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Regeneron announces analyses from Phase 3 C-Post trial

Regeneron announces analyses from Phase 3 C-Post trial

Regeneron (REGN) Pharmaceuticals announced detailed analyses from the Phase 3 C-POST trial, which evaluated PD-1 inhibitor Libtayo in patients with high-risk cutaneous squamous cell carcinoma, CSCC, after surgery. The results, shared during an oral session at the 2025 American Society of Clinical Oncology, ASCO, Annual Meeting and simultaneously published in the New England Journal of Medicine, NEJM, include additional data for the primary endpoint of disease-free survival, DFS, and the first presentation of key secondary endpoint outcomes. With a median duration of follow-up of 24 months, efficacy results for Libtayo compared to placebo, were as follows: 68% reduction in the risk of disease recurrence or death, with median DFS not reached for Libtayo-treated patients; At two years, DFS was 87% with Libtayo versus 64% with placebo; 80% reduction in the risk of locoregional recurrence; 65% reduction in the risk of distant recurrence
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Serena Williams on Using GLP-1s, Motherhood, and Redefining Diet Culture
Serena Williams on Using GLP-1s, Motherhood, and Redefining Diet Culture

Elle

time22 minutes ago

  • Elle

Serena Williams on Using GLP-1s, Motherhood, and Redefining Diet Culture

Every item on this page was chosen by an ELLE editor. We may earn commission on some of the items you choose to buy. The most famous female tennis player of our time is on a GLP-1 drug. If that makes you have some feelings, 23-time Grand Slam champion and decorated Olympian Serena Williams understands. 'GLP-1s have gotten a stigma, and I feel like there should be more open conversation,' she tells me. 'A lot of people are on them, and it's okay to be on them.' Williams is the new ambassador for the telehealth start-up Ro, joining former basketball star Charles Barkley, who also announced in April that he was on a GLP-1 drug via the company. (In full transparency, her team disclosed that Williams's husband, Alexis Ohanian, is a Ro investor and on the board.) Below, Williams talks to ELLE about why she decided to start using a GLP-1 and the diet-culture myths she hopes the drug will help dismantle. Did the decision to go on a GLP-1 come from your doctor? I do a lot of research on everything that's out on the market. After I had my second kid, I lost a lot of weight within two weeks. But after that [time], no matter what I did, I couldn't [lose any more weight]. Every single day, I would get my 30,000 steps. I ran and trained. Even after my first daughter, I never got back to the level that I wanted to be. In the HBO documentary Being Serena, my coach talks to me about my weight, and at the time, I was thinking, 'This is a tough conversation,' because you could already see me physically doing every single thing. I needed to try something different, so I was like, I'm going to have to try these GLP-1s and see how it affects my body. Are you on a specific GLP-1? I am on Zepbound through Ro. What's your experience like on the drug? I have a lot of illnesses, so I'm so used to injections, and they didn't bother me at all. I haven't had any side effects. But every single person and every body is different. My body is like a stallion. You posted some pictures recently, and fans 'defended' you by saying you weren't on a GLP-1 drug. Some even called the speculation negative. How do you feel about it being characterized that way? First off, I never heard or read that. I don't read any stuff, but it's important to talk about what I am doing. I like to have very honest conversations with myself. I've always been a pretty transparent person, probably because I grew up on the very public tennis court in front of millions of people. Everyone's journey is different. I work out. I don't 'just' take them. You can see all the work that I do and how my body really didn't change until I got on one. It was really important for me and for my confidence to be at the weight that I'm used to being on. It is also very healthy for me, especially for my body, joints, and knees, particularly as I get a little bit older. Everyone is allowed to have their own opinion. But it's important for me to own my own narrative and tell my own story. Like you alluded to, people sometimes think that going on a GLP-1 is the lazy way to lose weight. That's exactly why it is so important to tell my story. There are a lot of people out there who can relate—maybe they have had a child, and they're like, Okay, I've done everything. I've gone to the gym. [They may need to] hear that Serena not only did the gym, she played professional tennis, did all the training, and [even] she could never get to where she was at when she was her healthiest. I'm not trying to get to the way I was when I was 16, but I want to be at a healthy place. People want and need to hear that it's not the easy way out. It's not. It is something that I feel like my body personally needed. Do you think GLP-1 drugs are upending this long-held idea that losing weight comes down to willpower? I can speak to that personally. I was traveling on tour, playing a professional sport at a very high level, eating extremely healthy. It didn't matter what I did—there were just some things that wouldn't change. A lot of people can say, 'Well, I don't want to go on a GLP-1, because I can change the way I eat.' But they don't understand. Sometimes people do change the way they eat. They do change the way they work out. They do absolutely everything, and it doesn't work. That may not be everyone's story, but that's my story. I remember training before my last US Open. I was training for four hours in the sun in the summer in July or August. I didn't even eat that day because I was working out so hard, and I always eat after I work out. But I didn't lose anything. I actually had a stomach. I always was curious about that. I was like, How is it that I can be training for four hours, and I still have this extra mom weight on me? Has being on a GLP-1 affected your muscle mass? No, I actually weigh more than I look. I have a ton of muscle on me. I look lighter than what I actually am because of my muscle mass. So again, everyone's story could be different. That's just my personal body. Does it affect your appetite? Yes, and that's what I think a GLP-1 does. It definitely does make a difference in your appetite. I don't really know, but I think it also gave me something that my body may have been just missing. I am still trying to understand more of the science behind it. I know that some people haven't been able to eat as much, but I still have a pretty interesting appetite. Has it quieted any food noise? I've never been a foodie. I've never been a person that thinks about food or their next meal, because as a professional athlete, that's never what I think about. I never really had food noise. Sometimes I forget to eat, so it's totally different for me. Would you have considered using GLP-1 drugs while you were playing professional tennis? To be perfectly honest, I wish I had this after I had [my daughter] Olympia. I wonder what would have happened if I was actually able to lose the extra weight that I needed to lose, even though I had done everything that I could. It makes me think, but I try not to think too hard about it. This interview has been edited and condensed for clarity.

