Pole to pole: A Learjet will soon leave Wichita on a worldwide mission
A Learjet will depart from Wichita this week as pilots try to fly to the South Pole, then the North Pole and back to Wichita in three days.
The 'Polar Mission,' more formally known as polar circumnavigation, is a trip through both poles. The flight was organized by the Classic Lear Jet Foundation based in Wichita.
'No Learjet has ever attempted this aggressive mission,' foundation spokesperson Rick Rowe said.
The Rockwell Polar Flight in November 1965 was the first to complete a circumnavigation.
The mission is intended to raise money to restore Lear Jet 23-003, the first Learjet to ever be delivered to a customer on Oct. 13, 1964, Rowe said in a phone call.
The foundation is in the early stages of restoration and is dismantling the plane. Rowe could not say how much it would cost to restore it.
'We have to take all the wiring, plumbing, flight control cables and all the insulation out of the fuselage,' Rowe said. 'In other words, just make it, make it a skeleton.'
The Learjet 36A that will be flown across the world landed at Stearman Airfield in Benton on April 24. It will depart on April 30 and will return May 3.
The funding and plane were provided by Global Jetcare, an air ambulance company based in Florida. Bart Gray is the CEO of Global Jetcare and the vice president of the Classic Lear Jet Foundation.
'He is an avid Learjet pilot and a real aficionado of Learjet airplanes,' Rowe said. 'He is the one who suggested we do this and has done all the planning for it.'
Gray, along with three other pilots, will take turns flying the plane on the polar mission.
'At each stop on the flight, the crew will perform research by placing a scale on the wing of the plane to help determine if the Earth is bigger on the Equator and document it,' the foundation said.
There are 12 stops on the route, a flight path graphic shows.
Lear Jet was founded in 1962 by William Powell. It was later renamed Learjet. Bombardier acquired the company in 1990 and announced the end of production for all models in 2021, bringing roughly 60 years of Learjet history to an end.
Lear Jet 23-003 has historical significance.
'Business aviation was alive and well in 1962 to 1964 when Bill Lear first came to town and started building the jet,' Rowe said. 'But during that time they were flying piston prop planes, so when Bill got the Lear all figured out and designed and engineered and delivered, the world became a lot smaller because this airplane would go twice as far, twice as fast than the business aviation airplanes at that time.'
The Learjet used two General Electric turbojet engines.
Rowe added: 'It's iconic to civilian aviation as a business jet, just as Doc [B29] is to military aviation.'
A real-time tracker will be available to view the plane's route after it departs from Wichita at https://share.garmin.com/POLARMISSION
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New York Post
5 days ago
- New York Post
New longevity drug for dogs could extend your pet's life — and pave the way for humans to live longer too
Sit, stay… live longer? Research shows that owning a dog can help humans live longer, healthier lives. Now, a US biotech company wants to return the favor with anti-aging drugs designed to extend the lifespan of your canine companion. 'The longevity space is crowded right now, and for good reason,' Celine Halioua, founder and CEO of Loyal, told The Post. 'We all want to figure out how to get more happy, healthy years for our loved ones —especially the furry ones.' 6 Celine Halioua is leading the push to develop drugs that extend the lives of dogs. X/@loyalfordogs Before launching Loyal in 2019, Halioua worked on treatments for neurodegenerative diseases in humans — conditions that, much like aging in dogs, have no true preventive medicine. 'This combination of experience sparked my mission to develop the first drug approved for healthy lifespan extension,' she said. Good boys, great science Loyal has three longevity drugs in the pipeline, including two that specifically target bigger breeds, which typically have much shorter lifespans. While small dogs like Chihuahuas can live for 18 years or longer, giant breeds such as Great Danes would be lucky to make it to ten. That's where LOY-001 and LOY-003 come in. These drugs target dogs age seven and older that weigh at least 40 pounds. 