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The Inner Circle acknowledges, Thomas Su, MD as a Pinnacle Lifetime Member

The Inner Circle acknowledges, Thomas Su, MD as a Pinnacle Lifetime Member

Yahoo19-05-2025

TAMPA, Fla., May 19, 2025 /PRNewswire/ -- Prominently featured in The Inner Circle, Thomas Su, MD is acknowledged as a Pinnacle Lifetime Member for his contributions to Cosmetic and Aesthetic Liposuction.
Dr. Thomas Su is a dedicated medical professional specializing in liposuction procedures for cosmetic enhancement and for patients suffering from lipedema. His unique blend of artistic talent and medical expertise drives him to achieve perfection in every procedure, ensuring optimal results for his patients.
Operating in a private practice, Dr. Su serves the local community with a focus on providing personalized care. He received his Bachelor of Fine Arts from Rice University in Houston, Texas, before earning his Doctor of Medicine from the University of Texas, School of Medicine in San Antonio. Dr. Su completed his internal medicine residency at Jackson Memorial Hospital in Miami, practicing internal medicine for eight years before transitioning to cosmetic procedures. He further honed his skills through specialized training under the mentorship of Dwight Reynolds, MD, in Coral Gables, Florida.
A member of the American Academy of Cosmetic Surgery and the Florida Medical Association, Dr. Su is recognized for his innovative contributions to the field, particularly the development of the Interactive Lipo Method and Celebrity Arms Sculpting. His techniques are deeply influenced by his background as a figure artist and sculptor, allowing him to approach cosmetic surgery with a unique and artistic perspective.
Since establishing his full-time clinic in 2007, Dr. Su has been committed to helping patients achieve their aesthetic goals while providing compassionate care throughout their journeys.
Contact: Katherine Green, 516-825-5634, editorialteam@continentalwhoswho.com
View original content:https://www.prnewswire.com/news-releases/the-inner-circle-acknowledges-thomas-su-md-as-a-pinnacle-lifetime-member-302459281.html
SOURCE The Inner Circle

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CARsgen Presents Research Results on Satri-cel in The Lancet and at the 2025 ASCO Annual Meeting
CARsgen Presents Research Results on Satri-cel in The Lancet and at the 2025 ASCO Annual Meeting

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CARsgen Presents Research Results on Satri-cel in The Lancet and at the 2025 ASCO Annual Meeting

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Full article available at: The oral presentation at the 2025 ASCO Annual Meeting (Abstract 4003) was titled "Claudin18.2-specific CAR T cells (Satri-cel) versus treatment of physician's choice (TPC) for previously treated advanced gastric or gastroesophageal junction cancer (G/GEJC): Primary results from a randomized, open-label, phase II trial (CT041-ST-01)". Professor Lin Shen from Beijing Cancer Hospital, the principal investigator of this study, said, "The CT041-ST-01 trial represents the world's first randomized controlled clinical study of CAR-T cell therapy for solid tumors. In patients with heavily pretreated, advanced gastric/gastroesophageal junction cancer who have extremely limited treatment options and poor prognosis, satri-cel has demonstrated breakthrough efficacy with significant clinical benefits, including much improved progression-free survival (PFS), overall survival (OS), and tumor response rates. 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This year, satri-cel has been granted Breakthrough Therapy Designation and Priority Review by the Center for Drug Evaluation (CDE) of China's National Medical Products Administration (NMPA) for the treatment of Claudin18.2-positive advanced gastric/gastroesophageal junction adenocarcinoma (G/GEJA) in patients who have failed at least two prior lines of therapy. We plan to submit a New Drug Application (NDA) for satri-cel to the NMPA this month and anticipate its approval as the world's first commercially available CAR-T product for solid tumors, bringing benefits to patients." About Satri-cel Satri-cel is an autologous CAR T-cell product candidate against the protein Claudin18.2 that has the potential to be the first-in-class globally. Satri-cel targets the treatment of Claudin18.2-positive solid tumors with a primary focus on G/GEJA and pancreatic cancer (PC). 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Satri-cel has been granted Breakthrough Therapy Designation by the CDE of China's NMPA for the treatment of Claudin18.2-positive advanced G/GEJA in patients who have failed at least two prior lines of therapy in March 2025. Satri-cel was granted Regenerative Medicine Advanced Therapy designation by U.S. FDA for the treatment of advanced G/GEJA with Claudin18.2-positive tumors in January 2022. Satri-cel received Orphan Drug designation from the U.S. FDA in September 2020 for the treatment of G/GEJA. About CARsgen Therapeutics Holdings Limited CARsgen is a biopharmaceutical company focusing on developing innovative CAR T-cell therapies to address the unmet clinical needs including but not limited to hematologic malignancies, solid tumors and autoimmune diseases. CARsgen has established end-to-end capabilities for CAR T-cell research and development covering target discovery, preclinical research, product clinical development, and commercial-scale production. CARsgen has developed novel in-house technologies and a product pipeline with global rights to address challenges faced by existing CAR T-cell therapies. Efforts include improving safety profile, enhancing the efficacy in treating solid tumors, and reducing treatment costs, etc. CARsgen's mission is to be a global biopharmaceutical leader that provides innovative and differentiated cell therapies for patients worldwide and makes cancer and other diseases curable. Forward-looking Statements All statements in this press release that are not historical fact or that do not relate to present facts or current conditions are forward-looking statements. Such forward-looking statements express the Group's current views, projections, beliefs and expectations with respect to future events as of the date of this press release. Such forward-looking statements are based on a number of assumptions and factors beyond the Group's control. As a result, they are subject to significant risks and uncertainties, and actual events or results may differ materially from these forward-looking statements and the forward-looking events discussed in this press release might not occur. Such risks and uncertainties include, but are not limited to, those detailed under the heading "Principal Risks and Uncertainties" in our most recent annual report and interim report and other announcements and reports made available on our corporate website, No representation or warranty is given as to the achievement or reasonableness of, and no reliance should be placed on, any projections, targets, estimates or forecasts contained in this press release. Contact CARsgen For more information, please visit View original content to download multimedia: SOURCE CARsgen Therapeutics

