Teenagers being shot by Israeli soldiers – British surgeon in Gaza
We began by asking him what he can tell us about the shootings near the aid distribution sites this morning.
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Telegraph
4 hours ago
- Telegraph
New contraceptive pill for men is safe, study suggests
A new male contraceptive pill tested on British men in a world first is safe for use, a study suggests. Oral female contraceptive tablets have been available for 60 years but there has never been an authorised male version. Female tablets work by altering hormone levels to reduce the risk of conception but this approach has proven difficult in men because of severe side effects such as infertility and mood swings. These side effects are common in female versions. A third of men say they would take a contraceptive pill if one was available to them. YourChoice Therapeutics has developed the first non-hormonal contraceptive for men which works by blocking the production of a protein, which is needed to produce sperm, and not meddling with hormones. The drug stops production of retinoic acid receptor alpha (RAR-alpha) in the body and this prevents it binding to vitamin A compounds and subsequently prevents sperm production. Animal studies showed this mechanism to be 99 per cent effective and also found that sperm levels returned to normal after the medication was stopped, showing the contraceptive to be temporary and reversible. Human trials began in 2023 when 16 healthy men who had already had a vasectomy were recruited to test the safety of the drug in people. Data, published this week, show it to be safe and well-tolerated with no clinically relevant side effects in a significant step forward for the prospects of the drug, known as YCT-529. The trial of 16 British men gave participants either the tablet or a placebo and conducted analysis on the participants to measure their blood, urine, mood and overall health. Four different dosages were tested and all were found to be well-tolerated. The highest dose was the same as what was shown to be effective as a contraceptive in animal trials. 'Positive results' There was no reduction in testosterone levels, sex drive or any other hormonal imbalance, the scientists found. 'The positive results from this first clinical trial laid the groundwork for a second trial, where men receive YCT-529 for 28 days and 90 days, to study safety and changes in sperm parameters,' the study authors write in their peer-reviewed study in the journal Communications Medicine. Further trials will now gather more data on the long-term safety profile of the drugs and if this is found to be acceptable, the next stage of clinical trials will begin to determine its precise effectiveness in humans. The data are needed before regulators can make a decision on whether a drug is safe and effective enough to be approved for human use. The study authors add that the safety bar for contraceptives is much higher and harder to reach than it is for drugs designed to cure or treat a disease because it is preventative and used by healthy people daily for a long period of time. 'More attractive to men' Akash Bakshi, a co-founder and the chief executive of YourChoice, has previously suggested the medicine, if approved, could be sent out alongside at-home testing kits for men to check their sperm levels are too low to cause pregnancy. He said: 'YCT-529 blocks a protein – not hormones – to prevent sperm production. We believe this will be more attractive to men, most of whom view pregnancy prevention as a shared responsibility even despite today's limited contraceptive options, which are permanent or only moderately effective. 'The dearth of options reinforces the centuries-old view that pregnancy prevention is 'a woman's responsibility'. It's not, and we're committed to advancing the first hormone-free birth control pill for men that's effective, convenient, and temporary.' While non-hormonal male contraceptives are in trials and at the early stage of development and testing, other hormone-powered alternatives are also in the works. A gel which is rubbed into the shoulders of a man every day is one such medicine and contains Nestorone (segesterone acetate) and testosterone. This lowers sperm counts in around eight weeks and is in testing currently on more than 200 men in the US. The gel is rubbed into the shoulders or shoulder blades because it is easy to reach for the user and it is also unlikely a child or woman would come into direct contact with the gel in this location. The hormones soak into the skin and are absorbed by the bloodstream. But accidental exposure to the gel could cause premature puberty in children and acne or excessive hair growth in women.
Daily Record
5 hours ago
- Daily Record
Scots gran dies in Alicante airport after taking unwell in taxi on return from holiday
Angela McTier suffered a ruptured varicose vein which led to significant blood loss. A Scots gran tragically died in a Spanish airport on her way back from holiday. Angela McTier, from Blantyre in Lanarkshire, was heading to Alicante airport in a taxi when she suffered a ruptured varicose vein, causing significant blood loss. The 48-year-old reached the airport but she lost consciousness at the departure lounge and despite resuscitation attempts, she sadly died at the scene on July 22. Her daughter, Michelle Hilston, told STV that her mum had been trying to improve her health so she could watch her granddaughters grow up. The 24-year-old said: "My mum watched the grandkids at least two nights every week and always looked forward to them coming over. I'm heartbroken for my two girls who have just lost that special relationship with her. 'If there's one thing my mum loved, it was going on holiday, she thrived over there and this particular holiday to La Mata she just kept saying how amazing it was, it was her best holiday and she'd felt so well and couldn't wait to bring the grandkids over. 'She was due to go away with me and my two toddlers next month as well.' Michelle revealed that her mum gave her invaluable support when she was working towards achieving a degree in midwifery. She sent her mum a video of her 11-month-old granddaughter taking her first steps. Michelle added: 'She helped me out so much to pursue my dream degree after having my kids and always made sure I had all the childcare and financial support I needed. 'Her holidays were a special thing for her, she went multiple times a year, and it was one of the things she loved doing the most. 'But the thing she loved the most was her granddaughters and would ask for pictures of them multiple times a day. 'The day she died, I had sent her a video of my 11-month-old finally walking, and she was in tears over the video, phoning everyone to tell them, and I'm glad that's the last video she saw of the kids.' A FCDO Spokesperson said: 'We are supporting the family of a British woman who died in Spain.' A GoFundMe has been set up to help with the costs of repatriating Angela and her funeral.
