Priothera Appoints Dr. Jens Hasskarl as Chief Medical Officer to Drive Late-Stage Clinical Development of Mocravimod, a S1P Receptor Modulator for Acute Myeloid Leukemia (AML)
Priothera
Dr. Hasskarl to lead global Phase 3 MO-TRANS study evaluating mocravimod as an adjunctive treatment to allo-HCT in AML
Saint-Louis, France and Dublin, Ireland – 6th May 2025– Priothera Ltd., a late-stage biopharma company pioneering the development of mocravimod, a novel oral sphingosine 1 phosphate (S1P) receptor modulator, to treat hematologic malignancies, today announced the appointment of Jens Hasskarl, MD, PhD, as Chief Medical Officer (CMO). Dr. Hasskarl will oversee the global Phase 3 clinical study MO-TRANS of mocravimod, which is being developed as an adjunctive treatment in acute myeloid leukemia (AML) to enhance the curative potential of allogeneic hematopoietic cell transplantation (allo-HCT).
Dr. Hasskarl brings over two decades of international leadership experience in clinical development, translational science and medical affairs across top-tier pharma, biotech and academic institutions. Most recently, he served as CMO at Advesya AG, where he led the strategic development of novel immunotherapies in haemato-oncology and autoimmunity. He previously held senior executive roles at Tigen Pharma, Celgene and Novartis, where he was instrumental in the development and global approval of multiple cellular therapies including Breyanzi®, Abecma® and Kymriah®.
"Jens' deep expertise in hematology, cellular therapy and translational drug development, combined with his entrepreneurial mindset and proven track record in leading successful global clinical programs, make him the ideal fit," said Florent Gros, Co-Founder and CEO of Priothera. "His insight and leadership will be critical as we prepare for the final phase of clinical execution and regulatory engagement for mocravimod. We would like to thank Dr. Elisabeth Kueenburg, Priothera's former CMO, for her contributions and wish her every success in her future endeavors."
'I am thrilled to join Priothera during such an exciting phase,' said Dr. Hasskarl, CMO of Priothera. 'The company's science-driven approach and commitment to improving outcomes for patients with AML aligns perfectly with my focus on advancing innovation in hematology. I look forward to working closely with the team to bring this promising therapy to patients worldwide.'
Dr. Hasskarl holds an MD and PhD from Heidelberg University and the German Cancer Research Center. He completed a postdoctoral fellowship at Harvard Medical School and holds a diploma in Health Economics. He is a board-certified Internist with a specialty in hematology and oncology and continues to lecture at Freiburg Medical School in Germany.
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Forbes
an hour ago
- Forbes
14 Delicious Bourgogne (Burgundy) Wines From Five Different Regions
After recently visiting multiple producers and tasting 130 wines from the Bourgogne region in France, I selected the following 14 bottles from five of its wine producing sub-regions based on their overall quality and value. This renowned French wine region is now pressing to be called Bourgogne rather than its English translation of Burgundy (or Italian translation of Borgogna). The reasons are varied, including that most names of other French wine regions are not translated, and—intriguingly—that the color referred to as 'Burgundy' in English is called 'Bordeaux' in France and Italy. Bourgogne includes 84 distinct appellations, divided into Régional, Village (including Premier Cru) and Grand Cru distinctions, as well as over 1,800 climats—delineated vine plots with unique geological, exposure and hydrological characteristics that produce their own signature aromas/flavors. Prices for wines range widely within Bourgogne, and the region's overall cachet results in a small percentage of its wines commanding notably high prices (although Bourgogne produces 0.4% of the world's volume of wine, that accounts for 4% of global wine trade value). The selected wines below are listed from north to south, within the distinct sub-regions of Chablis & Grand Auxerrois, Côte de Nuits and Hautes Côtes de Nuits, Côte de Beaune and Hautes Côtes de Beaune, Côte Chalonnais and Couchois, and Mâconnais. All wines listed below are made either from white Chardonnay or red Pinot Noir grapes (although a smaller quantity of often excellent wines are made in the Bourgogne using Aligoté, César, Gamay and other grapes). 