New weight loss pill more ‘tolerable' than jabs shown to be effective in key trial
Its release will offer people with obesity a new and convenient alternative to jabs.
Pharmaceutical company Eli Lilly said it expects substantial demand when the new pill is launched.
Lilly said it will seek approval by international regulators as it published the results of a large study into orforglipron.
The new pill is a GLP-1 agonist, a type of medication which helps lower blood sugar levels, slows the digestion of food and can reduce appetite.
The manufacturer also makes Mounjaro, dubbed the King Kong of weight loss jabs.
Weight loss jabs have been hailed as transformative by health leaders.
But injections come with additional work for over-stretched health services so tablet forms of medication, which are expected to be cheaper and easier to use, may offer a new hope for the millions of people looking to lose weight.
The new study data on orforglipron showed that people taking the drug lost an average of 12.3 kilograms while taking the drug for 72 weeks compared with those not taking the drug.
Three in five (60 per cent) of people taking the highest dose of orforglipron lost at least 10 per cent of their body weight, while 40 per cent lost at least 15 per cent of their body weight, according to the study, which is to be presented to the European Association for the Study of Diabetes (EASD) Annual Meeting 2025.
In addition to weight loss the people in the study also showed other health benefits, including improvements in cholesterol, blood pressure and heart disease risk.
Experts highlighted how the tablet did not appear to yield the same benefits as some weight loss jabs, but said they will be more 'tolerable' for many patients.
Lilly said the safety profile of the tablet is similar to other GLP-1 drugs, with gastrointestinal issues the most commonly reported side effect.
The pill was assessed in a study of 3,127 adults who were obese or overweight, with a weight-related medical problem and without diabetes.
'With orforglipron, we're working to transform obesity care by introducing a potential once-daily oral therapy that could support early intervention and long-term disease management, while offering a convenient alternative to injectable treatments,' said Lilly's Kenneth Custer.
'With these positive data in hand, we are now planning to submit orforglipron for regulatory review by year-end and are prepared for a global launch to address this urgent public health need.'
Dr Simon Cork, senior lecturer in physiology at Anglia Ruskin University, said: 'These preliminary results on the effectiveness of orforglipron in promoting clinically significant weight loss are a positive step forward in the development of this class of drugs.
'It should be noted that their effects on weight loss are not as profound as that seen in injectable GLP-1 receptor agonists, such as Wegovy, with a lower percentage weight loss and fewer people achieving 10 per cent weight loss at the highest dose.
'Nevertheless, that this medication is an oral form, rather than injectable, will likely be seen as more tolerable for many patients.
'The manufacturing costs are also anticipated to be significantly lower than injectable drugs, meaning these medications may be more equitable in their availability.
'It should be noted that these are preliminary, non-peer reviewed results and we will need to see the full trial methodology and data before a more comprehensive analysis can be undertaken.'
It comes as a separate study highlighted the potential other benefits of using GLP-1s, also known as glucagon-like peptide 1 receptor-agonists.
They were initially developed as a treatment for people with type 2 diabetes and are now widely used to treat obesity and help people lose weight.
The separate paper, from McGill University and the Lady Davis Institute for Medical Research at the Jewish General Hospital in Canada, examined the benefits of these drugs beyond weight loss by looking at trials which had assessed the drugs in other areas of medicine.
Writing in the journal eClinicalMedicine, experts said GLP-1s may also play a role in improving liver disease; sleep apnoea; arthritis of the knee; polycystic ovary syndrome; Parkinson's disease; Alzheimer's disease and substance misuse.
But they also highlighted potential safety issues linked to the drugs including potential issues with the pancreas and gall bladder.
'The therapeutic landscape for obesity and related metabolic conditions has evolved substantially with the emergence of GLP-1 RAs,' they wrote.
'These agents now play a central role not only in weight management and diabetes care but are also being investigated in a growing number of conditions, including cardiovascular, renal, hepatic, neurologic, and substance use disorders.
'As their indications expand, so must our understanding of long-term efficacy, safety, and patient-centred treatment strategies.'
