Eligo Bioscience Awarded $5 Million to Advance Breakthrough Genetic Medicine Platform for Immuno-Dermatology
PARIS, May 13, 2025 /CNW/ -- Eligo Bioscience, a biotechnology company pioneering the development of novel genetic medicines, today announced it has secured a $5 million grant from the French government to accelerate the advancement and scaling up of Eligo's proprietary topical gene delivery platform, designed to enable local production of therapeutic biologics directly by skin-resident bacteria.
This grant follows recent key milestones for Eligo, including the publication of its microbiome base-editing platform in Nature, securing multiple foundational patents covering in situ editing of the skin microbiome, and successfully expanding its Series B funding round to $35 million. This latest non-dilutive financial support strengthens Eligo's capacity to rapidly advance its clinical pipeline.
Scaling up and advancing towards the clinic
Building on the development of its first-generation CRISPR-based topical therapeutic targeting moderate to severe acne vulgaris, Eligo will now optimize and scale up the bioproduction process of its innovative gene delivery vector ahead of later-stage clinical trials. In this endeavor, Eligo is partnering with Biose Industries, a globally recognized CDMO specializing in microbial fermentation. Biose's extensive GMP expertise in scaling complex microbial therapeutics will be instrumental in accelerating Eligo's progress toward clinical validation.
"This funding empowers us to establish a robust bioproduction process for our first-in-class topical microbiome-targeting gene-editing therapies, laying the groundwork for expanding into a wide range of immuno-dermatological indications," said Dr. Xavier Duportet, CEO and Co-Founder of Eligo Bioscience."It reinforces our ambition to deliver truly transformative therapeutic solutions, addressing critical medical challenges faced by millions of patients worldwide."
Expansion to immuno-dermatology targets
The skin microbiome plays a pivotal role in cutaneous immune regulation, and commensal bacteria residing within the hair follicle lie in immediate proximity to resident immune cells.
Eligo's unique in-situ delivery modality enables to perform in-situ genetic engineering of these commensal bacteria, turning them as localized bioreactors that can express high-potency biologics precisely where immune dysregulation occurs.
The new funding will support the exploration of multiple therapeutic payloads and the build-out of a diversified immuno-dermatology pipeline targeting chronic inflammatory and immune-mediated skin diseases with significant unmet need.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Montreal Gazette
4 hours ago
- Montreal Gazette
Libman: No vacation from language law excesses in Quebec
Even during the political dog days of summer, we can't seem to escape the absurdity and frustration caused by Quebec language law excesses. Every few weeks something else provokes a head slap. This week we learned about a barbershop owner in St-Léonard who — six months after opening his local business — started being hounded by Quebec's French-language watchdog (OQLF) regarding everything from his store signage to his online presence — informed, as the owner put it, that he was being 'too loud on Instagram with my English.' Earlier this month, we discovered that LaSalle College, a bilingual institution, is being fined $30 million by the CAQ government for enrolling too many students in its English-language programs, exceeding a cap established by Bill 96 aimed at public CEGEPs and subsidized private colleges like LaSalle. The school says international students, who make up about 70 per cent of those enrolled in English-language Attestation of College Studies, where the government claims it exceeded its cap, are entirely self-funded through tuition fees, with no subsidies from the government. This excessive aspect of Bill 96 is another counterproductive and short-sighted example of Quebec shooting itself in the foot. LaSalle College offers pre-university and technical programs, teaching various trades, skills and vocational training — essentially feeding our labour force, which is in desperate need of nourishment. Last month, the onerous new rules and regulations in Bill 96 regarding signage and packaging came into effect. The bill, adopted in 2022, allowed a three-year implementation window — but the regulations were published only last summer — forcing merchants to wait, then scramble to comply. Stores with trademark names, such as Canadian Tire, Footlocker and Best Buy, or any business with another language in its name, must change their signage to include a translation or a generic description in French on storefronts, occupying at least two-thirds of the area devoted to text. Municipalities have provisions in their zoning bylaws that often limit the size and scope of signage. The costs and inconveniences caused by these overzealous rules represent an infuriating impediment, among others, for many businesses. These new signage regulations also conjure up satirical images of language inspectors in trench coats showing up with tape measures, analyzing proportions and dimensions of a sign. With Bill 96, it takes only one complaint, even anonymous, to launch an investigation that could lead to hefty fines. The new rules on packaging could severely impact trademarked collectibles or specialty items made only in other countries, such as guitar strings or other music supplies, that can no longer be sold here if not labelled in French. Merchants will either go through hoops to do their own labelling — likely passing the price on to consumers — or be unable to provide certain items and take a hit, as customers turn to Amazon. We can expect the OQLF will send out secret shoppers to sniff out scofflaws. In France, the 1994 Toubon Law made French the official language, imposing its use in various contexts, including official communications, commercial contracts and advertising. However, that law is more accommodating, with exceptions for trademarks and in recognizing the importance of regional languages and linguistic diversity. Quebec's excesses make for embarrassing headlines abroad as with Pastagate, Bonjour-Hi and the Go Habs Go fiasco. There was a 60 Minutes report in 1998 that sardonically followed a language inspector on the job. Incidents that shine light on Quebec as an object of ridicule are inevitable when laws contain elements of intolerance, with regulations that go too far. They not only harm our province's image, economy and attractiveness, but they also caricature — and thereby undermine — the importance of protecting French itself. It's time to rethink language excesses, including the OQLF itself, unless we want one notable trademark sign to exemplify our province — Banana Republic.
