
The Wire China Publishes Broken Engagement, an E-Book Featuring Exclusive Interviews with Top U.S. Policymakers on China
NEW YORK, March 17, 2025 /PRNewswire/ -- The Wire China today announced the publication of Broken Engagement: Interviews with those who have made — and remade — the U.S.'s policy towards China, a new e-book featuring a collection of in-depth Q&A interviews conducted by Bob Davis, a distinguished former journalist at The Wall Street Journal.
Between 2022 and 2024, Davis interviewed some of America's most influential policymakers, diplomats, and experts to examine how the U.S.-China relationship has evolved over the past six presidential administrations. Through candid conversations with figures such as Robert Lighthizer, Kurt Campbell, Charlene Barshefsky, Matt Pottinger, Nancy Pelosi, Robert Rubin, Ash Carter and Robert Gates, Broken Engagement explores the key decisions that shaped U.S. policy on trade, security, human rights, and diplomacy—and how perspectives on engagement with China have shifted over time.
Davis, who covered China and international trade for The Wall Street Journal for decades, brings deep historical context to these discussions. Having reported on the Asian financial crisis, China's WTO accession, and the U.S.-China trade war, he revisits these events through the eyes of the officials who lived through them—providing invaluable insight into the successes, missteps, and ongoing challenges of U.S. policy toward China.
'Broken Engagement is a genuine marvel — sober, sharp, a joy to read, and rich with revelations on how the United States has wrestled with China for forty years,' says Evan Osnos, author of Age of Ambition and a National Book Award winner. 'With a reporter's eye, and a deep grounding in economics, Bob Davis poses the essential questions: do we isolate or engage, push for change or settle for stability, root for China's success or hedge against it?'
'The result is an indispensable guide to the real-world choices that have shaped the world's most important relationship — and the ones still ahead.'
The interviews in Broken Engagement: Interviews with those who have made — and remade — the U.S.'s policy towards China, were edited by Andrew Peaple, a former Wall Street Journal reporter and now news editor at The Wire China, ensuring a sharp and engaging narrative that provides readers with a comprehensive view of the shifting dynamics between the U.S. and China.
Published by The Wire China, a division of the New York-based firm, The Wire Digital Inc., 'Broken Engagement' is available for digital download starting March 14, 2025.
About The Wire Digital Inc.
The New York-based startup was co-founded by David Barboza, a Pulitzer Prize winning reporter who was based in China for The New York Times, and Lynn Zhang, an expert in corporate records. The Wire Digital publishes the online magazine, The Wire China, and owns WireScreen, the leading China-focused business intelligence platform.
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Newsweek
12 minutes ago
- Newsweek
Israel Says Goal Is Not Iran Regime Change as Trump Vetoes Ayatollah Strike
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The strikes hit a variety of Iranian targets, including military personnel and nuclear scientists, in what Israeli leadership has called "Operation Rising Lion." Israel's strikes have killed at least 406 people in Iran and wounded another 654, according to a human rights group that has long tracked the country, Washington-based Human Rights Activists. Iran's government has not offered overall casualty figures. Israel has said 14 people have been killed since Friday and 390 have been wounded, the Associated Press reported. Khamenei condemned the attacks and promised to retaliate, saying Israel had "sealed for itself a bitter and painful destiny." Iran's military vowed a "crushing response," according to the state-run IRNA news agency, and fired salvos of missiles and drones at sites and cities across Israel. Iranian officials have always denied seeking a nuclear weapon. The United States and Iran have held five rounds of negotiations regarding the country's nuclear program, with a sixth round scheduled for Sunday that ultimately did not happen as Israel and Iran each continue to carry out attacks on each other. Rocket trails are seen in the sky above the Israeli coastal city of Netanya amid a fresh barrage of Iranian missile attacks on June 15. Inset: Iranian Supreme leader Ali Khamenei during the Friday prayer... Rocket trails are seen in the sky above the Israeli coastal city of Netanya amid a fresh barrage of Iranian missile attacks on June 15. Inset: Iranian Supreme leader Ali Khamenei during the Friday prayer ceremony on October 4, 2024, in Tehran, Iran. More Jack Guez/AFP via Getty Images // Iranian Leader's Press Office - Handout/Getty Images What To Know Speaking with CNN anchor Bianna Golodryga, Sa'ar insisted that his country's goal is not to force regime change in Iran, saying, "The security Cabinet had decided on the objectives," and that regime change "was not one