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Top doc recommends getting rid of everyday tool to reduce risk of Alzheimer's

Top doc recommends getting rid of everyday tool to reduce risk of Alzheimer's

There is "such positivity" in Alzheimer's research at the moment, says top immunologist Luke O'Neill. A drug that slows down the disease was recently approved by the European Medicines Agency (EMA), and it is hoped that it will be available in Ireland soon.
However, the expert stresses that lifestyle changes can help lower a person's chance of developing the disease. Alzheimer's is the most common form of dementia, which is the umbrella term for memory loss and other cognitive abilities that are serious enough to interfere with daily life.
It is primarily caused by the build-up of protein deposits in the brain that eventually kills brain cells. While the exact cause of Alzheimer's is unknown, scientists believe that for most people it is caused by a combination of genetic, lifestyle and environmental factors.
In July 2024, the Lancet Commission reported that 45 per cent of dementia cases could be prevented by fully addressing 14 lifestyle factors. Here are Luke O'Neill's and the Lancet's lifestyle recommendations on reducing the risk of Alzheimer's- and it includes ditching a tool most of us use daily.
Google Maps is a tool that many of us use daily, however, studies suggest that keeping our brains as active as we can can reduces the risk of Alzheimer's. This can be done by learning a new language, doing puzzles, taking part in quizzes and also by navigating new areas and figuring out directions ourselves.
A study published in The BMJ in December 2024 found that taxi drivers and ambulance drivers have the lowest rates of death due to Alzheimer's. Other drivers such as airline pilots or bus drivers - those that have predefined routes - did not have a lower risk of developing the disease.
This suggests that occupations requiring frequent navigational and spatial processing could offer some protection against Alzheimer's.
Social interaction is a great way to keep the mind active, and scientists have identified social isolation as a risk factor for not only Alzheimer's but hypertension and coronary heart disease.
Loneliness can be associated with decreased cognitive activity, which can accelerate cognitive decline and poor mood.
Professor O'Neill told the Irish Mirror: "A big one is loneliness, that is a risk factor for developing Alzheimer's and Dementia. We have to mind older people, many older people get isolated and with some encouragement we can hopefully diminish the loneliness epidemic that's there."
Studies strongly suggest a link between hearing loss and a higher risk of developing dementia. One found that with every 10-dB decrease in hearing ability, there is a 4 per cent to 24 per cent higher risk of developing dementia.
Professor O'Neill encourages everyone to be conscious of their hearing and get it checked if they believe it might be declining. He added: "With a hearing aid you can stave that off, so the big message that's been given in the last while is if you are having trouble hearing go and get a hearing aid because it's a risk of getting Alzheimer's.
"These are things we can all do at decreasing our own risk of getting it, and they are very optimistic on that front."
The newest Lancet Commission study on dementia reported that high LDL cholesterol is associated with a higher risk of dementia. LDL is commonly known as "bad cholesterol", it's a condition where there's excessive amount of LDL cholesterol in the bloodstream.
This is usually checked during a routine bloods appointment, often in a GP office. Luckily, much can be done to reduce LDL cholesterol including a balanced diet low in saturated and trans fats.
This is usually found in foods like red meat, full-fat dairy, fried foods and processed snacks.
Lifelong learning is associated with improved brain health, with higher levels of cognitive activity. This doesn't mean you have to enroll in a degree programme, but learning a new language or taking up a new skill, even casually, can improve brain health.
The Lancet Commission found that those who did not complete secondary school education were more at-risk of developing Alzheimer's.
Being active is important for a healthier life, and it has been cited as one of the 14 factors that could reduce the risk of dementia. Physical activity can benefit brain health by reducing chronic inflammation, improving blood flow and increasing the release of protein that is good for brain cells.
The World Health Organisation recommends that adults get between 150 and 300 minutes of moderate-intensity aerobic physical activity a week. This would include walking briskly, biking, swimming or dancing.
It also recommends that on top of this adults should partake in muscle strengthening activities two times a week.
Obesity is also a risk factor for developing Alzheimer's disease. However, it's important to note that BMI is not definitive in diagnosing obesity- as some people can have a high percentage of muscle mass.
Calculating body fat percentage, or measuring waist-to-hip ratio can be used to determine a healthy body.
An analysis published in the National Library of Medicine with over five million people found that those with higher central obesity - measured by waist-to-hip ratio- was associated with a greater risk of cognitive impairment and dementia.