'Value' is determined by my proprietary Vino Value algorithm that normalizes and combines subjective tasting scores with objective bottle prices (retail, at cellar door) to identify wines of good (♫), excellent (♫♫) and superlative (♫♫♫) value—providing optimal 'bang for the buck.' Note that prices are local in France, and will be higher in the U.S. due to various factors. Note also that these selected wines represent only a very small sample of many high quality wines of desirable value from Bourgogne. Porte Noël in the city of Chablis, Bourgogne, France Domaine des Malandes. Fourchaume. AOC Chablis 1er Cru. 2023. 93-94 points. €40.00/$45.60. Excellent Value ♫♫. From Amandine Marchive and Richard Rottiers, whose grandmother began making wines in the region 50 years ago. The family ages most wines in a 70/30 blend of steel tanks and 500 liter Burgundian medium toasted barrels with oak from the Vosges forest. This Chardonnay includes complex aromas of honey and layered tropicals from one of the warmest climats in Chablis. Slightly nutty flavors in a crunchy, enticing mouthful of caramel and slight green apples in this Chardonnay. 'Our goal is to harvest quickly,' Amandine explained. 'Otherwise if it is hot in August you can lose acidity; if it is rainy there is a threat of mildew. We harvest 30 hectares [75 acres] in eight days, hand picking for Premier and Grand Cru plots.' Amandine Marchive of Domaine des Malandes, Chablis, Bourgogne, France Domaine Verret. Chardonnay. AOC Bourgogne Côtes d'Auxuerre. 2023. 91-92 points. €12.00/$13.70. Good Value ♫. From an estate with 148 acres (60 hectares), this 12.5% Chardonnay is vinified 50/50 in steel and used oak barrels and includes aromas of herbs, green apples, myrtle and slight salinity. Chewy, oily mouth feel in this semi-complex wine with a finish that includes slight caramel and lemon/line flavors. Domaine Gabin et Félix Richoux. Veaupessiot. AOC Irancy. 2021. 92-93 points. €25/$28.50. Excellent Value ♫♫. Irancy is an outlier—a village and appellation producing only red wines within Chablis, which is renowned for its dominant white wines. The village includes 250 residents, of which 10 are winemakers. With vines located above the River Yonne, these second generation winemaker brothers grow Pinot Gris, Pinot Noir and César—a rare grape with big clustered bunches. Most of their visitors come from Paris, which is only two hours away by train. This Pinot Noir from a cool year vintage aged two years in oak and includes classic Burgundian aromas, including black currants and black cherries as well as some flint and black pepper. Soft and silky tannins. Gabin Richoux of Domaine Richoux, Irancy, Chablis, Bourgogne, France Domaine Le Guellec-Ducouet. Clos Champ. AOC Gevrey-Chambertin. 2023. 96-97 points. €44.00/$50.20. Superlative Value ♫♫♫. This domaine is owned by two business partners—one a winemaker and the other with roots in banking. Michaël Le Guellec took control over vines controlled by his family since 1920, although previously leased out. They use no chemicals. 'We try to make wines fresh and fruity, which people like to drink soon,' Michaël explained. Wines are exported to Asia, Europe and the U.S. Vines that produced grapes for this 13.5% alcohol Pinot Noir wine were planted between 1933 and 1985. Classic Burgundian aromas, including black pepper and volatiles. Suave tannins in this powerful, hefty, structured beauty of a wine with spice rack and elegance on the finish. Compelling, classic and a bargain. Winemaker Michaël Le Guellec of Domaine Le Guellec-Ducouet in Brochon, Côte-de-Nuits, Bourgogne, France, Domaine des Beaumont. AOC Morey-Saint-Denis. 2022. 92-93 points. €43.00/$49.00. Excellent Value ♫♫. Brothers Tanguy and Exupèry, both in their 20's, are 8th generation producers for a family that owns a 13.5 acre (5.5 hectare) estate. The wine is produced from grapes from five different plots and includes edgy aromas of bacon, petrol and wild fennel. This is a dark and hardy Pinot Noir, reminiscent partially of a Colorino, with flavors that include black licorice and star anise. Firm tannic backbone. Pair with grilled beef. Keep going brothers— the results are well worth it! Brothers Tanguy (right) and Exupéry Beaumont, Domaine des Beaumont, Morey-Saint-Denis, Côte-de-Nuits, Bourgogne, France Domaine de Montmain. Les Jiromées Grande Tradition. AOC Bourgogne Hautes Côtes de Nuits. 2022. 