Researchers win prestigious UK grant for groundbreaking study on ‘Locked mouth' disorder
In a significant recognition of Indian medical research on the global stage, Gururaj Arakeri and Vishal Rao from HCG Cancer Hospital, Bengaluru, have been awarded a coveted endowment grant by the British Association of Oral and Maxillofacial Surgeons (BAOMS) for 2025.
This marks Dr. Arakeri's fourth BAOMS funding award making the Kalaburagi-based doctor the only non-British researcher to achieve this feat – an accomplishment that underscores the international relevance of his work on oral cancer and related disorders.
The grant will support a pioneering investigation into the causes of Oral Submucous Fibrosis (OSMF), a severe precancerous condition commonly caused by the consumption of gutka and arecanut, which leads to restricted mouth opening and significant deterioration in quality of life.
Challenging assumptions
While arecanut has long been classified as a primary carcinogen linked to OSMF, a recent pilot study by Dr. Arakeri's team challenges this long-standing belief. The researchers suggest that other substances, such as fluoride found in some smokeless tobacco products, may play a more damaging role than previously understood.
'This research challenges long-held assumptions,' Dr. Arakeri said. 'We're exploring the possibility that fluoride and other elements in gutka could be equally or more responsible for the condition than areca nut alone.'
Dr. Vishal Rao highlighted the human impact of the disorder, stating, 'OSMF severely limits basic functions like eating and speaking, leading to suffering and increasing the risk of oral cancer. Understanding its true causes can lead to more effective prevention and treatment.'
The international project includes distinguished collaborators like Professor Peter Brennan (UK), Dr. Antonio Celentano (The University of Melbourne, Australia), Dr. Krishnan Murugesan (Chennai), Dr. Shekar Patil, Dr. Roopa Reddy, and Dr. Satish, all working under the leadership of the Arakeri-Rao team.
With initial funding secured and further support anticipated, the team is poised to make significant strides in transforming the global approach to diagnosing and treating 'locked mouth' syndrome.
This prestigious award is not only a personal milestone for Dr. Arakeri but also a major step forward for Indian medical research on the international stage.
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