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AbbVie says blood cancer drug fails late-stage trial

AbbVie says blood cancer drug fails late-stage trial

Reuters6 hours ago

June 16 (Reuters) - AbbVie (ABBV.N), opens new tab said on Monday its treatment for a group of blood cancers failed to meet the main goal of overall survival in a late-stage trial.
The company was testing the drug in newly-diagnosed patients with higher-risk myelodysplastic syndromes, a group of cancers in which the bone marrow doesn't produce enough healthy blood cells.
The drug, Venclexta, is already approved for the treatment of another type of blood cancer called leukemia and is jointly developed by AbbVie and Swiss drugmaker Roche (ROG.S), opens new tab.
U.S.-based AbbVie reported global Venclexta sales of about $2.6 billion in 2024.

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EXCLUSIVE Experts reveal biggest challenge to Trump's Canada-funded $175B 'Golden Dome' defense dream
EXCLUSIVE Experts reveal biggest challenge to Trump's Canada-funded $175B 'Golden Dome' defense dream

Daily Mail​

time27 minutes ago

  • Daily Mail​

EXCLUSIVE Experts reveal biggest challenge to Trump's Canada-funded $175B 'Golden Dome' defense dream

When President Donald Trump first rolled out his plan for a new 'Golden Dome' to 'protect our homeland' he described it as a space age shield against growing threats. 'Ronald Reagan wanted it many years ago, but they didn't have the technology,' Trump said at the time, invoking Reagan's 'Strategic Defense Initiative or ' Star Wars ' missile defense system. He even told Canada the tab would be $61 billion if they wanted in on the project. Now, as Trump shuttles through meetings with G7 partners including Canada, some defense experts are questioning the origins of the plan and whether it can provide the security Trump claims. 'Trump thinks its cool. That's what's driving it,' Justin Logan, Director of Defense and Foreign Policy Studies at the libertarian Cato Institute told the Daily Mail. 'To me, the whole thing was undercooked,' he said. The idea, at a time when global powers like China and Russia are developing hypersonic missiles while 'rogue' states refine their own missile programs, is to use a network of space satellites and ground-based sensors to identify and blow up incoming threats to the U.S. It's a concept with considerable appeal at a time when Iran is lobbing missiles at Israel in response to a bombing campaign targeting their nuclear facilities and military leaders. But key elements of the satellite role are already coming into question, following a report that SpaceX head Elon Musk's role is now in doubt. Amid Trump's epic feud with the world's richest man, planners are now looking at a 'new framework' which would scrap the need for Musk's network of orbiting satellites. Instead the plan would be to focus on 'existing ground systems for missile defense instead,' according to one report. Musk's company had been expected to play a vital role in launching space sensors and even armed satellites that could play a role in defense. 'The Trump Administration is committed to a rigorous review process for all bids and contracts, prioritizing the best deal for America and leveraging the most advanced and innovative technology. Decisions will be made at the appropriate time, based on thorough evaluation, and will not be previewed in the press,' White House principal deputy press secretary Harrison Fields told the Daily Mail amid the uncertainty. There is already $25 billion for Golden Dome in the House tax reconciliation bill, but if Trump's 'big, beautiful' bill fails in the Senate, the program couldn't get off the ground. Sen. Rand Paul (R-Ky.) is already demanding more spending cuts, as Trump seeks to win his vote. It could be a heavy lift to really get the Canadians on board for paying for it. A new poll shows more than 60 percent of Canadians are against the idea. Canada's ambassador to the UN compared Trump's call for Canadian funding to a 'protection racket.' Trump had posted: 'I told Canada, which very much wants to be part of our fabulous Golden Dome System, that it will cost $61 Billion Dollars if they remain a separate, but unequal, Nation, but will cost ZERO DOLLARS if they become our cherished 51st State. They are considering the offer!' Trump posted. 'In another context, this would (be) called a 'protection racket,' Rae said. Comparison to Isreal's 'Iron Dome' are proving inexact. Wrote Paul Meyer, an professor of international studies at Simon Fraser University in British Columbia: 'The President seems to have failed to grasp that Israel's 'Iron Dome' system (which inspired his vision) has succeeded as a result of the relatively small size of its territory that has to be defended and the relatively slow re-entry speed of the short and medium range ballistic missiles it has countered. 'These advantages would not pertain to the territory of the US (let alone North America) against intercontinental ballistic missiles (ICBMs) with re-entry speeds of 7 kilometres a second.' Joe Cirincione of the Center for International Policy called national missile defense 'the longest-running scam in the history of the Department of Defense.' And even that system is experiencing occasional 'leakage,' with comparatively slow and easier-to-track Iranian missiles breaking through defenses to cause civilian deaths. 'The idea that you're going to model something on Iron Dome that's going to protect the us from Russia and China is just not a thing,' said Logan. 'In this case, it was like, Israel has Iron Dome. It's kind of cool. We should do the Golden Dome. And then a lot of people rush to fill the gaps without specifying what 'Golden Dome' was,' he said. There are also questions about how it might alter Cold War calculations on deterrence. If foreign adversaries conclude the Americans think they are protected, it could put the US in a more aggressive posture – which could in turn motivate foreign adversaries to strike first before it is too late. In what could be a telling sign, a senior administration official sketching out priorities for the G7 summit that gets underway Monday in Kananaskis mentioned trade, minerals, migration, drugs, wildfires, international security, AI, and energy.'

