‘Trevor Paglen: Cardinals' Review: Is the Truth Out There?
Before claims that 5G towers were being used for mind control or that the government was adding chemicals to the water that turned frogs gay, you could find plenty of questionable tales of odd phenomena of a more innocent kind. There was even a sort of regional pride behind certain cryptids: Folks from the Southwest had the chupacabra, West Virginians told stories about Mothman around the camp fire, and Garden State residents were so proud of their local creature that they named their hockey team after it.
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Associated Press
25 minutes ago
- Associated Press
Temporary barriers spared Alaska's capital from severe flooding. A long-term solution is elusive
The glacial flooding that sent residents of Alaska's capital city scrambling this week has become an annual ordeal for those who live along the picturesque river that winds from the nearby Mendenhall Glacier. This year, a giant wall of reinforced sandbags erected with the help of the U.S. Army Corps of Engineers held back the worst of the flooding in Juneau, to residents' great relief. The damage was nothing like what happened the last two years, when flooding was rampant and some homes washed away. But the wall is merely a temporary barrier. The effort to devise a permanent solution is complicated by what scientists don't yet know about how human-caused global warming will impact the yearly outbursts of water from an ice dam at the glacier. Juneau is just one of many communities around the globe struggling to engineer a way out of the worst damage from climate change. 'We can't keep doing this,' said Ann Wilkinson Lind, who lives on the banks of the Mendenhall River. 'We need a levee or some other permanent fix. ... This is an emergency situation that can't take 10 years for this study and that study and every other study. It needs to be done now.' The Mendenhall Glacier is about 12 miles (19 kilometers) from Juneau, home to 30,000 people in southeast Alaska, and is a popular tourist attraction due to its proximity and easy access on walking trails. Homes on the city's outskirts are within miles of Mendenhall Lake, which sits below the glacier, and many front the Mendenhall River. The glacial outburst flooding from the Mendenhall is itself a phenomenon caused by climate change, which is thinning glaciers around the world. A glacier nearby retreated, leaving behind a large bowl — Suicide Basin — that fills each spring and summer with rainwater and snowmelt dammed by the Mendenhall. When that water builds up enough pressure, it forces its way under or around the ice dam, enters Mendenhall Lake, and flows down the Mendenhall River toward Juneau. Flooding from the basin has been an annual concern since 2011 and has gotten worse, with new water-level records being set each of the last three years. City officials responded this year by working with state, federal and tribal entities to install the temporary barrier along roughly 2.5 miles (4 kilometers) of riverbank. The 10,000 'Hesco' barriers are essentially giant, reinforced sandbags intended to protect more than 460 properties, said emergency manager Ryan O'Shaughnessy. The Juneau Assembly required homeowners in the flood zone to cover 40% of the barrier's cost — about $6,300 each over 10 years. Additionally, a handful of homeowners were asked to chip in $50,000 toward reinforcing the river bank. About one-quarter of the residents formally objected, not enough to torpedo the project. This week, some water seeped between the bastions or through pipes underneath them that are designed to allow water to drain from yards into the river. Valves in the pipes are supposed to prevent floodwater from entering. But officials uniformly called the project a success, while acknowledging that some homes were damaged and that the barrier needs to be further extended. The barriers are designed to last for up to 10 years to allow time for a long-term solution. But questions abound. The capacity of Suicide Basin seems to be growing, and scientists aren't sure what a worst-case flood might look like. They predict that within a few decades, the Mendenhall itself will retreat far enough that it no longer acts as a dam, eliminating the risk of a flood outburst from Suicide Basin. But the persistent melting could also form other glacially dammed lakes that could function in a similar way. 'There's still a lot to be learned,' said Nate Ramsey, Juneau's engineering and public works deputy director. 'We have to assume this will be an annual event for the next many, many years. Is something like a temporary, soil-filled basket levy the best we can do over that period of time? ... We've got to keep looking for a long-term solution.' The Army Corps of Engineers has nearly $5 million set aside to begin working on a long-term solution, which for now largely consists of data collection. 'It's like trying to solve a math problem when the variables are always changing,' Army Corps Brig. Gen. Clete Goetz said Thursday. 'Seeing the problem is not the hard part. Engineering the solution is the challenge. That's what we're here for.' ___ Johnson and Attanasio reported from Seattle. Rush reported from Portland, Oregon.
