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Infection From Brain-Eating Amoeba Kills Boy in South Carolina

Infection From Brain-Eating Amoeba Kills Boy in South Carolina

New York Times6 days ago
A 12-year-old boy died last week in South Carolina from a rare brain-eating amoeba he contracted after swimming in a local reservoir, a lawyer for the boy's family said in a statement on Thursday.
Jaysen Carr, a middle school student, contracted the deadly infectious amoeba after swimming in Lake Murray, a reservoir roughly 15 miles from Columbia, S.C., the law firm of Tyler D. Bailey said on Facebook. Jaysen died on July 18.
In a briefing on Thursday, Prisma Health Children's Hospital in South Carolina confirmed that Jaysen died from Naegleria fowleri, a brain-eating amoeba that thrives in warm freshwater.
It was not immediately clear when he had gone swimming. Dominion Energy, which owns the lake and runs recreational access to it, could not be immediately reached on Saturday.
The amoeba is 'ubiquitous to any fresh water in the state of South Carolina' and much of the Southeastern United States, Anna-Kathryn Burch, a doctor of pediatric infectious diseases, said at the briefing.
As the weather heats up, the number of amoeba in the water increase while water levels decrease. That is often when infections occur.
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Doctors Explain What They Really Think of Biohacking
Doctors Explain What They Really Think of Biohacking

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Doctors Explain What They Really Think of Biohacking