Johnson & Johnson unveils first-in-human results for pasritamig, showing early anti-tumor activity in prostate cancer
Johnson & Johnson unveils first-in-human results for pasritamig, showing early anti-tumor activity in prostate cancer

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Johnson & Johnson unveils first-in-human results for pasritamig, showing early anti-tumor activity in prostate cancer

Pasritamig, a first-in-class bispecific T-cell-engaging antibody, shows potential in mCRPC with outpatient dosing designed for the community setting Data show low rates of treatment-related adverse events, signaling human kallikrein 2 (KLK2) as a novel, highly specific target CHICAGO, June 1, 2025 /PRNewswire/ -- Johnson & Johnson announced today new data from a Phase 1 study evaluating pasritamig (JNJ-78278343), a first-in-class bispecific antibody that activates T-cells to harness the body's immune system against prostate cancer cells, showing promise in patients with advanced disease who have progressed after multiple lines of therapy. These first data on pasritamig, from the first-in-human study, demonstrate that pasritamig appears well-tolerated and exhibits a promising antitumor activity in patients with metastatic castration-resistant prostate cancer (mCRPC), highlighting the potential of KLK2 as a novel target for T-cell engagement in advanced disease.1 These data were presented as an oral presentation (Abstract #5017) at the 2025 American Society of Clinical Oncology Annual Meeting and published simultaneously in The Journal of Clinical Oncology. Pasritamig is a novel T-cell engager designed to bind both CD3 on T-cells and KLK2—a prostate-specific antigen with minimal expression outside of the prostate. Pasritamig activates T-cells by binding to CD3 and directing them to KLK2- expressing tumor cells, engaging the body's immune system to specifically target these cancerous cells. This differentiated approach aims to deliver a targeted treatment for patients with advanced prostate cancer, while potentially reducing the high-grade toxicities historically associated with T-cell engagers. "These first-in-human results for pasritamig are highly encouraging, demonstrating that KLK2 is a viable target for T-cell engagers in metastatic castration-resistant prostate cancer," said Capucine Baldini*, M.D., Ph.D., Drug Development Department (DITEP), Institut Gustave Roussy, and presenting author. "The data show a promising safety profile, with manageable adverse events and no AEs leading to treatment discontinuations or ICANS observed, with 40 percent of patients having no treatment-related AEs at all. Given the limited treatment options for mCRPC, these findings support further investigation of pasritamig and the role of KLK2-targeted T-cell therapies as a potential new approach for patients with aggressive disease." "Metastatic castration-resistant prostate cancer remains one of the most difficult stages of prostate cancer to treat, particularly for patients who haven't responded well to previous treatments," said Jeff Infante, M.D., Vice President of Early Clinical Development and Translational Research at Johnson & Johnson Innovative Medicine. "This investigational approach underscores our commitment to developing innovative and practice-changing medicines that are well-tolerated and can be easily administered in community practice settings." The Phase 1 first-in-human study (NCT04898634) evaluated 174 patients with ages ranging from 36 to 89 years old and on average having received four prior therapies (range 1-13). The recommended phase 2 dose (RP2D) of pasritamig was 3.5mg on day 1, 18mg on day 8, 300mg intravenously on day 15 and then once every six weeks. The RP2D safety group also included patients treated once every three weeks as the toxicity profiles were very similar. The RP2D efficacy group only included patients treated at the RP2D once every six weeks.1 Within the RP2D safety group (n=45), treated once every three or six weeks, 100 percent had previously received androgen receptor pathway inhibitors, 75.6 percent had undergone taxane chemotherapy, and 37.8 percent had been treated with Lutetium 177 vipivotide tetraxetan prostate-specific membrane antigen radioligand therapy.1 The most common treatment- related adverse events (TRAEs) were Grade 1/2 infusion-related reactions (24.4 percent), Grade 1 cytokine release syndrome (CRS) presenting as fever only (8.9 percent, no steroid or tocilizumab was administered) and no reports of higher grade CRS. No TRAEs leading to treatment discontinuation or dose reduction were reported and no immune effector cell-associated neurotoxicity syndrome (ICANS) was observed. Grade 3 TRAEs were infrequent with 4.4 percent of patients reporting transient AST/ALT