Common sweetener in fizzy drinks and yoghurt ‘can kill off the deadliest cancer'
Researchers fermented the zero calorie sweetener and tested it against
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2
Stevia extract could be used to help fight pancreatic cancer, researchers suggested
Credit: Getty
2
They tested fermented extracts against pancreatic cancer cells in a lab dish
Credit: Getty
In the UK, about 10,800 people are diagnosed with
It's the fifth most common cause of
Previous research has suggested that stevia leaf extracts could have potential "anticancer effects".
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But isolating specific substances within the herb that could help protect against cancer and using them has remained challenging.
Researchers from Hiroshima University suggested fermenting stevia with bacteria can structurally change the extract and produce bioactive metabolites - compounds that can impact living organisms.
Study author Masanori Sugiyama, a professor in the Department of Probiotic
Science
for Preventive
Medicine
, said
The team tested their theory out against pancreatic cancer cells.
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"Pancreatic cancer is a highly malignant tumour of the digestive system with a poor prognosis," co-author Prof Narandalai Danshiitsoodol said.
"Globally, the incidence and mortality rates of pancreatic cancer continue to rise, with a five-year survival rate of less than 10 per cent.
The most common symptoms of pancreatic cancer - as patients share their stories
"The primary reason
"Furthermore, pancreatic cancer is highly invasive and prone to metastasis, showing significant resistance to existing treatments such as surgery, radiotherapy, and
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"Therefore, there is an urgent need to identify new and effective anticancer compounds, particularly those derived from medicinal plants."
Researchers used lactic acid bacteria to ferment stevia extracts.
They isolated over 1200 strains from fruits, vegetables, flowers, and medicinal plants and evaluated their health
benefits
.
They finally landed on
Lactobacillus plantarum
SN13T strain (FSLE) derived from banana leaves "to enhance the antioxidant and anticancer activities of stevia leaf extract through fermentation".
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They tested fermented and non-fermented stevia extracts against pancreatic cancer cells in lab dishes.
Fermented stevia killed pancreatic cancer cells more efficiently than the non-fermented extract, the study published in the
Symptoms of pancreatic cancer
PANCREATIC cancer doesn't always cause symptoms in its early stages.
As the cancer grows and you do begin to show signs, these may come and go and be unspecific, making it hard to diagnose, according to
Common symptoms include:
Indigestion - a painful, burning feeling in your chest with an unpleasant taste in your mouth
Diarrhoea and constipation - see a GP if you have runny poos for more than seven days, especially if you've lost weight as well
Steatorrhoea - pale, oily poo that's bulky, smells horrible and floats, making it hard to flush
Losing a lot of weight without meaning to
Jaundice - yellow skin and eyes, as well as dark pee, pale poo and itchy skin
This suggested that "the fermentation process enhances the bioactivity of the [stevia] extract", Prof Sugiyama said.
Researchers tested out different fermentation levels to see which was most effective against cancer cells.
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Lower concentrations didn't kill cancer cells immediately, but they slowed their growth.
Healthy kidney cells were mostly unaffected by the stevia extracts.
Researchers plan to study how fermented stevia affects cancer in mice
next
, to see how various dosages will work in living organisms.
'The present study has substantially enhanced our understanding of the mechanism of action of the
Lactobacillus plantarum
SN13T strain in the fermentation of herbal extracts, while also offering a valuable research perspective on the potential application of probiotics as natural anti-tumour agents,' Prof Danshiitsoodol said.
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Since the early 1990s, pancreatic cancer incidence rates have increased by 18 per cent in the UK.
The disease is often diagnosed at a late stage because it frequently lacks noticeable symptoms in the early stages.
Surgery,
chemotherapy
and radiation can help extend patients' li
ves.
Read more on the Irish Sun
A blood test to pick up early signs of pancreatic cancer
is being trialled in patients with a recent diagnosis of type 2
diabetes
- a known risk factor for the disease.
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Meanwhile,
researchers at Case Western Reserve University and Cleveland Clinic have developed a new type of jab to fight
.
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