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NYC Legionnaires' disease cluster grows to 99 cases, 4 deaths

NYC Legionnaires' disease cluster grows to 99 cases, 4 deaths

Yahooa day ago
Health officials in New York City say a cluster of Legionnaires' disease in Central Harlem has grown to 99 cases, including four deaths.
Health officials suspect the bacteria that causes the disease, Legionella, originated cooling towers — devices that uses water to cool large buildings and then disperse mist into the air. If the water inside becomes too warm, stagnant, or isn't properly disinfected, Legionella can grow and sicken people who inhale the mist.
On Thursday, the New York City Department of Health confirmed positive tests of the bacteria in 12 cooling towers serving 10 buildings in the area, including NYC Health + Hospitals/Harlem.
The Department of Health says 11 of the 12 cooling towers have already been repaired and the final tower should be remediated by Friday.
Health officials emphasized that plumbing systems are separate from cooling tower systems in affected buildings.
'This community outbreak is not related to a building's hot or cold water supply. Residents in these ZIP codes can continue to drink water, bathe, shower, cook, and use their air conditioner,' it said.
The current Legionnaires' cluster was first announced on July 25. Acting Health Commissioner Dr. Michelle Morse said inspectors are working with building owners to ensure compliance with testing and remediation.
'The good news is that new cases have begun to decline, which indicates that the sources of the bacteria have been contained,' Morse said. 'New Yorkers who live or work in the identified ZIP codes and have flu-like symptoms should contact a health care provider as soon as possible for timely diagnosis and treatment for the best chance at a good outcome.'
Legionnaires' disease causes flu-like symptoms, including cough, fever, headaches, muscle aches, and shortness of breath. It is treatable with antibiotics, but if left untreated, it can lead to shock and multi-organ failure, according to the World Health Organization. The US Centers for Disease Control and Prevention estimates that about 10% of people who contract the disease die from complications, with older adults and people with weakened immune systems at higher risk.
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TMO Receives FDA Approval for Oncomine Dx Target Test
TMO Receives FDA Approval for Oncomine Dx Target Test

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TMO Receives FDA Approval for Oncomine Dx Target Test

Thermo Fisher Scientific TMO recently received approval from the Food and Drug Administration ('FDA') for its Oncomine Dx Target Test as a companion diagnostic (CDx) to identify patients who may be candidates for HERNEXEOS (zongertinib tablets), a tyrosine kinase inhibitor (TKI). The HERNEXEOS, developed by Boehringer Ingelheim, is the first and only FDA-approved orally administered targeted therapy for adult patients with unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC). The recent approval is expected to bolster Thermo Fisher's Specialty Diagnostics arm. About TMO's Oncomine Dx Target Test The Oncomine Dx Target Test checks if NSCLC tumors harbor human epidermal growth factor receptor 2 (HER2/ERBB2) tyrosine kinase domain (TKD) activating mutations. It enables multi-biomarker analysis from a single tissue sample to aid treatment decisions in as little as four days. This reduces the need for second biopsies and avoids suboptimal therapy selection in the absence of a complete biomarker report. The test is fully reimbursed by Medicare, as well as by the top 20 commercial payers in the United States. Oncomine Dx Target Test's Global Approvals The Oncomine Dx Target Test received its first approval by the FDA as an NGS CDx in 2017, followed by regulatory approvals in 20 countries for 11 biomarkers and over 20 targeted therapies. The test is reimbursed by government and commercial insurers in the United States, Europe, Japan, South Korea and Israel, covering more than 550 million lives globally. In the United States alone, it is approved for targeted therapies in NSCLC, cholangiocarcinoma (CC), astrocytoma (AC) and oligodendroglioma (OG), anaplastic thyroid cancer (ATC), medullary thyroid cancer (MTC) and thyroid cancer (TC). Industry Prospects Favor TMO According to the American Cancer Society, lung cancer is the second most common cancer in both men and women in the United States, with NSCLC accounting for about 85-90% of all lung cancer cases. Research further indicates that roughly 2-4% of NSCLC patients carry a HER2 mutation. With lung cancer cases continuing to rise, the global market for NSCLC treatments is expected to expand significantly, reaching $66.04 billion by 2032 at a CAGR of 10.3% from 2024 to 2032 (per Fortune Business Insights). Another Development by TMO Thermo Fisher recently announced the FDA approval for Oncomine Dx Express Test on the Ion Torrent Genexus Dx Integrated Sequencer as an in vitro diagnostic (IVD) assay for use as a companion diagnostic (CDx) for Dizal's ZEGFROVY (sunvozertinib) and in tumor profiling. Offerings by TMO's Competitors In the oncology space, Thermo Fisher faces competition from some prominent MedTech players. 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What Happens to Your Cholesterol When You Walk Every Day
What Happens to Your Cholesterol When You Walk Every Day

