Will Trump's policies kill Massachusetts' life sciences leadership?
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Although the industry is centered in eastern Massachusetts, there's a statewide benefit from all the tax dollars those businesses and workers pay.
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In all, Massachusetts organizations — including universities, research institutes, and hospitals — received $3.5 billion in funding from the National Institutes of Health. Massachusetts-headquartered companies raised $3.26 billion in venture capital funding. Among all drugs in the development pipeline in the United States, 15 percent were being made by companies headquartered in Massachusetts.
But actions taken by President Trump and his administration — cutting funding for scientific research and universities, flirting with tariffs, fanning skepticism about vaccines — threaten to devastate the ecosystem. Today, the industry is at a precipice, and uncertainty abounds. Some companies are already feeling the pinch of terminated federal grants, while others are anxious about what might come. Taken together, Trump's policies could force some companies and scientists to take their money, talents, and products overseas.
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Christopher Locher, CEO of Lowell-based Versatope Therapeutics, which develops a platform to deliver vaccines and therapeutics, said he worries the Greater Boston life sciences ecosystem is 'being flushed down the toilet.'
For example, Trump is
Trump's funding cuts are already having a large impact on some local companies.
Part of the problem is the Trump administration isn't only cutting funding, but it's picking which technologies to fund — in some cases apparently based on politics more than science. Take flu vaccines.
The Trump administration recently announced a $500 million campaign to fund the development of a universal flu vaccine, which doesn't require annual updates, using technology being worked on
But simultaneously, he cut funding for other work on a universal flu vaccine. Versatope Therapeutics got $14 million in NIH funding and spent five years developing a universal flu vaccine. It had approval from the US Food and Drug Administration to begin clinical trials
when
Trump terminated the contract's remaining $8 million, with the reason given being 'convenience,' Locher said.
Trump also
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Company executives say decisions by Trump officials to disinvest in vaccine-related technology — and concerns about whether government will approve new technology — means it's nearly impossible to find private investment funding to replace lost federal dollars.
'We're faced with bankruptcy in the very near future,' Locher said.
Ironically,
given Trump's stated commitment to bringing businesses back to the United States, one potential option Locher is eyeing is opening a subsidiary abroad. Conducting clinical trials would be cheaper in another country, whether in Europe, Australia, or China, Locher said, and some countries are offering financial incentives to American companies to relocate.
Companies also face a potential workforce brain drain. There have been
MassBio officials said China has less rigorous — but faster — safety and research protocols than the US. Australia allows a faster timeline for clinical trials. If regulatory approval of medicines is held up because the FDA is understaffed, companies may seek European regulatory approval instead.
The loss of talent to foreign countries will be compounded if the pipeline of local university graduates dries up. One draw for life sciences companies to Boston/Cambridge is the presence of elite schools like Harvard and MIT, with their potential for faculty collaboration and skilled graduates.
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Trump is trying to
Chip Clark, CEO at Vibrant Biomedicines in Cambridge, said cuts to university research funding both 'shrink the pipeline of great ideas' that form the basis for many biotech startups and translate to fewer available scientists.
Clark said the administration's policies 'seem like a deliberate attempt to try to cede scientific leadership to Europe and Japan and Korea and China. ... They will be delighted to capitalize on our talent, technology, and investment capital to make their robust biotech sectors grow and ultimately compete successfully against the US industry,' he said.
Don Ingber, founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, said he has postdocs with US visas applying for jobs in Europe, and others who were accepted to work at Harvard but are going elsewhere. 'The fact that places like Harvard and MIT and American universities are magnets for the best and brightest from around the world is what's driven our technology economy and certainly the Boston/Cambridge ecosystem,' Ingber said. 'With this uncertainty, I fear we'll lose a generation.'
Ingber, who was forced to stop work on two government-funded projects on drugs designed to prevent injury from radiation exposure, compared administration policies to 'eating seed corn' needed to grow crops.
