Novo Nordisk shares jump as Eli Lilly's weight-loss pill data disappoints
The market had anticipated Eli Lilly's orforglipron pill to become a strong competitor to Novo's weight-loss drugs, Kepler Cheuvreux analyst David Evans said in an emailed comment.
However, with Thursday's results falling short of those expectations, Evans said investors were likely to rethink the competitive outlook in the GLP-1 obesity drug market, a shift that favours Novo's oral semaglutide.
Novo's shares plunged last week after it slashed its outlook for 2025 sales growth, marking the second forecast cut for the Danish drugmaker this year.
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The Sun
an hour ago
- The Sun
Why you should be putting bay leaves in your washing machine
YOUR laundry routine could be transformed with the help of a £1 seasoning. Bay leaves are most commonly used to flavour hearty dishes such as soups or stews, but they also have another hidden use. 3 3 For thousands of years, the leaves have also been used for their antibacterial and antifungal properties. If you toss a handful of the budget leaves in to your washing load, they are said to banish harsh odours such as sweat and cigarette smoke. How does it work? As the laundry spins in the machine, the leaves release compounds that eliminate bacteria, instead of simply masking the smell. Plus, they can also help to keep your washing machine clean. Over time, washing machines can end up smelly and mouldy, due to a build up of detergent. However, if you add bay leaves to your machine, they prevent odour causing micro-organisms from growing. To try out this hack, place a handful of dry bay leaves into a fabric bag, and stick it in alongside your washing load. Make sure to use detergent as well, as the leaves are not a replacement, but an addition to your laundry routine. A stain-remover too YouTube account Clever Hacks, also revealed that you can use bay leaves to remove tough stains. "A simple trick with bay leaves will save your clothes", they said. How to hang out your washing on the line and do no ironing, folding or sorting when it's dry "Simply throw a few bay leaves into the washing machine with your stained clothes, choose any setting and the stain problem should disappear." The Youtuber added, that if the stains are particularly bad you can place your clothes in a pot of boiling water with a handful of bay leaves, and leave them to boil for three hours. "The squeeze out the clothes and throw them in the washing machine with detergent", they added. "Take the clothes out and enjoy their cleanliness." Laundry tips Catherine Green, sustainable cleaning expert at smol shared her laundry tips. How often should you be remaking your bed? When it comes to your bed, maintaining a hygienic sleep setup can actually improve your sleep quality, helping you start every day better. Most people shed 500 million skin cells per day and a lot of that ends up in bed for dust mites to feed on. And those with asthma or allergies might see symptoms worsen by sleeping on dirty sheets! You want to be washing your sheets once a week - or every 10 days if you don't suffer from allergies and wear nightclothes. Bedding builds up with sweat, skin cells and oils quickly, even if it doesn't look dirty. Using an effective detergent like smol's will still give you a great clean on a 20°C cycle - that's better for the planet and your energy bills! What temperature do smol recommend then? For your regular weekly washes I recommend washing most loads at 20°C for 30 minutes. It's gentler on fabrics, slashes energy use, and still delivers excellent stain removal with the right detergent. A colder wash can actually be more effective if you opt for a bio detergent as its enzymes need cooler water; too hot and they lose their ability to digest stains. A wash at 60°c (unless you have silk sheets) every now and again can help kill off dust mites and other nasties. What's the difference between bio and non-bio detergent? Bio detergents contain enzymes, which are especially good at breaking down tough stains like food, grass, or sweat. It's best used in mid to low temperature washes (ideally between 20-40°C) as anything hotter can cause them not to work effectively. Non-bio skips the enzymes, which in turn makes it more suitable for those with sensitive skin or allergies. Although non-bio doesn't contain enzymes, it's still great at removing stains and keeping your clothes clean, you just may need to use a slightly higher temperature setting to aid with the cleaning process. However, not everyone is convinced of the effectiveness of bay leaves. 'I am not aware of any studies on the effectiveness of bay leaves in washing machines against bad odours,' Dr. Bernd Glassl from the German Cosmetic, Toiletry, Perfumery and Detergent Association told MyHomebook. The expert confirmed that bay leaves do have anti-microbial properties, but added: "Assuming that's true, I wonder how many leaves would be needed for the concentration of the active ingredient to be sufficient to have an antimicrobial effect in a washing machine when diluted with water.' Sceptical of the hacks effectiveness, the Dr instead recommend alternative hacks to keep your laundry smelling good, such as removing laundry promptly after a load is finished, and leaving the machine open after use, so that it can dry out. The expert also recommend cleaning the detergent drawer regularly and doing a hot wash with bleach once a month. 3
The Sun
2 hours ago
- The Sun
I was ‘six months pregnant' for years and had no idea – I thought I had PCOS but the truth was far more terrifying
A WOMAN has shared the horrific ordeal she went through after discovering she had been 'pregnant' for years without her knowledge. Darcie Kitchener went to her GP last year, after struggling with irregular periods and hair loss. 3 3 Her symptoms aligned with those of PCOS, so her GP referred her for a blood test and an ultrasound so that doctors could investigate the issue. Darcie was nervous during the invasive procedure, but her anxiety started to skyrocket after the doctor looked at the ultrasound screen and simply said: "I'm just going to get my colleague." The doctor brought a colleague over, whose jaw dropped when they too saw what was on the screen. "You should have the results in a few days", the second doctor said, without giving Darcie any inclination as to what they had found. A few days later, Darcie is called by the doctor, who informs her that "it's not just PCOS", and that she needs to come in and see the doctor again. Following an MRI scan, Darcie was informed that she had a teratoma, which is a rare type of germ cell tumour that can contain teeth, hair, bone and muscle. Teratoma are usually benign, and can go unnoticed for years, while they grow and grow inside you. Darcie's teratoma was a whopping 22cm, making it roughly the same size as a six month old foetus. "I'd been consistently gaining weight since I was about 20, and I never understood why", she revealed in a TikTok video. Darcie had put the weight gain down to a number of health issues and the fact that she "loves McDonald's", so had never properly investigated it. Understanding Teratoma Tumors She had also never questioned why her stomach was "hard", around the area where the cyst was growing. Darcie's teratoma didn't have any teeth, but did have lots of bone and hair. "We named her Gemma", she said. "I spent months in pure terror, just knowing that this was existing inside me. How serious are teratoma tumours? A teratoma is a rare type of germ cell tumour that can contain teeth as well as more complete body parts. They start in your reproductive cells, like the eggs and sperm. This is why they can turn into many different types of tissue, like hair, muscle, liver, brain and even eyes. Most teratomas are benign, meaning they are noncancerous. However, it's still important to have them removed. If not removed, they can rupture and cause infection. In some cases, they can turn malignant (cancerous). Malignant teratomas require chemotherapy to get rid of. In most cases, these tumours don't spread like aggressive cancers. As a result, most teratomas — even cancerous ones — have excellent survival rates with early diagnosis and treatment. What are the symptoms? People with teratomas may not show any symptoms at first. Once symptoms develop, they can vary significantly depending on the tumour's location. General teratoma symptoms may include: Pain Bleeding Swelling Slightly elevated levels of the hormone BhCG (beta-human chorionic gonadotropin) Slightly elevated levels of tumour marker AFP (alpha-fetoprotein) But you may also develop specific additional symptoms based on the location of the teratoma tumour. Source: Cleveland Clinic "It was just horrific to know that this thing was in there, and I had no idea what it was". Darcie had to live with "Gemma" inside her for five months before she was able to get surgery to remove it. "Everyone keeps asking me how I lost weight", she said. "Erm, childbirth. I birthed a baby named Gemma who was full of bones and hair and who is obviously no longer with us." Darcie's (@audhdarcie) video has likely left many open-mouthed, as it has gone viral, racking up over 1.1million views on the video sharing platform. TikTok users raced to the video's comments section to share their thoughts on her horrific ordeal. One person said: "This happened to me "It was so scary. Apparently mine had a lot of teeth." A second person said: "My dad had a teratoma in his leg and he used to say it was his evil twin." A third person said: "New fear unlocked."
