
HAYA Therapeutics Raises $65 Million in Series A Funding to Deliver Precision RNA-Guided Medicines for Chronic and Age-Related Diseases
LAUSANNE, Switzerland & SAN DIEGO--(BUSINESS WIRE)-- HAYA Therapeutics, SA, a biotechnology company pioneering precision RNA-guided regulatory genome targeting therapeutics that reprogram disease-driving cell states for rare, common, chronic and age-related diseases, announced that the company has raised $65 million in Series A funding. The financing will accelerate the clinical development of HAYA's lead long non-coding RNA (lncRNA) targeting candidate HTX-001 in heart failure and the continued expansion of its RNA-guided regulatory genome pipeline development engine. This investment emphasizes investor confidence in HAYA's groundbreaking science and positions the company to deliver on its mission of bringing disease-modifying, precision medicines faster and more efficiently to patients. The round was led by Sofinnova Partners and Earlybird Venture Capital, with participation from Eli Lilly and Company (Lilly), ATHOS, +ND Capital, Alexandria Venture Investments and LifeLink Ventures, with additional support from existing investors Apollo Health Ventures, Longview Ventures (an affiliate of Broadview Ventures), 4see ventures, BERNINA Bioinvest and Schroders Capital.
"This funding validates our vision for improving the way chronic and complex diseases are treated by creating a new generation of therapies that reprogram disease-driving cell states into healthy ones,' said Samir Ounzain, PhD, HAYA's CEO and co-founder.
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'This is a defining moment for HAYA as we are advancing our lead program into the clinic. This funding validates our organization, pioneering approach and vision for improving the way chronic and complex diseases are treated by creating a new generation of therapies that reprogram disease-driving cell states into healthy ones,' said Samir Ounzain, Ph.D., Co-founder and CEO of HAYA Therapeutics. 'We're excited that Sofinnova Partners, Earlybird and our syndicate of investors share our vision for the potentially industry changing nature of our platform as we move beyond traditional approaches by leveraging novel therapeutic targets emerging from the regulatory genome.'
The company will use the funds to initiate clinical trials for HTX-001, HAYA's first-in-class lncRNA-targeting therapy for heart failure, initially focused on non-obstructive hypertrophic cardiomyopathy (nHCM). In parallel, the company will strengthen its platform capabilities and expand its pipeline of disease-modifying therapies across multiple therapeutic areas—including pulmonary fibrosis, obesity and age-related common and chronic diseases.
'HAYA's platform unlocks the dark genome's therapeutic potential by targeting disease-driving cell states via long non-coding RNAs. This novel approach opens a new frontier in precision medicine, moving beyond traditional target classes to address disease at its epigenetic and cellular roots. Leading this round alongside Earlybird reflects our deep conviction in the HAYA team and their mission to develop safer, more effective therapies across a broad range of indications, including their lead program in nHCM, as they advance it toward the clinic to address a major unmet need,' noted Henrijette Richter, Managing Partner at Sofinnova Partners.
The core of HAYA's proprietary platform maps and decodes the biology of the regulatory genome, also referred to as the ' genome's dark matter' or 'Dark Genome," which constitutes 98% of the human genome. While the regulatory genome does not code for proteins it is now recognized as the master control layer of gene expression and cell identity. HAYA has developed the most comprehensive atlas of the regulatory genome by combining integrated multimodal functional genomics with a stack of proprietary computational and machine learning methodologies, enabling the precise identification and modulation of pathogenic cell states across diverse diseases. HAYA's regulatory genome platform enables the development of RNA-guided therapeutics with unprecedented precision, speed and scalability. This next-generation approach is designed to go beyond symptom management and directly reprogram the cellular drivers of disease.
To support its strategic growth, HAYA recently assembled an industry-leading C-level suite to drive scalable growth, business and clinical development and expand strategic collaborations with pharmaceutical and technology partners. The company recently announced a partnership with Lilly, one of the largest collaborations to date in the regulatory genome space, focused on RNA-based drug targets for obesity and metabolic disorders.
About HAYA Therapeutics
HAYA Therapeutics is a precision medicines company developing programmable therapeutics targeting regulatory RNAs derived from the dark genome, a cell information processing unit, to reprogram pathological cell states for a broad range of diseases, including cardiovascular and metabolic diseases and cancer. The company is using its innovative platform to gain novel insights into the biology of disease cell states and the long non-coding RNAs (lncRNAs) that regulate them. HAYA's lead therapeutic candidate is HTX-001, in development for the treatment of heart failure. HAYA is also developing a pipeline of lncRNA-targeting precision therapies for the cell-specific treatment of diseases in other tissues.
HAYA is headquartered at the life sciences park Biopôle in Lausanne, Switzerland with laboratory facilities in San Diego. For more information on the company, please visit our website at www.hayatx.com. Follow us on X and LinkedIn.
About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm in life sciences, specializing in healthcare and sustainability. Based in Paris, London, and Milan, the firm brings together a team of professionals from all over the world with strong scientific, medical, and business expertise. Sofinnova Partners is a hands-on company builder across the entire value chain of life sciences investments, from seed to later-stage. The firm actively partners with ambitious entrepreneurs as a lead or cornerstone investor to develop transformative innovations that have the potential to positively impact our collective future.