Canada News.Net
a day ago
- Canada News.Net
World Insights: With Gaza kids wasting away, Israeli blockade sparks global condemnation
"The level of evil that it takes to make a decision to starve a baby as a means of war, as a weapon of war -- what have we come to as humanity? What have we come to as a country?" GAZA, July 25 (Xinhua) -- As helpless doctors are watching children waste away from hunger in Gaza's shattered hospitals, international condemnation of Israel is growing, with governments and aid groups alike denouncing its siege as a humanitarian catastrophe. French President Emmanuel Macron on Friday announced that France will recognize Palestine as a state -- the first G7 member to make such a diplomatic statement. This landmark move came amid the snowballing global outrage over the "man-made" mass starvation in Gaza caused by Israel's blockade on aid into the enclave. Another 10 people died overnight from famine, pushing the total number of people starved to death to 111, the Gaza health ministry said Thursday, noting most of them have died in recent weeks. MAN-MADE MASS STARVATION Since Israel cut off all supplies to Gaza in March, citing concerns that aid was being diverted to Hamas, food stocks in the besieged enclave have been exhausted. Since then, the United Nations (UN) and its humanitarian partners have been unable to deliver food for nearly 80 days, World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus said on Wednesday, noting that even after the restrictions were lifted in May, the resumed deliveries remained inadequate. His remarks followed a joint statement issued Wednesday by more than 100 aid agencies, underlining that tons of food, clean water and medical supplies sit outside Gaza "untouched," as they were blocked from delivering the goods. "I don't know what you would call it other than mass starvation, and it's man-made, and that's very clear," Ghebreyesus said. "This is because of the blockade." Mohammed Abu Salmiya, head of Al-Shifa hospital in Gaza City, said Tuesday that 21 children have died across the Palestinian territory over the past three days "due to malnutrition and starvation." New cases were arriving at Gaza's hospitals "every moment," he added. Meanwhile, Rik Peeperkorn, WHO representative for the occupied Palestinian territory, said 5,100 children have been admitted to malnutrition programs in July alone, including 800 who were severely emaciated. Khalil al-Deqran, a spokesperson for the Hamas-run Gaza Ministry of Health, told Reuters that "Hospitals are already overwhelmed by the number of casualties from gunfire. They can't provide much more help for hunger-related symptoms because of food and medicine shortages." Deqran added that there were 600,000 people suffering from malnutrition symptoms such as dehydration and anemia, including 60,000 pregnant women. In a statement issued Tuesday, the UN Office for the Coordination of Humanitarian Affairs said many Palestinians arrived at hospitals "in a state of severe exhaustion caused by a lack of food, and others are said to be collapsing in the streets," noting that "many more may be dying unreported." "These deaths and the horrendous physical and psychological suffering caused by hunger are the result of Israel's interference with and militarization of humanitarian assistance," it said. "They are the foreseeable and repeatedly foretold consequences of Israel's closure, blockade and other unlawful impediments to the entry and distribution of humanitarian assistance into Gaza, which has left a severe lack of all humanitarian assistance, including food." "The Israeli military must immediately stop shooting at people trying to get food. Firearms must never be used simply to disperse a crowd, even as a warning," it added. MOUNTING GLOBAL PRESSURE ON ISRAEL As the humanitarian nightmare continues, global outrage is reaching a boiling point. Macron stepped up diplomatic pressure on Israel with his Friday statement, following public condemnation earlier this week by France and several other European countries over Israel's blockade of aid and the killing of hundreds of Palestinians trying to reach food. He said in a post on social media platform X that he will "make the solemn announcement" of France's recognition of Palestine's statehood in September's UN General Assembly. "The urgency today is to end the war in Gaza and to provide aid to the civilian population." "There must be an immediate ceasefire, the release of all hostages, and massive humanitarian aid to the people of Gaza," he wrote, noting "there is no alternative." As the biggest Western power to recognize