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Trump's vendetta will undermine one of the most vibrant state economies in the country and set back American science by years. And it's not just eastern Massachusetts that will pay a price; the entire country will. As Ingber noted, it might take years to see the impact of medicines or technologies that aren't developed because of these shortsighted cuts.
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USA Today
20 minutes ago
- USA Today
'I refuse to give up': Michigan researchers, health officials grapple with funding cuts
'I refuse to give up': Michigan researchers, health officials grapple with funding cuts Show Caption Hide Caption Video: MSU breast cancer researcher Jamie Bernard talks about funding uncertainty MSU breast cancer researcher Jamie Bernard talks about federal funding uncertainty on Thursday, May 8, 2025, at her lab in East Lansing. Michigan public health officers say they've had to cut services and lay off workers after the Trump administration slashed funding, affecting their ability to work to stop the spread of disease. Scientists from the University of Michigan and Michigan State University say federal cuts to their research could halt development for new cancer treatments and eviscerate the scientific workforce. Using words like "devastating," "heartbreaking," and "shortsighted," Michigan public health leaders and researchers at the state's largest universities described the effects of President Donald Trump's efforts to slash federal government spending — through executive orders, cuts to federal grants, and stop work orders — and the wide-reaching fallout. Some local health departments have laid off workers and cut back on the services they can provide at regional laboratories and at community and in-school health clinics, and have seen disruptions in their ability to stop the spread of infectious disease, said Norm Hess, executive director of the Michigan Association for Local Public Health. When the U.S. Department of Health and Human Services revoked $11.4 billion in COVID-19-related grants in late March, the effects were felt across Michigan in ways that might not have been anticipated, he said. 'While everyone agrees the emergency response phase of COVID-19 is over, the funding streams created for pandemic response have been supporting laboratories monitoring other diseases around the state, from legionella to tuberculosis to measles, as well as water quality inspections and other sampling work,' Hess said. 'Federal leaders rescinded those grants, clearly thinking it was a responsible way to recover money that was being misspent. Instead, it's a great example of unintended consequences. Everyone agrees government should spend public dollars efficiently and effectively, but it appears they did not check to see what they were actually eliminating when cutting grants that had 'COVID' on the label.' Although Michigan Attorney General Dana Nessel has joined other states in challenging many of the Trump administration's cuts to federal public health and university research funding, including the $11.4 billion in COVID-19-related grants, Hess said it's too risky for local health departments to count on money that may or may not be awarded to them in the end. "You can't turn it off, and then if money comes, turn it back on," he said. Cuts hit research on the science of aging When he took office, Trump pledged to eliminate waste, fraud and abuse in federal spending, and "make America healthy again" by shifting priorities of the nation's top health agencies and taking aim at research and programs that focused on diversity, equity and inclusion. But medical researchers at Michigan State University and the University of Michigan say his administration's abrupt cuts to funding for scientific studies, clinical trials and training programs have all but gutted their life's work and could halt the development of new treatments for diseases like cancer as well as eviscerate the future scientific workforce. University of Michigan psychology professor Toni Antonucci lost the $13 million federal grant that supported her research on health disparities among aging Americans. It focused on minority populations, including African Americans, and comes at a moment in history when the U.S. population is older than it ever has been and is growing increasingly diverse. "I have never thought that politics should be involved in research, and, unfortunately, this is clearly the case here," said Antonucci, who has worked at U-M since the 1970s. "We were focusing on our most vulnerable populations, and I think that's the reason that the money was ... rescinded. "It shows a kind of shortsightedness and, in a way, vindictiveness. ... My focus was on ... how can the social relations that people have improve their health? What kinds of relationships are positive for people or negative for people? How do we increase the positive, and reduce the negative? "What are the kinds of things that universally predict better health, longer longevity? ... The point is, if you know what's influencing different groups, it gives you some insight on how to intervene both