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Scottish Sun
4 hours ago
- Scottish Sun
I was so fat I ended up in a wheelchair with just 4 weeks to live – then I lost 20st without pricey jabs
After a brutal wake-up call which could have left her two sons without a mum, Suzanne shed two thirds of her body weight - without resorting to £150-a-month Ozempic or Mounjaro SHAPESHIFTER I was so fat I ended up in a wheelchair with just 4 weeks to live – then I lost 20st without pricey jabs 'SUGAR addict' mum-of-two Suzanne Evans was a chronic overeater who couldn't resist sweets and chocolate. She quickly soared to 31st and was forced to use a wheelchair just to move around. Then, she got the brutal wake-up call she needed; if she didn't slim down, and fast, she would be dead in four weeks. Suzanne eventually shed two thirds of her body weight - but it wasn't jabs like Ozempic that saw her do it. 13 Suzanne Evans before losing 20st without using jabs like Ozempic Credit: Jam Press/Suzanne Evans 13 The mum-of-two after her incredible transformation, sparked by doctors giving her four weeks to live Credit: Jam Press/Suzanne Evans Suzanne was always larger than her friends. But six years ago, unable to walk more than a few steps, she had to start using a wheelchair due to her size. After a trip to the doctor, the 40-year-old was told that her kidneys and liver were shutting down. Her heart was also under near-unbearable strain, and medics estimated that she had just four weeks to live due to imminent organ failure. Suzanne, from Hereford, Herefordshire, knew something had to change - and quickly. READ MORE ON WEIGHT LOSS JABS UP Can you get free fat jabs on the NHS? The 4 key criteria plus exact weight revealed 'I was terrified,' she tells Sun Health. 'When you look in the doctor's eyes and see they're scared, you know you're in trouble. 'It was the worst feeling and I was in the worst place. I didn't want to be 31st. 'Doctors said I was so ill because of my weight, but they didn't have faith in me that I would fight so hard to lose it. They thought the damage had been done.' Suzanne's health was in serious decline in 2018, with her being 'rushed into hospital every other week' for a year. 'Every single part of my body radiated pain,' she adds. 'I could hardly breathe or move without excruciating pain.' I was sick of trying fad diets and not losing weight but now I've shed FIVE STONE without fat jabs or silly eating plans The mum was terrified by the prospect of dying – with her sons just 10 and 13 at the time. 'I recorded videos for them to watch if I wasn't there any more,' Suzanne says. 'It was emotional. But I was determined to slim down and improve my health for them.' After her dad, Tony, died in hospital, she was hell-bent on not having the same outcome, and signed herself out in February 2019. Upon coming home, Suzanne vowed to turn things around for sons Gethin, now 19, and 16-year-old Evan. The mum had tried diets in the past but had always reverted to binge eating. I'd eat all day and all night. There was always something in my hand. I had drawers by my bedside full of sweets and crisps and chocolates Suzanne Evans 'My weight gain started after my father died unexpectedly when I was pregnant in 2008,' Suzanne says. 'I comfort ate and then suffered postnatal depression after giving birth. 'I became addicted to sugar – I would just eat anything sweet. 'My mum eventually became my carer when I became wheelchair-bound in 2014. 'I'd eat all day and all night. There was always something in my hand. 'I would have whatever I could get my hands on. I had drawers by my bedside full of sweets and crisps and chocolates. 'If I woke up in the night, I would gorge on them.' 13 After hitting 31st, Suzanne was forced to use a wheelchair to get around Credit: Jam Press/Suzanne Evans 13 She says she was addicted to sugar and couldn't resist sweets and chocolate Credit: Jam Press/Suzanne Evans 13 Doctors telling her she was on the brink of organ failure was the wake-up call she needed Credit: Jam Press/Suzanne Evans 13 Suzanne joined Simming World and the weight soon started to drop off Credit: Jam Press/Suzanne Evans But the stark warning from doctors proved to be the push she needed to, once and for all, drop the weight. Suzanne followed the Slimming World plan, which puts an emphasis on whole foods without counting calories. It costs £5.95 per week (or £23.80 per mont) - far less than injections which start at around £150 a month. Just one week into her weight loss journey, she had dropped 1st, and by the end of her first month she was 2st 7lbs lighter. But it wasn't all easy. 'I had the shakes from the sugar withdrawal,' she says. 