
Research Links how Literacy Impacts Health and Wellbeing
SYRACUSE, NY, June 27, 2025 (GLOBE NEWSWIRE) -- Health literacy is essential to improving health outcomes and empowering communities to manage their health and wellbeing. Adult education classrooms have long played a critical role in this empowerment process. But there remains an important question: How have adult education programs and instructors responded to new health care realities, like the increased use of digital technologies and more speakers of other languages who are utilizing the health care system?
In a special issue of Adult Literacy Education: The International Journal of Literacy, Language, and Numeracy, researchers studied what is being done to build health literacy among adults with low literacy and language skills.
In one study, researchers reviewed what health literacy interventions were in place across formal and informal educational settings for the growing migrant community worldwide and whether they met that population's needs. They found that, depending on the location and cause of migration, a lack of standardization among health literacy interventions created limitations when it came to outcomes. From this, the research team created a set of recommendations to improve the planning and reporting of interventions.
In another case study, a team from an adult literacy program in Arizona discusses how it created a mock patient portal that allows adult learners to practice interacting with the health care system digitally and what they learned about the importance of contextualized learning.
'For millions of adults, both in the US and around the globe, the ability to successfully manage their own health care evades them due to low literacy or language skills,' said ProLiteracy President and CEO Mark Vineis. 'It's imperative that adult educators have access to research like this to better understand the needs of adults and to help shape the way they approach instruction to build healthier communities.'
This edition of our journal includes further research about language-based health education, a review of the digital health landscape, and a Forum dialog that considers how we think about 'good learners,' 'good patients,' and language.
We partner with Rutgers University to publish Adult Literacy Education. The journal editors—Alisa Belzer, Amy Rose, and Heather Brown—are leading researchers in the adult literacy and education field who believe in the importance of research to complement practitioners' experiences, intuition, and professional learning.
In the research journal, adult literacy practitioners, researchers, funders, and policymakers can find evidence-based information to guide their practice, prompt important discussions, and build awareness.
We publish the free online journal three times per year to share the latest and best research and practices in adult literacy, numeracy, and English language education. Each article in Adult Literacy Education goes through a blind peer-review process to ensure we are publishing the highest quality information that the field can trust and use. By keeping our research free, we ensure that the important information shared in the journal will benefit all adult learners equally.
You can find the new issue of Adult Literacy Education at https://www.proliteracy.org/ALE-Journal. Writers interested in submitting articles for consideration in future issues of the journal can find author guidelines and a submission form on the journal's webpage.
About ProLiteracy
We are the world's leader in adult education practice, innovating and building the capacity of literacy programs everywhere—from small community-based organizations to large adult education programs and institutions. We serve over 5,000 adult literacy programs annually and work with partners in 28 countries worldwide. By providing comprehensive training and professional learning, accessible research, grant funding, and leading-edge digital and print learning resources through New Readers Press, we advocate for and unleash the power of literacy to transform lives.
Contact: Allison Bleyler McDonald
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32 minutes ago
- Business Upturn
Pliant Therapeutics Provides Update on BEACON-IPF
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Following an analysis of the full safety and efficacy data from the BEACON-IPF trial, the Company is discontinuing development of bexotegrast in IPF. Results showed that at doses of 160 mg and 320 mg, bexotegrast demonstrated an unfavorable risk-benefit profile. Compared to placebo, bexotegrast-treated participants showed an increased risk of experiencing adverse events associated with IPF disease progression, defined as events of worsening of IPF and acute IPF exacerbation, respiratory-related hospitalization, and/or all-cause mortality. The average time to disease progression for bexotegrast-treated participants was 33 weeks, suggesting that the safety risk may not be apparent with shorter dosing duration as was the case in the prior INTEGRIS-IPF Phase 2a trial. At Week 12, bexotegrast 160 mg and 320 mg treatment groups demonstrated improvements in forced vital capacity (FVC) decline of 72 mL (p<0.05) and 46 mL (p>0.05), respectively, compared to placebo. 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PLN-101095 is currently undergoing a Phase 1 open-label trial as monotherapy and in combination with pembrolizumab in patients with solid tumors that are resistant to immune checkpoint inhibitors. In March, the Company announced interim results from this trial showing that PLN-101095 was generally well tolerated with confirmed partial responses in 50% of patients at highest dose tested to date, across multiple tumor types. The trial is currently enrolling the fifth of five planned dose cohorts. Early Programs Supported by Proprietary Platform The Company's drug discovery platform consists of a proprietary library of over 15,000 integrin binding molecules, a comprehensive screening assay system (binding, integrin confirmation, ligand-induced internalization) and an advanced live human tissue program. 