Development of indigenous multi-stage Malaria vaccine 'AdFalciVax' is underway
ADVERTISEMENT AdFalciVax is the first indigenous recombinant chimeric malaria vaccine specifically designed to target two critical stages of Plasmodium falciparum, the parasite responsible for the most lethal form of malaria.
The vaccine aims to protect against human infection while also reducing vector-borne community transmission of the parasite.
According to the release, the vaccine has demonstrated excellent efficacy in the preclinical stage of development. Preclinical data suggest that AdFalciVax may have advantages over existing single-stage vaccines, including broader protection by targeting two vulnerable parasite stages, lower risk of immune evasion, potential for better long-term immunity, and extended thermal stability with functionality maintained for over nine months at room temperature.AdFalciVax is a recombinant multistage vaccine produced in Lactococcus lactis, designed to protect both individual humans and reduce the community transmission cycle.It represents one of the most advanced malaria vaccine candidates globally, with a rational design targeting two key stages of the parasite. This vaccine consists of a stable and functional recombinant chimaera between antigenic components that promises dual protection.
ADVERTISEMENT ICMR intends to license the technology for AdFalciVax to eligible organisations and manufacturers for further development, manufacture, and commercialisation under non-exclusive agreements. This approach aims to enable wider outreach and maximise public health benefits. All collaborations will adhere to ICMR's Intellectual Property Policy.
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As an indigenously developed vaccine candidate that fulfils the Make in India mandate, AdFalciVax holds the potential to contribute substantially to malaria eradication by preventing infection and minimising community transmission.This information is provided for awareness purposes only. The vaccine candidate is in its early research and development phases and is not yet available for any clinical use or commercialisation.
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News18
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ICMR study finds shortfall in radiotherapy utilisation across all cancer types
Agency: Last Updated: July 24, 2025, 21:30 IST Representational image (Image: News18) New Delhi, Jul 24 (PTI) A recent ICMR study has highlighted a substantial shortfall in radiotherapy utilisation across all cancer types and underscored the need for interventions to meet the gap in machines required for equitable cancer care. Published in the BMC Cancer journal, the study stated that 28.5 per cent of cancer patients receive radiotherapy, which is lower than the estimated optimal rate of 58.4 per cent. Breast, head and neck, lung and cervical cancer account for 60 per cent of India's radiotherapy needs, it said. Data from the Australian Collaboration for Cancer Outcomes Research and Evaluation (CCORE) were used by the researchers of ICMR-National Centre for Disease Informatics and Research, Bengaluru, for conducting the study. Epidemiological data on stage, subsite and histology from the National Cancer Registry Programme were used to assess the optimal utilisation proportion for India. A sensitivity analysis was carried out. Similarly, the optimal radiotherapy fraction has also been calculated. These measures have been used to estimate the existing radiotherapy utilisation gap by comparing with the current radiotherapy utilisation from the cancer registry as well as to estimate the optimal radiotherapy machines required for the country. 'This study provides a comprehensive assessment of radiotherapy demand and existing gaps in radiotherapy utilisation and in the number of machines in India based on an epidemiological analysis of the cancer burden from the National Cancer Registry Programme. Our analysis shows that approximately 58 per cent of all cancer cases in India should ideally receive radiotherapy based on clinical indications. 'However, the current radiotherapy utilisation in India is only 28.5 per cent, which is less than half of the required level," the researchers said. The study also recommended that India would require 1,585 to 2,545 machines, which may increase to a range of 2,016 to 2,291 external beam radiotherapy machines if the assumptions from previous benchmark studies are followed. The burden of four cancer sites — breast, head and neck, lung and cervical cancer — constitutes around 60 per cent of the total radiotherapy requirement for cancer care in India, the study said. This points towards an increasing demand for radiotherapy in the coming years as there is expected to be a 70-100 per cent increase in breast, head and neck and lung cancer in low and middle income countries (LMIC). Radiotherapy utilisation of most cancer sites is lower compared to optimal radiotherapy utilisation. Among the major indicated cancer sites, the deficit is more prominent in lymphoma and lung cancer (relative deficit of more than 70 per cent), followed by prostate, breast and oesophagus, it said. The study mentioned that India accounts for 7 per cent of global cancer incidence, ranking third after China and the USA. By the end of 2025, the incidence of cancer in India is projected to reach 1.57 million cases, posing a significant public health challenge. As the fifth leading cause of death in the country, cancer demands urgent attention to improve prevention, diagnosis and treatment, it said. Radiotherapy, a cornerstone of cancer treatment, plays a crucial role in controlling tumour growth, reducing tumour size pre-surgery, and alleviating pain in advanced stages. However, its availability in low and middle-income countries like India remains insufficient due to high setup and operational costs, creating a significant gap between demand and resources. The World Health Organization (WHO) recommends a minimum of one radiotherapy machine (external radiotherapy machine) per million population, with an optimal target of four per million, the study stated. For India's projected population of 1.45 billion in 2025, this translates to a need for a minimum of 1,450 machines. Yet, only 794 megavoltage (MV) machines are currently available. The shortfall is about 45 per cent from the minimal required standard, the study said. The study highlighted that in India, greater investment is needed to expand radiotherapy facilities to meet the growing demands of cancer patients. 