logo
Oil slides, stocks jump amid Iran-Israel ceasefire uncertainty

Oil slides, stocks jump amid Iran-Israel ceasefire uncertainty

LONDON: Oil prices sank and stock markets jumped Tuesday, even as uncertainty reined over a Israel-Iran ceasefire.
In volatile trading, crude futures slumped more than five per cent after US President Donald Trump's declaration of a ceasefire.
The oil market went on to reduce its losses, however, as Israel and Iran accused each other of breaking the ceasefire -- news confirmed by Trump.
The president berated the two sides, adding that he was "really unhappy" with Israel in particular.
Despite tensions igniting once more, oil prices were still down more than three per cent by early afternoon trading in Europe.
"Investors are reacting with relief to apparent news of a US-brokered ceasefire between Iran and Israel," noted AJ Bell investment director Russ Mould.
"Gold slipped back as its safe haven attributes were less in demand," Mould said, adding that the news weighed on share prices of oil producers and miners.
The dollar retreated against main rivals after Trump once more demanded that the US Federal Reserve cut interest rates in a bid to boost the world's biggest economy.
Escalating tensions in the Middle East has removed some focus from Trump's tariffs war, which threatens to dampen global economic growth.
In Germany, where the DAX stocks index rallied 1.9 per cent, Chancellor Friedrich Merz urged Iran and Israel to follow the ceasefire announced by Trump.
"We call on both Iran and Israel to heed this call from the American president," Merz told parliament.
"If this ceasefire succeeds... then it will be a very positive development that can make the Middle East and the world safer."
French President Emmanuel Macron said Tuesday that the situation surrounding Iran remained "volatile and unstable".
There are fears that Iran could shut the Strait of Hormuz, a chokepoint for about one-fifth of the world's oil supply.
Rystad Energy analyst Jorge Leon told AFP that he believed the risk of the waterway shutting had diminished despite Iran launching missiles at a US base in Qatar in retaliation for American strikes on Tehran's nuclear facilities.
Trump dismissed the attack as "very weak", and said Iran gave "early notice", adding no one was hurt or killed.
"I think the risk of closing Hormuz now has diminished rapidly because US and Iranian tension is already over," Leon argued.

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Wall Street Eyes Breakout Cancer Therapies Amid Soaring Drug Prices
Wall Street Eyes Breakout Cancer Therapies Amid Soaring Drug Prices