Palestine, France could pave the way for other countries to follow, the AP said in a Friday report. So far, over 140 countries recognize a Palestinian state, including more than a dozen in Europe like Slovenia, Norway and Spain, while Israel urged countries to hold off on recognition until the decades-old conflict is resolved. "We strongly condemn President Macron's decision," Israeli Prime Minister Benjamin Netanyahu said in a statement. "Such a move rewards terror and risks creating another Iranian proxy, just as Gaza became. A Palestinian state in these conditions would be a launch pad to annihilate Israel -- not to live in peace beside it." The Palestinian Authority welcomed it. "We express our thanks and appreciation" to Macron, said Hussein al-Sheikh, vice president of the Palestine Liberation Organization. "This position reflects France's commitment to international law and its support for the Palestinian people's rights to self-determination." In line with Macron, British Prime Minister Keir Starmer announced Thursday that "We are clear that statehood is the inalienable right of the Palestinian people." "A ceasefire will put us on a path to the recognition of a Palestinian state and a two-state solution which guarantees peace and security for Palestinians and Israelis," Starmer said in a statement, ahead of an "emergency call" on Friday with France and Germany on Gaza, regarding how to get food to the starving and how to stop the conflict. "The suffering and starvation unfolding in Gaza is unspeakable and indefensible," he added. While Canadian Prime Minister Mark Carney also accused Israel of violating international law over the humanitarian crisis, urging the country to "respect the territorial integrity of the West Bank and Gaza," the United States "strongly rejects" Macron's declaration. "This reckless decision only serves Hamas propaganda and sets back peace," U.S. Secretary of State Marco Rubio wrote in a post on X, soon after the country cut short Gaza ceasefire talks in Qatar, accusing Hamas of lacking "good faith." U.S. CUTS SHORT PEACE TALKS The United States is cutting short Gaza ceasefire talks and pulling its negotiating team out of Qatar for consultations, after Hamas's latest response "shows a lack of desire" to reach a truce, U.S. Special Envoy to the Middle East Steve Witkoff said Thursday. "While the mediators have made a great effort, Hamas does not appear to be coordinated or acting in good faith," Witkoff said in a statement. "We will now consider alternative options to bring the hostages home and try to create a more stable environment for the people of Gaza," without disclosing any details on what those alternatives might be. He added that it was "a shame that Hamas has acted in this selfish way" and that the United States is "resolute" in seeking an end to the conflict in Gaza. In response, Hamas said it was surprised by Witkoff's "negative remarks," noting it had shown responsibility and flexibility in the negotiations. It also reaffirmed its "keenness to continue the negotiations and to engage in a way that would ease obstacles and ensure reaching a permanent ceasefire." Despite the Trump administration positioning itself as a peacemaker and vowing to broker a resolution to the Gaza conflict, no breakthrough has been achieved so far. U.S. President Donald Trump, whose relationship with Netanyahu was described as "good" by the White House, hosted the Israeli leader for a four-day visit to Washington earlier this month. Though Trump said he expected some progress that week on a ceasefire, including the release of hostages held by Hamas and a significant increase in humanitarian aid, Netanyahu left the country with no agreement announced. As the two leaders were having a private dinner in the White House, hundreds of protesters gathered outside. Many wore Palestinian keffiyehs, waved Palestinian flags, and held signs reading "Stop Arming Israel" and "Say No to Genocide." Such protests have continued on and off, as Al Jazeera reported on a group of military veterans, doctors and former U.S. officials, as well as Congresswoman Rashida Tlaib, demonstrating Thursday against the administration's "unconditional support for Israel." "The level of evil that it takes to make a decision to starve a baby as a means of war, as a weapon of war -- what have we come to as humanity? What have we come to as a country?" Josephine Guilbeau, a 17-year U.S. Army veteran, told Al Jazeera outside the Capitol. Similarly, Tlaib said, "Americans serving in Congress, wake up because the American people are telling you over and over again: We're not in support of this."