'Aside from increasing the number of equipment, addressing the inequitable distribution of radiotherapy services is also crucial. To align with the country's cancer burden and ongoing cancer control efforts, India must meet evidence-based targets for radiotherapy machine availability. 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Swipe Left For Next Video View all Optimal radiotherapy utilisation (RTU) calculated for India was higher than optimal radiotherapy utilisation estimation done for developed countries like 48·3 per cent for Australia and 51 per cent for European countries, the study said. The optimal RTU calculation for middle income countries also has an average optimal radiotherapy utilisation value of 52 per cent ranging from 47 to 56 per cent. PTI PLB KSS KSS (This story has not been edited by News18 staff and is published from a syndicated news agency feed - PTI) view comments News agency-feeds ICMR study finds shortfall in radiotherapy utilisation across all cancer types Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
Time of India
14 hours ago
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News18
14 hours ago
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ICMR recommends interventions to meet gap in machines needed for cancer care
New Delhi, Jul 24 (PTI) A recent ICMR study has highlighted a substantial shortfall in radiotherapy utilisation across all cancer types and underscored the need for interventions to meet the gap in machines required for equitable cancer care. Published in the BMC Cancer journal, the study stated that 28.5 per cent of cancer patients receive radiotherapy, which is lower than the estimated optimal rate of 58.4 per cent. Breast, head and neck, lung and cervical cancer account for 60 per cent of India's radiotherapy needs, it said. Data from the Australian Collaboration for Cancer Outcomes Research and Evaluation (CCORE) were used by the researchers of ICMR-National Centre for Disease Informatics and Research, Bengaluru, for conducting the study. Epidemiological data on stage, subsite and histology from the National Cancer Registry Programme were used to assess the optimal utilisation proportion for India. A sensitivity analysis was carried out. Similarly, the optimal radiotherapy fraction has also been calculated. These measures have been used to estimate the existing radiotherapy utilisation gap by comparing with the current radiotherapy utilisation from the cancer registry as well as to estimate the optimal radiotherapy machines required for the country. 'This study provides a comprehensive assessment of radiotherapy demand and existing gaps in radiotherapy utilisation and in the number of machines in India based on an epidemiological analysis of the cancer burden from the National Cancer Registry Programme. Our analysis shows that approximately 58 per cent of all cancer cases in India should ideally receive radiotherapy based on clinical indications. 'However, the current radiotherapy utilisation in India is only 28.5 per cent, which is less than half of the required level," the researchers said. The study also recommended that India would require 1,585 to 2,545 machines, which may increase to a range of 2,016 to 2,291 external beam radiotherapy machines if the assumptions from previous benchmark studies are followed. The burden of four cancer sites — breast, head and neck, lung and cervical cancer — constitutes around 60 per cent of the total radiotherapy requirement for cancer care in India, the study said. This points towards an increasing demand for radiotherapy in the coming years as there is expected to be a 70-100 per cent increase in breast, head and neck and lung cancer in low and middle income countries (LMIC). Radiotherapy utilisation of most cancer sites is lower compared to optimal radiotherapy utilisation. Among the major indicated cancer sites, the deficit is more prominent in lymphoma and lung cancer (relative deficit of more than 70 per cent), followed by prostate, breast and oesophagus, it said. The study mentioned that India accounts for 7 per cent of global cancer incidence, ranking third after China and the USA. By the end of 2025, the incidence of cancer in India is projected to reach 1.57 million cases, posing a significant public health challenge. As the fifth leading cause of death in the country, cancer demands urgent attention to improve prevention, diagnosis and treatment, it said. Radiotherapy, a cornerstone of cancer treatment, plays a crucial role in controlling tumour growth, reducing tumour size pre-surgery, and alleviating pain in advanced stages. However, its availability in low and middle-income countries like India remains insufficient due to high setup and operational costs, creating a significant gap between demand and resources. The World Health Organization (WHO) recommends a minimum of one radiotherapy machine (external radiotherapy machine) per million population, with an optimal target of four per million, the study stated. 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'As a part of this, India is also ramping up efforts to develop and deploy affordable indigenous radiotherapy machines to improve access and reduce dependence on costly imports," the study stated. top videos View all Furthermore, a detailed situational study of radiation equipment deployment with its features and complexity, utilisation and throughput is required for informed planning and policymaking. Cancer screening and early detection programmes can facilitate the diagnosis of cancers at earlier stages. This could reduce the required quantum of radiotherapy shortly and thus, improve the overall survival of patients, the study said. The cancer registry data informs the policy-makers to identify gaps in radiotherapy access, assess resource needs and guide decisions to ensure equitable and effective cancer care delivery. PTI PLB KSS KSS view comments First Published: July 24, 2025, 18:15 IST News agency-feeds ICMR recommends interventions to meet gap in machines needed for cancer care Disclaimer: Comments reflect users' views, not News18's. Please keep discussions respectful and constructive. Abusive, defamatory, or illegal comments will be removed. News18 may disable any comment at its discretion. By posting, you agree to our Terms of Use and Privacy Policy.