Hurricane Erin Seen From Space in Satellite Camera's Live Video Stream
Hurricane Erin Seen From Space in Satellite Camera's Live Video Stream

Newsweek

timean hour ago

  • Newsweek

Hurricane Erin Seen From Space in Satellite Camera's Live Video Stream

Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. Video footage from a camera on the International Space Station (ISS) has captured Hurricane Erin swirling above the Atlantic Ocean. Why It Matters Erin is the fifth named storm of the 2025 Atlantic season, as well as the first hurricane. Forecasters have warned of "life-threatening" conditions across the U.S. East Coast as the system traverses the Atlantic. What To Know The footage of Erin was captured by the Sen SpaceTV-1 camera system mounted on the International Space Station in low Earth orbit. The space streaming company Sen says its SpaceTV-1 mission launched to the ISS in 2024, and its public livestream began in December that year. According to NASA, the ISS completes approximately 16 orbits each day, with each one taking between 90 and 93 minutes. The agency says that there may be less than 16 orbits depending on the station's altitude. As of Thursday morning, the National Hurricane Center (NHC) said Erin was located about 205 miles east-southeast of Cape Hatteras, North Carolina. Although it described the system as a "large and growing hurricane," the agency said that gradual weakening was forecast "during the next couple of days." A spectacular view of Hurricane Erin swirling north as lightning flashes throughout the system. — CIRA (@CIRA_CSU) August 21, 2025 Behind Erin, the NHC was also monitoring two disturbances in the Atlantic associated with tropical waves. The first—located near the Leeward Islands—was given a "high" 70 percent chance of cyclone formation through seven days, with the NHC saying a tropical depression could form this weekend. The second, further to the east, was given a 40 percent chance of development. An NHC graphic highlights features being monitored in the Atlantic. An NHC graphic highlights features being monitored in the Atlantic. National Hurricane Center What People Are Saying The National Hurricane Center said in a post on X on Thursday: "Erin just beginning to move away from the North Carolina coast. Beachgoers are cautioned against swimming at most U.S. East Coast beaches due to life-threatening surf and rip currents." Storm chaser Colin McCarthy said on X, Wednesday: "Hurricane Erin is absolutely massive, looming off the East Coast and stretching over 800 miles across. "To put that in perspective, if it were placed over the United States, it would span from Chicago all the way to New York City." NASA said in a post on X, Wednesday: "Erin went through a period of rapid intensification, strengthening from a Category 1 to a Category 5 hurricane in around 24 hours." What Happens Next The NHC expects Hurricane Erin to move between the East Coast of the U.S. and Bermuda early Friday, then pass south of Atlantic Canada on Friday and Saturday. A livestream of footage from SpaceTV-1 can be found here.

Enanta Pharmaceuticals to Participate in September Investor Conferences
Enanta Pharmaceuticals to Participate in September Investor Conferences

Yahoo

time2 hours ago

  • Yahoo

Enanta Pharmaceuticals to Participate in September Investor Conferences

WATERTOWN, Mass., August 21, 2025--(BUSINESS WIRE)--Enanta Pharmaceuticals, Inc. (NASDAQ:ENTA), a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and immunological diseases, today announced that members of management will participate in three investor conferences in September: Cantor Global Healthcare Conference 2025: Fireside Chat on Wednesday, September 3, 2025 at 8:35 a.m. ET H.C. Wainwright 27th Annual Global Investment Conference: Fireside Chat on Tuesday, September 9, 2025 at 2:00 p.m. ET Baird 2025 Global Healthcare Conference: Fireside Chat on Wednesday, September 10, 2025 at 12:15 p.m. ET A live webcast of each event will be accessible by visiting the "Events and Presentations" section on the "Investors" page of Enanta's website at A replay of the webcasts will be available following the presentation and will be archived for at least 30 days. About Enanta Pharmaceuticals, is using its robust, chemistry-driven approach and drug discovery capabilities to become a leader in the discovery and development of small molecule drugs with an emphasis on indications in virology and immunology. Enanta's clinical programs are currently focused on respiratory syncytial virus (RSV) and its earlier-stage immunology pipeline aims to develop treatments for inflammatory diseases by targeting key drivers of the type 2 immune response, including KIT and STAT6 inhibition. Glecaprevir, a protease inhibitor discovered by Enanta, is part of one of the leading treatment regimens for curing hepatitis C virus (HCV) infection and is sold by AbbVie in numerous countries under the tradenames MAVYRET® (U.S.) and MAVIRET® (ex-U.S.) (glecaprevir/pibrentasvir). A portion of Enanta's royalties from HCV products developed under its collaboration with AbbVie contribute ongoing funding to Enanta's operations. Please visit for more information. View source version on Contacts Media and Investors Contact: Jennifer Viera617-744-3848jviera@

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