Founded in 1972, Sofinnova Partners is deeply established in Europe, with 50 years of experience backing over 500 companies and creating market leaders around the globe. Today, Sofinnova Partners manages over €4 billion in assets. For more information, please visit: sofinnovapartners.com.

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Yahoo
5 days ago
- Yahoo
Ramp Metals Completes Spring Drill Program and Announces Additional Mineralization at Rush Target
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Figure 1: Rottenstone SW - 2025 Drill Collar Locations To view an enhanced version of this graphic, please visit: Ranger A total of 8 drill holes were completed at the Ranger target (Figure 2). Seven drill holes were completed around the Ranger-001 discovery hole. All 7 holes intersected significant widths of the quartz-diorite package which hosted the previously announced high grade gold intercept of 73.55 g/t Au over 7.5m as reported in the June 17, 2024 News Release. The remaining hole was designed to test a conductor located approximately 1.5km to the north-east, which was identified in the recently completed airborne geophysics (Figure 3). Altered tonalite and metasediments with Pyrrhotite mineralization were encountered. The hole was ended early at 200m due to time constraints. Management believes that further testing is warranted on the eastern Ranger anomalies. Figure 2: Ranger - 2025 Drill Hole Collars and Drill Traces To view an enhanced version of this graphic, please visit: Figure 3: Ranger Drill Collars and Drill Hole Traces with EM To view an enhanced version of this graphic, please visit: Rush A total of 10 holes were drilled at the newly identified Rush VMS target (Figure 4). Semi-massive to massive sulphide mineralization was noted in 5 drill holes, with the presence chalcopyrite and sphalerite being confirmed with a Thermo Scientific™ Niton™ XL5 Plus handheld XRF analyzer. Minor amounts of galena were also noted. Rush-010 intersected net textured to semi-massive sulphide over approximately 4.16m from 21.4m-25.56m (Photo 1). Disseminated to blebby sulphides were also intersected to a depth of approximately 47m (Photo 2). This intersection represents a 150m step-out to the north-east from the initial discovery area where Rush 001, 002, 003, and 009 were drilled. 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Figure 5: Rogue - 2025 Drill Collar Locations and Drill Hole Traces To view an enhanced version of this graphic, please visit: Photo 3: Rogue-005 Boxes 25 & 26 - Potassic alteration of diorite and hematite altered fractures To view an enhanced version of this graphic, please visit: Photo 4: Rogue-006 Boxes 61 & 62 - Coarse-grained diorite with potassic alteration To view an enhanced version of this graphic, please visit: Geophysics The Company has completed a magnetic and TDEM survey over the remainder of the Rottenstone SW property using the Xcite HTDEM system. A total of 3,342 line-km was flown at 100m spacing to provide a high-resolution Mag and EM dataset over the entire property. Data is currently being processed, and the Company will provide a further update once the data processing is completed. Next Steps With the present forest fire situation in northern Saskatchewan, the Company felt it prudent to relocate all drill core to a facility in the Prince Albert area to safely complete processing and preparation for assays. The first shipment of samples has been delivered and is being analyzed at Bureau Veritas Commodities Canada Ltd. ("BV") in Vancouver, BC. All remaining core has been fully logged and is currently being cut and sorted for shipping. The Company plans to return to the Rottenstone SW property for further mapping and sampling once the data from the airborne geophysics and drill programs have been analyzed, and the fire risk has subsided. A ground geophysics program is also planned for the summer to help better define the conductive targets on the property. An amendment to the current permits requesting up to 30,000m of additional drilling and a 30-person camp is being prepared and is expected to be submitted shortly. Acknowledgements Ramp Metals would like to thank the Lac La Ronge Indian Band and all land users for their continued support and working closely with the Company through the permitting process. The Company would also like to thank all the contractors who made the 2025 winter/spring drill program a success. Drilling: Flamingo Drilling through Athabasca Catering Limited Partnerships Geology and Geophysics: Axiom Exploration Group Ltd. (Mikaela Miller, Craig Cubbon, Logan Anaka) Accommodations: Thompson's Resort - Adventure Destinations Flight Services: Heli-Recon Aerial Support Services Inc. and Osprey Wings Ltd. Fuel Services: Millsap Fuel Distributors Ltd. Local Contractors: Cecil Mcleod, Alex Mcleod, Bradley McKenzie, Ethan Ballantyne, Joey McKenzie, Chris Roberts, Joe Stanley, Jimmy McKenzie, Riley Provencher Quality Assurance/Quality Control Uncut whole NQ drill core was analyzed by a Thermo Scientific™ Niton™ XL5 Plus handheld XRF, operated by Ramp Metals staff on site. The Portable X-Ray Fluorescence ("pXRF") data is exploratory in nature and is used predominantly as an internal workflow to assist in target prioritization and mineral identification through an early phase of exploration investigation. pXRF data is not provided as it is not an indicator of representative geochemistry of the entire rock mass and therefore should only be viewed as an initial screening prior to laboratory assays. Drill core is currently being sampled and cut by diamond saw. Samples will be shipped as they are processed for laboratory analysis at BV, an internationally recognized and ISO 17025:2017 accredited analytical services provider, at its Vancouver, BC laboratory. Drill core samples are marked in maximum intervals of up to 1.5m and cut in half using a diamond saw with half sent for assay and the other half saved for reference. Samples are then