of the objectives." "This is for the Iranian people to decide," Sa'ar said. "We, Israel, don't see the Iranian people as our enemies. We had great relations with Iran until 1979 until the Islamic Revolution, when a very fanatic and barbaric regime came to power. And these are the people that chant 'Death to America,' 'Death to Israel.' And they put as an objective to eliminate the State of Israel." "It's not for us to decide: That's for the Iranian people to act or to do what they want to do," Sa'ar added. "We took as an objective the nuclear program, the ballistic missiles program, the elimination program. It's all things we must stop and create the conditions for moves afterwards that also will able to achieve these objectives." When asked about what kind of advanced notice the U.S. had about the attack, Sa'ar said Israel had informed the Trump administration that "we are going to act," which occurred after the U.S. and Iran had an opportunity to reach a diplomatic solution. He accused Iran of wanting to just "waste time and continue" pushing forward their nuclear plans "even during negotiations." "Iran is in a situation of non-compliance. They breach everything they were committed to," Sa'ar said, noting that Iran's foreign minister had cancelled his interview with CNN, which would have immediately followed Sa'ar's own. "After all other options are gone, we must take care of our security and of our existence. Of course, we informed the US as friends and allies that we are going to operate," he said. Meanwhile, Trump wrote in a Saturday social media post that the U.S. "had not nothing to do with the attack on Iran, tonight." Iran has said it believes the U.S. is involved. Israeli officials have reportedly asked the Trump administration to join in on efforts to attack Iran, with Iran's nuclear program having long been a focal point of U.S. and Israeli concern. Trump talked to ABC News' Rachel Scott on Sunday about the matter, saying, "We're not involved in it. It's possible we could get involved. But we are not at this moment involved." Trump Rejected Israeli Plan to Kill Khamenei Reports on Sunday from the Wall Street Journal and Reuters revealed that Israel had attempted to execute a plan to take out Khamenei, but that Trump put a stop to it. Both outlets cited unnamed senior U.S. administration officials. One of the sources told Reuters: "Have the Iranians killed an American yet? No. Until they do we're not even talking about going after the political leadership," underscoring the U.S. desire to keep distance from the conflict. An unnamed U.S. official on Sunday told CNN that Trump did indeed reject the plan to assassinate Khamenei. Israel had the chance to kill Khamenei, but Trump opposed the plan, which prevented Israel from pursuing the opportunity. A second source told the outlet that Trump's opposition comes from a desire to avoid another protracted and involved war in the Middle East. However, Israeli Prime Minister Benjamin Netanyahu during an interview on Sunday with Fox News said: "There's so many false reports of conversations that never happened, and I'm not going to get into that." He added: "But I can tell you, I think that we do what we need to do, we'll do what we need to do. And I think the United States knows what is good for the United States." Photo taken after an explosion in downtown Tehran amid Israel's two-day campaign of strikes against Iran on June 15. Photo taken after an explosion in downtown Tehran amid Israel's two-day campaign of strikes against Iran on June 15. Khoshiran/Middle East Images/AFP via Getty Images What People Are Saying President Donald Trump wrote on Truth Social: "Iran and Israel should make a deal, and will make a deal, just like I got India and Pakistan to make, in that case by using TRADE with the United States to bring reason, cohesion, and sanity into the talks with two excellent leaders who were able to quickly make a decision and STOP! Also, during my first term, Serbia and Kosovo were going at it hot and heavy, as they have for many decades, and this long time conflict was ready to break out into WAR. I stopped it (Biden has hurt the longer term prospects with some very stupid decisions, but I will fix it, again!). Another case is Egypt and Ethiopia, and their fight over a massive dam that is having an effect on the magnificent Nile River. There is peace, at least for now, because of my intervention, and it will stay that way! Likewise, we will have PEACE, soon, between Israel and Iran! Many calls and meetings now taking place. I do a lot, and never get credit for anything, but that's OK, the PEOPLE understand. MAKE THE MIDDLE EAST GREAT AGAIN!" Israeli Prime Minister Benjamin Netanyahu said in a video address on Friday: "More is on the [Tehran] regime doesn't know what hit them. They don't know [what] will hit them." What Happens Next? Israel and Iran have shown no indication of decreasing their exchange of missiles, with more to follow as the U.S. seeks de-escalation and an end to the current conflict. This article included reporting by The Associated Press.

