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SOLVE FSHD and Modalis Announce Strategic Collaboration to Develop an Innovative CRISPR-Based Epigenome Editing Treatment for Facioscapulohumeral Muscular Dystrophy

SOLVE FSHD and Modalis Announce Strategic Collaboration to Develop an Innovative CRISPR-Based Epigenome Editing Treatment for Facioscapulohumeral Muscular Dystrophy

National Post3 days ago

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VANCOUVER, British Columbia & TOKYO & WALTHAM, Mass. — SOLVE FSHD, a venture philanthropy organization dedicated to accelerating treatments for facioscapulohumeral muscular dystrophy (FSHD), and Modalis Therapeutics Corporation (TSE 4883; 'Modalis'), a CRISPR-based epigenome editing therapeutics company focused on rare genetic diseases, today announced a strategic collaboration to develop an innovative therapy for FSHD, a debilitating muscular disorder affecting approximately 1 million individuals worldwide. The novel therapy leverages Modalis's proprietary CRISPR-GNDM ® (Guide Nucleotide-Directed Modulation) technology, which can dynamically modulate gene expression without introducing double-strand DNA breaks.
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SOLVE FSHD will provide strategic funding to support the development of Modalis's MDL-103 program. MDL-103 is an innovative therapeutic solution that continuously suppresses the expression of the DUX4 gene, the toxic disease-causing gene for FSHD, which becomes abnormally activated due to epigenetic changes in the D4Z4 repeat region on chromosome 4. MDL-103 is designed to have durable activity over long periods of time under the control of a strong, muscle-specific promoter, and is delivered to the muscles of patients using a muscle-tropic AAV delivery system. Modalis's CRISPR-GNDM ® technology has the potential to transform the treatment of FSHD by epigenetically silencing the expression of DUX4.
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'SOLVE FSHD is pleased to partner with Modalis and to add them to our diverse portfolio of collaborators that are advancing potential therapies for FSHD,' stated Eva Chin, Executive Director of SOLVE FSHD. 'SOLVE FSHD identified Modalis as a company committed to finding a cure for this debilitating condition. We were impressed by their unique approach to targeting the epigenetic cause of FSHD, using a platform technology that has shown promise in other neuromuscular diseases. We believe that the support from SOLVE FSHD will allow Modalis to accelerate the advancement of MDL-103 into clinical trials.'
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'We are delighted to be working in partnership with SOLVE FSHD and greatly appreciate the invaluable support for the development of MDL-103,' said Haru Morita, CEO of Modalis. 'This strategic collaboration is a strong validation of Modalis's CRISPR-GNDM ® technology and our MDL-103 program. As a pioneer in this technology, we have demonstrated promising long-term drug efficacy in mouse models, shown durable target engagement and safety in non-human primates, and exhibited excellent biodistribution in neuromuscular disorders. We believe that MDL-103, which incorporates CRISPR-GNDM ® technology with a muscle tropic AAV delivery system, has significant potential as a breakthrough treatment for FSHD.'
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About SOLVE FSHD
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SOLVE FSHD is a venture philanthropic organization established to catalyze innovation and accelerate key research in finding a cure for FSHD. Established by renowned Canadian entrepreneur and philanthropist, Chip Wilson, the Wilson family has committed $100 million to kick-start funding into projects that support the organizations' mission to solve FSHD by 2027. The goal of SOLVE FSHD is to find a solution that can slow down or stop muscle degeneration, increase muscle regeneration and strength, and improve the quality of life for those living with FSHD, visit https://www.solvefshd.com.
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Marimaca Copper Announces Closing of First Tranche of US$17.7 Million Non-Brokered Private Placement
Marimaca Copper Announces Closing of First Tranche of US$17.7 Million Non-Brokered Private Placement

Globe and Mail

time5 hours ago

  • Globe and Mail

Marimaca Copper Announces Closing of First Tranche of US$17.7 Million Non-Brokered Private Placement

Not for distribution to U.S. newswire services or for dissemination in the United States. Any failure to comply with this restriction may constitute a violation of U.S. securities law. VANCOUVER, British Columbia, June 11, 2025 (GLOBE NEWSWIRE) -- Marimaca Copper Corp. ('Marimaca' or the 'Company') (TSX: MARI) (ASX: MC2) is pleased to announce the closing of the first tranche of the previously announced non-brokered private placement (the 'Private Placement'). Pursuant to the Private Placement, Assore International Holdings Limited ('AIH') and Ithaki Limited ('Ithaki') each subscribed for 2,250,000 common shares of the Company (the 'Shares') at a price of C$4.60 per Share for total gross proceeds to the Company of approximately C$20,700,000 ('Tranche 1'). An additional institutional investor together with its affiliates (the ' Additional Investor ') will subscribe on the same terms as AIH and Ithaki for an additional 811,416 Shares ('Tranche 2') for total gross proceeds of C$3,732,514. Tranche 2 is expected to close on or around June 12 th, 2025 and is subject to standard irrevocable commitments. AIH is a related party of the Company by virtue of its significant shareholding and contractual right to nominate a director to the Company's board. Additionally, Ithaki is a related party of the Company by virtue of holding more than 10% of the issued and outstanding Shares. The net proceeds from the Private Placement will be used for exploration, to advance the Company's flagship Marimaca Copper Project located in the Antofagasta Region of northern Chile and for general corporate purposes. The Shares issued pursuant to the Tranche 1 are, and the Shares to be issued pursuant to Tranche 2 will be, subject to a statutory hold period of four months and one day in accordance with applicable Canadian securities laws and are being issued pursuant to the ASX Listing Rule 10.11 waiver granted to Marimaca at the time of admission. Related Party Transaction Disclosure The participation by AIH and Ithaki, each of which is a 'related party' of the Company under Multilateral Instrument 61-101 – Protection of Minority Security Holders in Special Transactions (' MI 61-101 '), constitutes a 'related party transaction.' The Company is relying on the exemptions from the formal valuation and minority shareholder approval requirements under sections 5.5(a) and 5.7(1)(a) of MI 61-101, respectively, as neither the fair market value of the Shares issued to, nor the consideration paid by, such related parties exceeds 25% of the Company's market capitalization. The securities being offered have not been, nor will they be, registered under the United States Securities Act of 1933, and may not be offered or sold in the United States or to, or for the account or benefit of, U.S. persons absent U.S. registration or an applicable exemption from the U.S. registration requirements. This news release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful. Other Information In connection with the Private Placement, Greenstone Resources L.P. and certain of its affiliates have agreed to waive their respective option to participate pro rata in equity financings by the Company. In addition, in connection with the Private Placement, Mitsubishi has been offered the option to purchase Shares pro rata on the same terms as the Private Placement within 30 business days of the closing of the Private Placement. Mitsubishi's current ownership, prior to giving effect to the Private Placement, is approximately 4.6% based on public filings. About Marimaca Marimaca is a copper exploration and development company focused on its 100%-owned flagship Marimaca Copper Project and surrounding exploration properties located in Antofagasta Region, Chile. The Marimaca Copper Project hosts the Marimaca Oxide Deposit (the ' MOD '), an IOCG-type copper deposit. The Company is currently progressing the Marimaca Copper Project through the Definitive Feasibility Study led by Ausenco Chile Ltda. In parallel, the Company is exploring its extensive land package in the Antofagasta region, including the >15,000ha wholly-owned Sierra de Medina property block, located 25km from the MOD. This news release is authorized for release by the Board of Directors of Marimaca. Contact Information For further information, please visit or contact: Tavistock +44 (0) 207 920 3150 Emily Moss / Ruairi Millar marimaca@ Forward-Looking Statements This news release includes certain 'forward-looking statements' under applicable Canadian securities legislation, including statements related to the anticipated participation in the Tranche 2 of the Private Placement, the closing date of Tranche 2 of the Private Placement, advisory fees payable and the use of proceeds. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Forward-looking statements reflect the beliefs, opinions and projections on the date the statements are made and are based upon a number of assumptions and estimates that, while considered reasonable by Marimaca, are inherently subject to significant business, economic, competitive, political and social uncertainties and contingencies. Many factors, both known and unknown, could cause actual results, performance or achievements to be materially different from the results, performance or achievements that are or may be expressed or implied by such forward-looking statements and the parties have made assumptions and estimates based on or related to many of these factors. Such factors include, without limitation: risks related to share price and market conditions, the inherent risks involved in the mining, exploration and development of mineral properties, the uncertainties involved in interpreting drilling results and other geological data, fluctuating metal prices, the possibility of project delays or cost overruns or unanticipated excessive operating costs and expenses, uncertainties related to the necessity of financing, uncertainties relating to regulatory procedure and timing for permitting reviews, the availability of and costs of financing needed in the future. The intended use of the proceeds of the Private Placement by the Company might change if the board of directors of the Company determines that it would be in the best interests of the Company. Many of these risks and uncertainties and additional risk factors generally applicable to the Company are described in the Company's annual information form of the Company dated March 27, 2025 and other filings made by the Company with the Canadian securities regulatory authorities (which may be viewed at Accordingly, readers should not place undue reliance on forward-looking statements. The Company undertakes no obligation to update publicly or otherwise revise any forward-looking statements contained herein, whether as a result of new information or future events or otherwise, except as may be required by law. None of the TSX, ASX or the Canadian Investment Regulatory Organization accepts responsibility for the adequacy or accuracy of this release.

Altura Energy Announces Closing of Brokered Private Placement
Altura Energy Announces Closing of Brokered Private Placement

Globe and Mail

time7 hours ago

  • Globe and Mail

Altura Energy Announces Closing of Brokered Private Placement

Vancouver, British Columbia--(Newsfile Corp. - June 11, 2025) - Altura Energy Corp. (TSXV: ALTU) (FSE: Y020) (the " Company") is pleased to announce that the Company has closed its previously announced (see news releases dated April 15, 2025, May 14, 2025 and May 26, 2025) brokered private placement offering of 19,855,000 units of the Company (the " Units") at a price of $0.10 per Unit (the " Issue Price") for gross proceeds to the Company of $1,985,500 (the " Offering"). The Offering Each Unit consisted of one common share of the Company (a " Common Share") and one Common Share purchase warrant (a " Warrant"). Each Warrant entitles the holder thereof to purchase one additional Common Share (a " Warrant Share") at an exercise price of $0.25 at any time on or before June 11, 2030. In the event that the closing price of the Common Shares on the TSX Venture Exchange (or such other stock exchange the Common Shares may be listed on from time to time) is equal to or greater than $0.75 for a period of twenty consecutive trading days (the " Acceleration Event"), the Company may, within five trading days following the Acceleration Event, upon issuing a news release, accelerate the expiry date of the Warrants to the date that is not less than 30 days following the date of such news release (the " Acceleration"). The securities issued under the Offering have a hold period of four months and one day from the closing of the Offering, expiring on October 12, 2025, in accordance with applicable securities laws. The Offering was conducted by Haywood Securities Inc. (the " Agent") as sole agent and bookrunner. 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Rendered Services Consulting Fees The Company and the Agent entered into a strategic advisory services agreement, as amended, pursuant to which the Agent provides the Company with certain strategic advisory services to the Company (the " Advisory Agreement"). Pursuant to the terms of the Advisory Agreement, the Company issued 1,500,000 units of the Company (the " Rendered Services Units") at a deemed price of $0.15 per Unit to the Agent for certain strategic advisory services rendered to the Company to date at a deemed value of $225,000. Each Rendered Services Unit is comprised of one Common Share and one Warrant, each Warrant entitling the holder thereof to purchase one Warrant Share at an exercise price of $0.25 at any time on or before April 11, 2030, subject to the Acceleration. The Rendered Services Units, and the securities underlying the Rendered Services Units, have a hold period of four months and one day from the date of issuance, expiring on October 12, 2025, in accordance with applicable securities laws. ABOUT ALTURA ENERGY CORP. Altura Energy Corp. is an exploration and production company with interests in the Holbrook basin of Arizona. For more information, please visit SEDAR+ ( FOR FURTHER INFORMATION Robert Johnston CEO & Director +1 604-609-6110 Forward Looking Statements Statements included in this announcement, including statements concerning our plans, intentions and expectations, which are not historical in nature are intended to be, and are hereby identified as, "forward-looking statements". Forward-looking statements may be identified by words including "anticipates", "believes", "intends", "estimates", "expects" and similar expressions. 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European Fintech Paynt Acquires Canada-Based E-xact Transactions to Accelerate North American Expansion
European Fintech Paynt Acquires Canada-Based E-xact Transactions to Accelerate North American Expansion

Globe and Mail

time7 hours ago

  • Globe and Mail

European Fintech Paynt Acquires Canada-Based E-xact Transactions to Accelerate North American Expansion

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