increases and neutropenia. There were no dose-limiting toxicities reported. The favorable safety profile of the RP2D regimen enabled convenient outpatient administration on a patient-friendly, once-every-six-weeks schedule.1 Of the patients in the RP2D efficacy group (n=33), treated once every six weeks, 42.4 percent achieved a 50 percent or greater reduction in their prostate-specific antigen (PSA) levels with a median rPFS of 7.9 months (95 percent confidence interval [CI] 2.9, not estimable [NE]) and 21.2 percent of patients continuing therapy. Treatment with pasritamig showed durable disease control and rPFS that compares favorably to historical data in heavily pretreated patients with mCRPC.1 Metastatic castration-resistant prostate cancer occurs in a significant portion of prostate cancer patients, with many progressing despite initial therapies.2 Overall survival from diagnosis of mCRPC patients ranges from 13.5 to 31.6 months, and lower in patients who have progressed on therapy.3 Treatment options remain limited, underscoring the urgent need for safer and more effective therapies.4 About Pasritamig (JNJ-78278343)Pasritamig (JNJ-78278343) is an investigational T-cell-engaging bispecific antibody (bsAb) targeting human kallikrein 2 (KLK2) on prostate cancer cells and CD3 on T-cells. This approach is being evaluated in heavily pretreated patients with metastatic castration-resistant prostate cancer (mCRPC), a patient population with limited treatment options. About Metastatic Castration-Resistant Prostate Cancer (mCRPC)Metastatic castration-resistant prostate cancer (mCRPC) is a challenging and aggressive stage of prostate cancer where the disease progresses despite androgen deprivation therapy.2 Patients often experience metastasis to bones and lymph nodes, leading to poor outcomes and limited treatment options, including chemotherapy and second-line hormone therapies.5 The median overall survival ranges from 13.5 to 31.6 months depending on the site of metastasis, with a typical range of 15–36 months across the broader population.3,6 Survival rates can vary significantly depending on factors such as prior treatment history, disease burden, and response to therapy. The need for more effective treatments is critical, as the disease continues to impact a large number of men globally, with mCRPC being responsible for a substantial number of prostate cancer-related deaths. About Johnson & JohnsonAt Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at or at Follow us at @JNJInnovMed. Janssen Research & Development, LLC, Janssen Biotech, Inc., Janssen Global Services, LLC and Janssen Scientific Affairs, LLC are Johnson & Johnson companies. Cautions Concerning Forward-Looking StatementsThis press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of JNJ-78278343. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's most recent Annual Report on Form 10-K, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at or on request from Johnson & Johnson. Johnson & Johnson does not undertake to update any forward-looking statement as a result of new information or future events or developments. Source: Johnson & Johnson *Dr. Capucine Baldini has provided consulting, advisory, and speaking services to Johnson & Johnson; Dr. Baldini has not been paid for any media work. 1 Baldini, C., et al. Phase 1 Study Results of Pasritamig (JNJ-78278343) in Metastatic Castration-Resistant Prostate Cancer. 2025 American Society of Clinical Oncology Annual Meeting. June 2025.2 Scher, H. I., et al. (2016). "Treatment of castration-resistant prostate cancer: Current and future strategies." Nature Reviews Clinical Oncology, 13(10), 577-590.3 Wallace KL, Landsteiner A, Bunner SH, Engel-Nitz NM, Luckenbaugh AN. Increasing prevalence of metastatic castration-resistant prostate cancer in a managed care population in the United States. Cancer Causes Control. 2021;32(12):1365-1374. doi:10.1007/s10552-021-01484-44 Ravi P, Mateo J, Lorente D, et al. Clinical prognostic factors and management of metastatic castration-resistant prostate cancer: a population-based study. PLoS One. 2015;10(10):e0139440. doi:10.1371/ Ryan, C. J., et al. (2015). "Abiraterone acetate in metastatic prostate cancer: A new era." Journal of Clinical Oncology, 33(10), 1051-1060.6 Kawahara, T., Saigusa, Y., Yoneyama, S. et al. Development and validation of a survival nomogram and calculator for male patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate and/or enzalutamide. BMC Cancer 23, 214 (2023). Media contacts:Oncology Media Relations oncology_media_relations@ Investor contact:Lauren Johnsoninvestor-relations@ U.S. Medical Inquiries +1 800 526-7736 View original content to download multimedia: SOURCE Johnson & Johnson Sign in to access your portfolio