There are plenty of health trends that pop up and fizzle out fast, but biohacking seems to have staying power. The practice of trying to 'hack' your health for longevity is showing up on podcasts, Netflix documentaries, and all over your For You feed, making it hard to miss. But for all the chatter about biohacking, it's easy to gloss over the actual definition of this practice. What is biohacking, and is it something you should be doing? It's important to state this upfront: Biohacking is a little controversial in the medical field. 'It's using your body as an experiment,' points out Mikhail Kogan, M.D., medical director of the George Washington University Center for Integrative Medicine. While some doctors have a broad view of biohacking that includes things like eating a healthy, varied diet, others view biohacking as more focused on less-proven strategies, like loading up on certain supplements that don't have robust data to back them up. (More on that in a bit.) Meet the experts: Mikhail Kogan, M.D., medical director of the George Washington University Center for Integrative Medicine; Bert Mandelbaum, M.D., sports medicine specialist and co-director of the Regenerative Orthobiologic Center at Cedars-Sinai Orthopaedics in Los Angeles; Kanwar Kelley, M.D., physician and co-founder of Side Health in Orinda, CA; Salim Hayek, M.D., chair of internal medicine at the University of Texas Medical Branch. Whatever your take on biohacking, it's important to at least know what's out there and what it all means. With that in mind, here's what doctors want you to know about biohacking, as well as how to decide if it's right for you. What is biohacking? Biohacking is a broad term used to describe the process of making tweaks to try to improve your health. It can involve sleep, workout routines, supplements, dietary changes, and more. 'Biohacking is essentially DIY biology—making intentional changes to your lifestyle, diet, or environment to optimize health and performance,' explains Salim Hayek, M.D., chair of internal medicine at the University of Texas Medical Branch. 'It ranges from simple tweaks like tracking your sleep or trying intermittent fasting, to more extreme practices like implanting microchips.' Biohacking in the traditional sense means that it's experimental, says Dr. Kogan. 'It wouldn't be called 'biohacking' if it's scientifically proven—that would be standard of care,' he says. But some doctors look at biohacking as people simply trying to improve their health beyond what they may discuss in a routine exam with their physician. 'It's a marketing term that describes things that enhance health, healthspan, and playspan,' says Bert Mandelbaum, M.D., sports medicine specialist and co-director of the Regenerative Orthobiologic Center at Cedars-Sinai Orthopaedics in Los Angeles. 'The essential aspect is that you are what you eat, think, drink, and do. Those are all very important.' The right ways to try biohacking—according to experts Dr. Mandelbaum prefers to look at biohacking as enhancing what you've got with the help of scientifically-proven methods. Kanwar Kelley, M.D., physician and co-founder of Side Health in Orinda, CA, also suggests this approach. 'Biohacking does not need to be overly complicated or require specialized equipment,' he says. 'Adjusting your approach to diet, supplementation, and sleep can help enhance performance and overall health, leading to increased productivity and longevity.' Even meditation and incorporating foods with beneficial properties can fall into this category, he says, among other things. On the supplement front, it's important to talk to your doctor before trying anything new—and your doctor may recommend a blood test to identify if you have any deficiencies. Dr. Hayek also recommends leaning into biohacking in the sense of adding new scientifically-proven healthy behaviors to your life vs. trying whatever crosses your social media feed. 'The real benefits come from evidence-based practices,' Dr. Hayek says, such as prioritizing sleep, exercising, and managing stress. 'The key is that most genuine benefits come from consistent, healthy lifestyle changes—not magic pills or high-tech gadgets,' he says. Some tech can be useful, though, especially in how it helps promote self-awareness: 'Use technology wisely—fitness trackers can keep you accountable, but don't become obsessed with the numbers,' Dr. Hayek says. His other tip? 'Try one change at a time so you can actually tell what's working.' Biohacking practices to avoid—according to experts There are several biohacking practices that doctors recommend taking a pass on, but Dr. Mandelbaum points out that the practice of taking several supplements without talking to a doctor first has been somewhat normalized, even though it's potentially risky. 'Those are the kinds of things you want to avoid: Things that are marketed with no scientific evidence.' Dr. Kelley also suggests being wary of techniques that are marketed as 'complete solutions' to health issues. 'While biohacking can help improve performance, no single method will solve all problems,' he says. 'Techniques should be plausible scientifically and have peer-reviewed scientific backing.' Dr. Hayek recommends avoiding biohacking treatments like "young blood" transfusions, DIY genetic engineering, and amateur implant surgeries. And of course, don't take prescription drugs that weren't prescribed to you, he says. 'Be wary of extreme diets promising miraculous results, or mega-dosing supplements,' he adds. 'If a practice could realistically land you in the hospital, think twice.' Risks of biohacking Because biohacking is such a broad category, there are plenty of potential risks involved in it, Dr. Kogan says. 'Almost anything you can think of is a risk,' he says. If used incorrectly, certain 'anti-aging' drugs may cause heart issues and even death, he points out. 'Many DIY biohacking experiments also lack regulation and safety oversight,' Dr. Hayek says. 'Misinformation is rampant online, and people might delay proven medical treatments for unproven hacks. Plus, it can become expensive and psychologically obsessive.' Does biohacking actually help you live longer and increase healthspan? 'We have no proven way to dramatically extend human lifespan through biohacking yet,' Dr. Hayek says, although who knows what the future may hold. For now: 'The best-documented longevity strategies are quite simple: Don't smoke, eat well, exercise, sleep enough, and manage stress,' he continues. 'Some biohacks that promote these behaviors can contribute to healthspan, living more years in good health. But the extreme anti-aging interventions making headlines? Most lack definitive proof and some are potentially dangerous.' Ultimately, if you want to try to enhance your healthspan and lifespan, doctors recommend sticking with the scientifically-proven basics. You Might Also Like Can Apple Cider Vinegar Lead to Weight Loss? Bobbi Brown Shares Her Top Face-Transforming Makeup Tips for Women Over 50

After a Long Day of Travel, She Woke Up Unable to Walk. Then Crawled to Her Car and Drove to the ER (Exclusive)
After a Long Day of Travel, She Woke Up Unable to Walk. Then Crawled to Her Car and Drove to the ER (Exclusive)

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After a Long Day of Travel, She Woke Up Unable to Walk. Then Crawled to Her Car and Drove to the ER (Exclusive)