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What Happens to Your Cholesterol When You Walk Every Day

Reviewed by Dietitian Maria Laura Haddad-Garcia Key Points Walking daily is one of the simplest low-barrier ways to support your overall heart health. Walking may help lower your LDL cholesterol and triglyceride levels and raise HDL cholesterol levels. Using weights, tracking your steps and walking post-meal are ways to make walking more effective. Trying to lower your cholesterol and support your heart health without hitting the gym? The good news is that you don't need a grueling fitness routine to make a difference in your cardiovascular health. Walking every day is a simple and accessible habit that can help improve your blood lipids (triglycerides, LDL or 'bad' and HDL or 'good' cholesterol levels) and protect your cardiovascular system in the long run. Why does this matter? 'High cholesterol is a major modifiable risk factor for the development of coronary artery disease,' says Bradley Serwer, M.D. 'By managing your cholesterol levels, you can potentially avoid or minimize heart attacks, strokes or peripheral vascular disease.' Your triglyceride levels are important, too. High triglycerides can happen on their own, but they can also go hand-in-hand with cholesterol levels, increasing your risk for heart disease. The Benefits of Walking for Cholesterol Daily walking delivers a range of benefits for cholesterol management and heart health. Here's an in-depth look at how it works. Lowers LDL Cholesterol When we talk about 'bad' cholesterol, we're referring to low-density lipoproteins or LDL, a waxy substance that can build up in your arteries. 'Elevated LDL increases the risk of heart attack and stroke by promoting plaque in critical vessels, particularly those of the heart and brain,' explains Alan Rozanski, M.D.. Research shows that for women with overweight or obesity, walking regularly for at least four weeks slightly lowers total cholesterol and 'bad' LDL cholesterol by about 7 mg/dL. Another study conducted on men found that consistent, moderate exercise for 12 weeks reduced LDL cholesterol by 5% to 7%. At the same time, more research on both men and women, ages 40 to 65, found that walking for three months or more produced mixed results, with some studies finding changes in cholesterol and triglyceride levels while others did not. While the effects may vary, incorporating regular walking into your routine is a simple and accessible way to support overall heart health. Supports Healthy HDL Cholesterol High-density lipoprotein (HDL) is often called the 'good' cholesterol because it removes cholesterol, protects against harmful oxidation, reduces inflammation and may help prevent blood clots. Higher levels of HDL are linked to lower risks of heart disease according to some (but not all) data. 'Aerobic activities such as walking help raise your high-density lipoprotein, HDL,' shares Serwer. Research shows that beyond just changing the numbers, exercise helps HDL particles mature and function better. Helps Lower Triglycerides Triglycerides are a type of fat in your blood, and elevated levels are another risk factor for cardiovascular disease. The good news? Walking is an effective way to lower them. During physical activity, your muscles use triglycerides as an energy source. Participating in physical activity, like walking, has been linked to reduced triglyceride concentrations in some studies. Supports Better Weight Management Walking is one of the simplest and most effective ways to support weight loss. It burns calories, supports metabolism and helps maintain lean muscle mass, all of which contribute to shedding extra pounds. Plus, it's an accessible and low-impact activity that can be easily incorporated into daily routines, making it a sustainable choice for long-term weight management. Carrying excess weight is closely linked to a range of heart-health concerns, including high cholesterol levels. People who carry extra body fat, particularly around the abdomen, tend to have higher LDL cholesterol levels. By making walking a regular habit, you can take a proactive step toward managing your weight and protecting your heart health. Helps Spark a Positive Feedback Loop Walking can also inspire a ripple effect of healthier choices. 'Walking can spark a positive feedback loop. As people become more active, they tend to feel better and adopt healthier habits—like improved eating—which further supports cholesterol management. That's why doctors often encourage movement as a starting point for lifestyle change,' explains Rozanski. This initial step toward activity often lays the groundwork for broader lifestyle improvements. By supporting energy levels and possibly improving mood, walking can make it easier to embrace other heart-healthy habits. Whether it's preparing more nutritious meals, getting better sleep or feeling motivated to try new activities, these changes work together to enhance overall health. Walking, therefore, isn't just exercise; it can be a catalyst for long-term, positive transformation. How Much Walking Do You Need? The Centers for Disease Control and Prevention recommends at least 150 minutes of moderate-intensity physical activity per week, which breaks down to about 30 minutes a day, five days a week. Brisk walking (about 3 to 4 miles per hour) fits the bill perfectly. If possible, aim for even more; 300 minutes weekly is linked to even greater heart benefits. 'But for the 25% of people who get no exercise at all, that can feel out of reach. The encouraging news is that even short bouts—like brisk five-minute walks—canimprove health,' says Rozanski. If you want to maximize results, adding some intensity can help. Try integrating inclines, walking at a faster pace, or even intervals where you alternate between slow and brisk walking. Tips to Make Walking Work for You Walking is simple, but a few tweaks can make it even more effective. Here are practical tips to make your daily walks count: Walk after meals to help with lipid metabolism. A 10- to 15-minute walk after eating can aid digestion and improve cholesterol processing. Add inclines or use hand weights for added cardio benefits. Walking uphill or using light weights engages more muscles and burns more fat. Track your steps with a pedometer or app to stay accountable and motivated. Many people find the goal of 10,000 steps a day achievable and rewarding. Pair your walking with . Start your day with oatmeal or snack on walnuts post-walk to double down on heart-health benefits. Small changes compound over time, so feel free to adjust these tips to your routine. Our Expert Take It's official! Walking daily is one of the simplest low-barrier ways to support your overall heart health. It's easy to incorporate into your lifestyle, whether that's a morning stroll, a post-dinner walk or active errands around town. Remember, you don't need fancy equipment, a big time commitment or extreme workouts. All it takes is lacing up your shoes and stepping outdoors. Starting small (like a 10-minute daily walk) can lead to big results over time. Your heart doesn't care how fast you go, just that you keep going. The sooner you start, the sooner your body and mind will feel the benefits. Take that first step today; your heart will thank you tomorrow. Read the original article on EATINGWELL

