New Covid Variant XFG Explained: Symptoms, Spread & Safety Tips You Need To Know

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Symptoms mirror Omicron's, that is, fever, cough, fatigue, sore throat, and muscle aches. Though India's Covid response offers a foundation, but XFG demands targeted strategies
As India navigates a post-Covid world, a new Omicron subvariant, XFG ('Stratus"), is raising concerns with its rapid spread and immune-evasive traits. First detected in Canada, XFG has reached 38 countries, including India, where it accounts for a growing share of cases.
With India's active Covid-19 cases at 7,000 as of June 2025, per the Union Health Ministry, let's examine XFG's characteristics, India-specific data, and how the nation can prepare for this and future pandemics, drawing lessons from long Covid.
What Is The XFG Variant?
XFG, a recombinant subvariant of Omicron, emerges from the fusion of LF.7 and LP.8.1.2 strains, formed when two variants infect a person simultaneously, mixing genetic material.
A Lancet study highlights four key spike protein mutations—His445Arg, Asn487Asp, Gln493Glu, and Thr572Ile—enabling 'strong immune evasion," allowing XFG to bypass antibodies from prior infections or vaccines.
Globally, XFG accounts for 22.7% of sequenced cases as of June 2025, up from 7.4% a month earlier, per GISAID (Global Initiative on Sharing All Influenza Data), and may soon dominate over NB.1.8.1 ('Nimbus"), per The Conversation. In India, it's the dominant strain in Madhya Pradesh, with 63.6% of sequenced samples, per AIIMS Bhopal.
Symptoms mirror Omicron's, that is, fever, cough, fatigue, sore throat, and muscle aches. However, XFG uniquely causes hoarseness—a scratchy or raspy voice—reported by doctors as a key marker, per Everyday Health.
Unlike JN.1, which caused low-grade fever and digestive issues, XFG's symptoms are mild to moderate, with no evidence of increased severity or hospitalisation rates, per WHO. Current vaccines, targeting JN.1, remain effective against severe disease, and antivirals like Paxlovid and remdesivir work, per Time.
How Many XFG Cases Have India Reported?
India has reported 206 XFG cases as of June 11, per INSACOG, with Maharashtra leading at 89 cases, followed by West Bengal (49), Tamil Nadu (16), Kerala (15), Gujarat (11), and Andhra Pradesh, Madhya Pradesh (6 each), Odisha (4), Puducherry (3), Delhi, Rajasthan, and Punjab (2 each), and Telangana and Haryana (1 each), per The Hindu.
Of these, 159 cases were detected in May, with two each in April and June, indicating a rapid rise. India's active Covid-19 cases reached 7,000 by June 11, with Kerala reporting the highest active cases (2,200), followed by Gujarat (1,223) and Delhi (757).
A 2024 ICMR survey notes 66% of respiratory viral infections in India are Covid-related, but hospitalisations remain low, News18 reported. AIIMS Bhopal's genomic analysis of 44 samples from May-June found XFG dominant in 28 (63.6%), with no NB.1.8.1 detected in Madhya Pradesh, highlighting regional variation. Dr Rajiv Behl, ICMR Director General, stresses XFG's low severity but urges vigilance for vulnerable groups—those over 70 or with comorbidities.
Why XFG Matters To India
India's 1.4 billion population and $3 trillion economy face significant risks from new variants. Long Covid, affecting 7% of India's 44 million Covid cases (3 million people), costs 1% of GDP annually, per a 2024 NITI Aayog estimate, with 40% reporting fatigue and 25% brain fog.
XFG's immune evasion could exacerbate this. Rural areas, with only 10% of health centres offering post-Covid care, face worse outcomes, per The Indian Express. A 2024 Times of India poll shows only 25% of Indians know about long Covid, limiting XFG awareness.
Vaccine hesitancy, at 30% in rural India, and low Omicron-specific booster uptake (18%) weaken defences, per ICMR 2024. With 74 Covid deaths in 2025, mostly among the elderly and immunocompromised, XFG's spread threatens vulnerable groups.
How India Should Prepare
India's Covid response—2.2 billion vaccine doses by 2025—offers a foundation, but XFG demands targeted strategies:
Enhanced Genomic Surveillance: INSACOG's 54 labs must expand sequencing, as only 0.1% of cases are sequenced, per The Hindu. AIIMS Bhopal's model, detecting XFG in 63.6% of samples, shows the value of regional labs. Scaling Truenat and RT-PCR testing to 80% of health centers, especially rural ones, could detect variants early, per Dr Balram Bhargava, a renowned cardiologist and public health leader.
Vaccination & Boosters: Only 18% of Indians have Omicron-specific boosters. A 2025 campaign targeting 50% booster coverage, especially for those over 70, could cut severe cases by 30%, per WHO. Mobile vaccination units, successful in 2021, should reach rural areas.
Hospital Preparedness: Only 50% of health centres have ventilators, and 30% lack oxygen, per a 2024 MoHFW report. The Centre's 2025 mock drills must ensure 75% of 1.5 lakh centers have isolation beds and antivirals, costing Rs 5,000 crore. Telemedicine, used by 15% of urban Indians, can expand to rural areas.
Masking and Ventilation: XFG's spread in crowded spaces, like Mumbai's trains, requires masks and improved ventilation. A 2023 Singapore study cut transmission by 20% with air purifiers. India's public buildings need similar upgrades.
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covid symptoms Long COVID omicron
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