2025 NFL schedule release betting, odds, lines: Buffalo Bills are only team to be favored in every game this season
Unfortunately for Buffalo, they still play in the AFC, and Patrick Mahomes' Kansas City Chiefs have ended their playoff runs in four of the past five seasons, including a heartbreaking 32-29 loss in the AFC championship game last season.
Expectations are high again this season, and after the 2025 NFL schedule release, oddsmakers have the Bills favored in all 17 games at sportsbooks. It is only the second time Buffalo has been favored in every game in a season since 1960, per Sports Odds History. The Bills were favored in all 16 games in the 2022 season, going 13-3 overall but only 8-7-1 against the spread.
The Bills are also favored in the largest projected spread this season: -12.5 in Week 4 against the New Orleans Saints. Buffalo is at least a 5.5-point favorite in 10 games.
The Bills are tied for the third-best odds — +750 with Chiefs — to win Super Bowl LX at BetMGM, and the second-best odds at +375 to win the AFC behind the Chiefs and Baltimore Ravens at +350.
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Cincinnati Bengals pass rusher Trey Hendrickson: Progressing Did you watch the same preseason opener we did? Where the Eagles' backups on offense tore through the Bengals' starters on defense? Yeah. Couple that with Hendrickson remaining engaged while holding in, and we're calling this one progressing toward a deal. The Bengals' need is clear as day. San Francisco 49ers WR Jauan Jennings: Progressing We'll tag this one as "progressing" too, considering head coach Kyle Shanahan indicated Monday that Brandon Aiyuk likely won't play until a month into the season, at least. There was also yet another injury to the 49ers' wide receiver room this week. Jennings reportedly did a light workout on Monday, but hasn't practiced since reportedly aggravating a calf injury on July 27 and is seeking a new contract. With the 49ers running thin at the position, it might motivate a deal to be done sooner than later. 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