Malaysian Reserve

time3 hours ago

  • Malaysian Reserve

Wall Street Eyes Breakout Cancer Therapies Amid Soaring Drug Prices

Equity Insider News Commentary Issued on behalf of Oncolytics Biotech Inc. VANCOUVER, BC, June 24, 2025 /PRNewswire/ — Equity Insider News Commentary – Rising rates of cancer are going to come at a major cost, and it's looking more and more like the solution is going to have to come from the private sector. Recent reports suggest the U.S. government may slash National Cancer Institute (NCI) funding by nearly 40%, while Bloomberg reports growing concern over affordability and access to cancer drugs whose prices are rising sharply. From Wall Street's point of view, the focus needs to shift towards up-and-coming treatments being developed by promising candidates, including from Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Indaptus Therapeutics, Inc. (NASDAQ: INDP), Perspective Therapeutics, Inc. (NYSE-American: CATX), SELLAS Life Sciences Group, Inc. (NASDAQ: SLS), and Autolus Therapeutics plc (NASDAQ: AUTL). Analysts at Nova One Advisor are currently projecting the global oncology drug market to hit US$366.24 billion by 2034, expanding at a 7.4% CAGR. Others are even more optimistic, with ResearchAndMarkets estimating the sector will reach US$866.1 billion by 2034, growing at a 10.8% CAGR, and Vision Research Reports anticipating the market will top US$903.81 billion by the same year, driven by accelerating demand for advanced diagnostics and treatments. All this points to an optimal timing period for breakout cancer stocks. Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC) has entered a new chapter with the appointment of Jared Kelly as Chief Executive Officer and member of the Board. With a background in high-value biotech transactions and late-stage development strategy, Kelly brings experience that may help position the company for its next phase of clinical and corporate progress. Prior to joining Oncolytics, Kelly was General Counsel at Ambrx Biopharma, where he played a key role in the company's $2 billion acquisition by Johnson & Johnson. He also advised a range of life sciences firms on partnerships, licensing, and M&A during his tenure at Kirkland & Ellis LLP and Lowenstein Sandler LLP. His arrival comes as Oncolytics continues advancing pelareorep, a viral-based immunotherapy being evaluated in combination with checkpoint inhibitors and other agents across multiple cancer indications. 'Pelareorep's clinical data across multiple tumors is striking and represents the potential for a true backbone immunotherapy to address many in-need indications. Importantly, the data show that pelareorep creates a robust immunologic response in difficult tumors and increases survival in a patient population where survival has historically evaded most patients,' said Jared Kelly, CEO of Oncolytics Biotech. 'With a renewed focus and sharpened clinical development plan, we believe we will move pelareorep forward effectively and efficiently to a place where potential partners will see the value of a de-risked immunotherapy. I am excited to get to work accelerating development and unlocking significant value for stakeholders.' Kelly's appointment appears aligned with a focused strategy: advancing pelareorep through late-stage development while maintaining capital efficiency and openness to potential partnerships. The company's lead program continues to generate data that support further investigation across several difficult-to-treat cancers. Pelareorep already holds FDA Fast Track designation in two separate indications — metastatic pancreatic ductal adenocarcinoma (mPDAC) and HR+/HER2- metastatic breast cancer (mBC) — a distinction that highlights regulatory interest in its potential. Across clinical studies, the viral-based immunotherapy has consistently shown signs of immune activation, combinability with checkpoint inhibitors and chemotherapy, and efficacy in heavily pretreated populations. In mPDAC, a Phase 2 cohort from the trial has reported objective response rates (ORR) above 60% in tumor-evaluable patients, exceeding historical benchmarks for this indication. Additional analyses have noted extended two-year survival rates compared to previous benchmarks. In HR+/HER2- mBC, two randomized Phase 2 trials (IND-213 and BRACELET-1) observed overall survival trends that support continued clinical evaluation. Elsewhere, a Phase 2 anal cancer cohort combining pelareorep with a checkpoint inhibitor demonstrated partial or complete response rates that exceeded historical control trials for checkpoint inhibitor monotherapy, suggesting potential utility beyond the company's lead programs. 'Mr. Kelly's vision and track record is an extraordinary fit with the standout clinical data pelareorep has generated to date,' said Wayne Pisano, Chair of the Board and outgoing Interim CEO of Oncolytics. 'We believe Mr. Kelly's well-documented ability to prioritize clinical program development, execute successful financings, and attract the attention of large industry peers will help maximize Oncolytics' potential to deliver transformative outcomes for patients and exceptional value for investors.' Kelly's compensation framework includes equity-based awards and performance-linked incentives tied to future financings and strategic outcomes. The structure is designed to align leadership priorities with long-term shareholder value while reinforcing a disciplined approach to capital and partnership development. As multiple cohorts advance within the GOBLET study — including those in pancreatic and anal cancers backed by external funding and regulatory support — Oncolytics appears positioned to continue its progress with a blend of clinical momentum, financial flexibility, and sharpened strategic direction. Prior to Kelly's appointment, Oncolytics presented new data from its GOBLET trial at the 2025 ASCO Annual Meeting, highlighting pelareorep's ability to stimulate both innate and adaptive immune responses in metastatic pancreatic cancer. With fresh clinical insights and new leadership in place, the company appears positioned to advance both its scientific and strategic priorities in tandem. CONTINUED… Read this and more news for Oncolytics Biotech at: In other recent industry developments and happenings in the market include: Indaptus Therapeutics, Inc. (NASDAQ: INDP) recently initiated dosing in a Phase 1b/2 study arm testing its lead candidate Decoy20 with PD-1 inhibitor tislelizumab in advanced solid tumors. 