
China Lifts Exports of Rare-Earth Products After Trade War Curbs
Customs data released Friday show exports of all rare-earth products rose 80% from a five-year low in May, when the country was in the midst of implementing sweeping export controls. Magnets — a component central to recent trade tensions — typically form the bulk of the 'products' category, but detailed export data on those won't be available until Sunday at the earliest.

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Asian shares, Aussie dollar climb on trade, earnings optimism
By Rocky Swift TOKYO (Reuters) -Shares in Asia rallied and the Australian dollar hit an eight-month high on Thursday as optimism over earnings and trade supported demand for higher yielding assets. Tokyo's broad Topix gauge of shares hit an all-time high, following new records on Wall Street overnight, after a trade pact between Japan and the U.S. stoked speculation more deals would appear soon to head off sweeping tariffs. Nasdaq and S&P futures rose after results by Google parent Alphabet beat estimates to kick off the "Magnificent Seven" earnings season. The U.S. has also reached deals with the Philippines and Indonesia and an agreement with the European Union is also expected. "Worst case concerns about tariffs in the U.S. are probably dissipating to some degree at the moment, but nonetheless, tariffs are going up and that is a hurdle for consumers," Brian Martin, ANZ's head of G3 economics, said in a podcast. The EU and U.S. are closing in a trade deal that would impose 15% tariffs on European imports, while waiving duties on some items, according to officials from the European Commission. Meanwhile, Treasury Secretary Scott Bessent said U.S. and Chinese officials will meet in Stockholm next week. Second-quarter earnings season is underway in the U.S., with 23% of the companies in the S&P 500 having reported. Of those, 85% have beaten Wall Street expectations, according to LSEG data. Results from Magnificent Seven members, whose results have powered indexes to previous peaks, are in the spotlight for guidance on spending and returns surrounding artificial intelligence (AI). Alphabet strongly beat estimates and cited massive demand for its cloud computing services as it hiked its capital spending plans. But electric car maker Tesla posted its worst quarterly sales decline in more than a decade and profit that trailed analyst targets. MSCI's broadest index of Asia-Pacific shares outside Japan was up 0.3%. Japan's Topix surged for a second day, rising 1.4% to surpass its previous all-time high reached last year. The Australian dollar, a common proxy for risk sentiment, fetched $0.66, just off $0.6604 hit earlier, which was the highest since November 2024. The U.S. dollar dropped 0.1% to 146.38 yen. U.S. crude climbed 0.4% to $65.5 a barrel. Spot gold was traded at $3,390.84 per ounce, up 0.1%. In early trades, pan-region Euro Stoxx 50 futures shot up 1.3% at 5,435, while German DAX futures were up 1.3%. U.S. stock futures, the S&P 500 e-minis, were up 0.13% and Nasdaq contracts climbed 0.4%. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
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Akeso Announces First Patient Enrollment in Phase III Trial of Ivonescimab for Pancreatic Cancer
HONG KONG, July 23, 2025 /PRNewswire/ -- Akeso, Inc. ( ("Akeso" or the "Company") is pleased to announce that the first patient has been enrolled in the pivotal/registration Phase III clinical trial (AK112-310/HARMONi-GI2) of ivonescimab, a first-in-class PD-1/VEGF bispecific antibody developed by the company. The trial is investigating ivonescimab in combination with chemotherapy, with or without ligufalimab (CD47 monoclonal antibody), for the first-line treatment of metastatic pancreatic cancer. Pancreatic cancer remains one of the most challenging types of tumors to find effective treatments for. While immunotherapies have demonstrated significant efficacy in different types of of solid tumors, pancreatic cancer's unique immune evasion mechanisms and its highly immunosuppressive tumor microenvironment (TME) have rendered it resistant to current therapies. As a result, previous Phase III studies on using immunotherapies as first-line treatments for metastatic pancreatic cancer have mostly failed. To date, no immunotherapy has been approved for first line metastatic pancreatic cancer. Ivonescimab, in combination with chemotherapy and/or ligufalimab, has the potential to address the current lack of effective options in first-line immunotherapy for metastatic pancreatic cancer. This randomized, controlled, multi-center Phase III trial is a key component of Akeso's broader strategy to address the significant unmet clinical needs in global oncology. Pancreatic cancer is an extremely aggressive form of malignancy that often result in poor patient prognosis. Its global incidence is on the rise, and the mortality rate closely mirrors the incidence, resulting in alarmingly low overall survival rates. In 2022, approximately 511,000 new cases of pancreatic cancer were diagnosed worldwide, and 467,000 deaths were recorded. Early diagnosis remains challenging, with around 80% of patients being diagnosed at an advanced stage. Even those diagnosed with early-stage or locally advanced disease may see progression to metastatic pancreatic cancer within a year following surgery or other treatments. Current first-line treatments