with that group and with other groups." Now, she said, that data will be lost. "If a government has policies that they want to enact, regardless of the data, then this is what you do," Antonucci said. "You just make sure there are no data. But just because you don't collect the data, that doesn't mean the association isn't still there." U-M professor: Slashed grants suggest 'you just don't matter' Gary Harper, a U-M professor of health behavior and health equity, learned in late March that his nearly $1.15 million five-year grant from the National Institutes of Health had been rescinded. "It's devastating," said Harper. "I am an openly gay man, and have been involved in activism, research, clinical work, and policy work in the HIV field for 40 years, starting out in 1985 as an old-time activist at a time when we were burying our friends every week. ... This is the first time in the history of my academic career that I've been without federal research or training funds." Harper is co-director of the SOAR at U-M, which stands for Student Opportunities for AIDS/HIV Research. It's a two-year intensive mentoring program that provides HIV-related research opportunities to undergraduate students, propelling them toward graduate school, and, eventually, the HIV research workforce. Many of those students are LGBTQ+ themselves, have disabilities, or come from low-income backgrounds, he said, but Harper noted that the program is open to anyone. "I'm a strong believer that we need to be making sure that we mentor researchers who reflect the communities that are most impacted," Harper said. More: Federal research cuts would rock Michigan economy, halt clinical trials, those affected say More: Trump's budget cuts could cost Michigan universities more than $200 million Discovering that the NIH canceled SOAR's grant funding "ripped me apart," Harper said. "We have one more cohort to get through their senior year." He said he won't let the Trump administration win and cancel the program before they graduate. "Basically, what they're saying is, 'We don't want to spend any money on you because you just don't matter,' " Harper said. " 'Your life has no value.' ... Well, I refuse to give up on them." Harper and SOAR's co-director are scrambling together the money themselves to pay for the final year of the program. Slowly, he said, that is coming together, but his other work through the Adolescent Medicine Trials Network (ATN) for HIV/AIDS Intervention has also been targeted by the federal cuts. A study on transgender youths was canceled, he said, and funding for the leadership group that oversees equity and inclusion in all ATN studies also was eliminated. He also lost grant funding to study gay and bisexual men in Kenya living with HIV. Still, he said, "I'm not going to let this get me down. "I try and show power and strength and resilience to the students, to give them hope that this, too, shall pass. This is a moment in time, but this is not your entire life. ... Your lives do matter. You are special and you are perfect, just the way you are." Breast cancer prevention studies in limbo The Trump administration isn't taking aim solely at research that fits its definition of DEI, said Jamie Bernard, an associate professor of pharmacology and toxicology at Michigan State University. "What I don't really think is being well communicated is that cancer research is also being threatened," said Bernard, who began studying interventions to prevent breast cancer in 2016, when her mother, Pamela O'Brien, was diagnosed with the disease at 61 years old. "This is something that Democrats and Republicans have always supported. In fact, we've come so far in the treatment of breast cancer due to federal funding, we diagnose women earlier. There's lots of options for treatment, and really, this research has saved a lot of lives and brought health care costs down." Her work is now focused on the environmental and lifestyle factors that can increase a woman's risk of getting aggressive breast cancers. "Not all breast cancers are curable, so that's what I really set off to focus on," she said, explaining that her work involves understanding how to kill cancer cells that are resistant to treatment and discovering new drug therapies. Earlier this year, she applied to renew a $2.07 million federal grant funded by the National Institutes of Health along with a new, $2.79 million grant, but both have been held up for months in a cloud of uncertainty. The initial reviews of her grants were postponed but eventually got through the first stage of the process; they now await the second step of review. There remain no guarantees. "How are they going to choose what they fund?" she said. "I don't know what's going to happen, really. So, we are in a time of uncertainty. Grant funding has always been uncertain. It's always been competitive, but there's always been a process and an infrastructure that researchers have relied on." Bernard runs a research lab at MSU, where a team of scientists are working to 'stop breast cancer from ever starting in the first place or prevent it so much that you've delayed it and you die of some other natural cause before