Wall Street Journal
17 minutes ago
- Wall Street Journal
Leonard Lauder, Who Turned His Mother's Beauty Business Into a Global Empire, Dies at 92
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Business Upturn
20 minutes ago
- Business Upturn
Intellia Therapeutics Announces Positive Three-Year Data from Phase 1 Trial of Lonvoguran Ziclumeran (lonvo-z) in Patients with Hereditary Angioedema (HAE) at the European Academy of Allergy and Clinical Immunology Congress
With up to three years of follow-up, a single dose of lonvo-z led to a 98% mean reduction in monthly HAE attack rate in all 10 patients All 10 patients were attack-free and treatment-free for a median of 23 months through the latest follow-up, demonstrating the potential of lonvo-z to become the first one-time therapy for most HAE patients Lonvo-z was well tolerated and continues to demonstrate a favorable safety profile The global Phase 3 HAELO trial of lonvo-z has concluded screening ahead of schedule with more than half screened from U.S. sites; Intellia to provide an update on enrollment in the future CAMBRIDGE, Mass., June 15, 2025 (GLOBE NEWSWIRE) — Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies, today announced three-year follow-up data from the Phase 1 portion of the ongoing Phase 1/2 study in patients with HAE after receiving a single dose of lonvoguran ziclumeran (lonvo-z, also known as NTLA-2002). Results were shared in an oral presentation at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2025, held June 13-16 in Glasgow, United Kingdom. 'Today's results underscore the promising potential of Intellia's approach to gene editing therapy – a one-time treatment that was well tolerated and offered a highly differentiated, durable effect for patients suffering from a serious disease,' said Intellia President and Chief Executive Officer John Leonard, M.D. 'Seeing all 10 patients in the Phase 1 portion of this study free from both HAE attacks and chronic therapy at nearly two years of median follow-up is incredibly encouraging. These data fuel our optimism for the outcomes of our ongoing Phase 3 HAELO study, which we expect to report in the first half of 2026, and highlight the strong value we believe it will offer patients, physicians and payers.' 'People living with HAE often report a reduced quality of life because they worry about the likelihood of their next attack, either because they still experience attacks or are reminded of it by their use of chronic therapy,' said Dr. Joshua Jacobs, Medical Director, Allergy and Asthma Clinical Research, Inc. 'Based on the data, it is reasonable to expect lonvo-z could offer patients the potential to be free from both physical HAE attacks and the burden of managing chronic HAE treatment.' In the Phase 1 portion of the study, a one-time dose of 25 mg (N=3), 50 mg (N=4) or 75 mg (N=3) of lonvo-z was administered via intravenous infusion and plasma kallikrein protein levels were measured along with HAE attacks. At the time of the February 12 data cutoff, patients were attack-free and treatment-free for a median of nearly two years. With up to three years of follow-up, a single dose of lonvo-z led to a mean reduction in monthly HAE attack rate of 98% over the study period, compared to pre-treatment baseline. For all 10 patients, deep, dose-dependent and durable reductions in plasma kallikrein protein continued to be observed through the latest assessment. Safety Across all three dose levels, lonvo-z has been well tolerated and continues to demonstrate a favorable safety profile consistent with earlier data presented at EAACI in 2024. The most frequent adverse events during the study period were infusion-related reactions (IRRs). IRRs were mostly Grade 1 and resolved with all patients receiving the full dose. With up to 3 years of follow-up, no treatment-emergent serious adverse events were observed, and no treatment-related adverse events were observed during the period following 28 days after dosing. Clinical Development Plans Intellia's global Phase 3, randomized, double-blind, placebo-controlled HAELO trial is ongoing to assess the safety and efficacy of lonvo-z at the 50 mg dosage. The Company announced today the HAELO trial has successfully completed screening ahead of schedule, with over half of the patients being screened in the United States. The study is no longer recruiting and Intellia will provide an update on enrollment in the future. New and longer-term data from the Phase 2 portion of the ongoing Phase 1/2 study is planned to be presented in the second half of 2025. Intellia expects to submit a biologics license application (BLA) in 2026 to support the Company's plans for a U.S. launch in 2027. For more information on HAELO (NCT06634420), please visit About the Lonvoguran Ziclumeran (lonvo-z, also known as NTLA-2002) Clinical Program Intellia's ongoing Phase 1/2 study is evaluating the safety and efficacy of lonvo-z in adults with Type I or Type II hereditary angioedema (HAE). The Phase 1 portion of the study is an international, open-label study designed to identify the dose level of lonvo-z selected for further evaluation in the Phase 2 portion