logo
The key to a long life is avoiding the ‘poisonous 5 P's,' says one of the world's top anti-aging experts

The key to a long life is avoiding the ‘poisonous 5 P's,' says one of the world's top anti-aging experts

Yahoo25-05-2025

Long before Bryan Johnson became famous for his extreme biohacking—undergoing countless tests, following strict eating habits, and taking dozens of supplements in the name of living forever—Valter Longo was obsessed with longevity.
In a profile of the scientist in the New York Times, Longo, a professor of gerontology and director of the USC Longevity Institute in California, says he wants to live 120 to 130 healthy years. His drive for longevity aligns with a growing interest in extending health span, the number of years lived free of disease, as opposed to life span—which refers to the number of years lived.
The Italian lifestyle has long been considered the gold standard for longevity, with the focus on the Mediterranean diet, walkability, and community. Sardinia, Italy, is one of the five original Blue Zones—regions where people live the longest, healthiest lives. Lessons from the residents of Sardinia were the focus of one of the episodes of Dan Buettner's Netflix documentary Living to 100.
Longo, who was born and raised in Italy, points out that today, 'almost nobody in Italy eats the Mediterranean diet.'
Italy's youth are facing obesity because of what Longo calls the 'poisonous five P's—pizza, pasta, protein, potatoes, and pane (or bread),' Jason Horowitz writes in the NYT. Longo fears Italians will live long but not healthfully if this pattern continues to dominate the culture.
How to reverse it? Longo, author of The Longevity Diet, is a proponent of the original Mediterranean diet, which consists of plant-based foods and nuts. He has his own recipes for longevity on his website, which include sweet and sour sardines, stuffed artichokes, cabbage patties, and onions in walnut sauce.
He also champions another relatively new concept in the space—faux fasting, or a fasting-mimicking diet. This refers to limiting food intake, which is supposed to help the body reap the benefits of fasting without fully abstaining from food. According to Longo's website, the protocol includes a diet low in carbohydrates and protein and high in fatty acids. 'The Fasting Mimicking Diet patented recipe allows your body to remain in a fasting like mode, which triggers a set of protectionist measures that the body has developed during natural selection,' his site reads. 'This allows the body to optimize its performance, rejuvenate its cells, and thrive under demanding circumstances.'
Research has found both benefits and drawbacks to intermittent fasting, but its continued popularity demonstrates the lengths people will go to in the hope of extending their lives.
A version of this story was originally published on Fortune.com on November 20, 2024.
For more on the longevity movement:
Wealthy men are spending millions to lower their biological ages and live longer. These women are lowering their biological age with cheaper solutions
Will you live to 150? Here's what 5 geneticists and aging researchers say
Move over, pina coladas: Get Botox and stem cells on this luxury wellness cruise
The longevity secrets of Singapore, the 6th blue zone city where people are living the longest, happiest lives
This story was originally featured on Fortune.com

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Billion-Dollar Breakthroughs: Inside The Global Race To Extend Human Healthspan
Billion-Dollar Breakthroughs: Inside The Global Race To Extend Human Healthspan