you have to deal with cancer," she said. "I am in a place where I don't know if I should be accepting students in the fall. What's my next move? Am I still allowed to study what I've been studying? So it's a confusing time, a frustrating time, a time of high anxiety in our department of pharmacology and toxicology.' Bernard said the NIH canceled a grant for a graduate student from Puerto Rico who is Hispanic, and had applied through a mechanism that provided funding for predoctoral students who are disabled, identify as Black, Hispanic, American Indian or Alaska Native, or who are from socioeconomically disadvantaged backgrounds. "Just simply because she was a minority, the grant mechanism that she applied with, they withdrew it," Bernard said. "The white woman in my lab, her grant is going to be reviewed. ... It's so awful." The work they're doing, she said, "really should be bipartisan, nonpartisan — not even partisan. It's freaking cancer research." Ph.D. student reexamines future in scientific research The political climate is chasing Alex Chapman, a Ph.D. student at MSU who is studying migraines and pain, away from a career in academia. Chapman, 24, who is originally from Richmond, Virginia, secured a federal grant studying a neuropeptide that's upregulated in people with migraines, before Trump took office in January. Many of her friends and colleagues haven't been so lucky. "Science is being so vilified that I'm considering careers in other places or different avenues because it's just hard to see a future in a place that doesn't value science at all," she said. "It's heartbreaking. ... My career options are kind of dwindling, and the more time that passes, the more fellowships and different opportunities just keep becoming defunded," Chapman said, noting that a fellowship she was eyeing through the U.S. Agency for International Development (USAID) has been axed. She considered shifting toward public policy work, helping government leaders understand "why we should fund pain research," but then she attended a symposium and heard a woman who works in public policy speak about the cuts there, too. "She was like, 'This is a great fellowship. It's been defunded. This was an awesome fellowship. It's been defunded,' " Chapman said. When entrepreneur Elon Musk, who headed the new Department of Government Efficiency early in the Trump administration, criticized the use of federal dollars on scientific studies of legumes and aggression in hamsters, Chapman said, it showed that he couldn't see the full impact of the work. "If you just simplify it like that, maybe it does seem silly, but you're looking at the small picture," she said. "The point of research is to zoom out and look at the bigger picture. When you understand the best process of planting beans or why certain strains of corn are more susceptible to different fungi, you help people more effectively and efficiently plant food. This will help us in the face of climate change. "If you understand why a hamster is aggressive after ingesting a certain substance, you understand the role of that substance and how it could potentially affect humans." That small-picture view — and the cuts made because of it — could have generational impacts on the United States and the world, Chapman said. "This isn't just shutting down one study that focuses on hamsters fighting," she said. "It's preventing a new generation of scientists from coming into the (field), which is going to stunt our growth as a nation, which is going to prevent new ideas from happening, which is going to lead to ... horrible damage that would take years, if not decades, to recover. "People are afraid to come out and criticize this because of the way the government has treated them, especially foreign students. When it gets to the point where the government can strike fear in your heart if you speak out against them, especially about something regarding science, it's a very scary place to be." Local public health departments rattled, services cut Nick Derusha, the director and health officer of the LMAS District Health Department, which also includes Luce and Mackinac counties, said his part of the eastern Upper Peninsula has been rattled by a Trump administration stop-work order that means there's no money to run clinics that provide medicine like methadone to help people wean off opioid drugs and reduce the risk of overdose deaths in Alger and Schoolcraft counties. "We take a really holistic approach to that program," Derusha said. "We're not just providing medication-assisted treatment. We have peer recovery coaches. We have community health workers. We have a lot of staff that are there to support them in many other ways, not just the medication. "When funding is abruptly eliminated like that, we can't just drop people off the caseload. We needed to find a way for them to be able to continue to receive services or some type of off-ramp. We worked with the local hospital, and we agreed for three more months, which is kind of nearing the end here, to continue to provide those services, absent the funding. But the long-term ability of us to do that is not likely." In addition, Derusha said