Yahoo
35 minutes ago
- Yahoo
Want Dewier Skin as You Age? This Nutrient May Help, New Study Suggests
Reviewed by Dietitian Jessica Ball, M.S., RD Key Points A new study suggests that carotenoids may help reduce skin aging. Carotenoids act like antioxidants and are abundant in fruits and vegetables. Eating carotenoid-rich foods with unsaturated fats may help your body better absorb them. It's no secret that eating more plants can be good for you. Besides their fiber, vitamins and minerals, they tend to be plentiful in antioxidants. Fruits and vegetables, especially, are loaded with antioxidants called carotenoids. Specifically, carotenoids are plant pigments responsible for the red, orange and yellow hues in many types of produce. The fruits and vegetables that contain carotenoids include sweet potatoes, pumpkins, carrots, mangoes, papayas, tomatoes, red and yellow peppers, oranges and apricots. And while not fitting into the expected color scheme, dark leafy greens, including spinach, kale and Swiss chard, fall into that category, too. There is some evidence that carotenoids may protect the skin. For this reason, some skincare companies even use these powerful plant compounds in their products. But what if you eat foods high in carotenoids? Can that also protect your skin? Researchers in Romania conducted a systematic review of previously published studies on carotenoids and skin aging. They published their results in Nutrients. Let's break down what they found. How Was This Study Conducted? Researchers searched for studies on the topic of skin health and carotenoids. After choosing ones that met their specific parameters, they ended up with 176 studies that were eligible for their systematic review. The included studies featured findings about topical carotenoids—like skincare products that include carotenoids—and dietary carotenoids. Only studies written in English were included in the analysis. What Did This Study Find? Researchers found that the included studies suggest that carotenoids protect skin from aging through several mechanisms. These include: Antioxidant Protection: Carotenoids may help neutralize and mitigate the effects of oxidative stress, a central mechanism in the pathology of skin aging. Plus, carotenoids' antioxidant mechanisms also support the production of hyaluronic acid, which plays a major role in skin hydration and elasticity. Photoprotection: Carotenoids may help dissipate UV rays and reduce the energy available to damage skin. Anti-inflammatory Properties: You may have heard of inflammaging, which is the result of chronic inflammation in our bodies, including our skin. Carotenoids may help calm inflammation and reduce the effect inflammation can have on skin. Collagen Production: Collagen is the most abundant structural protein in the dermis layer of the skin, the thick inner layer of our skin. It's necessary for maintaining skin's firmness and elasticity. Carotenoids may help enhance collagen synthesis and inhibit its breakdown. Skin Moisturization: Dry skin appears more aged and wrinkled, and unfortunately, as we age, our skin becomes drier. Carotenoids can help maintain skin's moisture levels by helping to enhance skin's barrier, along with their anti-inflammatory and antioxidant actions. Researchers also note that gut health is a key factor. When we eat foods rich in carotenoids, before they're broken down and released into the bloodstream to skin cells, they reside in the gut. The health of your gut environment will partly determine how much of the carotenoids your body can absorb and use—referred to as the bioavailability of the nutrients. Besides gut health, researchers also found that carotenoids have greater bioavailability when eaten with unsaturated fats or when lightly cooked. Because this was a systematic review, researchers may not have the same depth of interpretation of the results compared to the original study authors. In other words, the interpretation of results might be different from the original. Also, because studies are performed using varying methods, drawing consistent conclusions can be challenging. Lastly, there are no standardized guidelines for carotenoid consumption, so these researchers cannot make recommendations for an ideal amount of daily carotenoid intake. How Does This Apply to Real Life? We know that eating more plants—fruits, vegetables, nuts, seeds, whole grains and legumes—has many health benefits, from reduced inflammation and a healthier gut microbiome to a lower risk of disease and a healthier heart and brain. Now we can add healthier skin to the list. If you want to start including more carotenoids, go for delicious recipes that include deep orange winter squash, carrots and bell peppers. We have lots of leafy green recipes, including a few for smoothies. If tomatoes are your thing, you'll want to check out our healthy tomato recipes, which include soups, salads, apps, sandwiches and main dishes. Not to be outdone by the veggies, some fruits are also rich in carotenoids. Check out our healthy orange recipes (did you know you can eat the skin?). We also have lots of tasty mango recipes that will help you expand your tropical horizons. And this papaya smoothie recipe is creamy with warm cinnamon notes. To get the most from your carotenoids and increase their bioavailability, you can lightly cook them. (Tomatoes are an exception, as they can be cooked down