'I'd had 11 years of overeating, but I had hope at last. I really was fighting for my life and I felt so proud. 'I started incorporating walking into my daily routine - just a few steps at first until I could do more. 'Eventually I was able to take the dog for a walk and it felt great. 'My doctor cried a year later when I walked into the surgery; it was the first time they'd seen me walk in a long time.' 'It saved my life' Suzanne has now lost an incredible 20st and weighs 11st 4lbs. She is careful to maintain her svelte size, having two healthy meals a day - including overnight oats with fruit for breakfast and a chicken or beef stir fry for dinner. Suzanne adds: 'People have noticed my weight loss and ask me what I have done to lose so much. 'I tell them it is all down to determination, willpower and Slimming World. 'They ask me what else I did and the answer is nothing. I just made the decision to change my life and live. 'I am so grateful to Slimming World because their food plan saved my life. 'And I am so proud of myself for making it happen.' 13 The 40-year-old lost a staggering 20st in total - two thirds of her body weight Credit: Jam Press/Suzanne Evans 13 She overhauled her diet and started exercising Credit: Jam Press/Suzanne Evans 13 Suzanne with her dad Tony, who died in 2008, when she was a child Credit: Jam Press/Suzanne Evans 13 When people ask how she slimmed down, she tells them it was 'determination, willpower and Slimming World' Credit: Jam Press/Suzanne Evans As well as spicy stir fries and oats, the mum is a big fan of tuna pasta salad, ham and mushroom omelettes and Italian pork with beans and greens. Suzanne says: 'These are my weekly must-haves - I always have to have all the ingredients to create these meals at home. 'Every week I go out on a Sunday to shop for the week ahead. 'For me, preparation is key - whether it's quick and easy tuna pasta, which has serious filling power, leaving you fuller for longer, or my favourite gluten-free vegetable and beef stir fry. 'I love that I can have unlimited amounts and stay slim. 'These meals are also so tasty that I never get bored - and best of all, I can eat them guilt-free. 'When you optimise your food, you are guaranteed to lose weight. I just wish I knew that, and how important having a slimming group can be, earlier. 'When I was on my own, I was too embarrassed and ashamed to be around anyone. I needed a community of people who understood me, and now I have that. 'I never miss a week; we're all there for each other, supporting one another all the way to our targets and beyond. 'It's essential to have that beautiful support, especially on days when you're struggling.' How to lose weight safely Losing weight should be a long-term commitment to healthier living, rather than any drastic measures. The NHS tips - which can be adopted slowly - include: Get active for 150 minutes a week – you can break this up into shorter sessions Aim to get your 5 A Day – 80g of fresh, canned or frozen fruit or vegetables count as 1 portion Aim to lose 1 to 2lbs, or 0.5 to 1kg, a week Read food labels – products with more green colour coding than amber and red are often a healthier option Swap sugary drinks for water – if you do not like the taste, add slices of lemon or lime for flavour Cut down on food that's high in sugar and fat – start by swapping sugary cereal for wholegrain alternatives Share your weight loss plan with someone you trust – they can help motivate you when you have a bad day Read about: The five fat loss foundations The calorie formula for weight loss The perfect portion sizes for meals to lose weight Sun Health's 8-week weight loss kick start plan Suzanne is particularly conscious to emphasise that losing weight is a marathon, not a sprint. She says: 'Quick fix diets are not the answer as they don't help with the underlying problem. 'I've tried most diets but they didn't work because I needed help changing my mindset to help me overcome my overeating. 'I couldn't do that alone; I needed a consultant to guide me. 'It has taken me seven years to overcome all of my obstacles. 'But now, because of all my hard work, I'm more than confident I can stay at my target weight for the rest of my days.' 13 The mum-of-two with her sons, who inspired her weight loss journey Credit: Jam Press/Suzanne Evans 13 'Slimming World saved my life,' Suzanne says Credit: Jam Press/Suzanne Evans
The Sun
6 hours ago
- The Sun
I was so fat I ended up in a wheelchair with just 4 weeks to live – then I lost 20st without pricey jabs