the LMAS department lost $512,000 a year to pay for a courier system for its laboratory services. Because the district is so sprawling — it covers four U.P. counties — when test samples need to be shipped to the regional lab in Luce County, ordinary mail often doesn't get them delivered quickly enough. Without the courier system, it means slower results for important public health testing, he said, which could delay treatments and lead to poorer outcomes. The LMAS District Health Department isn't alone. The Mid-Michigan Health Department, which includes Clinton, Gratiot and Montcalm counties, announced in April it will no longer investigate or treat latent tuberculosis infections because of "funding cuts and workforce limitations." Mental health services for school-age children are being cut, too, said Andrea Cole, president of the Ethel and James Flinn Foundation, a Detroit-based nonprofit dedicated to improving the quality, scope, and delivery of mental health services in Michigan. A $1 billion grant was terminated through the Department of Education in late April to pay for in-school social workers, counselors and other mental health professionals — even though 70% of children who receive mental health services get them through their schools, she said. "A lot of the federal cuts were to the most vulnerable and underserved populations," Cole said. "Schools are faced with the possibility of laying off those people that they hired under that grant if they don't have funding to continue it." And the students will be left without that critical mental health support when "they need it more than ever," Cole said. Hess said all of these cuts, along with proposed legislation — the Big, Beautiful Bill Act, which has passed the U.S. House of Representatives and now is under consideration in the U.S. Senate — that would slash Medicaid and Supplemental Nutrition Assistance Program (SNAP) benefits, and a state Senate budget proposal that also seeks to trim funding even more, public health in Michigan could dramatically change. More: Whitmer: Trump's 'big, beautiful bill' could cost Michigan $900 million a year for food stamps More: 700,000 Michigan residents could lose health insurance under Medicaid cuts, report shows "We don't want to give the impression that the sky is falling, and that public health is going to pack up and go home," Hess said. "We've been here for 100 years, and we've seen ups and downs over the years. Health officers are used to kind of making things work, but this is sort of a unique situation. "Community residents are really going to feel this if all of these things that we are watching come to fruition. Public health will not look the same in their communities, in most places." Contact Kristen Shamus: kshamus@ Subscribe to the Detroit Free Press.
CNBC
21 minutes ago
- CNBC
What to know about Trump's deployment of National Guard troops to L.A. protests
President Donald Trump says he's deploying 2,000 California National Guard troops to Los Angeles to respond to immigration protests, over the objections of California Gov. Gavin Newsom. It's not the first time Trump has activated the National Guard to quell protests. In 2020, he asked governors of several states to send troops to Washington, D.C. to respond to demonstrations that arose after Minneapolis police officers killed George Floyd. Many of the governors he asked agreed, sending troops to the federal district. The governors who refused the request were allowed to do so, keeping their troops on home soil. This time, however, Trump is acting in opposition to Newsom, who, under normal circumstances, would retain control and command of California's National Guard. While Trump said that federalizing the troops was necessary to "address the lawlessness" in California, the Democratic governor said the move was "purposely inflammatory and will only escalate tensions." Here are some things to know about when and how the president can deploy troops on U.S. soil. Generally, federal military forces are not allowed to carry out civilian law enforcement duties against U.S. citizens except in times of emergency. An 18th-century wartime law called the Insurrection Act is the main legal mechanism that a president can use to activate the military or National Guard during times of rebellion or unrest. But Trump didn't invoke the Insurrection Act on Saturday. Instead, he relied on a similar federal law that allows the president to federalize National Guard troops under certain circumstances. The National Guard is a hybrid entity serving state and federal interests. Often it operates under state command and control, using state funding. Sometimes National Guard troops will be assigned by their state to serve federal missions, remaining under state command but using federal funding. The law cited by Trump's proclamation places National Guard troops under federal command. The law says that can be done under three circumstances: When the U.S. is invaded or in danger of invasion; when there is a rebellion or danger of rebellion against the authority of the U.S. government, or when the President is unable to "execute the laws of the United States," with regular