more, including into sauces, and have more carotenoids available compared to raw tomatoes.) Also consider eating carotenoid-rich foods with a source of unsaturated fat, like sunflower or olive oil. The lipids in the oils form micelles, which encapsulate the carotenoids and transport them, increasing their bioavailability. Out of all the carotenoid-rich foods, these researchers highlight the papaya as having superior carotenoid micellarization. Besides nutrition, researchers note other lifestyle habits that influence skin and overall health, including physical activity, sleep and social interactions. It's also important to avoid tobacco use and reduce UV ray exposure for healthy skin. The research team also suggests that there's evidence that combining topical carotenoids (like in face cream) and consuming foods rich in carotenoids should be part of the ideal skincare routine. Our Expert Take This systematic review suggests that carotenoid-rich foods may help improve skin's elasticity, hydration levels and overall health. They also suggest other lifestyle habits that play a role in skin health. While this study focused on carotenoid-rich foods, there's not one magic bullet for healthy skin. They are, however, an important piece of the puzzle, and should be included along with a variety of other foods that contain other types of antioxidants, vitamins, minerals, proteins and fats. 'Eating the rainbow' can provide you with more assurance that you're getting what your body needs for healthy aging—skin and all. Read the original article on EATINGWELL
Yahoo
2 hours ago
- Yahoo
OS Therapies to Report Second Quarter 2025 Financial Results and Provide Business Update on Tuesday, August 19th, 2025
New York, New York--(Newsfile Corp. - August 14, 2025) - OS Therapies Inc. (NYSE American: OSTX) ("OS Therapies" or "the Company"), a clinical-stage cancer immunotherapy and antibody drug conjugate biotechnology company, today announced that it will report second quarter 2025 financial results ended June 30, 2025 and provide a business update on the morning of Tuesday, August 19, 2025. About OS TherapiesOS Therapies is a clinical stage oncology company focused on the identification, development, and commercialization of treatments for Osteosarcoma (OS) and other solid tumors. OST-HER2, the Company's lead asset, is an immunotherapy leveraging the immune-stimulatory effects of Listeria bacteria to initiate a strong immune response targeting the HER2 protein. OST-HER2 has received Rare Pediatric Disease Designation (RPDD) from the U.S. Food & Drug Administration and Fast-Track and Orphan Drug designations from the U.S. FDA and European Medicines Agency. The Company reported positive data in its Phase 2b clinical trial of OST-HER2 in recurrent, fully resected, lung metastatic osteosarcoma, demonstrating statistically significant benefit in the 12-month event free survival (EFS) primary endpoint of the study. The Company anticipates submitting a Biologics Licensing Application (BLA) to the U.S. FDA for OST-HER2 in osteosarcoma in 2025 and, if approved, would become eligible to receive a Priority Review Voucher that it could then sell. OST-HER2 has completed a Phase 1 clinical study primarily in breast cancer patients, in addition to showing preclinical efficacy data in various models of breast cancer. OST-HER2 has been conditionally approved by the U.S. Department of Agriculture for the treatment of canines with osteosarcoma. In addition, OS Therapies is advancing its next-generation Antibody Drug Conjugate (ADC) and Drug Conjugates (DC), known as tunable ADC (tADC), which features tunable, tailored antibody-linker-payload candidates. This platform leverages the Company's proprietary silicone Si-Linker and Conditionally Active Payload (CAP) technology, enabling the delivery of multiple payloads per linker. For more information, please visit Forward-Looking StatementsStatements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of the federal securities laws. These forward-looking statements and terms such as "anticipate," "expect," "intend," "may," "will," "should" or other comparable terms involve risks and uncertainties because they relate to events and depend on circumstances that will occur in the future. Those statements include statements regarding the intent, belief or current expectations of OS Therapies and members of its management, as well as the assumptions on which such statements are based. OS Therapies cautions readers that forward-looking statements are based on management's expectations and assumptions as of the date of this press release and are subject to certain risks and uncertainties that could cause actual results to differ materially, including, but not limited to the risks and uncertainties described in "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in the Company's most recent Annual Report on Form 10-K, most recent Quarterly Report on Form 10-Q and other subsequent documents the Company files with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and, except as required by the federal securities laws, OS Therapies specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. OS Therapies Contact Information:Investor RelationsHarrison Seidner, PhDWaterSeid PartnersOSTX@ Public RelationsStephanie ChenElev8 New Mediastephanie@ To view the source version of this press release, please visit Sign in to access your portfolio