Nature of mpox necessitates rapid and accurate testing
PRETORIA - The South African Health Products Regulatory Authority has approved the country's first MPOX diagnostic test.
It marks a significant step in supporting global access to MPOX testing. The nature of MPOX as in any other virus, requires accurate and reliable testing.
The approval was made possible by reliance on prequalification and assessment by the World Health Organization.
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The authors of a recent Lancet report argue that obesity should not just be seen as a risk factor for other diseases — but in some cases, should be seen as a disease itself. The position could change how we treat obesity globally. In the first of this two-part Spotlight series, we break down the debate around the issue, and its implications for health policy. In 1990, just 2% of all young people around the world aged 5 to 24 were living with obesity. By 2021, this figure had more than tripled to over 6%. This is according to a recent study that relied on Body Mass Index (BMI) data from 180 countries and territories around the world. It estimates that the rise in obesity among children and young people will only continue in the coming decades. South Africa certainly isn't immune to the crisis. A survey conducted in 2021/2022 found that 16% of all children aged 6 to 18 were 'severely overweight'. Meanwhile, World Health Organization (WHO) data suggests that about 30% of all adults in South Africa are living with obesity, meaning a BMI of over 30, which is almost double the global level. BMI, which simply looks at a person's weight in relation to their height, is a crude measure of obesity. For instance, a person may have a high BMI simply because they have a lot of muscle rather than fat. But while it is agreed that BMI is a flawed indicator at the individual level, many experts recommend using it as a rough proxy for ' health risk at a population level '. For instance, a study that collected data on nearly three million people found that those who had very high BMI levels were, on average, more likely to die at an early age. The study also found that this was true of people with very low BMI levels (those who were underweight). In this context, the above figures paint a concerning picture. Given the rising rates, experts argue that we need health systems to be able to track and respond to obesity urgently. But, according to a Lancet Commission report published in January, health systems around the world may struggle to do this because of a failure to accurately conceptualise and measure what obesity actually is. The Lancet commission was developed by 58 experts from different medical specialties, and though it has been the subject of debate it has since been widely endorsed as a new way to understand obesity. Spotlight takes a look at what it concluded. Delaying treatment for no reason Obesity is often regarded as a risk factor for other diseases, for instance, type 2 diabetes. But according to the commission, there are certain cases in which obesity is not just a risk factor, but a disease itself — and one that should be immediately treated. One of the reasons for this is that obesity not only contributes to the emergence of other conditions, but sometimes leads to clinical symptoms directly. For example, the cartilage that protects the joints in a person's knees can sometimes become eroded when adults carry too much weight. In this case, a person could suffer from joint pain, stiffness and reduced mobility where obesity is clearly the cause. Take another example. If fat deposits build up in the abdomen, this may limit how much the lungs can expand, causing breathlessness. Similarly, a build-up of fat around the neck can narrow a person's upper airways, which can cause sleep apnoea. Thus, obesity is not simply something that increases the risk of developing a separate disease in the future — but something that can directly (and presently) affect the functioning of organs. More broadly, the commission argued that by hindering a person's 'mobility, balance and range of motion', obesity could in certain cases 'restrict routine activities of daily living'. In these instances, obesity is a disease by definition, according to the commission. This is given that it defines disease as a 'harmful deviation from the normal structural or functional state of an organism, associated with specific signs and symptoms and limitations of daily activities'. But why does this conceptual debate matter? Because at present, people often have to wait for other diseases to crop up before insurers or public health systems cover them for weight loss drugs or bariatric surgery — a procedure to help with weight loss and improve obesity-related health conditions. And when they do cover these services, it is often only after severe delays. Because obesity is only considered to be a risk factor, it isn't typically treated with the same urgency as life-threatening diseases, according to the authors of the commission. Professor Frances Rubino, the lead author of the commission, details how this problem manifests in the healthcare system. 