forces. But the law also says that orders for those purposes "shall be issued through the governors of the States." It's not immediately clear if the president can activate National Guard troops without the order of that state's governor. Notably, Trump's proclamation says the National Guard troops will play a supporting role by protecting ICE officers as they enforce the law, rather than having the troops perform law enforcement work. Steve Vladeck, a professor at the Georgetown University Law Center who specializes in military justice and national security law, says that's because the National Guard troops can't legally engage in ordinary law enforcement activities unless Trump first invokes the Insurrection Act. Vladeck said the move raises the risk that the troops could use force while filling that "protection" role. The move could also be a precursor to other, more aggressive troop deployments down the road, he wrote on his website. "There's nothing these troops will be allowed to do that, for example, the ICE officers against whom these protests have been directed could not do themselves," Vladeck wrote. The Insurrection Act and related laws were used during the Civil Rights era to protect activists and students desegregating schools. President Dwight Eisenhower sent the 101st Airborne to Little Rock, Arkansas, to protect Black students integrating Central High School after that state's governor activated the National Guard to keep the students out. George H.W. Bush used the Insurrection Act to respond to riots in Los Angeles in 1992 after the acquittal of white police officers who were videotaped beating Black motorist Rodney King. National Guard troops have been deployed for various emergencies, including the COVID pandemic, hurricanes and other natural disasters. But generally, those deployments are carried out with the agreement of the governors of the responding states. In 2020, Trump asked governors of several states to deploy their National Guard troops to Washington, D.C. to quell protests that arose after Minneapolis police officers killed George Floyd. Many of the governors agreed to send troops to the federal district. At the time, Trump also threatened to invoke the Insurrection Act for protests following Floyd's death in Minneapolis — an intervention rarely seen in modern American history. But then-Defense Secretary Mark Esper pushed back, saying the law should be invoked "only in the most urgent and dire of situations." Trump never did invoke the Insurrection Act during his first term. But while campaigning for his second term, he suggested that would change. Trump told an audience in Iowa in 2023 that he was prevented from using the military to suppress violence in cities and states during his first term, and said if the issue came up again in his next term, "I'm not waiting." Trump also promised to deploy the National Guard to help carry out his immigration enforcement goals, and his top adviser Stephen Miller explained how that would be carried out: Troops under sympathetic Republican governors would send troops to nearby states that refuse to participate, Miller said on "The Charlie Kirk Show," in 2023. After Trump announced he was federalizing the National Guard troops on Saturday, Defense Secretary Pete Hegseth said other measures could follow. Hegseth wrote on the social media platform X that active duty Marines at Camp Pendleton were on high alert and would also be mobilized "if violence continues."
Yahoo
22 minutes ago
- Yahoo
Massachusetts has the best state economy, according to WalletHub. Here's why
In order to determine America's best and worst state economies, WalletHub compared the 50 states and the District of Columbia across 28 key indicators of economic performance and strength. The data set ranges from changes in GDP to startup activity to the share of jobs in high-tech industries. Out of all 50 states, Massachusetts received the highest score, beating out the second-place state by over a full point. Here's what WalletHub had to say about the state's economy. According to WalletHub, Massachusetts has the best state economy for various reasons. Economic outlook: Emergency savings are crucial in a recession. Here's the dollar figure to aim for. Here's what the personal finance company had to say about Massachusetts' economy: "Massachusetts invests a lot more in both industry and academic R&D than most other states, which leads to big payoffs in economic growth. This has led to the state having the second-most invention patents per capita. The Bay State has a lot of workers in industries that propel the economy forward, too. It has the highest share of jobs in high-tech industries and the third-highest share of STEM professionals. In addition, Massachusetts has the highest percentage of firms that are listed on the Technology Fast 500 list." Here is WalletHub's list of the top 10 state economies: Massachusetts Utah Washington California New Hampshire North Carolina Idaho Texas Maryland Colorado This article originally appeared on The Patriot Ledger: Massachusetts' economy ranked top in US by WalletHub. Here's why Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
