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New weight-loss drug Wegovy is here, but is it a magical solution? Experts weigh in

New weight-loss drug Wegovy is here, but is it a magical solution? Experts weigh in

Hindustan Times15 hours ago

The obsession with weight loss injections is still going strong. After the social media frenzy around Ozempic last year and celebrities such as Meghan Trainor, Lizzo, and Amy Schumer admitting to using it, and the buzz when Mounjaro (Elon Musk revealed he used it too!) arrived in India this March, there's a new contender on the block: Wegovy. Earlier this week (June 24), Danish pharmaceutical giant Novo Nordisk launched this much-anticipated drug in India. But what makes it different from its predecessors, and why is everyone talking about it? Wegovy is designed for long-term weight management and to help reduce the risk of serious cardiovascular events in people living with obesity. It comes in a sleek, once-weekly pen device with five dosing options: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and a maintenance dose of 2.4 mg. New weight-loss drug Wegovy is here, but is it a magical solution? Experts weigh in(Photo: Adobe Stock)
Similar to Ozempic and Mounjaro, this new weight loss drug is also a prescription-only medication intended for adults who are obese or overweight and also have at least one weight-related health condition, like high blood pressure, type 2 diabetes, or high cholesterol. 'The active ingredient in Wegovy is semaglutide, which is a synthetic version of a naturally occurring hormone called GLP-1 (glucagon-like peptide-1). This hormone is released in the gut in response to food intake and helps regulate appetite and food intake,' informs Dr Kashish Gupta, Consultant Endocrinology at PSRI Hospital.
In essence, semaglutide helps you feel full sooner, slows digestion and reduces hunger. These effects can lead to reduced calorie intake over time and, eventually, weight loss. It may also improve blood sugar levels and help lower the risk of heart issues in certain individuals, particularly those with type 2 diabetes. Who can use it?
According to Dr Anjana Kalia, a dietitian at Diet Clinix, it's intended for adults with a Body Mass Index (BMI) of 30 or above, or 27 and above if there's a related health issue. 'But these are not miracle solutions. The decision to use it should always be taken with a qualified doctor after assessing medical history and risks,' she cautions. Who should avoid it?
People who have a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome, have had pancreatitis or severe digestive disorders, are pregnant, breastfeeding or planning to conceive, have eating disorders, or are allergic to semaglutide or its components. These drugs should be taken in full consultation with your medical practitioner. Wegovy vs Mounjaro vs Ozempic 1. Wegovy Active ingredient: Semaglutide
Approved for: Weight loss
Dosage: Once weekly
Benefits: Helps regulate blood sugar levels, lowers the risk of cardiovascular events
Side effects: Nausea, diarrhoea, vomiting
Price: ₹ 17,345 a month for 0.25mg, 0.5mg, and 1mg doses and ₹ 24,280 and ₹ 26,050 a month for 1.7mg and 2.4mg doses, respectively. 2. Mounjaro Active ingredient: Tirzepatide
Approved for: Type 2 diabetes
Dosage: Once weekly
Benefits: Helps regulate blood sugar levels, improves insulin sensitivity
Side effects: Nausea, diarrhoea, vomiting and pancreatitis or thyroid issues in rare cases
Price: ₹ 4,375 ($50.67) for a 5 mg vial, ₹ 3,500 ($40.54) for a 2.5mg vial. 3. Ozempic Active ingredient: Semaglutide
Approved for: Type 2 diabetes
Dosage: Once weekly
Benefits: Helps regulate blood sugar levels, decreases appetite
Side effects: Nausea, diarrhoea, upset stomach
Price: The injectable Ozempic can cost between ₹ 8,000 and ₹ 20,000 a shot.

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Doctors swear by these simple habits: Salad daily, screen-free mornings and phone-free sleep
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Doctors swear by these simple habits: Salad daily, screen-free mornings and phone-free sleep

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Endocrinologist Dr. Ambrish Mithal on the happy side-effects of weight-loss drugs
Endocrinologist Dr. Ambrish Mithal on the happy side-effects of weight-loss drugs

