Common fabric could save lives from most deadly disease
Turning silk like fairy floss into artificial blood vessels will provide a lifeline for cardiovascular patients, scientists say.
Cardiovascular disease is Australia's top killer, contributing to one in four deaths.
But after almost a decade of developing silk artificial blood vessels, researchers are confident they have found a solution to lower the numbers.
In a world-first test, Australians scientists were able to successfully put a silk blood vessel into a sheep in December.
Now they are turning their focus to using one of nature's strongest materials in humans.
"We're the first to bring this natural biomaterial this far along the translational pathway," University of Sydney cardiovascular bioengineering professor Steven Wise told AAP on Wednesday.
"Now we're at a place where we're in sheep and pigs, which are quite like a human."
The vessel starts as a silk cocoon plucked from a farm where it is cut, dried and washed to form a liquid.
It is then spat through a minuscule tube onto a cylindrical roll, where it forms a fluff similar to fairy floss.
Once the fairy-floss solution solidifies, it can be used in bypass surgery as a long-term artery or vein.
The technology will replace current artificial blood vessels, which are made from Gore-Tex, the same material as rain jackets.
"(The plastic is) really bad for you," Professor Wise said.
"They cause blood to clot, so our strategy is to build with a natural material that does belong in your body."
The scientific discovery comes as shovels dig into the ground at the University of Sydney to build a new biomedical centre.
Planned to be completed by 2028, the $780 million Sydney Biomedical Accelerator aims to find solutions to complicated health issues such as cancer and deadly diseases.
NSW is now in the box seat to advance medical technology, according to state Health Minister Ryan Park.
"It's been said for a long time that Victoria is the heart of medical research in this country," he said.
"This puts us back in front of centre in this race.
"This is putting money in our mouth of where we need to go ... (so) our communities can live the most healthy lives possible."
The research hub will play a key role in reducing cardiovascular disease worldwide, Sydney Local Health District chief executive Deb Willcox said.
The disease kills almost 18 million people per year globally, the World Health Organisation says.
"It's an enormous burden across the globe," Ms Willcox said.
"The work that this building bring us will bring treatments forward, provide new medication and procedures, and reduce the burden on people's lives."
The Sydney Biomedical Accelerator is expected to house more than 1200 researchers and clinician scientists once opened.
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The Advertiser
13 hours ago
- The Advertiser
The subtle, everyday hurting of LGBTQI Australians
Witnessing acts of casual homophobia usually involved Lea* turning away as a means of hiding from her own feelings. When initially navigating the LGBTQI world and figuring out her own sexuality, she worried about what would happen if she chose to come out. "When I was an anxious teenager still coming to terms with myself, I saw how people treated the only out lesbian at my all-girls school," she tells AAP. "The feelings I had there were fear of rejection, shame and all of that just built into me, and not wanting to come to terms with myself." Regardless of the forum, casual (or in Lea's terms 'acceptable') homophobia is the act of jokingly or subtly victimising LGBTQI people. Instead of directing slurs or physical violence, someone might say "I wish I was gay" or refer to another as "the gay best friend" or even buy someone a gift based on stereotypes of sexual orientation. About three in every hundred Australians identify as LGBTQI, approximately 40 per cent of whom hide their sexuality and/or gender in public spaces, according to the Australian Human Rights Commission. These days, Lea has reached the conclusion that casual homophobia isn't as much her issue as it is the fault of those who practice it. She regards them as immature and in need of a change in thinking. "I just get really disappointed in people who still think there's not the same legitimacy in queer relationships as there are in straight ones," she says. "I'm really disappointed when I have people in my life who still think that being a lesbian means I'm just thinking about tits all the time." LGBTQI individuals endure poorer mental health outcomes than straight people due to a lack of social acceptance, according to Aids Council of NSW co-ordinator Madhuraa Prakash. "LGBTQI people are six times more likely to be diagnosed with depression and two and a half more times more likely to be diagnosed or treated for a mental health condition in general," they say. "It's unfortunate because you want to be able to talk about your life without having to edit yourself. "It weighs on a person to have to do that in your day-to-day life and leads to some bad mental health outcomes." Academic and psychotherapist Pol McCann specialises in microaggression and says although it sometimes stems from ill-intention, it is primarily patronising and performative. At the same time casual homophobia isn't exclusively directed at LGBTQI people either. Mr McCann says he's also heard from straight men who don't align with "typical" feminine or masculine ideas who have been impacted. He spoke with two straight men who were emotional, artistic and bullied by their peers at school. "They were absolutely lovely, smart, engaged guys but you could just tell they still carried the weight of the pain," he says. In the course of his work within the school environment, Mr McCann has spent time with the perpetrators of discrimination too. Some boys would never appreciate the impact they've had on a person's life, as they regard what they've done to be no more than a joke, he says. "The boys who were doing it, were doing it casually and with no malice," he adds. "These guys actually seemed really nice as adults and I don't think they understood how controlling their behaviour was." With June marking Pride Month, LGBTQI advocates like Justin Koonin know raising these issues is important. As co-chair of the NSW LGBTIQ+ Advisory Body, he has been helping develop a strategy to better include minority voices in legislation. Ensuring schools, police, transport officers and health professionals know how to treat the LGBTQI community better is a key focus. "We see the impact of casual homophobia in terms of the reported experience of mental health and wellbeing, and of safety and self-harm in our communities" Dr Koonin says. "You can't control what's in people's heads and you, to some extent, can't control what people can say but you can try and make it clear to people what hurts and what doesn't. "A lot of our work will be on increasing the level of awareness and exposure to the impact casual homophobia has in our communities." Although LGBTQI people need to lobby against casual homophobia, the straight community also has to play its part, Mr McCann says. He considers Wallaby-turned-senator David Pocock a notable voice in the LGBTQI marriage equality debate after declaring he wouldn't tie the knot with his wife until LGBTQI people could. "Pocock is a football star, incredibly handsome, incredibly charming and when he puts that kind of statement out there... that's got a lot more weight than the gay community lobbying for rights," Mr McCann says. NSW, ACT, Victoria, South Australia and Tasmania have government LGBTQI advisory bodies but federal parliament doesn't. Although a health advisory has been established in Canberra, Dr Koonin says having a committee similar to NSW would benefit the community. *Lea is an anonymous name. Lifeline 13 11 14 Fullstop Australia 1800 385 578 Witnessing acts of casual homophobia usually involved Lea* turning away as a means of hiding from her own feelings. When initially navigating the LGBTQI world and figuring out her own sexuality, she worried about what would happen if she chose to come out. "When I was an anxious teenager still coming to terms with myself, I saw how people treated the only out lesbian at my all-girls school," she tells AAP. "The feelings I had there were fear of rejection, shame and all of that just built into me, and not wanting to come to terms with myself." Regardless of the forum, casual (or in Lea's terms 'acceptable') homophobia is the act of jokingly or subtly victimising LGBTQI people. Instead of directing slurs or physical violence, someone might say "I wish I was gay" or refer to another as "the gay best friend" or even buy someone a gift based on stereotypes of sexual orientation. About three in every hundred Australians identify as LGBTQI, approximately 40 per cent of whom hide their sexuality and/or gender in public spaces, according to the Australian Human Rights Commission. These days, Lea has reached the conclusion that casual homophobia isn't as much her issue as it is the fault of those who practice it. She regards them as immature and in need of a change in thinking. "I just get really disappointed in people who still think there's not the same legitimacy in queer relationships as there are in straight ones," she says. "I'm really disappointed when I have people in my life who still think that being a lesbian means I'm just thinking about tits all the time." LGBTQI individuals endure poorer mental health outcomes than straight people due to a lack of social acceptance, according to Aids Council of NSW co-ordinator Madhuraa Prakash. "LGBTQI people are six times more likely to be diagnosed with depression and two and a half more times more likely to be diagnosed or treated for a mental health condition in general," they say. "It's unfortunate because you want to be able to talk about your life without having to edit yourself. "It weighs on a person to have to do that in your day-to-day life and leads to some bad mental health outcomes." Academic and psychotherapist Pol McCann specialises in microaggression and says although it sometimes stems from ill-intention, it is primarily patronising and performative. At the same time casual homophobia isn't exclusively directed at LGBTQI people either. Mr McCann says he's also heard from straight men who don't align with "typical" feminine or masculine ideas who have been impacted. He spoke with two straight men who were emotional, artistic and bullied by their peers at school. "They were absolutely lovely, smart, engaged guys but you could just tell they still carried the weight of the pain," he says. In the course of his work within the school environment, Mr McCann has spent time with the perpetrators of discrimination too. Some boys would never appreciate the impact they've had on a person's life, as they regard what they've done to be no more than a joke, he says. "The boys who were doing it, were doing it casually and with no malice," he adds. "These guys actually seemed really nice as adults and I don't think they understood how controlling their behaviour was." With June marking Pride Month, LGBTQI advocates like Justin Koonin know raising these issues is important. As co-chair of the NSW LGBTIQ+ Advisory Body, he has been helping develop a strategy to better include minority voices in legislation. Ensuring schools, police, transport officers and health professionals know how to treat the LGBTQI community better is a key focus. "We see the impact of casual homophobia in terms of the reported experience of mental health and wellbeing, and of safety and self-harm in our communities" Dr Koonin says. "You can't control what's in people's heads and you, to some extent, can't control what people can say but you can try and make it clear to people what hurts and what doesn't. "A lot of our work will be on increasing the level of awareness and exposure to the impact casual homophobia has in our communities." Although LGBTQI people need to lobby against casual homophobia, the straight community also has to play its part, Mr McCann says. He considers Wallaby-turned-senator David Pocock a notable voice in the LGBTQI marriage equality debate after declaring he wouldn't tie the knot with his wife until LGBTQI people could. "Pocock is a football star, incredibly handsome, incredibly charming and when he puts that kind of statement out there... that's got a lot more weight than the gay community lobbying for rights," Mr McCann says. NSW, ACT, Victoria, South Australia and Tasmania have government LGBTQI advisory bodies but federal parliament doesn't. Although a health advisory has been established in Canberra, Dr Koonin says having a committee similar to NSW would benefit the community. *Lea is an anonymous name. Lifeline 13 11 14 Fullstop Australia 1800 385 578 Witnessing acts of casual homophobia usually involved Lea* turning away as a means of hiding from her own feelings. When initially navigating the LGBTQI world and figuring out her own sexuality, she worried about what would happen if she chose to come out. "When I was an anxious teenager still coming to terms with myself, I saw how people treated the only out lesbian at my all-girls school," she tells AAP. "The feelings I had there were fear of rejection, shame and all of that just built into me, and not wanting to come to terms with myself." Regardless of the forum, casual (or in Lea's terms 'acceptable') homophobia is the act of jokingly or subtly victimising LGBTQI people. Instead of directing slurs or physical violence, someone might say "I wish I was gay" or refer to another as "the gay best friend" or even buy someone a gift based on stereotypes of sexual orientation. About three in every hundred Australians identify as LGBTQI, approximately 40 per cent of whom hide their sexuality and/or gender in public spaces, according to the Australian Human Rights Commission. These days, Lea has reached the conclusion that casual homophobia isn't as much her issue as it is the fault of those who practice it. She regards them as immature and in need of a change in thinking. "I just get really disappointed in people who still think there's not the same legitimacy in queer relationships as there are in straight ones," she says. "I'm really disappointed when I have people in my life who still think that being a lesbian means I'm just thinking about tits all the time." LGBTQI individuals endure poorer mental health outcomes than straight people due to a lack of social acceptance, according to Aids Council of NSW co-ordinator Madhuraa Prakash. "LGBTQI people are six times more likely to be diagnosed with depression and two and a half more times more likely to be diagnosed or treated for a mental health condition in general," they say. "It's unfortunate because you want to be able to talk about your life without having to edit yourself. "It weighs on a person to have to do that in your day-to-day life and leads to some bad mental health outcomes." Academic and psychotherapist Pol McCann specialises in microaggression and says although it sometimes stems from ill-intention, it is primarily patronising and performative. At the same time casual homophobia isn't exclusively directed at LGBTQI people either. Mr McCann says he's also heard from straight men who don't align with "typical" feminine or masculine ideas who have been impacted. He spoke with two straight men who were emotional, artistic and bullied by their peers at school. "They were absolutely lovely, smart, engaged guys but you could just tell they still carried the weight of the pain," he says. In the course of his work within the school environment, Mr McCann has spent time with the perpetrators of discrimination too. Some boys would never appreciate the impact they've had on a person's life, as they regard what they've done to be no more than a joke, he says. "The boys who were doing it, were doing it casually and with no malice," he adds. "These guys actually seemed really nice as adults and I don't think they understood how controlling their behaviour was." With June marking Pride Month, LGBTQI advocates like Justin Koonin know raising these issues is important. As co-chair of the NSW LGBTIQ+ Advisory Body, he has been helping develop a strategy to better include minority voices in legislation. Ensuring schools, police, transport officers and health professionals know how to treat the LGBTQI community better is a key focus. "We see the impact of casual homophobia in terms of the reported experience of mental health and wellbeing, and of safety and self-harm in our communities" Dr Koonin says. "You can't control what's in people's heads and you, to some extent, can't control what people can say but you can try and make it clear to people what hurts and what doesn't. "A lot of our work will be on increasing the level of awareness and exposure to the impact casual homophobia has in our communities." Although LGBTQI people need to lobby against casual homophobia, the straight community also has to play its part, Mr McCann says. He considers Wallaby-turned-senator David Pocock a notable voice in the LGBTQI marriage equality debate after declaring he wouldn't tie the knot with his wife until LGBTQI people could. "Pocock is a football star, incredibly handsome, incredibly charming and when he puts that kind of statement out there... that's got a lot more weight than the gay community lobbying for rights," Mr McCann says. NSW, ACT, Victoria, South Australia and Tasmania have government LGBTQI advisory bodies but federal parliament doesn't. Although a health advisory has been established in Canberra, Dr Koonin says having a committee similar to NSW would benefit the community. *Lea is an anonymous name. Lifeline 13 11 14 Fullstop Australia 1800 385 578 Witnessing acts of casual homophobia usually involved Lea* turning away as a means of hiding from her own feelings. When initially navigating the LGBTQI world and figuring out her own sexuality, she worried about what would happen if she chose to come out. "When I was an anxious teenager still coming to terms with myself, I saw how people treated the only out lesbian at my all-girls school," she tells AAP. "The feelings I had there were fear of rejection, shame and all of that just built into me, and not wanting to come to terms with myself." Regardless of the forum, casual (or in Lea's terms 'acceptable') homophobia is the act of jokingly or subtly victimising LGBTQI people. Instead of directing slurs or physical violence, someone might say "I wish I was gay" or refer to another as "the gay best friend" or even buy someone a gift based on stereotypes of sexual orientation. About three in every hundred Australians identify as LGBTQI, approximately 40 per cent of whom hide their sexuality and/or gender in public spaces, according to the Australian Human Rights Commission. These days, Lea has reached the conclusion that casual homophobia isn't as much her issue as it is the fault of those who practice it. She regards them as immature and in need of a change in thinking. "I just get really disappointed in people who still think there's not the same legitimacy in queer relationships as there are in straight ones," she says. "I'm really disappointed when I have people in my life who still think that being a lesbian means I'm just thinking about tits all the time." LGBTQI individuals endure poorer mental health outcomes than straight people due to a lack of social acceptance, according to Aids Council of NSW co-ordinator Madhuraa Prakash. "LGBTQI people are six times more likely to be diagnosed with depression and two and a half more times more likely to be diagnosed or treated for a mental health condition in general," they say. "It's unfortunate because you want to be able to talk about your life without having to edit yourself. "It weighs on a person to have to do that in your day-to-day life and leads to some bad mental health outcomes." Academic and psychotherapist Pol McCann specialises in microaggression and says although it sometimes stems from ill-intention, it is primarily patronising and performative. At the same time casual homophobia isn't exclusively directed at LGBTQI people either. Mr McCann says he's also heard from straight men who don't align with "typical" feminine or masculine ideas who have been impacted. He spoke with two straight men who were emotional, artistic and bullied by their peers at school. "They were absolutely lovely, smart, engaged guys but you could just tell they still carried the weight of the pain," he says. In the course of his work within the school environment, Mr McCann has spent time with the perpetrators of discrimination too. Some boys would never appreciate the impact they've had on a person's life, as they regard what they've done to be no more than a joke, he says. "The boys who were doing it, were doing it casually and with no malice," he adds. "These guys actually seemed really nice as adults and I don't think they understood how controlling their behaviour was." With June marking Pride Month, LGBTQI advocates like Justin Koonin know raising these issues is important. As co-chair of the NSW LGBTIQ+ Advisory Body, he has been helping develop a strategy to better include minority voices in legislation. Ensuring schools, police, transport officers and health professionals know how to treat the LGBTQI community better is a key focus. "We see the impact of casual homophobia in terms of the reported experience of mental health and wellbeing, and of safety and self-harm in our communities" Dr Koonin says. "You can't control what's in people's heads and you, to some extent, can't control what people can say but you can try and make it clear to people what hurts and what doesn't. "A lot of our work will be on increasing the level of awareness and exposure to the impact casual homophobia has in our communities." Although LGBTQI people need to lobby against casual homophobia, the straight community also has to play its part, Mr McCann says. He considers Wallaby-turned-senator David Pocock a notable voice in the LGBTQI marriage equality debate after declaring he wouldn't tie the knot with his wife until LGBTQI people could. "Pocock is a football star, incredibly handsome, incredibly charming and when he puts that kind of statement out there... that's got a lot more weight than the gay community lobbying for rights," Mr McCann says. NSW, ACT, Victoria, South Australia and Tasmania have government LGBTQI advisory bodies but federal parliament doesn't. Although a health advisory has been established in Canberra, Dr Koonin says having a committee similar to NSW would benefit the community. *Lea is an anonymous name. Lifeline 13 11 14 Fullstop Australia 1800 385 578
Perth Now
a day ago
- Perth Now
‘Overwhelmed': Major virus breakthrough
Australian researchers have found a way to force the HIV virus out of hiding within cells, opening the way to eradicate the virus from the body. The human immunodeficiency virus is able to hide within white blood cells, presenting a serious roadblock for scientists pursuing a cure. Research from Melbourne's Peter Doherty Institute for Infection and Immunity, published in late-May, says work towards a cure is one step closer. The next hurdle is analysing whether revealing the virus allows the body's immune system to fight off the virus or if additional treatments need to be combined. Australian researchers are closer to a HIV cure. Credit: News Limited 'In terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing in terms of how well we are able to reveal this virus,' co-author Paula Cevaal told the Guardian. 'We were overwhelmed by how night-and-day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, 'Wow'.' The HIV that hides in white blood cells can reactivate. The Peter Doherty Institute researchers used custom-made fat bubbles to deliver mRNA into cells where HIV is hiding. The mRNA tells the cells to reveal the virus. Messenger RNA is a molecule that contains instructions for cells to make a protein. The technology rose to prominence during the Covid-19 pandemic. People with HIV have to take medication for their entire life to suppress the virus, avoid symptoms and to stop transmission to other people. About 30,000 Australians live with HIV. In 2023, 722 new cases were reported to health authorities. Globally, in 2023, an estimated 500,000 to 820,000 people died from HIV-related causes.
West Australian
a day ago
- West Australian
‘Overwhelmed': Major breakthrough from Aussie researchers in HIV study
Australian researchers have found a way to force the HIV virus out of hiding within cells, opening the way to eradicate the virus from the body. The human immunodeficiency virus is able to hide within white blood cells, presenting a serious roadblock for scientists pursuing a cure. Research from Melbourne's Peter Doherty Institute for Infection and Immunity, published in late-May, says work towards a cure is one step closer. The next hurdle is analysing whether revealing the virus allows the body's immune system to fight off the virus or if additional treatments need to be combined. 'In terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing in terms of how well we are able to reveal this virus,' co-author Paula Cevaal told the Guardian. 'We were overwhelmed by how night-and-day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, 'Wow'.' The HIV that hides in white blood cells can reactivate. The Peter Doherty Institute researchers used custom-made fat bubbles to deliver mRNA into cells where HIV is hiding. The mRNA tells the cells to reveal the virus. Messenger RNA is a molecule that contains instructions for cells to make a protein. The technology rose to prominence during the Covid-19 pandemic. People with HIV have to take medication for their entire life to suppress the virus, avoid symptoms and to stop transmission to other people. About 30,000 Australians live with HIV. In 2023, 722 new cases were reported to health authorities. Globally, in 2023, an estimated 500,000 to 820,000 people died from HIV-related causes.
