logo
OSU researchers create nasal spray that could stop the flu; blocks infection in mice

OSU researchers create nasal spray that could stop the flu; blocks infection in mice

Yahoo24-05-2025

An antibody that could revolutionize the prevention of influenza, other viruses and even non-viral diseases like cancer was recently engineered by Ohio State scientists.
In a study published April 29, this new molecule was successful in protecting a majority of the tested mice from lethal flu doses, even preventing some from experiencing any symptoms at all, according to a May 8 Ohio State News article.
Head researcher and the study's co-lead author Dr. Kai Xu said the engineered molecule — transmitted via nasal spray — works by triggering 'mucosal immunity,' meaning it coats the tissue that lines the body's organs and tracts before a virus can enter.
By contrast, current flu vaccines rely on 'systemic immunity,' which fights the virus after infection. Xu said combining both immune responses into one engineered antibody could 'enhance the protection' of conventional, injection-based vaccines.
'Our creation can complement the conventional vaccine in terms of targeting to prevent the seasonal flu infection,' Xu, also an Ohio State assistant professor of veterinary biosciences, said. 'It can be a replacement, but we believe that these two can synergize with each other.'
Researchers created the new antibody by combining two existing ones: immunoglobulin G, which makes up most antibodies in the human body and has two 'arms' to target specific viruses, and immunoglobulin M, the immune system's first line of defense with 10 'arms' to attack infection.
Traditionally, flu prevention has focused on IgG. The problem, Xu said, is that the flu virus can mutate, making it harder for IgG to identify and fight it. IgM, however, can still latch onto the virus even if a part of it changes, thanks to its many arms.
By combining IgM's 'stickiness' with IgG's precision, Xu said his lab engineered an antibody that could neutralize the flu more effectively than either antibody alone.
When tested on mice using a nasal spray, Xu said the antibody successfully stuck to their mucosal surfaces for a week, protecting most from lethal doses of common flu strains. Xu said this finding suggests the antibody could work similarly in humans.
If used to complement existing flu vaccines, the engineered antibody would be especially beneficial not only in years when medical professionals inaccurately predict the specific strain that spreads during flu season, but also for individuals who don't have a strong immune response to vaccines, Xu said.
Since this study was published, Xu said his team has continued its analysis to work toward a large-animal experiment — which is necessary before a clinical trial can take place — and optimizing the molecule's production so large amounts can be obtained quickly for further testing.
Xu said his team is also working on expanding the scope of this study to other kinds of illness beyond influenza — from bird flu to cancer to coronavirus. By working with other research programs at Ohio State and pharmaceutical company IGM Biosciences, Xu said he hopes his team's research can one day become a therapeutic drug.
'This research really benefits from multidisciplinary collaboration,' Xu said. 'I think that by enhancing the collaboration within OSU and even with the industry partner in the future, we will certainly enhance our research for a national medicine.'
Reporter Emma Wozniak can be reached at ewozniak@dispatch.com, or @emma_wozniak_ on X, formerly known as Twitter.
This article originally appeared on The Columbus Dispatch: OSU study finds new antibody to prevent the flu through nasal spray

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

RFK Jr. Purges CDC's Vital Vaccine Advisory Committee
RFK Jr. Purges CDC's Vital Vaccine Advisory Committee