'SUGAR addict' mum-of-two Suzanne Evans was a chronic overeater who couldn't resist sweets and chocolate. She quickly soared to 31st and was forced to use a wheelchair just to move around. Then, she got the brutal wake-up call she needed; if she didn't slim down, and fast, she would be dead in four weeks. Suzanne eventually shed two thirds of her body weight - but it wasn't jabs like Ozempic that saw her do it. 13 13 Suzanne was always larger than her friends. But six years ago, unable to walk more than a few steps, she had to start using a wheelchair due to her size. After a trip to the doctor, the 40-year-old was told that her kidneys and liver were shutting down. Her heart was also under near-unbearable strain, and medics estimated that she had just four weeks to live due to imminent organ failure. Suzanne, from Hereford, Herefordshire, knew something had to change - and quickly. 'I was terrified,' she tells Sun Health. 'When you look in the doctor's eyes and see they're scared, you know you're in trouble. 'It was the worst feeling and I was in the worst place. I didn't want to be 31st. 'Doctors said I was so ill because of my weight, but they didn't have faith in me that I would fight so hard to lose it. They thought the damage had been done.' Suzanne's health was in serious decline in 2018, with her being 'rushed into hospital every other week' for a year. 'Every single part of my body radiated pain,' she adds. 'I could hardly breathe or move without excruciating pain.' I was sick of trying fad diets and not losing weight but now I've shed FIVE STONE without fat jabs or silly eating plans The mum was terrified by the prospect of dying – with her sons just 10 and 13 at the time. 'I recorded videos for them to watch if I wasn't there any more,' Suzanne says. 'It was emotional. But I was determined to slim down and improve my health for them.' After her dad, Tony, died in hospital, she was hell-bent on not having the same outcome, and signed herself out in February 2019. Upon coming home, Suzanne vowed to turn things around for sons Gethin, now 19, and 16-year-old Evan. The mum had tried diets in the past but had always reverted to binge eating. I'd eat all day and all night. There was always something in my hand. I had drawers by my bedside full of sweets and crisps and chocolates Suzanne Evans 'My weight gain started after my father died unexpectedly when I was pregnant in 2008,' Suzanne says. 'I comfort ate and then suffered postnatal depression after giving birth. 'I became addicted to sugar – I would just eat anything sweet. 'My mum eventually became my carer when I became wheelchair-bound in 2014. 'I'd eat all day and all night. There was always something in my hand. 'I would have whatever I could get my hands on. I had drawers by my bedside full of sweets and crisps and chocolates. 'If I woke up in the night, I would gorge on them.' 13 13 13 But the stark warning from doctors proved to be the push she needed to, once and for all, drop the weight. Suzanne followed the Slimming World plan, which puts an emphasis on whole foods without counting calories. It costs £5.95 per week (or £23.80 per mont) - far less than injections which start at around £150 a month. Just one week into her weight loss journey, she had dropped 1st, and by the end of her first month she was 2st 7lbs lighter. But it wasn't all easy. 'I had the shakes from the sugar withdrawal,' she says. 'I'd had 11 years of overeating, but I had hope at last. I really was fighting for my life and I felt so proud. 'I started incorporating walking into my daily routine - just a few steps at first until I could do more. 'Eventually I was able to take the dog for a walk and it felt great. 'My doctor cried a year later when I walked into the surgery; it was the first time they'd seen me walk in a long time.' 'It saved my life' Suzanne has now lost an incredible 20st and weighs 11st 4lbs. She is careful to maintain her svelte size, having two healthy meals a day - including overnight oats with fruit for breakfast and a chicken or beef stir fry for dinner. Suzanne adds: 'People have noticed my weight loss and ask me what I have done to lose so much. 'I tell them it is all down to determination, willpower and Slimming World. 'They ask me what else I did and the answer is nothing. I just made the decision to change my life and live. 'I am so grateful to Slimming World because their food plan saved my life. 'And I am so proud of myself for making it happen.' 13 13 13 As well as spicy stir fries and oats, the mum is a big fan of tuna pasta salad, ham and mushroom omelettes and Italian pork with beans and greens. Suzanne says: 'These are my weekly must-haves - I always have to have all the ingredients to create these meals at home. 'Every week I go out on a Sunday to shop for the week ahead. 'For me, preparation is key - whether it's quick and easy tuna pasta, which has serious filling power, leaving you fuller for longer, or my favourite gluten-free vegetable and beef stir fry. 