. The younger they are when you start, the easier it is to do as they get older. First, you need the right tools: a pet-safe toothbrush and toothpaste. For puppies and kittens, start by getting them used to having a toothbrush in their mouth and the lifting of their lips. You can easily incorporate this into their regular grooming routine, so they are familiar with being brushed, having their nails trimmed and having their teeth checked and cleaned. Not all pets are comfortable with having their teeth brushed, so it may require some time, effort and patience to get your pet comfortable with it, especially if the animal is older. Fortunately, using a toothbrush isn't the only way to clean your pet's teeth. Keep reading for some toothbrush-free alternatives. Shop top-rated related products: Easy ways to clean your dog's teeth Our lives are busy, so frequent brushing of our pets' teeth isn't always feasible. Consider some of these alternatives that still allow you to clean their teeth, but might be a more manageable way to go about it. Let a professional handle it. Some pets don't do well with oral care, so ask your vet for a recommendation on where to get your pet's teeth professionally cleaned. However, depending on the pet and the dental care or work that's needed, it may require them to go under anesthesia and can be costly. Some pets don't do well with oral care, so ask your vet for a recommendation on where to get your pet's teeth professionally cleaned. However, depending on the pet and the dental care or work that's needed, it may require them to go under anesthesia and can be costly. Finger toothbrush. These fit on your finger and are an alternative to a traditional toothbrush. These are good for smaller dogs. However, keep in mind your pet's temperament and consider any potential risks of putting your finger in their mouth. These fit on your finger and are an alternative to a traditional toothbrush. These are good for smaller dogs. However, keep in mind your pet's temperament and consider any potential risks of putting your finger in their mouth. Plaque wipes. Use these to wipe their teeth and gums to help fight against plaque buildup. Wipes can be a good alternative if your pet isn't a fan of the toothbrush or considers it a toy, not a cleaning tool. Use these to wipe their teeth and gums to help fight against plaque buildup. Wipes can be a good alternative if your pet isn't a fan of the toothbrush or considers it a toy, not a cleaning tool. Powders or chews. These alternatives don't require as much work or risk of directly brushing your pet's teeth. These alternatives don't require as much work or risk of directly brushing your pet's teeth. Toys. Make teeth cleaning fun and let a toy do all the gritty work. Some rope toys can double as a flosser, while some harder toys can work on fighting plaque and other gunk on teeth. Just look at the label to see if the toy also doubles as a teeth cleaner. Also, check that the toy is appropriate for the size and age of your pet.
CNN
an hour ago
- CNN
Wall Street is making some seriously weird trades
Wall Street traders hunting for profits might find that the most lucrative investments are in the peculiar market for precious metals. Gold, silver and platinum prices have surged this year as investors have piled into precious metals in search of places to hide from trade war uncertainty. President Donald Trump's chaotic tariff plan has rocked markets, and investors have tried to minimize risk by putting some money in safe haven assets. While gold is historically considered a haven, demand for havens has spilled over into its wonky cousins like silver and platinum. The metals craze is reflected in the numbers: Precious metals are trouncing the US stock market this year. Gold has soared 27.5%, silver is up 24% and platinum has surged a whopping 36%. Meanwhile, after rising by 23% last year and 24% in 2023, the S&P 500 is up less than 3% so far this year; there is an unusual amount of jitters in the normally staid bond market; and the US dollar has broadly weakened after rising 7% last year. As bonds have been volatile and the dollar has weakened amid tariff turmoil, weird investments like silver and platinum have emerged as a way to hedge against the tremendous uncertainty. 'These dynamics have further incentivized investors to diversify away from traditional financial instruments and toward tangible assets,' Ole Hansen, head of commodity strategy at Saxo Bank, said in a Friday note. 'Gold continues to be the primary haven,' Hansen added, 'but with bullion demand showing signs of stalling as investors look for a fresh trigger to propel prices higher, we have instead in recent weeks seen heightened interest in silver (and) platinum.' Silver and platinum prices have surged higher in recent weeks as investors have sought ways to diversify their portfolios. Supply constraints have also pushed prices higher, Hansen said, and the metals increasingly look like a 'rational hedge against political and financial instability.' 'These commodities are viewed as politically neutral; unlike sovereign bonds or foreign currencies, they carry no counterparty risk and are not tied to any nation's credit rating,' Hansen said. 