'I've been doing bariatric surgery for 25 years in four different countries; in America, Italy, France and the UK,' he told Spotlight. 'In all of those countries, to meet the criteria for surgery people very often have to undergo six to 12 months of weight monitoring before their surgery is covered. So systematically you delay treatment.' He continued: 'Someone who has clinical obesity and has heart failure as a result of it is waiting for a year for what reason? That condition will only worsen, and if the patient is still alive the treatment is going to cost the same amount to the payer but it's going to be less effective.' Can't people just diet? One of the reasons that some academics have historically been reluctant to classify obesity as a disease is because of a fear that this may reduce people's agency — instead of taking proactive steps to diet and exercise, people with obesity may simply view themselves as afflicted by a disease. The belief that people with obesity can simply diet their way out of their situation is in fact partially why Rubino's patients were forced to wait long periods of time before receiving bariatric surgery. Rubino explained: 'In America, many private payers (i.e. medical insurance schemes) have required weight monitoring programmes, where patients do nothing else other than see a dietician for 12 months, and if they skip one appointment, they have to start all over again. I think that in some cases, this has been misguided by the idea that you want to see if obesity can be reversed by somebody going on a diet.' This, according to him, is a 'misconception', and he argues that if someone faces such severe levels of obesity that they require surgery, diet is unlikely to offer a solution. Indeed, research has shown that it's very rare for people with obesity to lose large amounts of weight quickly without surgery or medication. For instance, a study on more than 176,000 patients in the UK found that among men with 'simply obesity' or a BMI of 30-34.9, only one in 210 were able to achieve a 'normal' weight level within a year. Among men with morbid obesity or BMI of 35 or more, the chance was less than one than in 1,000. The chances for women were roughly twice as good as men's — but still exceedingly small. Thus, if someone is severely obese and their excess weight is causing life-threatening symptoms, putting them on a diet for a year is unlikely to result in the urgent changes that may be required for them to get better. In fact, Rubino argues that they may simply die of their condition in the interim. Taking a medical approach more quickly is easier now than ever before due to the regulatory approval of GLP-1 agonists like semaglutide and tirzepatide — Spotlight previously reported on the availability of these new diabetes and weight loss medicines in South Africa. An article by WHO officials from December states that because of the approval of these medicines 'health systems across the globe now may be able to offer a treatment response integrated with lifestyle changes that opens the possibility of an end to the obesity pandemic'. Not all people with obesity are ill There is a more scientific argument against categorising obesity as a disease. This is that while obesity can sometimes result in the negative health symptoms discussed above (like respiratory issues or reduced mobility) it doesn't always do this. In fact, the commission acknowledges that some people with obesity 'appear to be able to live a relatively healthy life for many years, or even a lifetime'. One of the reasons for this is that excess fat may be stored in areas that don't surround vital organs. For instance, if fat is stored in the limbs, hips, or buttocks, then this may cause less harm than if it is stored in the stomach. Since obesity doesn't always cause health problems, it isn't always a disease. In order to deal with this conceptual hurdle, the commission classifies obesity into two categories — clinical and preclinical obesity. If a person has pre-clinical obesity, this means they have a lot of excess fat, but no obvious health problems that have emerged as a result. In this case, obesity is not classified as a disease, though it may still increase the chance of future health problems (depending on a range of factors, like family history). For a person to have clinical obesity, they must have a lot of excess fat as well as health problems that have already been directly caused by this. It is this that the commission defines as a disease. This classification system, according to Rubino, ensures not only that we urgently treat people living with clinical obesity, but also that we don't overtreat people — since if a person falls into the pre-clinically obese group, then they may not need treatment. But if we're going to treat clinical obesity as a disease, we'll need clear methods of diagnosing people. Since BMI is deeply flawed and provides little information about whether a person is ill at the individual level, health systems will need something else. In part 2 of this Spotlight special series, we'll discuss the options offered by the commission, and how this all relates to the situation in South Africa. DM