Gizmodo

time22 minutes ago

  • Gizmodo

RFK Jr. Purges CDC's Vital Vaccine Advisory Committee

On Monday afternoon, the head of HHS enacted a "clean sweep" of the Advisory Committee on Immunization Practices. Robert F. Kennedy Jr. is continuing his ideological purge of the federal government. The Health and Human Services Secretary just terminated all 17 members of the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP)—the outside experts who help steer the country's vaccine policies. Kennedy announced the firings late Monday afternoon in an editorial published by the Wall Street Journal. He argued that by 'retiring' the ACIP's current members, he would restore the public's trust in vaccines. However, RFK Jr. himself has long overexaggerated the dangers of vaccination, and experts worry that he will stock the ACIP with anti-vaccination proponents. 'Today's action to remove the 17 sitting members of ACIP undermines…trust and upends a transparent process that has saved countless lives,' said Bruce Scott, president of the American Medical Association, in a statement provided to Gizmodo. 'With an ongoing measles outbreak and routine child vaccination rates declining, this move will further fuel the spread of vaccine-preventable illnesses.' The ACIP is a panel of outside experts assembled by the CDC. Their recommendations, formally adopted by the CDC, greatly influence which vaccines are routinely provided to the public. States often mandate that children receive vaccines universally recommended by the ACIP, such as the measles, mumps, and rubella (MMR) vaccine, before they can enter public school, for instance. Insurance plans are also typically required to cover ACIP-recommended vaccines without any cost-sharing. For two decades, RFK Jr. has regularly misrepresented the evidence on vaccine safety and other important health issues. And it didn't take long for him to signal that he would undermine the country's vaccine policies. In his opening speech as the head of HHS in mid-February, Kennedy stated that he would form a commission to investigate the childhood vaccine schedule as a potential culprit of chronic disease (no strong evidence supports a connection between the vaccine schedule and a population-level rise in chronic illness). Kennedy has previously argued that the ACIP's current and former members were rife with conflicts of interest, such as having received money from vaccine manufacturers. During the Senate committee hearings this January, for instance, he claimed that 97% of ACIP members had these conflicts—an unsurprisingly misleading claim. Kennedy was wrongly citing a 2009 report that found 97% of financial disclosure forms from people on advisory committees in 2007 had at least one error or omission, such as missing dates. Kennedy's latest WSJ editorial correctly describes the 97% statistic, though he still appears to imply these omissions are largely undeclared financial conflicts (the 2009 report found that 15% of members did not comply with ethics requirements during their committee stints). Aside from eliding the truth about the ACIP's ethical standards, Kennedy seems to have outright broken his promise to Senator Bill Cassidy (R-Louisiana) that he would 'maintain' the ACIP without changes—a promise that secured Cassidy's pivotal tiebreaker vote in early February to further his nomination through the Senate. On a X post late Monday, Cassidy acknowledged many people's fears that the ACIP will now 'be filled up with people who know nothing about vaccines except suspicion.' But Cassidy didn't acknowledge the broken promise, only stating that he would continue talking with Kennedy to 'ensure that this is not the case.' Of course, now the fear is that the ACIP will be filled up with people who know nothing about vaccines except suspicion. I've just spoken with Secretary Kennedy, and I'll continue to talk with him to ensure this is not the — U.S. Senator Bill Cassidy, M.D. (@SenBillCassidy) June 9, 2025 Of course, there's little reason to believe that RFK Jr's antivax agenda will be meaningfully constrained by anyone in the government. He's already enacted a renewed investigation into the debunked link between vaccines and autism—an investigation that will be led by notorious vaccine skeptic David Geier. Kennedy and the Trump administration have also impeded the development of newer, possibly more effective vaccines for both flu and covid-19, and are attempting to place testing roadblocks that will make future vaccine approvals harder to secure.

Archeologists using drones find new clues at 1,000-year-old indigenous farm site in Michigan's Upper Peninsula
Archeologists using drones find new clues at 1,000-year-old indigenous farm site in Michigan's Upper Peninsula

CBS News

time22 minutes ago

  • CBS News

Archeologists using drones find new clues at 1,000-year-old indigenous farm site in Michigan's Upper Peninsula