92-93 points. €36.00/$41.10. Excellent Value ♫♫. This wine estate is located up a beautiful valley west of, and perpendicular to, the axis of the hills that form the Côte d'Or. All wines are aged in oak, usually 30% new. Thirty-five year old Mathieu Piedcourt, originally from Cahors, has turned the valley and winery into a popular destination for visitors and sells wines via a thousand member club as well as by direct sales and export. The story of Mathieu is too fantastic to share in this brief space. This Chardonnay spent two years aging in new oak barrels. Aromas are bright, powerful and succulent and include grapefruit, limes and white flowers. The juice is not filtered. 4,000 bottles produced. 'We love what we do and we love to share it with others. Last year we had 8,000 visitors. We receive you whether you buy wine or not. I love wines that are powerful but with finesse.' Mathieu Piedcourt of Domaine de Montmain, Villars-Fontaine, Haut-Côte-de-Nuits, Bourgogne, France Maison Louis Latour. Pinot Noir. AOC Bourgogne. 2022. 91-92 points. €20.70/$23.60. Good Value ♫. Louis Latour, a venerable estate that has been in business since 1797, produces not only wines from 119 acres (48 hectares), but owns a cooperage that produces some 3,000 barrels a year—and has done so for centuries. Except for those barrels used in house, all are exported internationally to countries that include Australia and Canada. This 13% alcohol Pinot Noir of solid value includes firm tension between acidity and fruit and is an easy drinking wine to start of a summer gathering. Consider pairing with a dish that includes fat to match its tannic backbone. Cellars with old bottles within Domaine Louis Latour, Beaune, Bourgogne, France Maison Shaps. Les Vaumuriens. AOC Pommard. 2022. 95+ points. €48.00/$54.70. Superlative Value ♫♫♫. Hanna Shaps has been managing this winery for her American father Michael who also produces wine in Virginia in the U.S. 'It's important to be a French-American producer and not an American-French producer,' Hanna explained. The maison is a negociant, and produce some 15 different cuveés and 20,000 bottles per year from four hectares (10 acres) the family owns. This Pinot Noir wine aged 15 months in 50% new oak. Includes sunny, bright, striking and elegant aromas that include sage and black pepper. A wine with heft and structure, shouldered tannins and flavors that include black peppers. A dark, edgy and textured Pinot Noir with sesame and soy on the finish. Hotel de Ville, Beaune, France Bernard et Florian Regnaudot. Clos des Loyéres. AOC Maranges 1er Cru. 2020. €18.00/$20.50. 95+ points. Superlative Value ♫♫♫. This domaine is named after the father/son, 3rd/4th generation winemakers. Florian spent time making wine in Winona, Minnesota in the U.S. The Maranges appellation will be the site for the January, 2026 Saint-Vincent Tournante weekend long festival of music, wine and food. From vines planted in 1931, this Pinot Noir wines includes aromas of blackcurrants, black pepper, tobacco and tar. This is a deep, dark, peppery and elegant wine at astonishing value. Gentle fruit and light, slick tannins. Florian Regnaudot of Domaine Bernard and Florian Regnaudot, Santenay, Côte de Beaune, Bourgogne, France Domaine de l'Evêché. Édition Limitée. Pinot Noir. AOC Bourgogne Côte Chalonnaise. 2022. 92-93 points. €25.00/$28.50. Excellent Value ♫♫. Quentin Joussier, fourth generation winemaker, works with his father Vincent, who bought the winery in 1985. The name of the winery translates to 'the bishop.' This Pinot Noir ages in new barrels and is only produced on years when conditions are optimal. Deep, rich aromas of red cherries, raspberries and some Dutch dorp licorice as well as wild fennel. Well integrated and elegant tannins and easy drinking. Quentin Joussier of Domaine de l'Evêché, Saint-Denis-de-Vaux, Côte Chalonnaise, Bourgogne, France, Domaine Michel Juillot. Clos du Roi. AOP Mercurey Premier Cru. 2024. 93-94 points. €35.00/$40.00. Excellent Value ♫♫. Beautiful cheery, light, floral aromas in this Pinot Noir. Precise and focused flavors include red cherries. Winemaker Maxime Rolant said that, 'For me, Mercurey is cherries.' No disagreement with that. Maxime Rolant of Domaine Michel Juillot, Mercurey, Côte Chalonnaise, Bourgogne, France Domaine Montbarbon. En Pommetin. AOC Viré-Clessé. 2023. 92-93 points. €21.00/$24.00. Excellent Value ♫♫. From this estate, on a clear day you can look east and see Mont Blanc, tallest peak in continental Europe. They have 32 acres [13 hectares] of vines, exclusively Chardonnay. Jean-Jacques Féral was a journalist before becoming a winemaker, and won an award for his winemaking in the Mâconnais region in 2022. He works with Martin Froppier. The estate provides vine cuttings to a nursery in the Savoie, which creates massal (rather than clonal) replacement vines for them. This Chardonnay ages eight months in 500 liter oak barrels as well as six months in steel. Aromas of mandarins and menthol and slight salinity. A rich, creamy, delicious wine that includes precise flavors of tropical fruits and slight honey. Pair with chicken, or a caramelized apple tart (tarte tatin). Jean-Jacques Féral of Domaine Montbarbon, Virè, Mâconnais, Bourgogne, France Domaine Auvigue. Au Vignerais. AOP Pouilly-Fuissé 1er Cru. 2021. 94+ points. €34.00/$38.90. Superlative Value ♫♫♫. The winery is located in a beautifully renovated centuries old church. Sylvain Brenas explained their thinking. 'The idea is to show a different style of Chardonnay. We are in the extreme south of Mâconnais, only a few kilometers from where the Beaujolais appellation begins.' This Chardonnay aged 16 months in a 50/50 combination of steel and oak. Aromas of salinity, pineapple, mangos. Crisp and creamy mouthful with slight menthol and guavas on the finish. Pair with scallops and shallots. Sylvain Brenas of Domaines Auvigue, Fuissé, Máconnais, Bourgogne, France Domaine Corsin. L'Exception. AOP Pouilly-Fuissé. 94-95 points. €39.80/$45.50. Superlative Value ♫♫♫. This winery, founded in 1864, gathers grapes from 40 separate plots. The hosts, including Pauline Mussy and Tiphanie Fortune, are casual, down to earth, warm and unpretentious. Their welcoming tasting room inadvertently resembles an Alpine ski lodge. This Chardonnay is made by winemaker Jérémy Corsin using grapes from three different plots and 70 year old vines. It is barrel vinified and barrel aged. Flinty, slightly salty and classic Burgundian Chardonnay aromas. Rich and creamy mid palate with crisp acidity and rich tropical fruits. Winemaker Jérémy Corsin with a bottle of 1997 Domaine Corsin, Mâconnais, Bourgogne, France
Yahoo
4 hours ago
- Yahoo
Eve Air Mobility Twenty-Year Market Outlook Highlights Growth of Urban Air Mobility Globally
Outlook highlights a $280 billion passenger revenue and 30,000 aircraft opportunities driven by urban population growth, traffic concerns, and a commitment to sustainability. PARIS, June 15, 2025 /PRNewswire/ -- Eve Air Mobility (NYSE: EVEX; EVEXW), a global leader in electric vertical take-off and landing (eVTOL) aircraft, published its inaugural Global Market Outlook. The Outlook highlights the growth and demand surrounding the urban air mobility category for the next 20 years and provides insights into the societal, regional, and use case-specific factors driving demand. The Global Market Outlook leverages data on 1,800 cities on the UN's World Urbanization Prospects database, 1,000 airports, and over 27,000 civil helicopters currently in operation. "The Global Market Outlook furthers the excitement and momentum we have seen in collaborating with our customers and municipal partners worldwide," said Johann Bordais, CEO of Eve Air Mobility. "Today, the UAM market benefits from urban growth, higher traffic congestion, and a positive shift towards sustainable mobility. Demand for UAM is strong and marks the beginning of a major shift in how people will move and live in cities worldwide." This report sets the stage for the 2025 Paris Air Show, where a major highlight will be the unveiling of Eve Air Mobility's full-scale mockup, showcasing a design evolution that enhances the Eve-100 aircraft's performance. The mockup, to be displayed in the Embraer pavilion outside Chalet #300, will showcase several key enhancements. These include a new cabin design, the addition of four-blade propellers, and wheeled landing gear. These improvements are designed to significantly enhance the safety, accessibility, comfort, performance, and maneuverability of the Eve-100, setting a new standard in Urban Air Mobility. Transporting Three Billion Passengers by 2045The topline numbers from The Global Market Outlook show an estimated in-service vehicle fleet of 30,000 eVTOLs by 2045. This fleet figure will be needed to support the estimated three billion passengers, creating a potential revenue of $280 billion. Critical use cases driving growth include Urban Point-to-Point, Airport Shuttle, and Tourism, Medical Services, Corporate, Private and Charter. From a key driver perspective, the Outlook points to urban congestion as one of the critical factors demonstrating the need for alternative means of transportation as the 2022 United Nations World Population Prospects points to over two billion more people living in cities by 2050. Other data highlighting these congestion challenges include: By 2035, more than eight hundred cities will have a population of more than one million, accounting for over 2.5 billion people (World Cities Report, United Nations 2022). This growth will only accelerate the congestion challenges seen to date. In 2024, congestion continued to be a significant issue in major markets. For example, cities such as London (226 hours), New York (196 hours), Bengaluru (234 hours), Sao Paulo (222 hours), and Johannesburg (112 hours) saw significant annual time lost per person due to congestion. Regional BreakdownEve anticipates significant Asia-Pacific growth driven by dense megacities and a rising middle class. North America shows promise due to substantial investment and an established aviation ecosystem. Europe may grow more slowly because of regulatory challenges. Latin America presents opportunities with eVTOLs addressing urbanization and renewable energy. While smaller, the Middle East is an early adopter focused on innovation and sustainable transportation. The Africa market is driven by the opportunity to overcome infrastructure challenges from high urban population growth and enhance tourism experience. Key UAM Enablers and ChallengesWhile the future of urban air mobility is strong and shows great promise, the industry will have to overcome numerous challenges to realize its full challenges include: Safe operations: High safety is a non-negotiable requirement for high-scale operations. Regulatory approval: A comprehensive but accessible regulatory environment for a safe ecosystem is critical. Air traffic management (ATM): Airspace integration and future uncrewed operations are two areas where ATM will play a key role in high-density operations. Ecosystem: Existing heliport infrastructure is necessary to accommodate near-term operations. Battery technology: Higher battery densities are required for broader and longer-range applications. The public acceptance of UAM will depend on a combination of these factors. Click here to request a copy of the UAM Global Market Outlook. About Eve Air Mobility Eve Air Mobility is dedicated to accelerating the Urban Air Mobility (UAM) ecosystem. Benefitting from a start-up mindset, backed by Embraer S.A.'s more than 50-year history of aerospace expertise, and with a singular focus, Eve is taking a holistic approach to progressing the UAM ecosystem, with an advanced eVTOL project, comprehensive global services and support network and a unique air traffic management solution. Since May 10, 2022, Eve is listed on the New York Stock Exchange where its shares of common stock and public warrants trade under the tickers "EVEX" and "EVEXW". For more information, please visit Forward-Looking Statement DisclosureCertain statements contained in this release are forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements may be identified by words such as "may," "will," "expect," "intend," "anticipate," "believe," "estimate," "plan," "project," "could," "should," "would," "continue," "seek," "target," "guidance," "outlook," "if current trends continue," "optimistic," "forecast" and other similar words or expressions. All statements, other than statements of historical facts, are forward-looking statements, including, but not limited to, statements about the company's plans, objectives, expectations, outlooks, projections, intentions, estimates, and other statements of future events or conditions, including with respect to all companies or entities named within. These forward-looking statements are based on the company's current objectives, beliefs and expectations, and they are subject to significant risks and uncertainties that may cause actual results and financial position and timing of certain events to differ materially from the information in the forward-looking statements. These risks and uncertainties include, but are not limited to, those set forth herein as well as in Part I, Item 1A. Risk Factors and Part II, Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations of the company's most recent Annual Report on Form 10-K, Part I, Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations and Part