'Most breast cancer drugs are ineffective in Pakistan'
According to the research, Pakistan's genetic makeup, particularly in relation to breast cancer, is significantly different from that of Western countries, where these drugs are manufactured and tested before the use.
According to Dr. Ishtiaq Ahmed, Associate Professor at IBCCS in University of Karachi and leader of the research team on cancer genomics, breast cancer therapies have various options, but all the drugs used in Pakistan are manufactured in Western countries. Clinical trials for these drugs are also conducted in these Western countries, without considering the genetic differences between populations.
He explained that the genetic differences between Pakistani and Western populations are significant, and this difference has been clearly identified in their research study. The research recommends the need for undertaking more studies and development of cancer treatments tailored to Pakistan's population. The study's findings also suggest that the use of imported chemotherapy drugs in Pakistan may not be effective in treating cancer, particularly breast cancer, due to genetic differences. "We tested a well-known chemotherapy drug on both Pakistani and European origin cell lines, and the results were extremely low on Pakistani breast cancer cell lines," Dr Ishtiaq said while citing the research, adding that researchers also mentioned that Pakistan has a high cancer rate, particularly breast cancer. If a large-scale study is conducted, we'll know our genetic needs and can validate which drugs are useful.
Researcher Samra Khan stated that Pakistan ranks seventh in breast cancer cases in South Asia, and fifth in mortality rates. In Pakistan, breast cancer is mostly reported in women aged between 30 to 45 years. Treatment guidelines and data are being used from European countries, while the types of breast cancer, BRCA 1 and BRCA 2, are extremely different in Pakistan and Europe.
Other researchers, Dr. M. Shakil, Warda Qureshi, and Humera Salim, observed that patients who are responding to chemotherapy are experiencing a recurrence of the disease earlier than expected.
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