The Guardian
2 hours ago
- The Guardian
Learning to live with the torture of tinnitus
One night, I heard a dripping tap. I asked my husband to check all the taps – upstairs bathroom, downstairs toilet, the kitchen. He assured me there were no dripping taps. He refused to check again. We argued. I checked. I desperately wanted to find the source of the noise. Nothing. What was that sound? Where was it coming from? I tried to ignore it. Then I was told. My husband, a GP, explained – calmly, with all the understanding he could muster – that I had tinnitus, like Lara Williams (A moment that changed me: on the day of my first book deal, a mysterious hum overcame me, 6 August). How did I get it? Where had it come from? He couldn't tell me. 'It just comes,' he said. I hated him. I didn't sleep at all that night, nor the night after. The noise was unbearable. On the third night, I remember standing on the landing, crying. I was filled with rage. Then my son, David, came to the rescue. He put his headphones on my head, and a beautiful sound replaced the racket in my ears. It was How Deep Is Your Love by the Bee Gees. Tears still streamed down, but I began to feel a sense of calm. I stopped hearing the awful noise. I listened to the Bee Gees, Puccini and Chopin. I listened myself to sleep. I taught myself relaxation techniques. But when the noise becomes unbearable, then I need all my techniques – music, poetry etc – to calm down and ignore the falling bombs, the dripping tap, the loud drums. It's hard. But I can do it. And I want to tell people who suffer from this terrible condition: accept it. Forget the anger. Don't ask why. Don't think you've been punished. You haven't. Just learn to cope with it as best as you Ursi AmesburyBristol I have suffered with tinnitus for nearly 10 years, following an incident of uncontrolled loud music in a badly run venue. The resulting damage ended my musical performance and teaching career, and left me in a state of grief that will be with me until the day I die. While it is true to say that habituation does occur in time, it is no substitute for not damaging one's hearing in the first place. Even though I am as habituated as I can ever expect to be, the tinnitus still dominates my life and activities. It impairs my sleep, and makes socialising difficult and listening to or making music impossible. I urge gig-goers, venues and musicians to take great care, because to wake up one day and realise that irreparable damage has been done to such a precious part of being human is devastating yet avoidable. I also encourage anyone affected to visit the Tinnitus UK ParishLancaster Why has there been virtually no progress on 'fixing' tinnitus? Lara Williams elucidates the desperation we all go through when acute tinnitus sets in. Her 'acceptance' of the sensory handicap as the only path to coping with the condition mirrors my experience. However, that doesn't always work. Other anxieties can derail our blocking. Then we have to build up the resilience all over again. It can be an exhausting WoodinHitchin, Hertfordshire Tinnitus is exhausting, painful and isolating. At my first self‑help group, a gentle old lady told me she heard it as the angels urging her to carry on. Mine sounded more like a wasp trapped in a tin mug – but perhaps Lara Williams might find the angels version comforting?Ian GarnerOxenhope, West Yorkshire I read with empathy Lara Williams' article describing the onset of tinnitus. Sudden onset in adulthood must be very distressing. In my case it has been lifelong (I'm 76), and I only gradually became aware of it in my youth. She describes hearing something between an electronic hiss and the roar of the ocean; my symptoms are similar. I don't remember a specific onset, except that in adolescence I once or twice asked if anyone else heard high-pitched sounds from the TV and no one did. I didn't have access to the kind of professional help Williams consulted, but seemingly came to the same conclusion. It's there, part of me that isn't going away; fighting against myself is futile. Letting go of the idea that this is something that shouldn't be happening works better. Should and shouldn't have nothing to do with it. It just is. Williams' analogy to snowfall is beautiful and illuminating. Paying full attention to the moment or engaging fully in activity helps to simply not notice the tinnitus, or at least not as much, depending on the perceived volume at the time. Or maybe, sometimes, it's just forgetting to hear the tinnitus while listening to the silence. Bryan T DavisCedar Rapids, Iowa Have an opinion on anything you've read in the Guardian today? Please email us your letter and it will be considered for publication in our letters section.