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Cork man says he is being blocked from leaving Philippines to access vital cancer treatment at home
Cork man says he is being blocked from leaving Philippines to access vital cancer treatment at home

Irish Independent

time2 days ago

  • Irish Independent

Cork man says he is being blocked from leaving Philippines to access vital cancer treatment at home

73-year-old John O'Neill, originally from Gerald Griffin Street in Blackpool, says that he was denied leave from the Philippines earlier this year, having been told to return home for treatment of prostate cancer, which the Cork native says is killing him. Mr O'Neill says he was told by authorities at the airport that he owed 'immigration fees', which he disputes, and is now in limbo as the case gets resolved while he is dying from cancer. 'I came here to the Philippines in 2013 to open my charity 'Rice for Life', to feed women and children in awful poverty,' John explains, who lives in Dumaguete, on the southern tip of Negros Island with his wife Frizell and son Clovesky. However, John said the work he was doing wasn't appreciated by everyone, and that he had received death threats on multiple occasions by radical groups, in an area in which he says is dangerous to be a foreigner. 'Two weeks before COVID, I had decided to go back home to live the rest of my life out there, but when that kicked off, I was stuck in the Philippines for five years,' John said, adding that for weeks he was forced to stay at home, while his Filipino partner was allowed out to do the family's weekly shop. After restrictions were lifted, John went back to his charity work until a crushing diagnosis of Prostate Cancer in March of last year turned his life on its head. 'I was in the hospital here for 12 days, but they told me they couldn't do any more for me,' John explains from his bed, as the country enters its rainy season. 'I tried two hospitals in Cebu, and was told by one Chinese surgeon they did not have the technology to treat me here like they could in my own country. 'He said, 'I think Cork can guarantee you 15 years of life, would you be happy about that?'. 'I saved a few bob to fly back to Cork, and I had organised for my records to be sent over and to get treatment in a Cork hospital. I booked the flight with my 9-year-old son, from Cebu to the capital Manila, then onwards to Cork via China and London. 'We had no problem on the first flight, but when we got to the queue to give our passports and flight ticket, we were refused permission to fly. 'They said I may owe them immigration fees, which I totally disagreed with, and they told me that it would take 6 months to sort out. 'I won't live that long without treatment, and I told the supervisor that they were abusing my human rights, however, he just said, 'Sorry Sir, these are the laws of our country.'' John says that in the time since, he cannot get a clear answer from the government on how much exactly he owes the Filipino government, who say the fees relate to COVID-related costs. John claims that he has paid the requisite fees, but claims the goalposts have been changed by the government. In limbo, Mr O'Neill says he can't get an answer to exactly what he owes until the six-month review of his case is concluded, which the Cork native says was confirmed by two separate lawyers. In the nine weeks since, John said he has contacted local TDs and the Irish embassy in a bid to get some help in trying to waive the substantial fees and finally board a flight that may save his life. However, the Cork native is still in limbo, and says he is getting weaker every day that passes without treatment. An old Irish friend, Waterford-based writer and musician Billy Costine, has started a GoFundMe for the 73-year-old, which he's hoping will cover the cost of whatever amount the 'immigration fee' bill that will arrive at the Cork native's door. Billy said he's left 'angry' by what he's called a 'corrupt' government decision, and that if something isn't done shortly, his friend John will be 'coming home in a box'. 'I'm not a great believer in religion, but I would be totally lifted if I could come home,' an emotional John says. 'Even though I am not frightened of death, because every single one of us has to die – from mouse to man – you start counting on our figures and thinking about what it means. 'Going down to Crosshaven, heading out fishing, it makes you think totally differently. 'If I die, I want it to be under an Irish blue sky,'

Top doc recommends getting rid of everyday tool to reduce risk of Alzheimer's
Top doc recommends getting rid of everyday tool to reduce risk of Alzheimer's