'While we remain cautious about predicting an imminent surge to new all-time highs, the macroeconomic backdrop is increasingly supportive of precious metals.' Precious metal prices have also pushed higher as investors have picked up on budding rallies, building a momentum-driven trend, according to Steve Sosnick, chief strategist at Interactive Brokers. Bank of America's survey of global fund managers in May showed that gold was the most crowded trade for the second month in a row. That snapped the Magnificent Seven tech stocks' 24-month streak as the most crowded trade. During the first quarter of the year, gold posted its strongest quarterly return since 1986. The yellow metal is up 27.5% this year, following its 27% surge from last year. Gold surged higher this year as investors fretted over the uncertain outlook for tariffs. Spot gold prices in April briefly rose above a record high of $3,500 a troy ounce. Gold traded around $3,350 a troy ounce as of Wednesday. Gold is considered a resilient investment and a hedge against inflation, with investors betting it will retain its value when prices rise. While Wall Street has gold fever, the price of gold has also been boosted by central banks around the world, including in India and China, buying bullion to add to their reserves. Gold demand from central banks was a key driver of its price surge in 2024, according to the World Gold Council, a trade group. Another factor driving gold prices higher has been a weaker US dollar, Sosnick said. When the dollar weakens, commodities like gold tend to perform well as it becomes cheaper for foreign investors to buy bullion. The US dollar index, which measures the dollar's strength against six major foreign currencies, is down almost 9% this year. 'Gold continues to consolidate above $3,300, underpinned by persistent geopolitical risks, uncertainty on trade and a soft dollar,' said Peter A. Grant, vice president and senior metals strategist at Zaner Metals, in a Tuesday note. As gold has soared higher, silver has started to catch up. Spot silver prices have surged 24% this year after soaring 21% in 2024. Silver this week crossed $36 a troy ounce and hit its highest level since 2012. Michael DiRienzo, president and CEO at the industry group Silver Institute, told CNN that silver prices have surged higher due to industrial demand and heightened economic uncertainty. 'There's just a lot of concern about the global economy, and when that happens, people turn to hard assets like silver,' DiRienzo said. 'Silver tends to follow gold upwards,' he added. Silver is widely used for industrial purposes, including data centers, solar panels and smartphones, and uncertainty about tariffs has caused demand for silver to surge, DiRienzo said. 'It's really reverting back to its dual use as an industrial metal and as a precious metal,' he said. 'And both sides of the ledger are kind of coming together to push this price forward.' Sustained demand for silver, driven by investors and industry, could push the metal to record highs, according to commodities research firm CPM Group. 'Silver offers an attractive entry point for investors seeking alternatives to high-priced gold, bolstered by its extensive industrial applications,' analysts at CPM Group said in a May note. People can invest in silver or gold in the form of bars and coins, or in the form of exchange-traded funds. The iShares Silver Trust ETF has surged 25% this year alongside the price of silver. The SPDR Gold Trust ETF has surged 27% this year. Sosnick at Interactive Brokers said he also thinks silver's rise has been momentum-driven as traders have tried to join in on the rally. Platinum has also surged alongside silver as a less costly investment than gold. Platinum has gained a whopping 36% this year after falling almost 10% across 2024. Spot platinum prices this week rose above $1,200 a troy ounce and hit their highest level since 2021. 'While gold has dominated the performance of the metals complex over the last year, we are starting to see the laggards like platinum … emerge from bases to catch-up a bit,' said Jonathan Krinsky, chief markets technician at global financial services firm BTIG, in a recent note. The precious metal, which is used in industries including automotive and jewelry, has rallied largely due to demand exceeding supply. Platinum has surged higher in recent weeks after the World Platinum Investment Council, a trade group, projected a deficit for the third year in a row. 'This anticipated shortfall, which will draw down existing above-ground inventories, is being driven by demand from the automotive sector and, notably, a surge in Chinese interest in jewelry, bars and coins,' Saxo Bank's Hansen said. 'Jewelers are the second-biggest platinum buyer after the auto industry,' analysts at Bank of America said in a Friday note. 'After years of declining demand, there is anecdotal evidence that interest in platinum jewelry is now bouncing back in China.' 'Rising gold prices are incentivizing jewelers to diversify, in what represents a change to historical patterns,' the analysts noted.