Four sick across two states as health officials warn of salmonella tied to pistachio spread
Four sick across two states as health officials warn of salmonella tied to pistachio spread

The Independent

time28 minutes ago

  • The Independent

Four sick across two states as health officials warn of salmonella tied to pistachio spread

A salmonella outbreak has left four people sick and health officials warning about a dessert spread. Three people in Minnesota and one in New Jersey fell ill between March 10 and May 19, including one person who was hospitalized. The outbreak is tied to Emek brand pistachio cream with a use-by date of Oct. 19, according to the Centers for Disease Control and cream, a nut butter spread, is used in desserts and other dishes, federal health officials said Monday. The spread, which may be packaged in 11-pound tubs, was imported from Turkey and sold online to wholesale distributors, restaurants and food service locations nationwide. It has a production code of 241019. The product should not be sold, distributed or served, the CDC said. Symptoms of salmonella poisoning can occur within hours or days of consuming contaminated food and include diarrhea, fever and stomach cramps. Most people recover within a week, but some can become sick enough to be hospitalized. Young children, people older than 65 and those with weakened immune systems are most at risk. According to the CDC, Salmonella is responsible for 1.35 million infections each year. Of those, about 26,500 are hospitalized and 420 are killed annually. Roughly 23 percent of Salmonella cases come from eating chicken and turkey.

Kevin Durant's tenure in Phoenix looks finished as Suns 'make major trade decision' on future Hall of Famer
Kevin Durant's tenure in Phoenix looks finished as Suns 'make major trade decision' on future Hall of Famer

Daily Mail​

time36 minutes ago

  • Daily Mail​

Kevin Durant's tenure in Phoenix looks finished as Suns 'make major trade decision' on future Hall of Famer

Kevin Durant may want to play in South Florida or Texas next season, but that doesn't matter much in Arizona 's Salt River valley. As previously reported by ESPN's Shams Charania, the Phoenix Suns star wants to be traded to the Miami Heat, San Antonio Spurs or Houston Rockets this summer. However, on Monday, NBA insider Jake Fischer reported on Marc Stein's Substack page the Suns will seek the best trade they can find for Durant and not necessarily a move to one of his preferred destinations. Daily Mail has reached out to Suns spokespeople and Durant's agent Rich Kleiman for comment. This would open up considerably more possibilities for Durant, who is eyeing a move to a potential fifth franchise for a chance at a third NBA title at age 36. He remained effective in 2024-25 despite his advancing age by ranking seventh in scoring at 26.6 points a game thanks to 43-percent accuracy from beyond the arc – better than all but 10 players in 2024-25. Although it's unclear who the Suns are speaking with about Durant, The Athletic's Kelly Iko reported earlier this month that Phoenix has gradually reduced its asking price for the Olympic gold medalist. Durant was the crown jewel of the team makeover after owner Mat Ishbia bought the Suns in 2022. The former Texas Longhorns star did not come cheaply, however, as Phoenix surrendered four unprotected first-round picks and a future pick swap as well as Mikal Bridges and Cameron Johnson to the Brooklyn Nets in the deal. At the time, then-ESPN NBA insider Adrian Wojnarowski reported the trade was Ishbia's idea, writing it was 'very much on the ownership level' between the Suns boss and Nets governor Joe Tsai. Ishbia pushed back on that reporting soon after, saying the decision was unanimous. 'It wasn't a tough decision,' he told reporters in Phoenix. 'We really didn't want to give up some of the guys, because we love those guys. They were winners and we didn't want to give them up. 'But at the end of the day the right decision was, what do we do to maximize our team for today and for the next three to four years? This is going to be what the Phoenix Suns are about.' The Suns would go on to add high-scoring Washington Wizards guard Bradley Beal to a core that already included Devin Booker, while Ishbia reiterated his desire to keep Durant in Phoenix. Ishbia shot down any trade speculation in 2024 when the Rockets were reportedly interested. 'Everyone talking about the drama and storylines, some are right and some are just wrong,' Ishbia wrote on social media. 'My turn. Phoenix loves Kevin Durant and Kevin Durant loves Phoenix, and we are competing for a championship this year because we have the team to do it.' The billionaire even told reporters in November he expected to sign Durant to a contract extension. Then the Suns fell off the map, missing the playoffs at 36-46 as Durant, Booker and Beal once again struggled to gel under coach Mike Budenholzer, who was fired after the season. Ishbia owned up to the debacle with reporters after the season finale. 'Embarrassing season, right?' Ishbia said. 'Disappointing. Awful. I watch every game like all you guys do and no one's proud of it, no one's happy with it, from me, to the front office, to the coaches and players, to the marketing executives to the security guards. 'It was a failure.' If Ishbia did have one success in 2024-25, it was his popular decision to reduce concessions prices with a new $2 menu. Although they don't currently have their own first-round pick, the Suns do have the 29th selection in this month's NBA Draft. As for the head-coach vacancy, the Suns have brought in Jordan Ott, whom Ishbia said 'embodies the culture of excellence and accountability we're going to prioritize.' Ott had worked under 2025 NBA Coach of the Year Kenny Atkinson in Cleveland after the two previously worked together in Brooklyn

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