Irish Daily Mirror

time3 days ago

  • Irish Daily Mirror

Top doc recommends getting rid of everyday tool to reduce risk of Alzheimer's

There is "such positivity" in Alzheimer's research at the moment, says top immunologist Luke O'Neill. A drug that slows down the disease was recently approved by the European Medicines Agency (EMA), and it is hoped that it will be available in Ireland soon. However, the expert stresses that lifestyle changes can help lower a person's chance of developing the disease. Alzheimer's is the most common form of dementia, which is the umbrella term for memory loss and other cognitive abilities that are serious enough to interfere with daily life. It is primarily caused by the build-up of protein deposits in the brain that eventually kills brain cells. While the exact cause of Alzheimer's is unknown, scientists believe that for most people it is caused by a combination of genetic, lifestyle and environmental factors. In July 2024, the Lancet Commission reported that 45 per cent of dementia cases could be prevented by fully addressing 14 lifestyle factors. Here are Luke O'Neill's and the Lancet's lifestyle recommendations on reducing the risk of Alzheimer's- and it includes ditching a tool most of us use daily. Google Maps is a tool that many of us use daily, however, studies suggest that keeping our brains as active as we can can reduces the risk of Alzheimer's. This can be done by learning a new language, doing puzzles, taking part in quizzes and also by navigating new areas and figuring out directions ourselves. A study published in The BMJ in December 2024 found that taxi drivers and ambulance drivers have the lowest rates of death due to Alzheimer's. Other drivers such as airline pilots or bus drivers - those that have predefined routes - did not have a lower risk of developing the disease. This suggests that occupations requiring frequent navigational and spatial processing could offer some protection against Alzheimer's. Social interaction is a great way to keep the mind active, and scientists have identified social isolation as a risk factor for not only Alzheimer's but hypertension and coronary heart disease. Loneliness can be associated with decreased cognitive activity, which can accelerate cognitive decline and poor mood. Professor O'Neill told the Irish Mirror: "A big one is loneliness, that is a risk factor for developing Alzheimer's and Dementia. We have to mind older people, many older people get isolated and with some encouragement we can hopefully diminish the loneliness epidemic that's there." Studies strongly suggest a link between hearing loss and a higher risk of developing dementia. One found that with every 10-dB decrease in hearing ability, there is a 4 per cent to 24 per cent higher risk of developing dementia. Professor O'Neill encourages everyone to be conscious of their hearing and get it checked if they believe it might be declining. He added: "With a hearing aid you can stave that off, so the big message that's been given in the last while is if you are having trouble hearing go and get a hearing aid because it's a risk of getting Alzheimer's. "These are things we can all do at decreasing our own risk of getting it, and they are very optimistic on that front." The newest Lancet Commission study on dementia reported that high LDL cholesterol is associated with a higher risk of dementia. LDL is commonly known as "bad cholesterol", it's a condition where there's excessive amount of LDL cholesterol in the bloodstream. This is usually checked during a routine bloods appointment, often in a GP office. Luckily, much can be done to reduce LDL cholesterol including a balanced diet low in saturated and trans fats. This is usually found in foods like red meat, full-fat dairy, fried foods and processed snacks. Lifelong learning is associated with improved brain health, with higher levels of cognitive activity. This doesn't mean you have to enroll in a degree programme, but learning a new language or taking up a new skill, even casually, can improve brain health. The Lancet Commission found that those who did not complete secondary school education were more at-risk of developing Alzheimer's. Being active is important for a healthier life, and it has been cited as one of the 14 factors that could reduce the risk of dementia. Physical activity can benefit brain health by reducing chronic inflammation, improving blood flow and increasing the release of protein that is good for brain cells. The World Health Organisation recommends that adults get between 150 and 300 minutes of moderate-intensity aerobic physical activity a week. This would include walking briskly, biking, swimming or dancing. It also recommends that on top of this adults should partake in muscle strengthening activities two times a week. Obesity is also a risk factor for developing Alzheimer's disease. However, it's important to note that BMI is not definitive in diagnosing obesity- as some people can have a high percentage of muscle mass. Calculating body fat percentage, or measuring waist-to-hip ratio can be used to determine a healthy body. An analysis published in the National Library of Medicine with over five million people found that those with higher central obesity - measured by waist-to-hip ratio- was associated with a greater risk of cognitive impairment and dementia.