Forbes

time25 minutes ago

  • Forbes

Billion-Dollar Breakthroughs: Inside The Global Race To Extend Human Healthspan

Hevolution CEO Dr. Mehmood Khan in conversation with GSK Chair Sir Jonathan Symonds In a luxurious conference center buzzing with Nobel laureates, biotech executives and Saudi royalty, one number kept surfacing during presentations: eight billion. Not dollars—though investment figures approached that scale—but people. The potential market for healthspan technologies encompasses every human on earth, creating what might be the ultimate investment opportunity of the 21st century. At the Hevolution Global Healthspan Summit 2025, the world's largest gathering for healthspan science, the discussion wasn't if humans could live longer, healthier lives, but how quickly we could make it happen. "I'm a firm believer, when you put several hundred scientists collectively working in a connected manner in the world, not in any one country, but in the world, from the west to the east, to solve a common challenge, that is how you put a man on the moon," declared Dr. Mehmood Khan, CEO of Hevolution. "That is your moonshot." Hevolution is a first of its kind global non-profit organization incentivizing independent research and entrepreneurship in the emerging field of healthspan science. The urgency behind this global mobilization is clear. Dr. Anshu Banerjee, Director at the World Health Organization, presented sobering statistics: "The number of older people above 60 is going to double by 2050, from 1.1 billion to 2.1 billion, and soon we'll have more people above 60 than under 10." Even more concerning: "Life expectancy is increasing, but healthspan is actually worsening. The increase in healthy life expectancy is not following the same pace as life expectancy overall." Global Lifespan versus Global Healthspan Women face particular challenges in this equation. While they "live longer than men," Banerjee noted they "spend more years in poor health," with the healthspan gap between genders widening since 2002. While American researchers navigate the FDA's complex pathway, Saudi Arabia is positioning itself as the global accelerator for healthspan innovations. His Excellency, addressing attendees, detailed the kingdom's "Innovation Pathways" designed for rapid approval of promising medicines, AI systems, and medical devices. This regulatory agility represents a strategic advantage in what has become a geopolitical race to commercialize healthspan technologies. With "maturity level four" recognition from the WHO and pending "world listed Authority" status, Saudi Arabia is creating an ecosystem where longevity science can flourish without traditional regulatory bottlenecks. The summit's scientific presentations ventured far beyond traditional human-centered research. Comparative biology—studying extraordinarily long-lived species like bowhead whales that can live over 200 years—emerged as a frontier with untapped potential. "These are models of disease resistance, healthspan, and lifespan," explained Dr. Vera Gorbunova, whose work on naked mole rats has revealed remarkable cancer resistance mechanisms. Pedro Magalhães, developer of a comprehensive database tracking lifespans across species, argued that understanding "why we live as long as we live" requires examining the evolutionary innovations that allow certain animals to far outlive humans. This approach faces funding challenges, however. Despite promising discoveries, researchers called for "more consortia" and a "big effort in comparative biology of aging" to translate animal longevity secrets into human applications. The unexpected star of the summit wasn't a new compound but an existing class of medications: GLP-1 agonists, originally developed for diabetes and now famous for weight loss. Dr. Christoph Westphal, co-founder of Longwood Fund, made a stunning prediction: "If all of us in this room, within three or four or five years, can prove that with GLP-1s you can extend healthy lifespan, it will actually be the first healthy lifespan increasing drug available. It's going to totally change the world." Westphal's enthusiasm reflects a paradigm shift in longevity research. "If you had told me that you would take something that has an effect in the brain and all over the body, and it's perfectly safe and it actually makes you live longer, I would have said, no way. But that's exactly what a GLP-1 is." The lesson for investors is clear, according to Dr. Srinivas Akkaraju of Samsara BioCapital: "A drug that shows measurable effects in a modest time with a modest number of patients can lead to longer studies for confirmation." The challenge is finding "near- to medium-term measurements that de-risk the investment." Perhaps the summit's most ambitious initiative is already underway in the UK. Professor Rahid Ali's "Our Future Health" program