New research assisted by drone technology has added more details and understanding of what was already known to be a series of ancient farming fields in Michigan's Upper Peninsula. The study was led by Dartmouth College in Hanover, New Hampshire, with the findings recently published in Science. "Through this research, we get this little window of preservation into pre-Colonial farming in the Upper Peninsula of Michigan," said senior author Jesse Casana, a professor of anthropology. The research is pointing to the ancient agricultural area in the Anaem Omot region being 10 times larger than what was previously thought; making it the most complete ancient agricultural site confirmed in the eastern United States. Research site at an ancient indigenous farm along the Menominee River in Michigan's Upper Peninsula. Madeleine McLeester/Dartmouth College The site is along the Michigan-Wisconsin border. "Our work shows that the ancestral Menominee communities were modifying the soil to completely rework the topography in order to plant and harvest corn at the near northern extent of where this crop can grow," Madeleine McLeester, assistant professor of anthropology, said. "This farming system was a massive undertaking requiring a lot of organization, labor, and know-how to maximize agricultural productivity." Ancestors of what is now known as the Menominee Indian Tribe of Wisconsin constructed a series of raised ridge garden beds that were 4 to 12 inches in height and used to grow corn, beans, squash and other plants. That's the series of fields that the researchers took a look at. The agriculture region is near already identified burial mounds and a village site that were excavated during the 1950s through 1970s. It was initially mapped and excavated in the 1990s, and is listed on the U.S. National Register of Historic Places. On the request of Menominee tribal leaders, Dartmouth archaeologists were invited to survey and document the area. The team worked with David Grignon, tribal historic preservation officer for the Menominee Indian Tribe of Wisconsin, and the late David Overstreet, a consulting archaeologist for the College of the Menominee Nation. The survey took place in May 2023, after the snow had melted but before the forest tree leaves had emerged. Lidar images taken in 2023 that were used to assist archaeology work at the Menominee Sixty Islands site. Lidar images by Carolin Ferwerda and Jesse Casana The team used drones equipped with lidar, a remote sensing technology that uses pulses of light from a laser. The lidar could detect changes in topography that are normally hidden under the forest tree canopy; while the drones could get close to ground level for a better look. The lidar found signs of agricultural ridges across the landscape, a circular ring, remains of a building foundation, and even previously unknown burial mound locations. Then in August 2023, the excavation team worked at three of the agricultural ridges near the Menominee River. They found broken pieces of ceramics, charcoal and soil additions. They also determined through radiocarbon dating of charcoal samples that the construction was around the year 1000 and rebuilt over the following 600 years. The survey work focused on 330 acres, but researchers said there are signs that the site goes well beyond the designated area and was probably double that in size. Research work will continue at the Menominee Sixty Islands site, the college said.

Sam's Club nearly done with plan to remove 40 harmful ingredients from its food and drink
Sam's Club nearly done with plan to remove 40 harmful ingredients from its food and drink

Fox News

time27 minutes ago

  • Fox News

Sam's Club nearly done with plan to remove 40 harmful ingredients from its food and drink

Heeding the call of HHS Secretary Robert F. Kennedy Jr. to remove synthetic dyes from the foods and beverages of Americans, Sam's Club is one of the latest organizations to hop on board. The brand's "Made Without" initiative has reached 96% of its goal of removing artificial colors, additives, dyes and high-fructose corn syrup from its Member's Mark food and beverages, its private brand. The "Made Without" initiative lists 40 ingredients that the membership-based warehouse hopes to remove by 2025. "This accomplishment underscores how Sam's Club prioritizes what matters most to members, by aligning its offerings with evolving dietary preferences and developing products made with simpler, more recognizable ingredients," Sam's Club announced in a press release. "It also highlights the Member's Mark brand's broader purpose — to provide access to a better quality of life — through high-quality products made without certain ingredients," the release also noted. Sam's Club pointed to the demands of its customers, noting that 72% of its members surveyed are "actively seeking minimally processed foods" and 90% want to either "live or aspire to live a healthier lifestyle." The Make America Healthy Again Commission, chaired by Sec. Kennedy, released a recent report assessing chronic diseases, particularly those suffered by children. The report said that nearly 70% of calories consumed by American children come from ultraprocessed foods, which are "high in added sugars, chemical additives, and saturated fats, while lacking sufficient intakes of fruits and vegetables." Ultraprocessed foods have been linked to chronic diseases, including obesity, type 2 diabetes, cardiovascular disease and certain cancers, the report states. Julie Barber, chief merchant at Sam's Club, said in the press release that the company takes "pride in the high-quality ingredients that go into our products." "What truly differentiates us are the ingredients we consciously leave out … Our 'Made Without' commitment underscores our aspiration to be members' go-to destination for quality at a disruptive value," said Barber. Aside from food, the "Made Without" list also includes phthalates, which are commonly used in personal care products, food packaging and synthetic fabrics. "Continuous exposure to certain phthalates can trigger hormone dysregulation and reproductive and developmental problems for babies in-utero and infants," noted the MAHA report. "The FDA has restricted the use of several phthalates in food packaging and industry has discontinued use over time." Fox News Digital reached out to Walmart, owner of Sam's Club, for further comment.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into the world of global news and events? Download our app today from your preferred app store and start exploring.
app-storeplay-store