'Hope on horizon' as new drugs tested for Alzheimer's treatment
'Hope on horizon' as new drugs tested for Alzheimer's treatment

RTÉ News​

time4 days ago

  • RTÉ News​

'Hope on horizon' as new drugs tested for Alzheimer's treatment

Dementia experts have said that "hope is on the horizon" after a new review shows a rise in the number of potential drugs that could treat or prevent Alzheimer's disease. Some 138 new treatments are being assessed for the treatment and prevention of Alzheimer's. A third of drugs currently being trialled are "repurposed" medications that are already being used to tackle other diseases, including diabetes, multiple sclerosis and cholesterol, according to the new review. One such trial is assessing whether semaglutide, the main ingredient for the weight loss and diabetes drug Ozempic and weight loss drug Wegovy, can slow the progression of dementia. And four late-stage trials are looking at preventing disease. Experts said that drugs targeting amyloid protein build up in the brain, such as lecanemab and donanemab, are "only one part of the overall strategy" as they expressed excitement over the variety of new drugs, which are being tested among patients. The new review of Alzheimer's disease in clinical trials in 2025 found 182 clinical trials assessing the impact of 138 drugs. The number of trials represents an 11% increase on the previous year, according to the review, which was led by an expert from the University of Nevada in the US and has been published in the journal Alzheimer's and Dementia: Translational Research and Clinical Interventions. Commenting on the paper, Dr Sheona Scales, director of research at Alzheimer's Research UK, said: "This year has really given us real cause for optimism." She said that as well as more drugs coming through the pipeline, the treatment targets are "more diverse" and "looking at all stages of the disease". She added: "What this paper is showing us is that the pipeline of drug development is growing, it's diversifying and accelerating." "This latest report shows us that there is hope on the horizon for people with Alzheimer's, building on lecanemab and donanemab." Dr Emma Mead, chief scientific officer of the Oxford Drug Discovery Institute, added: "Today we are at a tipping point in dementia research as we understand more and more about the diseases that drive dementia. "This gives us opportunities to slow and ultimately stop this devastating condition and today's announcement demonstrates that researchers are able to translate these understandings towards potential new treatments." James Rowe, professor of cognitive neurology at the University of Cambridge and consultant neurologist, said: "What strikes me is not just the number of new drugs, which is increasing year on year, but their range of targets (and) the range in which they work, giving us multiple shots on goal." On the drugs which are being investigated for the prevention of disease, Prof Rowe said: "One of the most exciting things of this report is the number of large-scale late-stage trials on prevention. "And the aspiration to prevent, not just treat, is starting to be seen in the figures we see in these charts today." He added: "One way this can work is you take a treatment that you show to be working in people with symptoms with the illness, and then you simply bring it forward by some years. "The ones that are in trial at the moment are really... bringing forward an effective treatment to earlier stage." For instance, people with a genetic risk of Alzheimer's could receive some drugs earlier to see if they protect against the disease. On the repurposing of current drugs, Dr Mead said that it can usually take ten to 15 years for new drugs to be tested and approved for use. "Being able to repurpose drugs licensed for other health conditions could help to accelerate progress and help to open up other avenues to prevent or treat dementia causing diseases," she said. "A really promising example of this is the drug semaglutide, which is currently being trialled in people with mild cognitive impairment." Meanwhile, academics said lecanemab and donanemab, which can be used for treating mild cognitive impairment in Alzheimer's patients, are an "important first step" in the battle against the disease. The treatments were initially approved for UK use by regulators but then deemed not cost-effective for NHS use. The National Institute for Health and Care Excellence (NICE) is taking more evidence on donanemab and lecanemab and is expected to announce its decision in the summer. Dr Scales added: "Lecanemab and donanemab have represented a huge leap forward in our understanding and ability to be able to treat Alzheimer's disease. "What they've done is they've proved that we're able to modify the course of Alzheimer's disease, and what that has done is opened up the door to future treatments that we hope are more effective, easier to deliver and able to deliver for our patients." She said studies are showing "even more complexities" around Alzheimer's and that in the future, people may be treated with a combination of drugs, depending on when they are diagnosed and the type of dementia they have.

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