9 Things No One Tells You About Sex After 70
9 Things No One Tells You About Sex After 70

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9 Things No One Tells You About Sex After 70

There's a lot of mystery surrounding sex in your 60s, 70s and beyond. Look online and you'll find countless threads where curious younger people ask if older people are having sex at all, and if they are having it, what it's like. 'What does it feel like?' others wonder. (Good, we imagine? It's still sex!) Related: The mystery surrounding sex in older age stems from a combination of factors, according to Shannon Chavez, a licensed psychologist and sex therapist in Beverly Hills, California. First, societal taboos and ageist attitudes have led to a marginalization of older adults' sexuality. No one wants to imagine people their grandparents' or parents' age having sex, so we cast out those thoughts. What we get as a result are limited discussions and representations of sex in later life; think of how few scenes we see of older people getting it on in movies and TV, and how often post-50 sex and Viagra are the butt of the joke for late-night comedians. We're all going to get older eventually (hopefully, anyway) but because we've stigmatized post-50 sex so much, we're ill-prepared for the realities of it, Chavez said. 'There's a lack of comprehensive sex education tailored to older age groups, leaving many individuals uninformed about the changes and challenges they may face regarding sexuality as they age,' she told HuffPost. 'This all leads to misconceptions and curiosity about what sexual experiences are like in later life,' she said. 'Overall, increased awareness, education, and open dialogue about sex and aging can help eliminate the mystery and promote healthier attitudes toward sexuality in older age groups.' The heartening reality is that those who are AARP-aged are still having, enjoying and desiring sex, even when they're not coupled up. Four out of 10 people ages 65-80 are still sexually active, according to a 2018 studyfrom the National Poll on Healthy Aging. And whether or not they have an active sex life, nearly two-thirds of older adults said they're interested in sex. More than half said sex is important to their quality of life, according to the same study. To shed some light on post-70 sex, we asked sex therapists and people over 70 to share some things people should know about sex in the golden years. See what they had to say below. Responses have been lightly edited for clarity and length. Your need to feel desired doesn't just disappear. 'I can only speak for my wife and I, but I think one of the biggest things not talked about is the drive for sex and physical enjoyment ― to be desired, to be wanted, to have that feeling of giving and receiving the physical, as well as emotional release ― never goes away. When we're young, we don't want to believe that old, saggy humans still want sex. But we do. Physical attraction and satisfaction, communication and personal hygiene are still important, even in our 70s. 'There are certain things that have to be worked out, of course: erectile dysfunction, extreme dryness, pain and limited positions. But it's great to be alive at a time when science has solved some of these issues with easy solutions. Drugs and creams for both women and men, as well as physical exercises and therapies, make it possible to enjoy sex at this late stage. I understand that there are many people at this age who have debilitating diseases or physical limitations that make it very difficult or even undesirable to have sex. And I certainly respect that. But there are also many older people, older than us even, who still want and have sex. 'I think the biggest problem is the stigma of being old, with gray hair or bald, saggy breasts and butts, means that there's no longer a need for sex. When we were in our 50s, we thought that if we were alive in our 70s, we'd be done. To our pleasant surprise, it's just the opposite.' ― Frank, 76, who lives in the Texas panhandle and has been married for almost 53 years The frequency decreases but the quality often increases. 'I think the most surprising thing about sex after 70 for many folks is that it has the potential to be better than ever. Many of my clients in their 70s (and 80s!) report that while the frequency of sex generally declines with age, the quality improves. Sometimes this is related to so-called sexual dysfunction which leads them to discover new pathways to pleasure. For example, if penetration is painful or uncomfortable, they often learn to explore and enjoy full-body pleasure. Or if erectile issues arise, many folks finally discover that the hands, tongue, lips, toys and skin can lead to intense pleasure and orgasms in the absence of penile erections.' ― Jess O'Reilly, a sexologist and the host of the Sex With Dr. Jess podcast Erectile dysfunction doesn't need to end your sex life. 