6 Loyal's drugs aim to increase and quality of life for senior dogs. X/Celine Halioua They work by reducing levels of insulin-like growth factor 1 (IGF-1), a hormone that fuels cell growth. Scientists believe that high levels of IGF-1 shorten the lifespan of large dogs, which can have up to 28 times more of the hormone than smaller breeds. One version, LOY-001, is an injectable given a few times a year at the vet. The other, LOY-003, is a daily chewable pill. Both drugs are currently in pilot studies, and Loyal is eyeing conditional FDA approval by 2027. Loyal's third longevity drug, LOY-002, is even further along in development. The treatment targets senior dogs age 10 and up that weigh at least 14 pounds. It's currently being tested in a large-scale clinical trial involving more than 1,200 dogs across 70 clinics, making it one of the biggest studies in veterinary history, according to Halioua. 6 Small dogs tend to have a longer lifespan than larger breeds. X/Celine Halioua The drug works by targeting metabolism — the complex system of chemical reactions that powers essential functions like breaking down food, producing energy and repairing cells. As metabolism slows with age, it can lead to insulin resistance and trigger a range of health issues in both humans and dogs, including cognitive decline, osteoarthritis and cancer. 'Improving metabolic health is one of the most well-validated pathways for extending both lifespan and healthspan,' Halioua said. 'Research [shows] it can improve health and reduce the risk of age-related diseases across species — from mice to humans,' she added. So far, things are looking paws-itive. A pilot study of 48 dogs showed no adverse effects after three months of LOY‑002. 6 Both LOY-002 and LOY-003 are administered via a daily pill. X/Celine Halioua Loyal previously told The Guardian it's hoping the drug could add at least one extra year to a dog's life — and they'll be healthier during that time, too. Once it's approved, Halioua hopes LOY‑002 will become a common preventive tool, like flea and tick medication. 'We expect all dogs to benefit from its ability to protect against, and even reverse, some of the harmful effects of metabolic dysfunction,' she said. Loyal anticipates that the drug will receive conditional approval by the FDA in 2026. 6 Loyal is aiming to enroll 1,300 dogs in it's LOY-002 study. X/Celine Halioua But the dogs aren't the only ones who could benefit. 'We're on track to develop the first-ever FDA-approved drug for longevity — for any species,' Halioua said. 'Dogs share our environments and develop remarkably similar age-related diseases at similar stages of life, making them valuable models for human health and scientific research,' she added. Dogs make us healthier, too Halioua's lifelong love of animals runs deep. 'I've always been surrounded by animals — growing up, my family had 15 pets and rehabilitated wild animals,' she said. 'My Rottweiler, Della, is always by my side and is a major influence on the work I do.' It turns out dogs don't just bring love — they could bring health benefits as well. Studies show that dogs can ease loneliness, stress and anxiety. One even found that just 10 minutes of petting a pooch can significantly reduce levels of cortisol, the body's main stress hormone. 6 Dogs are known for their unconditional love and companionship. yurakrasil – Even locking eyes with your dog gives your brain a boost. A 2009 Japanese study found that staring into their eyes raises oxytocin — the 'love hormone' linked to bonding and happiness. Dogs might even help you live longer. A sweeping review of research from 1950 to 2019 found that dog owners consistently have a lower risk of death compared to those without pets. It's no accident. Research shows that dog owners tend to have lower blood pressure, cholesterol and a reduced risk of heart disease. Plus, they get more exercise, which builds muscle, strengthen bones and joints and keeps weight in check. That's no coincidence. Dog owners tend to have lower blood pressure, cholesterol, and less risk of heart disease. Plus, they're more active — walking their dogs regularly strengthens muscles, bones and joints, and helps keep weight in check. Some research even links dog ownership to bigger brains and sharper thinking, with faster processing speed and better memory. And here's the kicker: a major study found owning a dog lowers dementia risk — a benefit not shared by cat owners.
Yahoo
12-06-2025
- Yahoo
Medicus Pharma Ltd. to Present at 2025 Bio International Convention
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Cleveland Clinic Abu Dhabi (CCAD) is the principal investigator, along with Sheikh Shakbout Medical City (SSMC), Burjeel Medical City (BMC), and American Hospital of Dubai (AHD). Insights Research Organization and Solutions (IROS), a UAE-based contract research organization, is coordinating the clinical study for the Company. IROS is a M42 portfolio company. In April 2025, the Company announced entering into a binding letter of intent to acquire Antev Ltd. ("Antev"), a UK-based late clinical stage biotech company, developing Teverelix, a next generation GnRH antagonist, as first in market product for cardiovascular high-risk advanced prostate cancer patients and patients with first acute urinary retention relapse (AURr) episodes due to enlarged prostate. For further information contact: Carolyn Bonner, President (610) 636-0184cbonner@ Anna Baran-Djokovic, SVP Investor Relations (305) 615-9162adjokovic@ About Medicus Pharma Ltd: Medicus Pharma Ltd. (NASDAQ: MDCX) is a biotech/life sciences company focused on accelerating the clinical development programs of novel and disruptive therapeutics assets. SkinJect Inc. a wholly owned subsidiary of Medicus Pharma Ltd, is a development stage, life sciences company focused on commercializing novel, non-invasive treatment for basal cell skin cancer using patented dissolvable microneedle patch to deliver chemotherapeutic agent to eradicate tumors cells. The Company has completed a phase 1 safety & tolerability study (SKNJCT-001) in March of 2021, which met its primary objective of safety and tolerability; the study also describes the efficacy of the investigational product D-MNA, with six (6) participants experiencing complete response on histological examination of the resected lesion. The Company is currently conducting a randomized, controlled, double-blind, multicenter clinical study (SKNJCT-003) in United States and Europe. The Company has also commenced a randomized, controlled, double-blind, multicenter clinical study (SKNJCT-004) in UAE. In April 2025, the Company also announced entering into a binding letter of intent to acquire Antev, a UK-based late clinical stage biotech company, developing Teverelix, a next generation GnRH antagonist, as first in market product for cardiovascular high-risk advanced prostate cancer patients and patients with first acute urinary retention relapse (AURr) episodes due to enlarged prostate. The transaction with Antev is subject to the completion of satisfactory due diligence by Medicus, negotiation of definitive agreements, obtaining applicable corporate, regulatory and other third-party approvals and the fulfillment of customary closing conditions. No assurances can be made that the parties will successfully negotiate and enter into a definitive agreement, or that the proposed transactions will be consummated on the terms or timeframe currently contemplated, or at all. Cautionary Notice on Forward-Looking Statements Certain information in this news release constitutes "forward-looking information" under applicable securities laws. "Forward-looking information" is defined as disclosure regarding possible events, conditions or financial performance that is based on assumptions about future economic conditions and courses of action and includes, without limitation, statements regarding the commencement of the SKNJCT-004 study and the potential results of and benefits of such study, the potential Antev transaction, including the entry into a definitive agreement in respect of the Antev transaction, the closing of the transaction or the timing thereof, the potential benefits of the Antev transaction, if consummated, including plans and expectations concerning, and future outcomes relating to, the development, advancement and commercialization of Teverelix, and the potential market opportunities related thereto, the results of the interim analysis, which may or may not correlate with the findings of the clinical study report that will be compiled following completion of the phase 2 study, the Company's plans and expectations concerning, and future outcomes relating to, the submission and advancement of the phase 2 clinical protocol, the randomization of patients and size of the study, the Company's intention to complete and submit an interim data analysis to the FDA and to request a Type C meeting and the timing thereof, the Company's aim to fast fast-track the clinical development program and convert the SKNJCT-003 exploratory clinical trial into a pivotal clinical trial, and approval from the FDA and the timing thereof. Forward-looking statements are often but not always, identified by the use of such terms as "may", "on track", "aim", "might", "will", "will likely result", "would", "should", "estimate", "plan", "project", "forecast", "intend", "expect", "anticipate", "believe", "seek", "continue", "target" or the negative and/or inverse of such terms or other similar expressions. These statements involve known and unknown risks, uncertainties and other factors, which may cause actual results, performance or achievements to differ materially from those expressed or implied by such statements, including those risk factors described in the Company's public filings on EDGAR and on SEDAR+, which may impact, among other things, the trading price and liquidity of the Company's common shares. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement and reflect our expectations as of the date hereof and thus are subject to change thereafter. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. Readers are cautioned that the foregoing list is not exhaustive, and readers are encouraged to review the Company's long form prospectus accessible on the Company's profile on EDGAR at and on SEDAR+ at Readers are further cautioned not to place undue reliance on forward-looking statements as there can be no assurance that the plans, intentions or expectations upon which they are placed will occur. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. To view the source version of this press release, please visit Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data


Business Wire
11-06-2025
- Business Wire
Capsida Receives FDA IND Clearance for Its IV-Administered Gene Therapy for Parkinson's Disease Associated With GBA Mutations
THOUSAND OAKS, Calif.--(BUSINESS WIRE)--Capsida Biotherapeutics ('Capsida') today announced the U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for CAP-003, its potential best-in-class intravenously (IV) administered gene therapy, to enter clinical trials for Parkinson's disease associated with GBA mutations (PD-GBA). This is the second wholly owned clinical program developed by Capsida with a cleared IND. Both programs utilize a proprietary IV-delivered, blood brain barrier-crossing engineered capsid and proprietary cargo that is detargeted from off-target tissues, like liver and dorsal root ganglia (DRG). In addition, Capsida uses a proprietary manufacturing process and CAP-003 is manufactured in Capsida's state-of-the-art wholly owned Good Manufacturing Practice (GMP) facility. 'PD-GBA is an area of substantial unmet need given the lack of approved treatments that target GCase, which is the protein encoded by the GBA gene, and provide meaningful slowing or halting of disease progression,' said Swati Tole, M.D., Chief Medical Officer of Capsida Biotherapeutics. 'We recognize the urgency for new treatment approaches, so we are working diligently to initiate the Phase 1/2 clinical trial for CAP-003 with the aim of dosing the first patient in the third quarter of this year.' About CAP-003 and the Phase 1/2 Clinical Trial In non-human primate (NHP) studies to date, a single IV infusion of CAP-003 resulted in dose-dependent increases in GCase activity in critical brain regions including the substantia nigra, frontal cortex, caudate nucleus, and putamen substantially above the established 30% efficacy threshold expected to restore enzyme activity levels back to normal in patients with PD-GBA. The NHP Good Laboratory Practices (GLP) toxicology study demonstrated a well-tolerated safety profile with no adverse histopathology. Capsida expects to dose the first patient in the Phase 1/2 clinical trial in the third quarter of this year. For more information about the Phase 1/2 clinical trial, please visit (NCT07011771). About Parkinson's disease associated with GBA mutations (PD-GBA) Mutations in GBA, the gene expressing the GCase enzyme, affect up to 15% of Parkinson's patients and are the most common genetic risk factor for PD. Post-mortem studies demonstrate an approximate 30% GCase activity deficit in patients compared to healthy individuals 1. There are no approved treatments that target GCase and there are no approved disease modifying treatments for PD. Other investigational treatments for PD-GBA have been limited by their inability to cross the blood-brain barrier and supplement GCase enzyme activity in sufficient quantities to overcome the deficit in patients and impact the disease. In an attempt to overcome these challenges, those treatments have required invasive direct brain or cerebrospinal fluid (CSF) administration, with limited results, and a significant burden for patients. About Capsida Biotherapeutics Capsida Biotherapeutics is a clinical-stage, fully integrated next-generation genetic medicines company. It has a central nervous system (CNS) pipeline consisting of disease-modifying and potentially curative treatments for rare and more common diseases across all ages. Capsida's wholly owned pipeline includes its first-in-class investigational treatment for STXBP1 developmental and epileptic encephalopathy (STXBP1-DEE), CAP-002; and potential best-in-class investigational treatment for Parkinson's disease associated with GBA mutations (PD-GBA) CAP-003. Both have received FDA Investigational New Drug (IND) clearance to initiate clinical trials. Capsida's pipeline also includes a potential best-in-class treatment for Friedreich's ataxia (FA). In addition to its wholly owned programs, the Company has validating partnerships with AbbVie, Lilly, and CRISPR Therapeutics. Capsida was founded in 2019 by lead investors Versant Ventures and Westlake Village BioPartners and originated from groundbreaking research in the laboratory of Viviana Gradinaru, Ph.D., a neuroscience professor at Caltech. Visit us at 1 Leyns, C. E, G. et al (2023). npj Parkinson's Disease, 74(9).