'I love that I can have unlimited amounts and stay slim. 'These meals are also so tasty that I never get bored - and best of all, I can eat them guilt-free. 'When you optimise your food, you are guaranteed to lose weight. I just wish I knew that, and how important having a slimming group can be, earlier. 'When I was on my own, I was too embarrassed and ashamed to be around anyone. I needed a community of people who understood me, and now I have that. 'I never miss a week; we're all there for each other, supporting one another all the way to our targets and beyond. 'It's essential to have that beautiful support, especially on days when you're struggling.' Suzanne is particularly conscious to emphasise that losing weight is a marathon, not a sprint. She says: ' Quick fix diets are not the answer as they don't help with the underlying problem. 'I've tried most diets but they didn't work because I needed help changing my mindset to help me overcome my overeating. 'I couldn't do that alone; I needed a consultant to guide me. 'It has taken me seven years to overcome all of my obstacles. 'But now, because of all my hard work, I'm more than confident I can stay at my target weight for the rest of my days.' 13 13
Telegraph
6 hours ago
- Telegraph
The race to find a party-friendly replacement for alcohol
There are mad inventions, such as weight-loss drugs or the contraceptive Pill, that come out of the blue and change the world forever. Then there are the much heralded 'breakthroughs' that never come to much. Along with flying cars and lab-grown steaks, the lifelong dream of Prof David Nutt has always been the stuff of science fantasy. We're here in the Commonwealth Building of Imperial College, London, a tall and unlovely structure in the outskirts of the city, because Prof Nutt believes that is about to change. When Prof Nutt was a medical student at Downing College, Cambridge, in 1969, doctors believed the odd drink was good for you. Now alcohol consumption is blamed for diabetes, heart disease, depression and dementia alike. That consensus has emerged gradually over the 50 years Prof Nutt has been working to rid the world of alcohol, by replacing the ethanol in our drinks with another, more well-behaved molecule. Down the road is Wormwood Scrubs prison where, according to Government estimates, two thirds of inmates will be alcohol-dependent. Next door is Hammersmith Hospital. 'About three people a week in Britain die of alcohol poisoning,' Prof Nutt points out. 'They just drink so much that they stop breathing.' It's a serious matter, but Prof Nutt is friendly and optimistic, with a jolly West Country accent, and the practised stage manner of a celebrity academic. He is the world's most famous psychopharmacologist – 'That means I study the effects of drugs on the brain,' he explains – and at 74, he is still ambitious and determined. As a graduate student in the 1980s, he thought he was in line for a Nobel Prize when he found a chemical 'antidote' to alcohol that could sober up a rat. That didn't come to pass because, as his supervisor pointed out, 'blocking the brain effects wasn't going to stop the toxicity'. Instead he made his name as an expert in psychedelic drugs, namely LSD and psilocybin 'magic' mushrooms, and in the early 2000s he became an adviser to the government on drug policy. Prof Nutt was very publicly forced to resign from that post in 2009 after claiming in a research paper that alcohol was far more dangerous than both LSD and the clubbers' drug MDMA. It would have ended any ordinary scientist's career, but the fiasco drew the attention of investors, who were keen to bring his solution for the world's drinking problem to market. Months later, The Telegraph reported Prof Nutt's renewed efforts to create a 'synthetic alcohol' that was non-addictive and non-toxic. It took a decade, but then it was announced: his team had successfully produced a safe but otherwise identical stand-in for alcohol. Prof Nutt had tried it out on himself. He called it Alcarelle, and it would be on shelves by 2026. That is not going to happen, Prof Nutt admits – though 'maybe we will be able to [sell it] by 2027'. He is currently preparing to take Alcarelle through food safety testing in the US, in the hopes that it might then be rolled out in Britain, too, and across the world. That process, including safety testing in human trials, will cost at least £3m. 'It's such an important thing to do,' he says. 