Is there a new global health threat? Fungal superbugs spread panic with climate change expanding its reach

Economic Times

07-05-2025

Another dangerous fungus causes lung issues
WHO lists 19 fungal species as urgent priorities
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Climate change could exacerbate the spread
Urgent need for antifungal innovation
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A new global health threat is emerging—drug-resistant fungal infections . These microscopic fungal spores like Coccidioides , responsible for valley fever , are infecting people who inhale them from air or soil, even in their own backyards.Torrence Irvin from California became critically ill after he unknowingly inhaled the spores. Doctors took nearly a year to correctly diagnose him. However, by that time, he had lost a significant amount of weight and nearly died.As per a CNN report, another survivor Rob Purdie contracted fungal meningitis after he inhaled spores while gardening and now depends on lifelong toxic treatments. Aspergillus fumigatus , another dangerous fungus, could spread across Europe, Asia, and the Americas, and will affect millions of vulnerable individuals. This fungus, a study said, thrives in warm, damp environments and could potentially infect people by invading their lungs, particularly those who have underlying health issues like asthma, cystic fibrosis, or weakened immune systems.The World Health Organisation (WHO) reportedly has enlisted nearly 6.5 million invasive fungal infections. This, they said, results in 3.8 million deaths globally each year and the numbers are climbing due to increasing drug resistance.They listed 19 fungal species under urgent priorities for new drug development, among which Aspergillus fumigatus is one. Other dangerous species include Cryptococcus neoformans (deadly meningitis), Candida auris (highly drug-resistant hospital infections) and Candida albicans (common yeast that can become invasive).The CNN report stated that developing antifungal drugs is especially challenging since fungi are genetically closer to humans than bacteria. This means, the treatments can harm human cells, which could result in kidney failure, liver damage, or other severe side effects.Dr Neil Clancy, an infectious disease specialist and associate professor of medicine at University of Pittsburgh, told CNN that if an antifungal drug is being made, it is crucial to come up with formulations that will not harm genes and human proteins.Experts have noted that changing climate patterns, wildfires, and dust storms likely expand the fungi's geographic reach. Reportedly, cases of Coccidioides infection have been reported in over 20 US states, including regions which previously were unaffected.The study on Aspergillus fumigatus stated it could expand across an additional 77 per cent of global territory by 2100 as climate change is accelerated. Researchers have estimated that 9 million people in Europe alone could be exposed to infection risks if fungus takes hold.Reportedly, the fungus can grow rapidly in compost at high temperatures and can survive the human body's internal heat of 37°C. It was also found thriving in extreme environments like Chernobyl's nuclear reactors.Experimental drugs like Olorofim offer hope, however, experts have warned that limited specialist access and lack of public awareness could leave many patients untreated or misdiagnosed. More research, better treatments, and physician training are urgently needed to confront this growing fungal superbug threat, stated the CNN report.Professor Elaine Bignell, co-director at the MRC Centre for Medical Mycology at Exeter University, said that the development of new antifungal treatments has been slow. One key reason, as per an NDTV report, is financial unattractiveness of investing in antifungal medicines.Reportedly, the antifungal medicines are costly to develop and often spotted as less profitable compared to others in drug market.They are fungal infections that no longer react to usual antifungal treatment, so they are more difficult to treat and are possibly fatal.WHO includes species such as Aspergillus fumigatus, Candida auris, Cryptococcus neoformans, and Coccidioides among the most lethal ones.