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Because such statements deal with future events and are based on our current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Pliant Therapeutics could differ materially from those described in or implied by the statements in this press release. These forward-looking statements are subject to risks and uncertainties, including those related to the development and commercialization of our product candidates, including any delays in our ongoing or planned preclinical or clinical trials, the impact of current macroeconomic, geopolitical and marketplace conditions on our business, operations, clinical supply and plans, our reliance on single-source third parties located in foreign jurisdictions, including China, for critical aspects of our development operations, the risks inherent in the drug development process, the risks regarding the accuracy of our estimates of expenses and timing of development, our capital requirements and the need for additional financing, including the availability of additional term loans under our loan facility, and our ability to obtain and maintain intellectual property protection for our product candidates. 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Associated Press
8 hours ago
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Research Links how Literacy Impacts Health and Wellbeing
SYRACUSE, NY, June 27, 2025 (GLOBE NEWSWIRE) -- Health literacy is essential to improving health outcomes and empowering communities to manage their health and wellbeing. Adult education classrooms have long played a critical role in this empowerment process. But there remains an important question: How have adult education programs and instructors responded to new health care realities, like the increased use of digital technologies and more speakers of other languages who are utilizing the health care system? In a special issue of Adult Literacy Education: The International Journal of Literacy, Language, and Numeracy, researchers studied what is being done to build health literacy among adults with low literacy and language skills. In one study, researchers reviewed what health literacy interventions were in place across formal and informal educational settings for the growing migrant community worldwide and whether they met that population's needs. They found that, depending on the location and cause of migration, a lack of standardization among health literacy interventions created limitations when it came to outcomes. From this, the research team created a set of recommendations to improve the planning and reporting of interventions. In another case study, a team from an adult literacy program in Arizona discusses how it created a mock patient portal that allows adult learners to practice interacting with the health care system digitally and what they learned about the importance of contextualized learning. 'For millions of adults, both in the US and around the globe, the ability to successfully manage their own health care evades them due to low literacy or language skills,' said ProLiteracy President and CEO Mark Vineis. 'It's imperative that adult educators have access to research like this to better understand the needs of adults and to help shape the way they approach instruction to build healthier communities.' This edition of our journal includes further research about language-based health education, a review of the digital health landscape, and a Forum dialog that considers how we think about 'good learners,' 'good patients,' and language. We partner with Rutgers University to publish Adult Literacy Education. The journal editors—Alisa Belzer, Amy Rose, and Heather Brown—are leading researchers in the adult literacy and education field who believe in the importance of research to complement practitioners' experiences, intuition, and professional learning. In the research journal, adult literacy practitioners, researchers, funders, and policymakers can find evidence-based information to guide their practice, prompt important discussions, and build awareness. We publish the free online journal three times per year to share the latest and best research and practices in adult literacy, numeracy, and English language education. Each article in Adult Literacy Education goes through a blind peer-review process to ensure we are publishing the highest quality information that the field can trust and use. By keeping our research free, we ensure that the important information shared in the journal will benefit all adult learners equally. You can find the new issue of Adult Literacy Education at Writers interested in submitting articles for consideration in future issues of the journal can find author guidelines and a submission form on the journal's webpage. About ProLiteracy We are the world's leader in adult education practice, innovating and building the capacity of literacy programs everywhere—from small community-based organizations to large adult education programs and institutions. We serve over 5,000 adult literacy programs annually and work with partners in 28 countries worldwide. By providing comprehensive training and professional learning, accessible research, grant funding, and leading-edge digital and print learning resources through New Readers Press, we advocate for and unleash the power of literacy to transform lives. Contact: Allison Bleyler McDonald


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9 hours ago