India Today

time15 hours ago

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New-age weight-loss drugs are exploding the pharmaceutical market, offering better results than traditional medicines. Top endocrinologist Dr. Ambrish Mithal deconstructs the many facets, including side-effects, of these GLP-1 drugs in his recently published book The Weight Loss Revolution, in an episode of India Today's said that while the GLP-1 field -- drugs that belong to the class of GLP-1 targeting the same hormone in the body -- is just beginning to explode, there'll be many newer drugs with less and less side effects and easier to most cases have shown muscle loss as a prominent result of using GLP-1 medications like tirzepatide or semaglutide, Dr. Mithal explains that losing muscle is an accompanying factor to weight loss. "In the long run, if you're not following a healthy diet, you will end up with significant muscle loss. And this is not because of the weight-loss drugs. Whenever we lose weight, we also lose muscle. If you lose 10 kg, you've lost 2-3 kg of muscle. Now, if you want to preserve that, you have to ensure adequate protein and fibre in your diet. Along with that, you have to make sure that you're exercising regularly and that exercise should include strength training," Dr. Mithal also shared what many people experience loose skin after taking these medicines. "When you lose weight rapidly, you lose subcutaneous fat. Particularly in older people where skin tends to sag anyway. If you suddenly lose weight, don't hydrate yourself well, not eating the right kind of balanced diet, then you get that little sagging on the face which people have started calling Ozempic face. Before these drugs came into the market, anyone we put on a very strict diet or someone who had bariatric surgery would see similar results," he gastrointestinal side-effects, nausea, and vomiting, Dr. Mithal addressed concerns about thyroid cancer, highlighting that there's no evidence to link the also explained the "happy side-effects" of GLP-1 medications. Besides growing body of evidence suggesting how semaglutide is linked to Alzheimer's disease, Dr. Mithal said that the benefits of the drugs are moving beyond weight loss."The evidence that they might be helping Alzheimer's by helping obesity in the brain may actually be very exciting, and even for cardiac health, Parkinson's disease. Cardiac events are reduced. Fatty liver is reduced. Kidney disease progression is reduced. But the brain effects are particularly fascinating. Sleep apnea has also gone down," he said, adding that the drugs have also helped improve fertility outcomes in women with PCOS (Polycystic Ovary Syndrome).Currently, most GLP-1 drugs are injectable and expensive, limiting their access in India. However, new formulations and more research are on the way. Novo Nordisk's Wegovy and Eli Lilly's Mounjaro, two blockbuster fat-busting medicines, are set to gain ground in India to tackle the diabetes and obesity crisis."Remember, the GLP-1 field is just beginning to explode. There'll be many newer drugs with less and less side effects and easier to use," Dr. Mithal sayssaid.- EndsMust Watch

New weight-loss drug Wegovy is here, but is it a magical solution? Experts weigh in
New weight-loss drug Wegovy is here, but is it a magical solution? Experts weigh in

Hindustan Times

time15 hours ago

  • Hindustan Times

New weight-loss drug Wegovy is here, but is it a magical solution? Experts weigh in

The obsession with weight loss injections is still going strong. After the social media frenzy around Ozempic last year and celebrities such as Meghan Trainor, Lizzo, and Amy Schumer admitting to using it, and the buzz when Mounjaro (Elon Musk revealed he used it too!) arrived in India this March, there's a new contender on the block: Wegovy. Earlier this week (June 24), Danish pharmaceutical giant Novo Nordisk launched this much-anticipated drug in India. But what makes it different from its predecessors, and why is everyone talking about it? Wegovy is designed for long-term weight management and to help reduce the risk of serious cardiovascular events in people living with obesity. It comes in a sleek, once-weekly pen device with five dosing options: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and a maintenance dose of 2.4 mg. New weight-loss drug Wegovy is here, but is it a magical solution? Experts weigh in(Photo: Adobe Stock) Similar to Ozempic and Mounjaro, this new weight loss drug is also a prescription-only medication intended for adults who are obese or overweight and also have at least one weight-related health condition, like high blood pressure, type 2 diabetes, or high cholesterol. 'The active ingredient in Wegovy is semaglutide, which is a synthetic version of a naturally occurring hormone called GLP-1 (glucagon-like peptide-1). This hormone is released in the gut in response to food intake and helps regulate appetite and food intake,' informs Dr Kashish Gupta, Consultant Endocrinology at PSRI Hospital. In essence, semaglutide helps you feel full sooner, slows digestion and reduces hunger. These effects can lead to reduced calorie intake over time and, eventually, weight loss. It may also improve blood sugar levels and help lower the risk of heart issues in certain individuals, particularly those with type 2 diabetes. Who can use it? According to Dr Anjana Kalia, a dietitian at Diet Clinix, it's intended for adults with a Body Mass Index (BMI) of 30 or above, or 27 and above if there's a related health issue. 'But these are not miracle solutions. The decision to use it should always be taken with a qualified doctor after assessing medical history and risks,' she cautions. Who should avoid it? People who have a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome, have had pancreatitis or severe digestive disorders, are pregnant, breastfeeding or planning to conceive, have eating disorders, or are allergic to semaglutide or its components. These drugs should be taken in full consultation with your medical practitioner. Wegovy vs Mounjaro vs Ozempic 1. Wegovy Active ingredient: Semaglutide Approved for: Weight loss Dosage: Once weekly Benefits: Helps regulate blood sugar levels, lowers the risk of cardiovascular events Side effects: Nausea, diarrhoea, vomiting Price: ₹ 17,345 a month for 0.25mg, 0.5mg, and 1mg doses and ₹ 24,280 and ₹ 26,050 a month for 1.7mg and 2.4mg doses, respectively. 2. Mounjaro Active ingredient: Tirzepatide Approved for: Type 2 diabetes Dosage: Once weekly Benefits: Helps regulate blood sugar levels, improves insulin sensitivity Side effects: Nausea, diarrhoea, vomiting and pancreatitis or thyroid issues in rare cases Price: ₹ 4,375 ($50.67) for a 5 mg vial, ₹ 3,500 ($40.54) for a 2.5mg vial. 3. Ozempic Active ingredient: Semaglutide Approved for: Type 2 diabetes Dosage: Once weekly Benefits: Helps regulate blood sugar levels, decreases appetite Side effects: Nausea, diarrhoea, upset stomach Price: The injectable Ozempic can cost between ₹ 8,000 and ₹ 20,000 a shot.

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