are predominantly chemotherapies and have showed very limited success, with a median overall survival (OS) of less than one year. PD-1 and VEGF are often co-expressed in the tumor microenvironment. As a PD-1/VEGF bispecific antibody, Ivonescimab can accumulate in the TME and effectively block both the PD-1 and the VEGF signaling pathways. While these pathways are independently active, they are also complementary. Inhibition of both PD-1 and VEGF enhances immune cells' ability to target and destroy tumor cells. In addition, ligufalimab binds to CD47 on tumor cells, disrupting the interaction with signal regulatory protein alpha (SIRPα) on phagocytic cells. This process boosts phagocytosis and inhibits tumor growth. The combination of ivonescimab with ligufalimab is expected to synergistically enhance anti-tumor activity, offering a potential breakthrough in the first-line treatment for metastatic pancreatic cancer. Professor Yu Xianjun, Director of Fudan University Shanghai Cancer Center, Professor Ying Jie'er from Zhejiang Cancer Hospital, and Professor Tai Sheng from Harbin Medical University Cancer Hospital are the co-principal investigators of HARMONi-GI2 study. Forward-Looking Statement of Akeso, announcement by Akeso, Inc. ( "Akeso") contains "forward-looking statements". These statements reflect the current beliefs and expectations of Akeso's management and are subject to significant risks and uncertainties. These statements are not intended to form the basis of any investment decision or any decision to purchase securities of Akeso. There can be no assurance that the drug candidate(s) indicated in this announcement or Akeso's other pipeline candidates will obtain the required regulatory approvals or achieve commercial success. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; Akeso's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the Akeso's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. Akeso does not undertake any obligation to publicly revise these forward-looking statements to reflect events or circumstances after the date hereof, except as required by law. About AkesoAkeso (HKEX: is a leading biopharmaceutical company committed to the research, development, manufacturing and commercialization of the world's first or best-in-class innovative biological medicines. Founded in 2012, the company has created a unique integrated R&D innovation system with the comprehensive end-to-end drug development platform (ACE Platform) and bi-specific antibody drug development technology (Tetrabody) as the core, a GMP-compliant manufacturing system and a commercialization system with an advanced operation mode, and has gradually developed into a globally competitive biopharmaceutical company focused on innovative solutions. With fully integrated multi-functional platform, Akeso is internally working on a robust pipeline of over 50 innovative assets in the fields of cancer, autoimmune disease, inflammation, metabolic disease and other major diseases. Among them, 24 candidates have entered clinical trials (including 15 bispecific/multispecific antibodies and bispecific ADCs. Additionally, 7 new drugs are commercially available, and 2 new drugs with 2 new indications are under regulatory review for approval. Through efficient and breakthrough R&D innovation, Akeso always integrates superior global resources, develops the first-in-class and best-in-class new drugs, provides affordable therapeutic antibodies for patients worldwide, and continuously creates more commercial and social values to become a global leading biopharmaceutical enterprise. For more information, please visit and follow us on Linkedin. View original content: SOURCE Akeso, Inc. 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Europe and China holding scaled-back trade talks with expectations low for major agreements
BRUSSELS (AP) — European leaders are meeting with top Chinese officials in Beijing on Thursday to discuss trade, climate change and global conflicts, with observers saying expectations were low for any solid agreements. The talks, initially supposed to last two days but scaled back to one, come amid financial uncertainty around the world, wars in the Middle East and Ukraine, and the threat of U.S. tariffs. Neither the EU nor China is likely to budge on key issues dividing the two economic juggernauts. European Commission President Ursula von der Leyen and European Council President António Costa will meet with Chinese President Xi Jinping and Premier Li Qiang to mark 50 years of relations between Brussels and Beijing. Von der Leyen and Costa were expected to challenge China's strategies on a number of issues during the talks. They include Beijing's position on Russian President Vladimir Putin's full-scale invasion of Ukraine; and China's trade imbalance with the EU, persistent cyberattacks and espionage, a near-monopoly of rare earth minerals and its human rights record in Tibet, Hong Kong and Xinjiang. The EU, meanwhile, has concerns about a looming trade battle with the United States. 