II, Item 1A. Risk Factors of the company's most recent Quarterly Report on Form 10-Q, and other risks and uncertainties listed from time to time in the company's other filings with the Securities and Exchange Commission. Additionally, there may be other factors of which the company is not currently aware that may affect matters discussed in the forward-looking statements and may also cause actual results to differ materially from those discussed. The company does not assume any obligation to publicly update or supplement any forward-looking statement to reflect actual results, changes in assumptions or changes in other factors affecting these forward-looking statements. other than as required by law. Any forward-looking statements speak only as of the date hereof or as of the dates indicated in the statement. View original content: SOURCE Eve Air Mobility Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
5 hours ago
- Yahoo
Edinburgh woman sues charity and earns £8k compensation payout over 'holiday row'
A French woman who sued an Edinburgh charity is entitled to thousands of pounds in compensation from her former employers, a judge has ruled. Lydia Magloire took legal action against Edinburgh non-profit Earth in Common. Edinburgh Live covered the proceedings at the Employment Tribunal in February where Ms Magloire alleged she suffered detriment due to being French, among other claims. Employment Judge Macleod ruled that Ms Magloire should be paid "£7,642.48 by way of compensation for financial loss and injury to feelings". READ MORE: Hollywood actor spotted on Edinburgh city centre street leaving fans starstruck READ MORE: Edinburgh emergency services descend on residential block as street locked down The judge released his decision on June 5, dismissing the claims of racial discrimination but carrying other claims. A report states: "The claimant's claim of indirect discrimination on the grounds of race fails, and is dismissed". However, Judge Macleod found the respondent refused to grant Ms Magloire annual leave and warned her "if she took her holidays she would be dismissed". The report also states Ms Magloire "was dismissed because she raised a protected disclosure" and "was therefore automatically unfairly dismissed". At the Edinburgh Employment Tribunal, Ms Magloire claimed she was 'humiliated' by the company on the basis of her English proficiency. She also claimed one of her managers had a 'strong Aberdeen accent' that was 'hard to understand'. Representing herself at the tribunal, Ms Magloire alternated between answering questions in English and speaking through an interpreter. She became involved with the organisation as a volunteer in 2019, eventually beginning employment at the charity in 2021 as a coordinator. Her employment was terminated on August 21, 2023. The court heard that Earth in Common dismissed Ms Magloire for 'unsatisfactory performance,' which she contested. The court heard Earth in Common dismissed Ms Magloire due to 'unsatisfactory conduct'. The charity claimed Ms Magloire refused to engage with email correspondence, lead workshops, and she booked an extended holiday without approval during one of the charity's busiest months in 2023. Ms Magloire contested that her performance was unsatisfactory, claiming Ms Murray was aware of her intention to take holiday and that she booked the trip prior to her leave being approved to secure cheaper tickets. She told the court she was 'surprised' by her dismissal as she thought that she was doing a 'great job' in her role. She acknowledged her English speaking and writing was not the best but she was improving her proficiency. Ms Magloire added: 'I was very sad. I invested myself a lot in the company. I was totally destroyed emotionally.' Ms Magloire secured new employment at the Edinburgh Zoo in December 2023 where she works 37.5 hours per week as a groundskeeper. She now earns more income than when she was employed at Earth in Common, where she worked 26 hours per week. Earth in Common was founded in 2013 by Evie Murray in an effort to give locals access to outdoor spaces in an urban environment. It repurposed unused land at the northern extremity of Leith Links into community crofts. The charity also runs a cafe and farm shop, which sells local produce. It regularly holds community events focusing on skill-building, exercise, and mental wellbeing. Join Edinburgh Live's Whatsapp Community here and get the latest news sent straight to your messages.