bagged and zip-tied, with 15 bagged samples placed into sealed rice bags and then 20 rice bags placed in mega bags for transport to BV. Sample QA/QC procedures were applied by inserting a regular and systematic schedule of standards, blanks and duplicates into the sample stream. Control samples consisting of certified reference samples and blank samples were systematically inserted into the sample stream and analyzed as part of the Company's QA/QC protocol at a rate of 1:15 or better in addition to BV's internal quality assurance programs. Rock samples are prepared using the PRP70-250 package, where samples are weighed, dried, and crushed to greater than 70% passing a 2mm sieve, then pulverized to greater than 85% passing 75 microns. Samples are analyzed in accordance with BV's MA300 and FA330 packages, for both multi-element ICP analysis (0.25 g, multi-acid and ICP-ES analysis) and gold analysis by fire assay (30g fire assay with AAS finish). Gold returning >10ppm is automatically analyzed by gravimetric method in accordance with BV's standard of practice. Qualified Person Brett Williams, VP Operations and Senior Geologist for Ramp Metals, and a "qualified person" under National Instrument 43-101 Standards of Disclosure for Mineral Projects, has reviewed and approved the technical content in this news release. About Ramp Metals Inc. Ramp Metals is a grassroots exploration company with a focus on a potential new Saskatchewan gold district. The Company currently has a new high-grade gold discovery of 73.55 g/t Au over 7.5m at its flagship Rottenstone SW property. The Rottenstone SW property comprises 32,715 hectares and is situated in the Rottenstone Domain. Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. FORWARD-LOOKING STATEMENTS This news release contains "forward-looking statements" within the meaning of applicable securities laws. All statements contained herein that are not clearly historical in nature may constitute forward-looking statements. Generally, such forward-looking information or forward-looking statements can be identified by the use of forward-looking terminology such as "plans", "expects" or "does not expect", "is expected", "budget", "scheduled", "estimates", "forecasts", "intends", "anticipates" or "does not anticipate", or "believes", or variations of such words and phrases or may contain statements that certain actions, events or results "may", "could", "would", "might" or "will be taken", "will continue", "will occur" or "will be achieved". The forward-looking information and forward-looking statements contained herein include, but are not limited to, statements regarding the Company's exploration activities. These statements involve known and unknown risks, uncertainties and other factors, which may cause actual results, performance or achievements to differ materially from those expressed or implied by such statements, including but not limited to: requirements for additional capital; future prices of minerals; changes in general economic conditions; changes in the financial markets and in the demand and market price for commodities; other risks of the mining industry; the inability to obtain any necessary governmental and regulatory approvals; changes in laws, regulations and policies affecting mining operations; hedging practices; and currency fluctuations. Although the Company has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking statements, there may be other factors that cause actions, events or results to differ from those anticipated, estimated or intended. Accordingly, readers should not place undue reliance on any forward-looking statements or information. No forward-looking statement can be guaranteed. Except as required by applicable securities laws, forward-looking statements speak only as of the date on which they are made and the Company does not undertake any obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise. For further information, please contact: Ramp Metals Inc. Jordan BlackChief Executive Officerjordaneblack@ Prit SinghDirector905 510 7636 To view the source version of this press release, please visit


New York Post
5 days ago
- New York Post
An ‘international gold rush' could be on its way — and it's because of a ‘significant' discovery in Finland
A single drill hole in Finland has unearthed a significant gold deposit, sending shockwaves through the global markets in what could likely be a new international gold rush. The significant discovery was confirmed to be found in bedrock samples taken from the site in February along the Karelian Gold Line in Ukkolanvaara, according to mining and exploration company Endomines. The initial drill hole, named UKKO-001, hit three major gold-rich sections and has exceeded expectations, the company's CEo, Kari Vyhtinen, said. 'An impressive result was achieved with the very first drill hole,' he notes. 'The result confirms the great gold potential of the Ukko-deposit in Ukkolanvaara. Three such high-grade gold zones in the same drill hole is something we have never seen before in exploration.' Vyhtinen said their plan was to conduct only a three-to four-week research campaign in the area, but the company has now decided to continue the investigations indefinitely. 'The iron deposit in Ukkolanvaara is very extensive,' he adds. 'Additionally, observations of visible gold in several drill holes indicate that gold is present over a wider area in connection with the iron deposit.' The significant discovery was confirmed to be found in bedrock samples taken from the site in February along the Karelian Gold Line in Ukkolanvaara. Roman Bodnarchuk – The initial drill hole, named UKKO-001, hit three major gold-rich sections and has exceeded expectations. Dmitry Naumov – Vyhtinen believes the gold discovery will prove to be 'significant.' The company's findings show various samples of gold ranging upwards of nearly 10 grams per metric ton. To date, 12 holes have been drilled, with more results pending.