Experts warn of dramatic spikes in US households' energy bills this summer: 'Unprecedented'
Experts warn of dramatic spikes in US households' energy bills this summer: 'Unprecedented'

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Experts warn of dramatic spikes in US households' energy bills this summer: 'Unprecedented'

A new AccuWeather report forecasts searing temperatures, more frequent droughts, and higher power bills across large swaths of the United States this summer. According to the news release shared by PR Newswire, hotter weather is expected to impact millions of Americans, with meteorologists predicting temperatures three degrees or higher above average for much of the U.S. Higher energy bills are expected as people crank up the air conditioning to find relief. "Make sure your air conditioners are ready for another hot summer across much of the country, especially the western and central U.S. We expect a summer with more extremes, including extreme heat waves, expanding drought and the potential for big wildfires and major hurricanes later in the summer," AccuWeather Lead Long-Range Expert Paul Pastelok said. Droughts across the western U.S. could spark wildfires, even during monsoon season when thunderstorms trigger lightning strikes that hit dry landscape and potentially cause it to burn. Overall temperatures are projected to climb above historical averages in 45 states, with 14 in the central and western U.S. expected to see the highest temperatures. Heatwaves are extremely dangerous for the elderly, young, immunocompromised, or anyone without air conditioning, as extreme heat causes more deaths than hurricanes, floods, tornadoes, and cold weather combined, according to AccuWeather senior meteorologist and climate expert Brett Anderson. The impacts of scorching summer temperatures are usually worse in major cities, where the urban heat island effect makes the surrounding air feel hotter than it would in rural or suburban areas because of the dark-colored asphalt and concrete buildings. If someone lacks air conditioning, they're at a higher risk of experiencing heat-related illnesses and other health issues. In highly humid climates, warm weather can be even deadlier because the body struggles to maintain a safe core temperature without the ability to cool down through sweating. Recent studies show an alarming increase in heat-related deaths over the past two decades across the U.S., and the trend is likely to continue as global temperatures continue to climb because of the shifting climate. Human activities — namely the burning of dirty fuels such as oil and gas — are driving rapid changes in the climate that are contributing to more extreme weather. Scientists have been observing these long-term shifts in weather patterns since the mid-1800s, but the effects haven't been felt to an extreme degree until the past decade. How often do you worry about your energy bills? Every day A few times a week A few times a month Only when I pay it Click your choice to see results and speak your mind. NASA reported that "the rate of change since the mid-20th century is unprecedented over millennia." "While Earth's climate has changed throughout its history, the current warming is happening at a rate not seen in the past 10,000 years," it added. Rising global temperatures act like "steroids for weather," as climate tech investor Molly Wood explained. Burning dirty fuels causes the atmosphere to trap excess heat and hold more moisture, which triggers more intense storms, hurricanes, wildfires, and every other kind of natural disaster. Addressing the overheating planet is costly, but ignoring the consequences is far more expensive. Luckily, governments, climate tech companies, and other organizations have come up with solutions to help us withstand the effects of the warming world. For example, the U.S. government just unlocked $7 billion in solar panel incentives that will help homeowners switch to cleaner energy that can reduce the pollution in the atmosphere, thereby contributing to a cooler planet. Companies have also made breakthroughs in battery tech that allow for longer storage, increasing grid resiliency and ensuring people have enough power at night when demand peaks. Installing solar panels with a backup battery system can make your home safer and more prepared to handle extreme weather events during power outages. Plus, your energy costs will be drastically lower or even reduced to nothing, allowing you to save that money for other home improvements that increase security as the climate shifts. If you're interested in going solar, the online marketplace EnergySage offers a free service that allows you to compare quotes from vetted installers and save up to $10,000 on solar installations. Join our free newsletter for good news and useful tips, and don't miss this cool list of easy ways to help yourself while helping the planet.

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