has collected data from over 1.5 million participants, with 1.3 million providing blood samples, making it the "world's largest health research study of its type." By deploying collection points in everyday locations like supermarkets and pharmacies, the program has democratized participation across socioeconomic and ethnic backgrounds. The goal: five million participants creating an unprecedented dataset that could reveal the early signals of disease and the effectiveness of preventative interventions. Notably, Ali reported that "about 80% of the general population, once they understand the importance of working with industry, are willing to participate" despite growing privacy concerns around health data. "We're investing across the entire value chain, from idea all the way into clinical trials and beyond," explained a senior Hevolution executive. The foundation isn't just writing checks—it's creating an "action shop and a money shop" designed to shepherd promising longevity science from laboratory concepts to market-ready interventions. Dr. William Greene, Chief Investment Officer at Hevolution Foundation, emphasized the need to "invest in translation, since there's a valley of death between interesting laboratory observation and something that seems to actually impact health." The goal is finding "the outcome that we're looking for that will actually make humans into big mice"—transitioning laboratory findings into human benefits. This fundamental challenge was echoed by Dr. Jarod Rutledge: "If you're trying to do genomic management, or something that's purely preventative, commercial models are very challenging, but if you can start from a state of disease and walk all the way back to state of youthful health, then I think that is really promising." In an industry where early adopters could pay millions for unproven therapies, Hevolution's emphasis on global equity stood out. Arthur Caplan, head of medical ethics at NYU Grossman School of Medicine, emphasized that proposals undergo rigorous ethical review centered on one question: "Is the science good, but can it help fulfill the commitment to benefit all?" This principle—extending healthspan advancements to "all of human humanity" rather than creating a longevity gap between wealthy and developing nations—appears foundational to Hevolution's approach. HRH Dr. Haya Al Saud, SVP of Research at Hevolution, outlined the broader societal benefits: "First, we'll be able to reduce healthcare costs. Healthcare spending is skyrocketing worldwide, so this is a crucial and immediate impact. Second, we can tackle the workforce challenge we're seeing today... If we're able to extend healthspan, people can live—and work—longer, in good health." Dr. Haya at Global Healthspan Summit 2025. She also highlighted a surprising social benefit: "Many women leave the workforce because they are the primary caregivers for sick family members. By extending healthspan, we can support and encourage women to remain in the workforce." The summit highlighted how philanthropic organizations are evolving from passive funders to active ecosystem builders. Her Royal Highness Princess Dr. Haya bint Khaled Al Saud described philanthropy as a "catalyst for change" in the healthspan field. Yet Dr. Khan insists that true global access requires commercial involvement: "I do not believe there is an example, other than maybe mass polio vaccine campaigns, where the public sector can, on its own, democratize something. Every example I can think of in democratization has happened because the private sector figured out how to get something into the hands of as many people as possible." He added a historical perspective: "Government invented the internet, the private sector scaled it, and then leveraged it for core commerce." As Dr. Khan concluded the summit, he emphasized that it's not heroic individuals but collective wisdom that will transform aging: "It is not heroes that we are developing. It is the future of this collective wisdom that we're actually investing behind, because it's going to take the village, not a hero." The fundamental question remains: Can we translate scientific breakthroughs into practical interventions that meaningfully extend the healthy human lifespan? The convergence of unprecedented funding, regulatory innovation, massive datasets, and ethical frameworks suggests we're entering a new phase in longevity science—one where theory meets application. Whether the first beneficiaries emerge from clinical trials in Riyadh, research labs in Boston, or digital health platforms in London remains to be seen. What's clear is that the race for extended healthspan has evolved from fringe science to mainstream pursuit. With eight billion potential customers waiting, the winners stand to transform not just healthcare, but the fundamental human experience of aging itself.