'Europe is being very careful not to antagonize President Trump even further by looking maybe too close to China, so all of that doesn't make this summit easier,' said Fabian Zuleeg, chief economist of the European Policy Center. "It will be very hard to achieve something concrete.' There's also unlikelihood of a major breakthrough amid China's hardening stance on the EU, despite a few olive branches, like the suspension of sanctions on European lawmakers who criticized Beijing's human rights record in Xinjiang, a region in northwestern China home to the Uyghurs. China believes it has successfully weathered the U.S. tariffs storm because of its aggressive posture, said Noah Barkin, an analyst at the Rhodium Group think tank. Barkin said that Beijing's bold tactics that worked with Washington should work with other Western powers. "China has come away emboldened from its trade confrontation with Trump. That has reduced its appetite for making concessions to the EU," he said. 'Now that Trump has backed down, China sees less of a need to woo Europe.' China is the EU's second-largest trading partner in goods, after the United States, with about 30% of global trade flowing between them. Both China and the EU want to use their economies ties to stabilize the global economy, and they share some climate goals. But deep disagreements run through those overlapping interests. Division on trade China and the EU have multiple trade disputes across a range of industries, but no disagreement is as sharp as their enormous trade imbalance. Like the U.S., the 27-nation bloc runs a massive trade deficit with China — around 300 billion euros ($350 million) last year. It relies heavily on China for critical minerals, which are also used to make magnets for cars and appliances. When China curtailed the export of those minerals in the wake of U.S. President Donald Trump's tariffs, European automakers cried foul. The EU has tariffs on Chinese electric vehicles in order to support its own carmakers by balancing out Beijing's own heavy auto subsidies. China would like those tariffs to be revoked. The rapid growth in China's market share in Europe has sparked concern that Chinese cars will eventually threaten the EU's ability to produce its own green technology to combat climate change. Business groups and unions also fear that the jobs of 2.5 million auto industry workers could be put in jeopardy, as well those of 10.3 million more people whose employment depends indirectly on EV production. China has also launched investigations into European pork and dairy products, and placed tariffs on French cognac and armagnac. They have criticized new EU regulations of medical equipment sales, and fear upcoming legislation that could further target Chinese industries, said Alicia García-Herrero, a China analyst at the Bruegel think tank. In June, the EU announced that Chinese medical equipment companies were to be excluded from any government purchases of more than 5 million euros (nearly $6 million). The measure seeks to incentivize China to cease its discrimination against EU firms, the bloc said, accusing China of erecting 'significant and recurring legal and administrative barriers to its procurement market.' European companies are largely seeing declining profitability in China. But the EU has leverage because China still needs to sell goods to the bloc, García-Herrero said. 'The EU remains China's largest export market, so China has every intention to keep it this way, especially given the pressure coming from the U.S.,' she said. It was unclear why the initial plan for the summit of two days was curtailed to just one in Beijing. War on Europe's doorstep The clear majority of Europeans favor increasing aid to Ukraine and more sanctions on Russia. The latest sanctions package on Russia also listed Chinese firms, including two large banks that the EU accused of being linked to Russia's war industry. China's commerce ministry said that it was 'strongly dissatisfied with and firmly opposed to" the listing and vowed to respond with 'necessary measures to resolutely safeguard the legitimate rights and interests of Chinese enterprises and financial institutions.' Xi and Putin have had a close relationship, which is also reflected in the countries' ties. China has become a major customer for Russian oil and gas, and a source of key technologies following sweeping Western sanctions on Moscow. In May, Xi attended a Victor Day celebration alongside Putin in Moscow, but didn't attend a similar EU event in Brussels celebrating the end of World War II. Von der Leyen and Costa will press Xi and Li to slash their support of Russia, but with likely little effect. Beyond Beijing and Washington Buffeted between a combative Washington and a hard-line Beijing, the EU has more publicly sought new alliances elsewhere, inking a trade pact with Indonesia, heaping praise on Japan and drafting trade deals with South America and Mexico. 'We also know that 87% of global trade is with other countries — many of them looking for stability and opportunity. That is why I am here for this visit to Japan to deepen our ties,' Von der Leyen said in Tokyo during an EU-Japan summit on her way to Beijing. 'Both Europe and Japan see a world around us where protectionist instincts grow, weaknesses get weaponized, and every dependency exploited. So it is normal that two like-minded partners come together to make each other stronger." Promoting ties with Europe is one third of Japan's new 2025 military doctrine, after sustaining defense links with the U.S. and investing in capabilities at home like missiles, satellites, warships, and drones. ___ Mark Carlson contributed to this report. Sam Mcneil, The Associated Press Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data