'I've dealt with ED for over 20 years. My wife could never orgasm with [penis in vagina] but now has at least two or three orgasms and often more. I guess you could call it advanced foreplay: I use my mouth, hands and leg to stimulate her. She then stimulates me until I'm finished.' ― Norm, 71, southeast Michigan Related: Aging may cause physical barriers, but there are workarounds. 'Aging may cause physical changes that don't have to be barriers to having sex. Aging naturally causes changes in physical comfort and mobility such as arthritis, joint pain, or mobility limitations that can be addressed easily by using products such as pillows for support, trying different sexual positions that are less physically demanding, or incorporating lubricants to reduce discomfort which contribute to a more enjoyable and fulfilling sexual experience. Also, being open to experimenting and adapting to the changing needs of one's body can help older adults continue to engage in pleasurable sexual activities. In older age, sex is less performative and more adaptable to experiences providing pleasure and connection.' ― Chavez Sexual adventurousness and creativity expand with experience. 'Just because our bodies get worn out doesn't mean our minds do. Adventurousness and imagination expand with experience. I may be different from other people, but I find myself giving myself permission to explore and be interested in diverse activities even more than when I was younger. When you get toward the end of your life you realize the rules don't matter as much anymore, including in bed. No one is going to give you a disapproving glance and no one is going to discourage you from doing something you want to do and, really, who cares if they do?' ― David Daniel, a 70-something in Cedar Rapids, Iowa It can be painful, especially for women. 'The aging process has a tremendous impact on sexual functioning and satisfaction. In addition, as we age, we tend to have more medical issues and many medications can impact sexual function. As we age, we often experience changes in our sexual behavior, desire, what we find arousing, and overall sexual well-being. Some of the biological changes we experience as we age involve hormones: When women reach middle age, they experience menopause. This happens because the body stops producing estrogen. Some of the results of decreased estrogen production include vaginal dryness, decreased lubrication, and loss of elasticity in the vaginal tissues. This often leads to discomfort and even pain during intercourse. In some cases, there may be a decrease in nipple and clitoral sensitivity. The good news is, lube and longer-acting vaginal moisturizers can help.' ― Rachel Needle, a psychologist in West Palm Beach, Florida, and the co-director of Modern Sex Therapy Institutes Related: Sometimes, it's more about the emotional connection. 'Emotional connection and intimacy are a priority and sex becomes intentional and more of the experience they are having. It is less about the sexual scripts and acts of sex and more about the type of connection and closeness that can be gained from mutually enjoyable experiences together. The motivation for sex may be less about looking good, pleasing your partner only, feeling like an obligation or task, and being more intentional about feeling good together and enjoying the experience.' ― Chavez Sexual desire is 'supposed' to be spontaneous but it's not always that way, especially as we age. 'Some data suggests that very few women commonly experience sexual desire postmenopause. One study found that 24% never experience desire and 41% rarely experience desire postmenopause. But 91% experience arousal (and pleasure). What we can learn from this is that you don't have to experience spontaneous desire to enjoy sex; if you don't find yourself in the mood, you can put yourself in the mood — with fantasy, conversation, touch, and other forms of arousal.' ― O'Reilly It's all about managing your expectations. 'If you believe Reddit and other online forums, some folks make love several times a day. I've told the folks on Reddit that we make love every Friday. We tell anyone that wants to see us on Friday that we have a previous engagement. Our family knows that Friday is our chill day and never bothers us. Could we have sex more often? Maybe, but it's very exhausting and we talk about it all of the time to keep it exciting. It's Wednesday today, so it's Friday, eve, eve. Lots of hugging and kissing during the week, just to be close.' ― Norm Related... The Best Sex Positions For People Over 60, According To Sex Experts Sex Experts Say You're Missing Out On Lube. Here Are 8 Highly Rated Options. I Became A Huge OnlyFans Star At 56. Then Someone Outed Me To My the daily Crossword

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