Scottish Sun
21 hours ago
- Scottish Sun
Tattoos can boost body positivity and even heal trauma, mental health experts say
Dr Mark Griffiths explains all of the positive benefits tattoos can have POSITIVE INKING Tattoos can boost body positivity and even heal trauma, mental health experts say Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) THE great British High Street may be in decline but there's one type of shop that is still firmly making its mark – the tattoo parlour. In the past decade the number of inking businesses has soared from 1,637 to 3,394 — up 107 per cent — and 14million of us now have one, nearly a third of all adults. Sign up for Scottish Sun newsletter Sign up 5 The number of inking businesses has soared from 1,637 to 3,394 in the past decade 5 The tattoo parlour is still firmly making its mark on the British High Street Credit: Refer to Source - Alamy 5 14million of us now have a tattoo, nearly a third of all adults Credit: Alamy The tattoo market was worth around £659million in 2023, rising to £702million in 2024. Experts say that although tattoos may seem unsightly to some, for those who have them, they can boost positivity, provide a sense of security, help people cope with depression and even help to heal childhood trauma. Dr Mark Griffiths, Distinguished Professor of Behavioural Addiction at Nottingham Trent University, told The Sun on Sunday: 'Most people who get tattoos experience positive benefits. 'For example, someone who is experiencing depression or anxiety may feel empowered by a tattoo, or view it as a way of demonstrating control in their life. 'Bad infections' 'A tattoo can help some individuals feel better about their body and help them feel as though they are part of a community. 'Tattoos may help promote body positivity, boost self-confidence and, for a minority, help to lower stress levels. "For a small minority, tattoos may also be a symbol for trauma survivors, for example of PTSD, sexual assault and healing from childhood trauma.' Derby-based tattooist Kevin Paul, who has inked dozens of celebrities including Ed Sheeran, Harry Styles, Lady Gaga and Rhianna, says that being tattooed is so 'powerful' it is like a medicine to some. He said: 'People use tattoos now as a therapy or a way to bring families closer or to mourn the loss of a loved one. "A lot of people have tattoos to mark traumatic things they have been through. I'm tattooed all over & even removed my NOSE to keep in a little jar… people can't believe the difference 4 years makes 'The majority of people I see are using it as some form of therapy. 'I had a customer with a history of self-harm and when I covered her scars she said it gave her her life back.' Prices for a tattoo start at £50 for a tiny design but can rise to well over £2,000 for a larger work covering the limbs or back — and there is no shortage of takers. The UK currently ranks as the third most-inked nation in the world, accounting for almost eight per cent of all tattoos globally and we are only out-tatted by the US and Germany. However, the trend has also led to a rise in unqualified and inexperienced would-be 'artists' cashing in. Unlicensed tattoo artists, often referred to as 'scratchers', operate outside legal regulations and do not register with their local said: 'Tattooing is being pulled apart by everyone thinking they can just have a go. 'People will go to the closest and normally cheapest place so it's much harder for real, trained artists to get customers through the door. 'There will be a lot of people needing cover-ups [of bad work] in the future. 5 Derby-based tattooist Kevin Paul has inked dozens of celebrities including Ed Sheeran Credit: Getty 5 Former 1D singer Harry Styles has also been inked by him Credit: Getty "Hygiene should be the biggest part of your training, but I have seen so many bad infections come from dodgy tattooists who don't know what they are doing.' Research last year suggested that as many as four in ten of us had considered getting a tattoo removed. The most likely reason is going off the design, poor quality, fading work or having made an impulsive decision to begin with. And another expert warned that getting tattoos may not always combat major self-esteem issues. Aleksandra Pamphlett, a psychotherapist specialising in body image, said: 'I've had many patients describe their tattoos as part of their healing journey — daily reminders of survival, identity, hope and self-worth. 'There have been quite a few studies suggesting that body modifications can serve as a coping mechanism or form of self-expression for people with trauma histories. 'IT'S MY LIFE STORY IN PICTURES' TATTOO fan Chesney Wright, 29, has spent more than £4,000 on her 200 inkings, which she describes as her 'life in pictures'. The mum-of-three, from Grantham, Lincs, admits some are 'horrified' by her heavily inked look but she has no plans to stop. Chesney said: 'I've been told the tatts are disgusting. That I'm a bad example to other women and a bad mum. Tattoos are like Marmite, you love them or hate them – I'm obsessed with them. 'OAPs are often horrified and tell me off, but I just smile sweetly. My body art is my history.' Ex-barber Chesney has tattoos of everything from a ghost to SpongeBob. She added: 'Most women get flowers and butterflies – I have a different approach. Each tattoo holds a story of love, happiness, mother- hood, sometimes grief.' 'Most of my patients with tattoos related to past trauma found them helpful and empowering, but there was one case where the tattoo became a painful reminder — less a symbol of healing, more a flashback to a time they wanted to move past.' Anna Woolley spent years struggling with substance addiction and poor mental health, leaving her with scars on her arms that were so obvious she was ridiculed about them while shopping in Primark. It led the 35-year-old to cover them with a 'sleeve' design with butterflies and branches in 2016. The move gave her such new-found confidence she is now preparing to become a support worker in a rehab clinic to help others. She told the Sun on Sunday: 'I'd gone through a lot of past trauma and I'd caused damage to my arms from lashing out during night terrors over several years. 'I just felt horrific, I was so full of self-doubt. 'Before getting the tattoos I wouldn't have dreamed of wearing a T-shirt but now I wear what I want to. People say it's just a tattoo but it's changed my life.'