The Market Online
a day ago
- The Market Online
dynaCERT's emissions-cutting tech now deployed at a major port in France
dynaCERT Inc. is taking its HydraGEN™ technology global and this time, it's landed in one of Europe's major shipping corridors. The company just announced its emissions-cutting tech is now deployed at the Port of Rochefort-Tonnay in France, a serious move into industrial-scale decarbonization at one of the continent's key logistics hubs. Lyndsay Malchuk recently sat down with Kevin Unrath, the Chief Operating Officer of dynaCERT, a company rewriting the playbook for clean tech in heavy industry. He's here to talk about the rollout, what it means for adoption, and where they're going next. The following is a transcription of the above video, and The Market Online has edited it for clarity Lyndsay: Kevin, let's get right into it. HydraGEN™ is now live at the major French port. How big of a statement is this deployment for the industrial side of your business? Kevin: Basically, this deployment in the port over in France is a major milestone, especially for our France distributor, as it marks his first intro in the off-road applications and into the industrial environment. Over there in France we already have proven success in a lot of transportation fleets across the whole country and across a wide range of truck manufacturers. Now, by integrating HydraGEN™ into a crane operation, we are demonstrating broader potential also in that country, not only across the world and globally, and not only in Canada, North America, or maybe let's say our European hub here in Germany. It shows that reducing emissions and saving fuel is possible even in demanding industrial settings as this harbor. Lyndsay: Kevin, let's be honest here. The emission space is full of buzzwords and broken promises. We all know that. So what makes this rollout real? What kind of impact is it actually delivering in the field? Kevin: What makes it real basically is that this rollout is tangibly on the scientific approach. So what we always try to do is follow a scientific approach, which also means going into pre studies, going into trials with our customers, and also this implementation performed competitive gas emission measurements on the crane operations with and without HydraGEN™ before the final installation. And it allowed us to quantify the greenhouse gas reduction and fuel savings under real operating conditions already before we got into the final contracts and the installation, which is installed now. It's not a pilot anymore. That's important. Now, this is really a working measurable solution after a first pilot. Lyndsay: We all know too that ports are notorious for emission zones. Is this just the beginning of a broader play into European or global logistics? What's the vision beyond this port? Kevin: I think we have to differentiate the answer a little bit in two or three categories. So the first topic is definitely on the harbor side. It's our first public step to go in there. But as we see, it's already generating momentum. Also the celebration during the installation and everything is already showing high interest out of the harbor market to us. And we are already in several other port discussions, and we are looking forward to seeing maybe further follow up projects after this. Beyond this, we are seeing increased traction all across Europe. If we talk about logistics for sure, we talk about harbors, but for us also very important on that intermodal part of logistics. We also look on, for example, transport logistics on streets. So that means commercial vehicles and things like this, but also into intralogistic topics in harbors and other topics like forklifts and things like this. This where we are, we are seeing supported by our strong presence at the Bauma, which you also shared, and we had a joint video at our evening event. And even at the transport logistics only four to five weeks ago here in Munich, we had a real strong presence and we really see a lot of discussions coming out of this and a high interest in the market. So concluding your questions. Yeah, we are going deeper into these topics. We are more looking on the European market and also this is shown by the fact that I'm not only COO of the company internationally. I also, alongside this campaign, did take over the responsibility for the GMBH in Europe as Managing Director and taking care of the European business there. Lyndsay: Your tech is very innovative, and we all know with that type of tech, it usually faces some pushback from operators who don't want any downtime. So let's talk about that. What are you hearing on the ground from the people actually running the hardware? Kevin: The feedback from the operators is very positive. Let's say basically like this. The system integrates smoothly into your running applications. That's the most important point for them. So they do not want to have long down times for installation or getting to know the product. So this is why smoothly integration is very, very important for them. And users already see fuel savings from the beginning. So there is no time needed like a few months or something to realize the full fuel savings. It's basically an installation of two to three hours. It's an aftermarket product and you directly, if you switch on the truck or the harbor crane, again, you will see the fuel savings. There's also growing anticipation for upcoming carbon credit programs for sure, as we are working on the carbon credit side with VERRA also, and which will make HydraGEN™ installations even more financially attractive to all of the customers by having really the fuel saving, the emission reduction and the carbon credit generation. This adds another layer of value for the customers for sure, but also important for us, we are still looking on the environmental and economic effect of all our customers. Lyndsay: I want to dive a little bit deeper into the investor lens of things. I mean, how should we be thinking about this deployment? Is this a one-off win or the first domino in a bigger commercial wave? Kevin: No, for us looking onto Europe in general, but also looking on France in specific. In France alone, we have had already equipped a large number of different trucks across the country, so different brands, and we have proved from that the technology works. So this for us is now very, very important in the further, let's say succession on the market over here in Europe, which we are striving for. We have already proven that technology works across different engines, different fuels, including things like HVO also testing over here in Germany at some customers. So we see a broad range of success and this is exactly what we are trying and striving for further success. dynaCERT is now trading under the ticker DYA on the TSX. To learn more about how they're turning real-world logistics into a clean tech revolution, visit This is no longer about future potential. They're already plugged in and scaling up Company shares last traded at $0.155 Join the discussion: Find out what everybody's saying about this stock on the dynaCERT investor discussion forum, and check out the rest of Stockhouse's stock forums and message boards. The material provided in this article is for information only and should not be treated as investment advice. For full disclaimer information, please click here.