of the study. Enrollment in both portions of the Phase 1/2 study is complete. Intellia dosed the first patient in the global Phase 3, randomized, double-blind, placebo-controlled HAELO trial in January of 2025. Visit (NCT05120830) for more details. About Lonvo-z Based on Nobel Prize-winning CRISPR/Cas9 technology, lonvo-z has the potential to become the first one-time treatment for hereditary angioedema (HAE). Lonvo-z is an investigational in vivo CRISPR-based gene editing therapy designed to prevent HAE attacks by inactivating the kallikrein B1 ( KLKB1 ) gene, which encodes for prekallikrein, the kallikrein precursor protein. Interim Phase 1/2 clinical data showed dramatic reductions in attack rate, as well as consistent, deep and durable reductions in kallikrein levels. Lonvo-z has received five notable regulatory designations, including Orphan Drug and RMAT Designation by the U.S. Food and Drug Administration (FDA), the Innovation Passport by the U.K. Medicines and Healthcare products Regulatory Agency (MHRA), Priority Medicines (PRIME) Designation by the European Medicines Agency, as well as Orphan Drug Designation (ODD) by the European Commission. About Intellia Therapeutics Intellia Therapeutics, Inc. (NASDAQ:NTLA) is a leading clinical-stage gene editing company focused on revolutionizing medicine with CRISPR-based therapies. Since its inception, Intellia has focused on leveraging gene editing technology to develop novel, first-in-class medicines that address important unmet medical needs and advance the treatment paradigm for patients. Intellia's deep scientific, technical and clinical development experience, along with its people, is helping set the standard for a new class of medicine. To harness the full potential of gene editing, Intellia continues to expand the capabilities of its CRISPR-based platform with novel editing and delivery technologies. Learn more at and follow us @intelliatx. Forward-Looking Statements This press release contains 'forward-looking statements' of Intellia Therapeutics, Inc. ('Intellia' or the 'Company') within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, express or implied statements regarding Intellia's beliefs and expectations concerning: the safety, efficacy, success and advancement of its clinical programs for lonvoguran ziclumeran or 'lonvo-z' (also known as NTLA-2002) for hereditary angioedema ('HAE'), including the ability to successfully complete its global Phase 3 HAELO study; its expectation to present additional data regarding lonvo-z, including reporting outcomes of the Phase 3 HAELO study in the first half of 2026 and presenting new and longer-term data from the Phase 2 portion of the ongoing Phase 1/2 study of lonvo-z in the second half of 2025; and its expectation to be able to support a biologics license application for lonvo-z for the treatment of HAE by 2026 for a U.S. launch in 2027. Any forward-looking statements in this press release are based on management's current expectations and beliefs of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to: risks related to Intellia's ability to protect and maintain its intellectual property position; risks related to Intellia's relationship with third parties, including its contract manufacturers, licensors and licensees; risks related to the ability of its licensors to protect and maintain their intellectual property position; risks related to Intellia's ability to protect and maintain its intellectual property position; risks related to valid third party intellectual property; risks related to Intellia's relationship with third parties, including its licensors and licensees; risks related to the ability of its licensors to protect and maintain their intellectual property position; uncertainties related to regulatory agencies' evaluation of regulatory filings and other information related to our product candidates, including lonvo-z; uncertainties related to the authorization, initiation and conduct of studies and other development requirements for our product candidates, including uncertainties related to regulatory approvals to conduct clinical trials, including our ability to complete the Phase 3 HAELO study for HAE; the risk that any one or more of Intellia's product candidates, including lonvo-z, will not be successfully developed and commercialized; and the risk that the results of preclinical studies or clinical studies will not be predictive of future results in connection with future studies for the same product candidate or Intellia's other product candidates. For a discussion of these and other risks and uncertainties, and other important factors, any of which could cause Intellia's actual results to differ from those contained in the forward-looking statements, see the section entitled 'Risk Factors' in Intellia's most recent annual report of Form 10-K and quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in Intellia's other filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Intellia undertakes no duty to update this information unless required by law. Intellia Contacts: Investors:Brittany ChavesSenior Manager, Investor Relations [email protected]