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Most participants experienced improvements on the Hammersmith Functional Motor Scale – Expanded (HFMSE), Revised Upper Limb Module (RULM), and/or Clinical Global Impression of Change (CGI-C; assessed by investigator or caregiver) after transitioning to the higher dose regimen. These improvements were observed across phenotypes, functional status and age. For example, non-ambulatory participants improved by +2.5 (95% CI: 0.49, 4.56) on average on the HFMSE, and ambulatory participants improved by +1.1 (95% CI: -0.68, 2.89). 'These emerging data indicate that additional gains in function might be possible even in those with established disease who have been on therapy for years,' said Richard Finkel, M.D., director, Center for Experimental Neurotherapeutics (CENT) at St. Jude Children's Research Hospital. 'This effort to optimize the dosing of SPINRAZA is very exciting for the field and could fundamentally change how we treat our patients.' 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No participants required permanent ventilation, and the majority (20 of 25 participants) went without any ventilatory support throughout the study. Ninety-two percent of participants achieved the ability to walk independently, many within normal developmental timeframes. Participants with elevated levels of neurofilament light chain (NfL) at baseline experienced rapid and sustained reductions in NfL after initiation of nusinersen, reinforcing the potential utility of NfL as an objective biomarker of disease activity and treatment response in SMA. Nusinersen was generally well tolerated with no new safety concerns identified with eight years of follow-up. All participants had at least one AE, the majority of which were mild to moderate in severity; no AEs led to treatment discontinuation or study withdrawal. About SPINRAZA SPINRAZA (nusinersen) 12 mg/5 mL injection is approved in more than 71 countries to treat infants, children and adults with spinal muscular atrophy (SMA). As a foundation of care in SMA, more than 14,000 individuals have been treated with SPINRAZA worldwide.1 The currently approved 12 mg regimen for SPINRAZA is comprised of four loading doses administered over approximately 60 days, followed by maintenance dosing every four months thereafter. SPINRAZA is an antisense oligonucleotide (ASO) that targets the underlying cause of motor neuron loss by continuously increasing the amount of full-length survival motor neuron (SMN) protein produced in the body.2 It is administered directly into the central nervous system, where motor neurons reside, to deliver treatment where the disease starts.2 SPINRAZA has shown sustained efficacy across ages and SMA types with a well-established safety profile based on data in patients treated up to 10 years,3,4 combined with unsurpassed real-world experience. The nusinersen clinical development program encompasses more than 10 clinical studies, which have included more than 460 individuals across a broad spectrum of patient populations, including two randomized controlled studies (ENDEAR and CHERISH). The most common adverse events observed in clinical studies were respiratory infection, fever, constipation, headache, vomiting and back pain. Laboratory tests can monitor for renal toxicity and coagulation abnormalities, including acute severe low platelet counts, which have been observed after administration of some ASOs. Biogen licensed the global rights to develop, manufacture and commercialize SPINRAZA from Ionis Pharmaceuticals, Inc. (Nasdaq: IONS). Please click here for Important Safety Information and full Prescribing Information for SPINRAZA in the U.S., or visit your respective country's product website. About Biogen Founded in 1978, Biogen is a leading biotechnology company that pioneers innovative science to deliver new medicines to transform patients' lives and to create value for shareholders and our communities. We apply deep understanding of human biology and leverage different modalities to advance first-in-class treatments or therapies that deliver superior outcomes. Our approach is to take bold risks, balanced with return on investment to deliver long-term growth. We routinely post information that may be important to investors on our website at Follow us on social media - Facebook, LinkedIn, X, YouTube. Biogen Safe Harbor This news release contains forward-looking statements, including related to the potential clinical effects of a higher dose regimen of nusinersen; the potential benefits, safety and efficacy of higher dose regimen of nusinersen; the clinical development program for higher dose regimen of nusinersen; the identification and treatment of SMA; our research and development program for the treatment of SMA; the potential of our commercial business and pipeline programs, including SPINRAZA; and risks and uncertainties associated with drug development and commercialization. These forward-looking statements may be accompanied by words such as 'aim,' 'anticipate,' 'believe,' 'could,' 'estimate,' 'expect,' 'forecast,' 'intend,' 'may,' 'plan,' 'potential,' 'possible,' 'will,' 'would' and other words and terms of similar meaning. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. Results in early-stage clinical trials may not be indicative of full results or results from later stage or larger scale clinical trials and do not ensure regulatory approval. You should not place undue reliance on our forward-looking statements. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including without limitation, uncertainty of success in the development and potential commercialization of higher dose regimen of nusinersen; the risk that we may not fully enroll our clinical trials or enrollment will take longer than expected; unexpected concerns may arise from additional data, analysis or results obtained during our clinical trials; regulatory authorities may require additional information or further studies, or may fail or refuse to approve or may delay approval of our drug candidates, including SPINRAZA; the occurrence of adverse safety events; the risks of unexpected hurdles, costs or delays; failure to protect and enforce our data, intellectual property and other proprietary rights and uncertainties relating to intellectual property claims and challenges; product liability claims; results of operations and financial condition. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from our expectations in any forward-looking statement. Investors should consider this cautionary statement, as well as the risk factors identified in our most recent annual or quarterly report and in other reports we have filed with the U.S. Securities and Exchange Commission. These statements speak only as of the date of this news release. We do not undertake any obligation to publicly update any forward-looking statements. References: