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Four astronauts launch to the space station as NASA grapples with strange twist in leak issue

Four astronauts launch to the space station as NASA grapples with strange twist in leak issue

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A private astronaut mission that just took flight has exposed a new twist in a lingering — and potentially dangerous — issue at humanity's most frequently visited destination in space.
Axiom Space Mission 4, or Ax-4, lifted off from NASA's Kennedy Space Center in Florida at 2:32 a.m. ET Wednesday after an extended delay triggered by tests related to leaks plaguing the International Space Station.
For years, air has been slowly leaking out of a Russia-controlled module that typically remains sealed off from the rest of the space station. Recently, however, station operators realized the gradual, steady leak had stopped. And that raised an even larger concern.
It's possible that efforts to seal cracks in the module's exterior wall have worked, and the patches are finally trapping air as intended. But, according to NASA, engineers are also concerned that the module is actually holding a stable pressure because a new leak may have formed on an interior wall — causing air from the rest of the orbiting laboratory to begin rushing into the damaged area.
Essentially, space station operators are worried that the entire station is beginning to lose air.
Much about this issue is unknown. NASA revealed the concerns in a June 14 statement. The agency said it would delay the launch of the private Ax-4 mission, carried out by SpaceX and Houston-based company Axiom Space, as station operators worked to pinpoint the problem.
'By changing pressure in the transfer tunnel and monitoring over time, teams are evaluating the condition of the transfer tunnel and the hatch seal,' the statement read.
More than a week later, the results of that research are not totally clear. After revealing the new Wednesday launch target Monday night, NASA said in a Tuesday statement that it worked with Roscosmos officials to investigate the issue. The space agencies agreed to lower the pressure in the transfer tunnel, and 'teams will continue to evaluate going forward,' according to the statement.
NASA deferred further comment on the leak problem to the Russian space agency, Roscosmos, which did not reply to a list of emailed questions.
The leaks, first identified in 2019, are located in a tunnel that connects a Russian module called Zvezda to a docking port that welcomes spacecraft carrying cargo and supplies.
The cracks are minuscule and mostly invisible to the naked eye, hence the difficulty attempting to patch problem areas.
The situation gained new urgency last year when the leak rate hit its highest reading yet. And it became clear that technical teams in the United States and Russia did not see eye to eye on what exactly might be causing the problem, according to Bob Cabana, chair of NASA's ISS Advisory Committee, during a November meeting on the issue.
'The Russians believe that continued operations are safe — but they can't prove that to our satisfaction,' Cabana added. 'And the US believes that it's not safe, but we can't prove that to the Russian satisfaction.'
Neither NASA nor Roscosmos responded to requests for comment last week about how they currently evaluate the safety risk of the leaks.
As NASA and Roscosmos attempted to sort through the issue, the four crewmates now flying on Ax-4 remained locked in quarantine in Florida for about a month, waiting for their chance to launch.
The private mission includes decorated former NASA astronaut Peggy Whitson, who is now an Axiom Space employee, as well as three spaceflight novices who will become the first from their respective countries to visit the space station: Shubhanshu Shukla of India, Sławosz Uznański-Wiśniewski of Poland and Tibor Kapu of Hungary.
The group is expected to be in space for about two weeks, helping to carry out roughly 60 science experiments before returning home.
It's not yet clear whether — or how — the leaking Zvezda transfer tunnel could affect broader operations on the space station.
While privately funded missions to the space station such as Ax-4 are fairly rare occurrences, NASA and Roscosmos routinely send up rotating crews of astronauts and cosmonauts to keep the space station staffed.
Crew-11, which will mark the 12th crew rotation mission that SpaceX carries out on NASA's behalf, is currently slated to take off as soon as July.
That crew includes NASA astronauts Zena Cardman and Mike Fincke; Japan Aerospace Exploration Agency astronaut Kimiya Yui; and Roscosmos cosmonaut Oleg Platonov. They are on track to spend about six months in space, as is typical for staffing missions.

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New NPG Forum Paper Highlights Pro-aging Policy Options
New NPG Forum Paper Highlights Pro-aging Policy Options

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New NPG Forum Paper Highlights Pro-aging Policy Options

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Ionis announces Biogen to advance salanersen into SMA registrational studies based on positive interim Phase 1 results
Ionis announces Biogen to advance salanersen into SMA registrational studies based on positive interim Phase 1 results

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Ionis announces Biogen to advance salanersen into SMA registrational studies based on positive interim Phase 1 results

– Investigational salanersen (ION306/BIIB115) developed using novel Ionis antisense chemistry with the potential to achieve high efficacy and once-yearly dosing – – Interim Phase 1 data show children with SMA previously treated with gene therapy experienced a substantial slowing of neurodegeneration and clinically meaningful improvements in motor function following initiation of salanersen – – Biogen is engaging with regulators to advance salanersen to registrational stage studies – CARLSBAD, Calif., June 25, 2025--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that its partner, Biogen, shared positive topline results from the Phase 1 study of salanersen (ION306/BIIB115), an investigational antisense oligonucleotide (ASO) being developed for the potential treatment of spinal muscular atrophy (SMA). Leveraging the same mechanism of action as SPINRAZA® (nusinersen) but designed to achieve greater potency, salanersen has the potential to achieve high efficacy and enable once-yearly dosing. Both dose levels tested, 40 mg and 80 mg, given once a year, were generally well-tolerated and led to substantial slowing of neurodegeneration, as shown by reductions in neurofilament. Exploratory clinical outcome data show clinically meaningful improvements in function and attainment of new World Health Organization (WHO) milestones over one year. These data will be presented today at the SMA Research & Clinical Care Meeting hosted by Cure SMA in Anaheim, Calif. The Phase 1 single ascending dose study was designed to evaluate the safety, tolerability and pharmacokinetics of salanersen. The trial consisted of two parts: Part A, a randomized and placebo-controlled segment in healthy adult male volunteers and Part B, an open-label segment in pediatric participants with SMA who previously received ZOLGENSMA® (onasemnogene abeparvovec) and had investigator-reported suboptimal clinical status. Interim results are from Part B (n=24) in individuals who received either 40 mg or 80 mg salanersen once a year. In participants with elevated baseline concentrations of neurofilament light chain (NfL), indicating ongoing neurodegeneration, initiation of salanersen led to mean reductions in NfL of 70% at 6-months which were sustained through the one-year dosing interval. "These encouraging interim results reflect the potential of Ionis' leading technology to continue to improve the lives of people living with SMA," said Holly Kordasiewicz, Ph.D., senior vice president of neurology, Ionis. "We're proud to have discovered salanersen, which builds on the foundation we established with SPINRAZA and further supports Ionis' long-standing leadership in neurology and innovative RNA-targeted medicines. We are deeply grateful to the patients, families and investigators who participated in this study and look forward to continuing to work with Biogen to support the SMA community." Salanersen was invented by Ionis using a novel antisense chemistry designed to enhance potency, stability and durability. This advanced molecular design has the potential to deliver long-term results with long-interval dosing. In addition to safety and NfL, exploratory clinical outcome data were evaluated for the subgroup of participants with at least one year of follow-up at the time of the interim analysis (n=8 participants aged 2-12 who received 40 mg of salanersen). Half (4/8) of these participants achieved new WHO motor milestones that they previously could not achieve on their own or for which they required assistance, such as walking, crawling, standing or sitting. Furthermore, these participants experienced clinically meaningful improvements in motor function from baseline to one year, including a 3.3-point (SD 4.46) mean improvement from baseline on the Hammersmith Functional Motor Scale – Expanded (HFMSE) and a 5.3-point (SD 4.75) improvement on the Revised Upper Limb Module (RULM). "Despite the remarkable therapeutic advancements in the field of SMA over the past decade, there remains critical unmet needs. Salanersen represents the next phase of Biogen's ongoing pursuit to address these needs," said Stephanie Fradette, Pharm.D., Head of the Neuromuscular Development Unit at Biogen. "We are encouraged by the available data and eager to move salanersen into the next stage of development as quickly as possible. We are deeply grateful for the trial participants and their families, investigators, and site staff." The cumulative interim data from the Phase 1 study indicate that salanersen was generally well tolerated at the 40 mg and 80 mg doses, with most adverse events (AEs) mild to moderate in severity. The most common AEs were pyrexia and upper respiratory tract infection. Biogen is currently engaging with global health authorities regarding the design of the Phase 3 studies. Ionis discovered salanersen and licensed the global development, manufacturing and commercialization rights to Biogen Inc. About Spinal Muscular Atrophy (SMA) SMA is a rare, genetic, neuromuscular disease that affects individuals of all ages. It is characterized by a loss of motor neurons in the spinal cord and lower brain stem, resulting in progressive muscle atrophy and weakness. SMA is caused by a deficiency in the production of survival motor neuron (SMN) protein due to a damaged or missing SMN1 gene, with a spectrum of disease severity. Some individuals with SMA may never sit; some sit but never walk; and some walk but may lose that ability over time. In the absence of treatment, children with the most severe form of SMA would usually not be expected to reach their second birthday. SMA impacts approximately 1 in 10,000 live births, is a leading cause of genetic death among infants and causes a range of disability in teenagers and adults. About SPINRAZA SPINRAZA® (nusinersen) 12 mg/5 mL injection is approved in more than 71 countries to treat infants, children and adults with spinal muscular atrophy (SMA). As a foundation of care in SMA, more than 14,000 individuals have been treated with SPINRAZA worldwide. SPINRAZA is an antisense oligonucleotide (ASO) that targets the underlying cause of motor neuron loss by continuously increasing the amount of full-length survival motor neuron (SMN) protein produced in the body. It is administered directly into the central nervous system, where motor neurons reside, to deliver treatment where the disease starts. SPINRAZA has shown efficacy across ages and SMA types with a well-established safety profile based on data in patients treated up to 10 years, combined with unsurpassed real-world experience. The most common adverse events observed in clinical studies were respiratory infection, fever, constipation, headache, vomiting and back pain. Laboratory tests can monitor for renal toxicity and coagulation abnormalities, including acute severe low platelet counts, which have been observed after administration of some ASOs. Biogen licensed the global rights to develop, manufacture and commercialize SPINRAZA from Ionis Pharmaceuticals, Inc. (Nasdaq: IONS). Please click here for Important Safety Information and full Prescribing Information for SPINRAZA in the U.S., or visit your respective country's product website. About Ionis Neurology Ionis has been at the forefront of discovering and developing leading neurological disease medicines, including SPINRAZA® (nusinersen), the first approved treatment for spinal muscular atrophy, WAINUA™ (eplontersen), a medicine to treat hereditary transthyretin-mediated amyloid polyneuropathy (ATTRv-PN), and QALSODY® (tofersen) for SOD1-ALS. The clinical-stage portfolio includes 13 therapies, of which eight are wholly owned by Ionis. Ionis' investigational portfolio includes medicines for which there are few or no disease modifying treatments, such as rare diseases including Angelman syndrome, Prion disease and Alexander disease and more common conditions such as Alzheimer's and Parkinson's disease. About Ionis Pharmaceuticals, Inc. For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis currently has six marketed medicines and a leading pipeline in neurology, cardiology, and select areas of high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep understanding of disease biology and industry-leading technology propels our work, coupled with a passion and urgency to deliver life-changing advances for patients. To learn more about Ionis, visit and follow us on X (Twitter), LinkedIn and Instagram. Ionis Forward-looking Statements This press release includes forward-looking statements regarding Ionis' business and the therapeutic and commercial potential of salanersen (ION306/BIIB115), our commercial medicines, additional medicines in development and technologies. Any statement describing Ionis' goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties including those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ionis' forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis' forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. Except as required by law, we undertake no obligation to update any forward-looking statements for any reason. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2024, and most recent Form 10-Q, which are on file with the Securities and Exchange Commission. Copies of these and other documents are available from the Company. In this press release, unless the context requires otherwise, "Ionis," "Company," "we," "our" and "us" all refer to Ionis Pharmaceuticals and its subsidiaries. Ionis Pharmaceuticals® is a trademark of Ionis Pharmaceuticals, Inc. SPINRAZA® and QALSODY® are registered trademarks of Biogen. WAINUA™ is a registered trademark of the AstraZeneca group of companies. View source version on Contacts Ionis Investor Contact: D. Wade Walke, 760-603-2331 Ionis Media Contact: Hayley Soffermedia@ 760-603-4679 Error while retrieving data Sign in to access your portfolio Error while retrieving data Error while retrieving data Error while retrieving data Error while retrieving data

NEW STUDY IDENTIFIES ADDITIONAL LINKS BETWEEN POULTRY ANTIBIOTIC USE AND HUMAN DRUG RESISTANCE
NEW STUDY IDENTIFIES ADDITIONAL LINKS BETWEEN POULTRY ANTIBIOTIC USE AND HUMAN DRUG RESISTANCE

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NEW STUDY IDENTIFIES ADDITIONAL LINKS BETWEEN POULTRY ANTIBIOTIC USE AND HUMAN DRUG RESISTANCE

Ionophores, Commonly Used in Animal Agriculture, Found to Contribute to Antibiotic Resistance in Humans Salisbury, MD, June 25, 2025 (GLOBE NEWSWIRE) -- A new study, published in mSphere, a journal of the American Society for Microbiology, suggests some antibiotics used in conventional poultry farming may contribute to the development of antibiotic resistance in humans. This research, conducted by Dr. Alex Wong, Asalia Ibrahim and Jason Au of Carleton University's Department of Biology, focuses on ionophores, a class of antibiotics commonly used in conventional poultry farming and previously described as 'not important to human medicine.' 'This research underscores the importance of understanding the interconnectedness of animal and human health,' explains Dr. Alex Wong. 'While ionophores have long been considered safe for use in poultry to prevent parasitic infections, this study suggests that ionophore use could fuel the growth of antibiotic resistance to medically relevant drugs.' This study highlights the ongoing research and critical discussion about responsible antibiotic use in animal agriculture, showcasing the potentially negative long-term human and animal health effects of using antibiotics in animal production, even those not presently deemed 'important to human medicine." The study found: Bacterial pathogens around the world have genes (narA and narB) that allow them to resist ionophores. These genes are often found linked to other resistance genes that protect bacteria from human antibiotics. When ionophores are used, they can unintentionally encourage bacteria to carry both types of resistance – making them harder to kill with medicines we need and increasing the risk of clinically significant antimicrobial resistance spreading from animal agriculture to human healthcare systems. The study's findings contribute to the ongoing scientific conversation about antibiotic resistance and inform future research and policy decisions and provides evidence that the widespread use of ionophores potentially threaten human health. 'This study surprised me. Personally, I've been dismissing the use of ionophores for years because we didn't have this evidence. This study suggests that it could be driving resistance to the drugs we do care about. When animal producers use ionophores they can drive the growth of bacteria that are resistant to our most important medicines,' Lance Price, M.S. Ph.D., Professor at George Washington's (GW) Milken Institute School of Public Health and Founding Director of GW's Antibiotic Resistance Action Center. Perdue Takes No Chances with Animal or Human Health, Standing Firm on Its Decade-Long 'No Antibiotics Ever' Commitment Ionophore use in poultry has been on the rise after a reintroduction of usage by large producers—with some poultry companies relying on routine use of the drug class for preventing illness. However, Perdue Farms took a trailblazing approach by committing to No Antibiotics Ever (NAE) in 2016, shunning the use of all antibiotics including ionophores. Perdue Farms remains committed to its No Antibiotics Ever (NAE) program. 'We started our NAE transition initially due to consumer demand, however with time we have seen, and appreciate, the animal welfare and human health benefits of this approach,' states Dr. Bruce Stewart-Brown, DVM, Chief Science Officer at Perdue Farms. 'For a decade now, our No Antibiotics Ever commitment has reflected our belief that what's good for the bird is also good for people– and this study confirms that belief is well-founded. At the end of the day, it's a promise that gives consumers peace of mind and sets a higher standard for responsible poultry production.' This research was funded by the Canadian Government, Natural Sciences and Engineering Research Council of Canada (NSERC) and Perdue Farms. Learn more about the study and Perdue Farms' commitment to NAE at For media interested, there will be a virtual briefing today, June 25, at 10 AM ET. You can join that briefing using this link starting at 10 AM ET, or reach out to for more detail. ### About Perdue FarmsWe're a fourth-generation, family-owned, U.S. food and agriculture company. Through our belief in responsible food and agriculture, we are empowering consumers, customers, and farmers through trusted choices in products and services. Perdue Foods consists of a premium protein portfolio, including our flagship PERDUE® brand, Niman Ranch®, Coleman Natural®, Pasturebird®, and Yummy®, as well as our pet brands, Full Moon® and Spot Farms®, and is available through various channels including retail, foodservice, club stores and our direct-to-consumer website, Perdue AgriBusiness is a leading merchandiser, processor, and exporter of agricultural products and the largest U.S. manufacturer of specialty, organic, and non-GMO oils. It also ranks as one of the largest suppliers of organic feed ingredients in the world. Now in our company's second century, we never use drugs for growth promotion in raising poultry and livestock, and we are actively advancing our animal welfare programs. Our brands are leaders in no-antibiotics-ever and in USDA-certified organic proteins. Learn more at Attachment Ionophores Report Infographic CONTACT: Kerri McClimen Perdue Farms

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