'It would be crazy if people didn't invest, but you certainly can't count your chickens.' Proof of concept If Prof Nutt succeeds in bringing Alcarelle to market, will anyone want to drink it? Alcohol is a special sort of drug, not only because it is legal in most of the world. We've been chasing its high, despite the harm and addiction it causes us, for 10 million years at least. Our ape ancestors sought out rotted fruit to booze on long before they made fire. It has a pull on us because it is the perfect social crutch, says Prof Nutt – we human beings 'desperately need to socialise, but often need help doing it'. Alcarelle is designed to give a happy, two-drinks kind of tipsiness. 'I'm not trying to get anyone drunk,' he says. 'Most people, they drink in social situations, and they just want to relax.' Bans on alcohol have never worked. The 1920s roared in America despite prohibition laws, and in much of the Muslim world, alcohol consumption has always been relatively common 'despite Islam's best efforts,' says Prof Rudi Matthee, a historian who studies drugs as forces in history. But in the West, alcohol consumption 'is now going down dramatically'. It's a pattern driven by young people: a third of under-25s in Britain now don't drink at all, some surveys suggest. For the past five years, Prof Nutt has also worked on a 'proof of concept' product aimed at people who want to drink less. Sentia, his range of three mock-spirits, is made with a blend of exotically named plants – including magnolia bark, passionflower and ashwagandha – to give drinkers a relaxed, happy buzz. It works by 'stimulating the GABA receptors in your brain to mimic the pleasant effects of alcohol,' Prof Nutt says – GABA being a neurotransmitter, like serotonin or dopamine, that disinhibits behaviour. He has sold more than 300,000 bottles since Sentia's official launch in 2021. Alcohol works on this same GABA system. Prof Nutt proved that when he sobered up his lab rats, achieved by 'blocking' that system's effects. But whereas alcohol is a 'complicated' drug that impacts GABA throughout the whole brain as well as many other systems, Sentia instead works on specific 'targets', and is therefore hangover-free and non-addictive, he says. Alcarelle will work in the same way but is 'much stronger', and would be licensed to existing drinks companies as an additive. Three major drinks companies have already approached Nutt because they 'want access to our technology', he claims. 'We're not giving it to them yet, because we're slightly concerned that they might just buy it to destroy it. But I think it's almost past that now. It would be self-defeating to destroy something that could keep them profitable.' Prof Nutt and his team initially experimented with benzodiazepines, a class of strong anti-anxiety drugs that are known to work on the brain's GABA system. In recent years their tactics have changed, and the molecule set to be tested in the US is a different sort of compound, the specifics of which are, as yet, undisclosed. How it makes consumers feel may not actually matter. While drinking is in decline, young people are happily replacing alcohol with other drugs of all kinds. British charities and rehab clinics report that the use of ketamine by under-30s has risen, along with benzodiazepines such as Xanax and Valium. Nearly 3 per cent of people under 25 admitted to using psychedelic drugs last year. The use of mephedrone, a newer drug that has been compared to both cocaine and MDMA, appears to be having a second boom in clubs and bars in London, despite its ban in 2010. Mephedrone emerged from Israel in the early 2000s. It was sold legally at first, by an enterprising chemist called Ezekiel Golan, 55, who, after a stint on the Human Genome Project, was working as head of bioinformatics for a leading plant genetics company. He was studying the molecule octopamine, a neurotransmitter in the brains of smart invertebrates such as octopuses, when he noticed a 'funny-looking' cluster in the bottom of its chemical diagram. 'I wondered what that felt like,' says Dr Golan. After creating it in his laboratory and road-testing it on himself, he released mephedrone to the world. A 'just right' feeling of mild drunkenness Dr Golan bills himself as the world's foremost inventor of new legal recreational drugs. Where Prof Nutt has sought the Nobel prize, Dr Golan had 'always envied Albert Hofman', the accidental inventor of LSD. 