Why We're So Obsessed With Coffee's Health Claims
Why We're So Obsessed With Coffee's Health Claims

WebMD

timean hour ago

  • WebMD

Why We're So Obsessed With Coffee's Health Claims

Or is it? For decades, studies have linked drinking coffee to a longer life and reduced risk of an array of health problems. This week, a big study grabbed headlines linking coffee to healthy aging – women who drank caffeinated coffee were less likely to develop physical problems, cognitive impairment, and chronic diseases as they aged. In January, another study found that morning coffee drinkers lived longer than people who drank coffee later in the day. Another recent analysis suggested those longevity benefits may be limited to those whose coffee doesn't contain a lot of added sugar or saturated fat. Sorry, mocha and Frappuccino fans. Maybe wait for the next study. 'Coffee is like the science version of a celebrity – it makes headlines no matter what,' said Susan Albers, PsyD, a clinical psychologist at the Cleveland Clinic. 'I think that's because it crosses age, culture, and socioeconomic status. It's a substance that everyone enjoys and drinks. And it's one of the most widely consumed psychoactive substances on the planet. We forget that it is actually a drug that is paired with an enjoyable drink.' Three out of four adults in the U.S. report they are coffee drinkers. Half of Americans drink it daily. That's a huge number available to researchers, who can then examine countless variables and look for associations. If we're all doing something and it turns out to be bad for us – or good – public health officials want to let us know. Coffee is loaded with micronutrients, such as polyphenols that have antioxidant and anti-inflammatory benefits, and most coffee also contains the drug caffeine. 'It's such a window into the brain and how what we put in our bodies impacts us on every different level, in positive and negative ways,' Albers said of our own and researchers' seemingly insatiable thirst for more info on coffee. So will there ever be a verdict? We've been let down before. First it was red wine, touted as healthy until recently, when all alcohol has been frowned upon. And like coffee, chocolate seems to forever be switching sides between healthy and unhealthy. What Is It About Coffee Stories That We Just Can't Resist? 'We want to have healthy habits. We want to keep this enjoyable ritual in our lives but make sure that we're not sabotaging our health,' Albers said. 'And so, the more information that we obtain about it, the better. What I think happens is that there might be a little bit of a click bias.' Coffee lovers click to hear scientific confirmation that their habit is healthy, and people who don't like coffee click in hopes of confirming their choice to avoid the drink. Be skeptical of health claims about coffee, especially on social media, advised Jamie Mok, a registered dietitian nutritionist based in Los Angeles, California, and spokesperson for the Academy of Nutrition and Dietetics. Unqualified health influencers are everywhere these days, so look for someone with credentials who cites evidence from scientific journals. Extreme or ultra-simple claims made in absolute terms are a sign to keep scrolling. Is There a Consensus About the Health Benefits of Coffee? Yes. But the benefits may not apply to everyone. 'Large observational studies are generally showing a consistent positive association between moderate coffee consumption – so like two to three, maybe four cups a day – and the reduced risk of several diseases, including cardiovascular disease, liver disease, or cancer,' Mok said. Some people may not get all those benefits, she said – like those who already eat a diet rich in polyphenols (you're a blueberry lover, for example), or who aren't drinking black coffee, since that's what is usually studied. And even if you do just have a couple of cups of straight black and only in the morning, it may not be healthy if you have a condition like irritable bowel syndrome or anxiety. Do Your Own Coffee Study 'Coffee really is a gold mine for neuroscientists and psychologists who want to study the brain,' Albers said. 'It gives them this wealth of information about how what we put in our body impacts us. And as a psychologist, that's incredibly exciting and interesting to see how something like caffeine impacts our sleep and our mood.' Both Albers and Mok said that when they are working with clients who have anxiety or sleep problems, caffeine is one of the first places they examine. Most people don't realize the deep impact it can have on other parts of their health, they said. Albers suggested a 'mindfulness drinking' exercise to examine your relationship with coffee that she often shares with clients: Sit down to drink your coffee (riding in the car or on the subway doesn't count). Breathe deeply to smell the aroma, maybe wrap your hands around the cup to feel its warmth, and use the moment to slow down and be present. This can be quick, but run through your senses of taste, touch, smell, sight, even hearing. Before you start drinking, rate your energy level and mood each from 1 to 10. For the next hour, keep track of how you feel, and at the end of the hour do the 1-to-10 rating again for your energy level and mood. 'For many people, after they drink their cup of coffee, their mood boosts significantly,' said Albers, who has authored best-selling self-help books including Eating Mindfully. Repeat the experiment on other days, perhaps taking your coffee black or adding a flavor and see if the results change. You may find that coffee affects your energy or sleep, or it enhances your relationships by adding ritual to a shared coffee date. Maybe coffee helps boost your mood and the steaming cup and familiar taste simply bring you pleasure. 'There isn't anything to feel bad about with that,' Albers said.

Italy in defensive injury crisis ahead of World Cup qualifiers after latest training blow
Italy in defensive injury crisis ahead of World Cup qualifiers after latest training blow

Yahoo

time2 hours ago

  • Yahoo

Italy in defensive injury crisis ahead of World Cup qualifiers after latest training blow

Italy and CT Luciano Spalletti have hit crisis mode in defence ahead of June's World Cup qualifiers against Norway and Moldova, as Milan centre-back Matteo Gabbia has now come down with a calf issue in training. According to reports from Sky Sport Italia, Gabbia was forced out of the Italy national team training session on Tuesday with a calf injury, which is likely to be a tendon issue according to the initial updates. Advertisement The severity of the issue, and whether Italy will need to call in a replacement, remains to be seen. Matteo Gabbia in action during a Italy training session at Centro Tecnico Federale di Coverciano on October 08, 2024 in Florence. (Photo by) Gabbia adds to Italy's defensive injury crisis The Azzurri are already without regular first-team centre-backs Riccardo Calafiori of Arsenal and Napoli's Alessandro Buongiorno through injury. Inter's Francesco Acerbi has recently refused a call-up to join the national team for June's World Cup qualifiers, while there are ongoing fitness concerns over Federico Gatti of Juventus and Napoli captain Giovanni Di Lorenzo, both of whom trained separately on Tuesday. Riccardo Calafiori goes down with an injury during the UEFA Nations League quarterfinal leg one match between Italy and Germany at Stadio San Siro on March 20, 2025 in Milan. (Photo by) Additionally, Juventus midfielder Manuel Locatelli, who is also able to cover in defence, also dropped out of the squad as a result of an injury issue on Monday. Advertisement That means that Inter's Alessandro Bastoni is the only capped central defender currently available in the Italy national team squad. The injury crisis at centre-back could be good news for Fiorentina captain Luca Ranieri, who was called into the squad to replace Buongiorno earlier this week, while the uncapped 21-year-old Diego Coppola could also be in line for an opportunity in his first camp.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into the world of global news and events? Download our app today from your preferred app store and start exploring.
app-storeplay-store