These ancient ice cores are more than a million years in the making
:: Cambridge, England
This week, these cylinder ice samples arrived in the UK for climate analysis, more than a million years after they captured some of the Earth's atmosphere at the time.
Dr Liz Thomas leads the Ice Cores team at the British Antarctic Survey at this cold laboratory in Cambridge.
"So this is a really exciting project to work on because we really are exploring a completely unknown time in our history and what we're hoping is we're going to unlock all these amazing secrets."
:: This Earth
:: BAS
The ice core was drilled from a depth of 1.7 miles in the East Antarctic Peninsula…
:: PNRA:IPEV
:: Little Dome C, Antarctica
…before it was sawed into carefully labelled segments and shipped to Europe.
It's expected to hold a climate record stretching back over 1.5 million years, nearly doubling the current 800,000-year ice core record.
A key objective is to understand a massive shift in Earth's glacial-interglacial cycles - that's the recurring shift from warm to cold climates and back - that's occurred over the past million years.
Thomas says that could help us predict future climate responses to rising greenhouse gas levels.
'During that time there's evidence to suggest that the ice sheets were actually smaller, sea levels were potentially higher and CO2 similar to today. So it's a really interesting potential analogue for our future climate."
Ice cores capture direct evidence of past atmospheric conditions through trapped air bubbles.
:: Continuous Flow Analysis
Those will be analysed as they are released from the ice as it is slowly melted in a process called
Continuous Flow Analysis.
The findings will offer the first continuous environmental reconstructions spanning 1.5 million years.
:: PNRA:IPEV
That will shed light on the link between atmospheric CO2 and climate during a previously uncharted period.
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Trained dogs can smell Parkinson's disease before symptoms show up, study finds
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Yahoo
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- Yahoo
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The Ethical Minefield of Genetic Testing for All
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Some of these variants, which currently evade our 21st century understanding of genetics, will inevitably be associated with diseases. This project could undoubtably illuminate many of those missing gaps and transform our knowledge of inherited risk. So, what undermines DNA's predictive value in determining who we grow up to be? We can break the answer down into three reasons: incomplete penetrance, variable expressivity, and being heavily shaped by environment. Incomplete penetrance is a fancy term used by geneticists. It refers to a scenario in which individuals carry a specific genetic mutation but do not always express the associated disease or trait. We see this with the BRCA1 gene, which increases the risk for breast and ovarian cancer, but not all carriers develop these diseases. Then we have variable expressivity, which often gets confused for penetrance but is a distinct concept. Where penetrance concerns itself with whether the trait (or condition) will appear, expressivity describes its severity or types of symptoms once present. Finally, the interplay between genes and environment is vital for the presence of disease. But have you ever considered how the knowledge of genetic susceptibility may affect one's behaviour? If you were to know that your genes confer a greater risk for, say, diabetes, could that lead to behaviour modification? Fewer takeaways and more exercise? The Ethical Minefield Make no mistake, having access to genetic information will save lives and reduce suffering. It will further our understanding of genetics, a foundational pillar of medical science. This doesn't make the debate a foregone conclusion, however, as the ethical terrain is incredibly complex. The Generation Study is not sequencing parents' genes. However, it would mean universal screening of babies' genomes before they can consent. Few could argue that telling parents that their child has a noncurable condition will unleash significant anxiety and stress. Some may argue it is not worth the potential benefits, while others may prioritise the long-term gains in scientific advancement. Research published in the Nature journal European Journal of Human Genetics suggests that most parents would plan to tell their children their screening results in childhood, whilst some would postpone this news due to the potential negative impacts it may have on their self-esteem. Perhaps, then, this scheme should report only on a predefined panel of conditions where early treatment makes a significant impact on outcomes. What makes a disease "treatable" or not is also not black and white and will raise further difficult questions. But this is where we have to be careful. The argument against screening for diseases that are not treatable in 2025 overlooks the fact that such programmes generate valuable data, which can play a role in the development of future breakthroughs and therapies. Consider knowledge as a burden for a moment. We know of genetic variants that are associated with Alzheimer's disease. How are parents supposed to raise a child that they know has a genetically increased risk of developing Alzheimer's? For some, the answer is simple: Do nothing. The exact cause of Alzheimer's is not understood, which means there is no certain way to prevent it. But this reductionist approach of simply deciding to do nothing is much easier said than done. Regardless of whether you choose to report on only a predefined panel of conditions, patients will know that the data exist. Once the genome is sequenced, it cannot be unsequenced. Doctors, geneticists, and academics will have to carry the moral burden of knowing more than they can responsibly act on. And what about patients? If they know that the data exist but are withheld because conditions are deemed nonactionable, what will stop them demanding the information and paying a third party to interpret the results? If so, we risk creating a two-tier system where genomic knowledge is in the hands of the most affluent. The Slippery Slope to Discrimination The most common fear that populates headlines is the misuse of genetic data. A reference to George Orwell's 1984 is never too far when data acquisition for 'the greater good' is mentioned. Maybe we can begin a new movement, calling this Orwell's Law? But this concern deserves to be taken seriously. In philosophy, a slippery-slope argument is when a decision is rejected because the arguer believes it will lead to a chain reaction that results in an undesirable end. The issue with slippery-slope fallacies is that they are incredibly easy to make and the proponents often fail to do the hard work of logically connecting each step to show why one outcome would lead to the next. So, are the concerns legitimate? Genetic test results can affect insurance policies. In the UK, insurers cannot ask you to take a genetic test, but they can ask for results of a test if you have already taken one. If genetic testing becomes widespread, it may prove difficult to keep this information from insurers. Others may also want access. Genomic data are akin to your identity. The acquisition of this information creates a layer of vulnerability that understandably makes many nervous. Could employers make decisions on whether to hire someone with a predisposition to a mental illness, for instance? And yet despite all this, it would be terse to flat-out ignore what this technology may be able to bring. Identification of, say, spinal muscle atrophy at a presymptomatic stage can significantly improve outcomes and slow the progression of disease. This debate is complex but at the same time fascinating. We are remoulding healthcare and shifting the timescale for where medicine begins. But this comes with risk and ethical questions.