'This is an important milestone in our clinical development,' said Jeffrey Meckler, CEO of Indaptus. 'We have long believed the Decoy platform has the potential to be a game-changing approach to treating solid tumors.' The combination is being evaluated in patients previously treated with checkpoint inhibitors or with tumor types typically unresponsive to immunotherapy. Early preclinical findings showed Decoy20 could synergize with PD-1 blockade to activate stronger anti-tumor immunity. The trial will monitor safety and preliminary signals of efficacy before broader enrollment. Perspective Therapeutics, Inc. (NYSE-American: CATX) has recently opened enrollment for Cohort 3 of its Phase 1/2a trial testing [212Pb]VMT-α-NET in patients with unresectable or metastatic somatostatin receptor 2 (SSTR2)-positive neuroendocrine tumors. 'We are excited to start exploring a higher dose level of VMT-α-NET after successfully completing an interaction with the FDA that was agreed prior to commencement of this trial,' commented Markus Puhlmann, Chief Medical Officer of Perspective. 'We are encouraged by the overall clinical profile observed at the second dose level of VMT-α-NET—including evidence of anti-tumor activity and primarily low-grade adverse events—and we believe it is important to assess whether a higher dose could further improve the therapeutic profile. Meanwhile, we remain committed to engaging with the FDA to evaluate the clinical utility of dosimetry estimates and analyses in the development of our proprietary RPTs.' The newly approved dose level represents a 20% increase over the previous cohort and will be evaluated for safety and early signals of efficacy. Interim results presented at American Society of Clinical Oncology (ASCO) Annual Meeting and Society of Nuclear Medicine & Molecular Imaging (SNMMI) Annual Meeting showed evidence of anti-tumor activity and favorable tolerability at lower doses. The company expects to submit additional clinical updates in the second half of 2025 following extended patient follow-up. SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) recently presented new preclinical data at the 2025 ASCO Annual Meeting showing that its CDK9 inhibitor SLS009 demonstrated potent activity in ASXL1-mutated colorectal cancer cell lines. 'These results provide strong rationale for continued advancement of SLS009 as a potential treatment for ASXL1-mutated cancers,' said Dr. Dragan Cicic, Senior Vice President, Chief Development Officer at SELLAS. 'The ability to selectively target ASXL1-driven tumors at concentrations well below the known safety threshold opens the door for tolerable and effective therapy. Based on the findings, we believe that ASXL1 mutation status could serve as a potential biomarker for response to SLS009 inhibition, which may allow us to further refine patient selection and improve outcomes. We look forward to presenting these results at ASCO.' In the study, 75% of lines with ASXL1 frameshift mutations responded at low nanomolar concentrations, while no response was observed in wild-type lines. These findings suggest that ASXL1 mutation status may serve as a potential biomarker for patient selection. Autolus Therapeutics plc (NASDAQ: AUTL) has released updated results from its FELIX study, showing that obe-cel, a next-generation CAR T cell therapy, may provide long-term remission for adults with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). With a median follow-up of nearly 33 months, more than 50% of patients were still in remission at 24 months, and 38% had not needed any additional therapy. 'Obe-cel's durability of response without any subsequent therapy in two out of every five responders is a key factor leading the transformation of therapy for adult r/r B-ALL patients. At a median follow up of 33 months, we are encouraged to see a continuation of the long-term plateau we observed at the last data cut,' said Dr. Christian Itin, CEO of Autolus. 'A well-tolerated, effective, durable treatment option for ALL patients who often have a poor prognosis and have had multiple prior treatments is of significant clinical benefit.' The data suggested obe-cel could serve as a standalone option for some patients, reducing the need for transplants or further treatment. The company also reported a strong safety profile and plans to continue advancing obe-cel as a potential cornerstone in adult B-ALL care. Source: CONTACT: Equity Insider info@ 265-2873 DISCLAIMER: Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. Equity Insider is a wholly-owned subsidiary of Market IQ Media Group, Inc. ('MIQ'). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice commencing immediately and ongoing. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material, including this article, which is disseminated by MIQ has been approved by Oncolytics Biotech Inc.; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles. While all information is believed to be reliable, it is not guaranteed by us to be accurate. Individuals should assume that all information contained in our newsletter is not trustworthy unless verified by their own independent research. Also, because events and circumstances frequently do not occur as expected, there will likely be differences between the any predictions and actual results. Always consult a licensed investment professional before making any investment decision. Be extremely careful, investing in securities carries a high degree of risk; you may likely lose some or all of the investment. Video – – – View original content:

US Fed chair signals no rush for rate cuts despite Trump's pressure
US Fed chair signals no rush for rate cuts despite Trump's pressure

New Straits Times

time4 hours ago

  • New Straits Times

US Fed chair signals no rush for rate cuts despite Trump's pressure

WASHINGTON: US Federal Reserve Chair Jerome Powell told lawmakers Tuesday that the central bank can afford to wait for the impact of tariffs before deciding on further interest rate cuts -- despite President Donald Trump's calls to slash levels. The Fed has a duty to prevent a one-time spike in prices from becoming an "ongoing inflation problem," Powell said before the House Committee on Financial Services. "For the time being, we are well positioned to wait to learn more about the likely course of the economy before considering any adjustments to our policy stance," he added. Powell's reiteration that the Fed can wait to lower rates comes after two officials recently expressed openness to cuts as early as in July. Asked about other policymakers' views on a pathway to rate cuts, Powell declined to comment. But he said officials could be inclined to lower rates sooner if inflation were weaker than expected or if the labor market deteriorated. The Fed has held the benchmark lending rate steady this year following its last reduction in December, bringing the level to a range between 4.25 per cent and 4.50 per cent. After last week's announcement that the bank will keep rates unchanged for a fourth straight policy meeting, Powell told reporters that it would make smarter decisions if it waited to understand how Trump's tariffs impact the economy. But hours before Powell's testimony Tuesday, Trump again urged the Fed chair to slash rates, saying these should be "at least two to three points lower" given that inflation remains benign. "I hope Congress really works this very dumb, hardheaded person, over," Trump wrote on his Truth Social platform. Powell maintained Tuesday that it remains unclear how concerns over US trade policies could affect future spending and investment. "Increases in tariffs this year are likely to push up prices and weigh on economic activity," he said, although adding that it would be "inappropriate for us to comment on the policy of tariffs." For now, Powell said: "Despite elevated uncertainty, the economy is in a solid position." Since returning to the presidency, Trump has imposed a 10 per cent tariff on almost all trading partners and steeper rates on imports of steel, aluminum and autos. Economists warn the levies could fuel inflation and bog down economic growth, although widespread effects have so far been muted. This is partly because Trump has backed off or postponed his most punishing salvos. Businesses also stocked up on inventory in anticipation of the duties, avoiding immediate consumer price hikes. But Powell expects to learn more about the tariffs' effects over the summer, giving them time to filter through. Although the Fed has penciled in two rate cuts this year, there is growing divergence among policymakers about whether the central bank can lower rates at all in 2025. Powell said a "significant majority" of the Fed's rate-setting committee still feels it will be appropriate to reduce rates later this year. While inflation has eased significantly from highs in mid-2022, Powell said Tuesday that it remains "somewhat elevated" relative to the bank's longer-run two percent goal. On conflict in the Middle East, Powell said "it's too early to know what any economic implications might be," adding that officials are monitoring the situation. - AFP

Iran Wont Breach Truce If Israel Doesnt Do So: Pezeshkian
Iran Wont Breach Truce If Israel Doesnt Do So: Pezeshkian

Malaysia Sun

time4 hours ago

  • Malaysia Sun

Iran Wont Breach Truce If Israel Doesnt Do So: Pezeshkian

If the Zionist regime does not violate the ceasefire, Iran will not do so, Pezeshkian said in a telephone conversation with the prime minister of Malaysia on Tuesday after a ceasefire put a halt to 12 days of Israeli aggression against Iran and to the Islamic Republics retaliatory missile strikes. Pezeshkian said the Zionist regime and its supporters had hoped to create dissatisfaction among Iranians. However, the Iranian people demonstrated that, despite some problems, they remain united against enemy aggression. The Israeli regime attacked Iran amid the indirect negotiations between Iran and the US in the mistaken belief that Tehran lacked the capacity to respond and would surrender within a few days, the president added. The Zionist regime and its supporters also relied on inciting dissatisfaction and mobilizing the Iranian people, Pezeshkian added, his official website reported. He also lashed out at the self-proclaimed advocates of human rights and civilization for observing the crimes of the Zionist regime against the Iranian scientists and ordinary people. When the Zionist regime failed to achieve its objectives, the US directly participated in anti-Iran crimes and, contrary to all international rules, attacked Iranian nuclear sites, the president said. Pezeshkian also stressed that Iran regards all neighboring and regional countries as friends and brothers, and has always sought to deepen and strengthen relations and cooperation with them. Iran was compelled to respond to the US crimes by attacking an American airbase in Qatar, the president said, noting that this does not mean Iran is in conflict with the Qatari government and people.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store