Ella Katenkamp opens up to PEOPLE about the week she spent in the hospital, the unexpected condition that sidelined her, and what she wishes others understoodNEED TO KNOW Ella Katenkamp was days from finishing school when she woke up unable to walk At first, she assumed the pain in her calves was from working out after a long trip A week later, she left the hospital with a diagnosis that changed how she views her healthElla Katenkamp was days away from finishing school when she woke to a sharp, searing pain in her calves, her feet curled into a locked position and muscles frozen. What followed was a weeklong hospital stay, a terrifying diagnosis and a viral TikTok that sparked a conversation amongst millions. 'I took a trip the week before to Georgia, and it was a lot of, like, hiking,' Katenkamp tells PEOPLE, looking back on what seemed like a fun getaway before things spiraled. 'On the last day, we did a hike with thousands of stairs, and then I drove 13 hours straight back to Florida.' The former college athlete wasted no time jumping back into her routine. 'As soon as I got back, I did a leg workout at the gym,' she says, noting that cramps didn't seem like a big deal at first. 'I got, like, really bad calf pain after that,' she explains. 'My feet locked into a pointed toe position, and I couldn't walk flat-footed. My calves were stuck like that.' Assuming it was a standard athletic cramp, Katenkamp drank water, stretched, and went to bed. But by 5 a.m., the pain was excruciating, and her legs refused to move. 'I lived with a roommate at the time, but it was, like, five in the morning and I didn't want to wake her up,' she says. 'So I crawled to my car and drove myself to the hospital.' At the ER, her condition worsened. 'As soon as I got in there, they ran over and put me in a wheelchair, and that was it for about a week,' she recalls. Throughout her hospital stay, walking was nearly impossible. 'If I walked at all, someone had to hold me up because I couldn't move my calves,' she says. 'They just stopped working.' Doctors struggled to identify the cause of her symptoms. 'It took them about three or four days to figure it out,' Katenkamp notes. 'The nurses would come in and just be Googling my symptoms — no one knew what it was.' Eventually, she received a diagnosis: rhabdomyolysis, a rare condition that causes muscle fibers to break down and release toxins into the blood. 'It's like the breakdown of your muscle to the point that it poisons your blood,' she explains. Katenkamp was shocked to learn her creatine kinase (CK) level, a marker of muscle breakdown, was well above normal. 'Your CK level's not really supposed to be above 200, and when I got to the hospital, it was in the thousands,' she says. Treatment involved flushing her system with fluids and monitoring her blood multiple times a day. 'They had to take my blood like three times a day,' she says. 'After two days, my CK level actually went up, which was really frustrating.' By the time she was discharged, her CK level was still around 600–700. 'I wasn't where I was supposed to be, but I was starting to walk again,' she says. 'It was just my legs.' Doctors attributed the onset to a combination of factors. 'They told me it was probably from the Red Bulls I drank in Georgia, not enough water, my birth control and going from sitting for 13 hours straight into an intense leg workout,' Katenkamp says. The experience permanently changed her approach to fitness and health. 'I took a huge step back from energy drinks,' she shares. 'I didn't touch them for a long time, and now I only drink them very moderately.' Once hyperactive with early-morning practices, classes and games, Katenkamp is now far more mindful. 'I drink so much more water now,' she says. 'And I definitely think about what days to go hard in the gym — like, was I sitting a lot the day before?' The condition was new to her and to many. 'I had no idea what it was,' Katenkamp says. 'Even the doctors didn't know.' She posted about the ordeal on TikTok, with the text overlay, 'She doesn't know it yet... but the next morning she was gonna crawl out of bed on all 4s and drive herself to the hospital at 6am to stay for the next week because her legs were paralyzed with rhabdomyolysis.' While some followers offered support, others jumped to conclusions. But for Katenkamp, it was a moment that turned criticism into community. 'I didn't even really have to defend myself,' she says. 'Other people did it for me.' Many shared their own experiences or those of loved ones. 'A lot of people said they'd been through something similar and knew how painful it was,' she says. 'There were tons of comments wishing me a good recovery.' Looking back, she says the condition was more than just muscle cramps. 'My legs weren't even the same size when I left the hospital,' she says. 'It's definitely a process, but luckily, I'm past it now.' Still, the risk of lasting damage was real. 'They say it can ruin your kidneys,' Katenkamp says. 'Luckily, I didn't get to that point, but if I hadn't gone to the hospital, it could have destroyed my organs.' That's why her message is firm. 'It's more than just cramps,' she says. 'People kept saying, 'Push through it,' but I couldn't have done that — I had to go to the hospital.' Two years later, Katenkamp's advice to others in recovery is simple and compassionate. 'Make sure you're taking care of yourself and read your body,' she says. 'Keep up with your water, stretch and don't overdo it.' She encourages anyone experiencing similar symptoms to investigate all possibilities. 'Follow the steps your doctors give you,' Katenkamp adds. 'It can definitely come back.' Never miss a story — sign up for to stay up-to-date on the best of what PEOPLE has to offer​​, from celebrity news to compelling human interest stories. If she could tell social media users one thing, it's this: don't pretend to be an expert. 'You never know what's going on,' she says. 'There were over 20 different comments guessing the cause. It's different for every person.' Katenkamp says she understands the appeal of quick judgments, especially online. But she hopes her story shows why empathy matters. 'Don't speak on other people's health,' she says. 'If there's one thing I learned, it's that you really don't know what someone's going through.' Read the original article on People Solve the daily Crossword

