New Guideline Improves Patient Access to Advanced Ultrasound Assessment of Liver Diseases and Transplant Options, Experts Say
Patients with liver diseases will have expanded access to advanced ultrasound imaging and transplant options, thanks to new policy.
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'This eliminates a significant roadblock to the appropriate use of CEUS at a time when patient lives are at stake,' said Dr. Yuko Kono, a transplant hepatologist and CEUS expert at the University of California San Diego and a member of the ICUS Board of Directors.
ICUS was an early and strong supporter of the inclusion of CEUS as an approved imaging option for evaluation of a prevalent form of liver cancer known as hepatocellular carcinoma (HCC) under guidelines and policies established by the Organ Procurement and Transplantation Network (OPTN).
While OPTN plays a crucial role in the evaluation and allocation of livers for transplantation, its guidelines and policies often have a broader impact on the clinical practice of hepatology and the use of CEUS to evaluate liver disease, according to Dr. Andrej Lyshchik, a professor of radiology at Thomas Jefferson University and CEUS expert. Dr. Lyshchik is also a member of the ICUS Board of Directors.
'We cannot underestimate the clinical importance of having CEUS officially included in our imaging tool boxes,' said Dr. Lyshchik.
ICUS called the new OPTN policy 'a critical step toward modernizing the diagnostic framework for HCC.'
ICUS also said that the policy change will 'promote consistency, reduce interpretation errors, and enhance communication with referring physicians' by aligning OPTN imaging classification criteria with a standardized reporting and data collection system known as LI-RADS ®.
CEUS is a safe, low-cost diagnostic imaging tool that is routinely used worldwide to assess abdominal and pelvic organs and tumors, heart and vascular disease, chronic gastro-intestinal diseases and other serious medical conditions, and to monitor therapy.
'CEUS solves many clinical problems efficiently, without exposure to ionizing radiation, and with sensitivity and specificity comparable to and sometimes better than contrast-enhanced CT and MRI,' said Dr. Stephanie Wilson, a clinical professor of radiology and gastroenterology at the University of Calgary and Co-President of ICUS.
Because ultrasound systems are readily available in many medical centers throughout the world and provide reliable diagnostic information in real time, CEUS often streamlines clinical workflows and reduces delays in diagnosis and treatment, she added.
Three ultrasound contrast agents are currently approved by the US Food and Drug Administration: Definity (Lantheus); Lumason (Bracco Imaging) and Optison (GE Healthcare).
ABOUT ICUS:
The International Contrast Ultrasound Society (ICUS) is a nonprofit medical society dedicated to advancing the safe and medically appropriate use of contrast enhanced ultrasound (CEUS) to improve patient care globally. Membership in ICUS is free of charge and there is no fee for ICUS educational programs, CME credits, newsletters or other resources.
To join ICUS and learn more about CEUS, visit www.icus-society.org and download ICUS CONNECT, the free ICUS mobile app.
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As a result, subscription requests for a total amount below €100,000 per investor were not allocated. The Offering, launched on July 23, 2025, amounted to a total gross proceed of 23.9 million euros, including the issuance premium. The Company exercised the extension clause granted by the Board of Directors as part of the transaction for an amount of 1.9 million Euros. "I would like to thank all our investors—both institutional and individual—for their support and trust during this capital increase. We are particularly proud to have expanded and strengthened our shareholder base with the participation of renowned Swedish, US, French, German and UK investors (Lungstrom Family Office, Lion Point Life Science Partners, Celestial Successor Fund, Matignon Finance, Invus, Herald Investment Trust, et Tragara Holdings). We also welcome the continued commitment of representatives of the Brag family and friends, who have renewed their trust in the future of the Company. 'This equity financing adds to the up to €37.5 million EIB financing line signed in July 2025 and allows us to meet the contractual conditions to draw down the first €19 million tranche. The Company's cash runway is now extended through the fourth quarter of 2026, and potentially way beyond with the full exercise of the warrants, which can generate additional equity of €51.7 million', said Fredrik Brag, CEO and Founder of Median Technologies. 'This transaction provides us with the solid financial resources needed for the commercial launch of our Software as a Medical Device eyonis® LCS in the United States, while also strengthening our position to finalize negotiations with commercial partners for the distribution of our eyonis® LCS product. 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In total, the Offering resulted in the issuance of 14,424,541 new ordinary shares of the Company (the 'New Shares'), each accompanied by a warrant (the 'Warrants' and, together with the New Shares to which they are attached, the 'ABSA'). The new ABSA were issued at a price of €1.66 per ABSA, including the issuance premium, representing approximately 72.3% of the Company's existing share capital on a non-diluted basis. This price reflects a nominal discount of 17.9% compared to the volume-weighted average price (VWAP) of the Company's shares over the twenty trading days preceding and through the date of July 18, 2025. 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Forward-looking statements This press release contains forward-looking statements. These statements are not historical facts. They include projections and estimates, as well as the assumptions on which these are based, statements concerning projects, objectives, intentions, and expectations with respect to future financial results, events, operations, services, product development and potential, or future performance. These forward-looking statements can often be identified by the words "expects," "anticipates," "believes," "intends," "estimates" or "plans" and any other similar expressions. Although Median's management believes that these forward-looking statements are reasonable, investors are cautioned that forward-looking statements are subject to numerous risks and uncertainties, many of which are difficult to predict and generally beyond the control of Median Technologies, that could cause actual results and events to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. All forward-looking statements in this press release are based on information available to Median Technologies as of the date of the press release. Median Technologies does not undertake to update any forward-looking information or statements, subject to applicable regulations, in particular Articles 223-1 et seq. of the General Regulation of the French Autorité des Marchés Financiers. About Median Technologies: Pioneering innovative software as a medical device and imaging services, Median Technologies harnesses cutting-edge AI to enhance the accuracy of early cancer diagnoses and treatments. Median's offerings include iCRO, which provides medical image analysis and management in oncology trials, and eyonis®, an AI/ML tech-based suite of software as a medical device (SaMD). Median empowers biopharmaceutical entities and clinicians to advance patient care and expedite the development of novel therapies. The French-based company, with a presence in the U.S. and China, trades on the Euronext Growth market (ISIN: FR0011049824, ticker: ALMDT). Median is also eligible for the French SME equity savings plan scheme (PEA-PME). 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Any invitation, offer or agreement to subscribe, purchase or otherwise acquire securities to which this press release relates will only be engaged with Relevant Persons. Any person who is not a Relevant Person should not act or rely on this press release or any of its contents. This press release may not be distributed, directly or indirectly, in or into the United States. This press release and the information contained therein does not constitute an offer of securities for sale, nor the solicitation of an offer to purchase, Median Technologies' securities in the United States or any other jurisdiction where restrictions may apply. Securities may not be offered or sold in the United States absent registration or an exemption from registration under the U.S. Securities Act of 1933, as amended (the 'U.S. Securities Act'). The securities of Median Technologies have not been and will not be registered under the Securities Act, and Median Technologies does not intend to conduct a public offering in the United States. The distribution of this press release may be subject to legal or regulatory restrictions in certain jurisdictions. Any person who comes into possession of this press release must inform him or herself of and comply with any such restrictions. Any decision to subscribe for or purchase the shares or other securities of Median Technologies must be made solely based on information publicly available about Median Technologies. Such information is not the responsibility of TP ICAP Midcap and has not been independently verified by TP ICAP Midcap.
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