Alnylam reaches new highs on strong sales of closely watched rare disease drug
Alnylam reaches new highs on strong sales of closely watched rare disease drug

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Alnylam reaches new highs on strong sales of closely watched rare disease drug

This story was originally published on BioPharma Dive. To receive daily news and insights, subscribe to our free daily BioPharma Dive newsletter. Dive Brief: Sales of an Alnylam Pharmaceuticals rare disease medicine substantially outpaced Wall Street expectations in the drug's first full quarter since U.S. regulators expanded its use, lifting the biotechnology company's market value to new highs on Thursday. According to Alnylam, sales of the drug, called Amvuttra and sold for two types of transthyretin amyloidosis, or ATTR, reached $492 million between April and June, well above consensus estimates of about $350 million. About $150 million of that total was attributed to patients with the 'cardiomyopathy' form of the disease that regulators cleared Amvuttra for in March. Some 1,400 people were on therapy at the end of the quarter, Alnylam said. Alnylam also hiked its 2025 financial projections by hundreds of millions of dollars, guiding between $2.18 billion and $2.28 billion in net revenue from Amvuttra and Onpattro, its other transthyretin amyloidosis drug, compared to the previous $1.6 billion to $1.73 billion range. Alnylam now expects $2.65 billion to $2.8 billion in total net revenues. Company shares climbed by more than 15%, taking Alnylam's market value past $50 billion. Dive Insight: Alnylam has for years been among biotech's most valuable companies. But it has never been consistently profitable, and is banking on Amvuttra to change that. A March expansion into ATTR cardiomyopathy, a progressive condition that causes heart failure, hospitalizations and death, was a vital step. ATTR cardiomyopathy is believed to be more common than the 'polyneuropathy' form Amvuttra was first cleared to treat in 2022. Sales of the leading cardiomyopathy treatment, Pfizer's tafamidis, topped $5 billion last year. Amvuttra, an injectable medicine, competes with Pfizer's drug and BridgeBio Pharma's Attruby, both of which are taken orally. Attruby reached market earlier and is also off to a faster-than-expected start. Alnylam priced Amvuttra in cardiomyopathy at $476,000 per year, a significant premium to its rivals, despite the fact clinical results didn't appear strong enough to indicate its drug is clearly superior. Alnylam executives have said they expect Amvuttra to grow the market for ATTR cardiomyopathy medicines, as most patients still aren't on treatment. They've also expressed confidence Amvuttra could become a standard option. The drug works differently than its competitors and, because it's only injected four times a year, could have better adherence, they've said. So far, its optimistic projections appear to be playing out. On a conference call Thursday, some analysts questioned whether the better-than-expected numbers were driven by a surge of initial prescriptions for sicker people whose disease had been progressing on other medicines. CEO Yvonne Greenstreet said the company is seeing 'broad uptake' that includes newly diagnosed patients as well. Chief Commercial Officer Tolga Tanguler added many commercial and Medicare insurers already have policies out and are clearing use in newly diagnosed patients, indicating they aren't requiring people take Pfizer or BridgeBio's drugs first. A month into the quarter, Alnylam began to see a 'very healthy and accelerating trend in first-line use,' he said. The results are 'not just a flash in the pan,' Greenstreet added. 'We expect continuous, sustainable growth,' she said. Following the call, Stifel analyst Paul Matteis wrote in a research note the higher guidance still 'looks beatable' and raised his projections for Amvuttra's peak annual sales to $9 billion, up from about $7 billion previously. Alnylam intends to gradually lower Amvuttra's net price through rebates and pay-for-performance deals as patient uptake increases. On Thursday's call, CFO Jeff Poulton said to expect a 'mid-single digit reduction in net price' this year. Recommended Reading BridgeBio sales of new heart drug outstrip expectations Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

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