'I've made things that take you through Aldous Huxley's doors of perception, up the stairs and all the way to Australia,' he boasts. In 2005, he made 'a molecule that was so extremely bland that I put it in my drawer and forgot about it'. Then, in 2009, Dr Golan heard about Prof Nutt's sacking as a government advisor, and his plan to 'invent his way around the alcohol problem'. Dr Golan realised then that he had 'something that would fit the bill.' For several years, Prof Nutt and Dr Golan worked together in 'the war against alcohol', as they put it. In 2017, they co-wrote a research paper on the effects and safety of Dr Golan's new compound, called MEAI. Rather than influencing the brain's GABA system, MEAI worked on its serotonin receptors, they found. There was also some more (legal) hands-on testing. Members of Prof Nutt's department at Imperial College were invited to 'Friday afternoon MEAI' sessions over the course of several months, a sort of end-of-week party, Dr Golan says. Prof Nutt insists that there was only ever a single 'sampling session'. Either way, enough people had tried MEAI for Dr Golan to be sure that it reliably gives a 'just right' feeling, a wash of happy, mild drunkenness. It is 'incredibly one-directional,' he says, being free of trippy visions and spiritual breakthroughs. Crucially, users do not feel inclined to binge on it. At very high doses, MEAI feels 'like the scene in Harry Potter where he actually meets Voldemort – totally white, quiet and serene'. In 2014, Dr Golan patented the compound, and he planned to give it to Prof Nutt to develop as a binge drinking mitigator. But the two had a falling out. 'David's advisers didn't get along with my advisers from a business point of view,' Dr Golan says. It was 'neither my fault nor his'. Dr Golan's 'advisers' were the predecessors of a novel medicines company called Clearmind, incorporated in Canada and led by Dr Adi Zuloff-Shani, an Israeli businesswoman. Dr Golan sold the patent family for MEAI to Clearmind in 2021, in return for shares, which he expects will one day be extremely valuable. In December, Clearmind signed a deal with a separate biotechnology company to commercially produce MEAI. Like Prof Nutt, Dr Zuloff-Shani expects her alcohol replacement to be on shelves within the next two years. Clearmind is currently going through a regulatory approval process itself, in an undisclosed country that is 'not in North America'. MEAI has been licensed for testing in human trials in Israel and the US, putting it a step ahead of Prof Nutt's Alcarelle. So far the safety profile of MEAI is 'very good', Dr Zuloff-Shani says. There is real-world evidence for its feasibility as a replacement for alcohol, too: it has already been sold in Canada. Tens of thousands of Canadians bought $10 bottles of Pace, billed as an alcohol alternative as well as an alcohol enhancer (they can be drunk together) and a binge drinking mitigator, before it was ruled against at the end of 2018. Canada's health authority released warnings not to use Pace on the grounds that it was an unregulated substance, but they 'never found a case where MEAI had caused someone physical harm,' Dr Zuloff-Shani says. Health Canada confirmed this in an email, though it also pointed out that MEAI is 'similar in structure to amphetamines' such as MDMA (the inventor of which, incidentally, described it as a 'low-calorie martini' on first try). Prof Nutt cut ties with Dr Golan in 2019, 'for reasons we do not wish to go into,' he says. His erstwhile partner in the mission to end drinking has since had 'no visibility of our molecule development.' Dr Golan maintains a 'great respect' for Prof Nutt, but he does not believe that the professor has an 'active compound' ready to sell as Alcarelle. 'I'm a discovery scientist. All credit goes to David for his pioneering vision, but he does not have that kind of methodology in mind.' Is the future synthetic or botanical? After I spoke to Prof Nutt about his dream, I was left thinking it would be a personal disaster for him if someone else arrived at it first. But he has seen this coming. While he was in their good books, Prof Nutt authored a paper for the Labour government called Drug Futures 2025. Scientists could already 'produce a recreational substance with similar effects to alcohol but fewer harms', he wrote in 2005. Within the next two decades, rogue chemists would also create 'new synthetic recreational substances', or legal highs. Some of them might feel like alcohol, Prof Nutt predicted, and they could even stand in as safer alternatives. I couldn't try Alcarelle for myself because, under the Psychoactive Substances Act of 2016, new recreational drugs – what were once legal highs – are illegal to produce, sell or supply. Alcohol itself is only exempt 'on the grounds of precedence', says Prof Nutt. The law was brought in to stop the proliferation of drugs like mephedrone, and it had the side-effect of knocking on the head Nutt's road-testing with willing participants at Imperial Colleg. International conventions on medical research mean that it remains legal for him to experiment on himself – a practice he keeps up to this day, at his lab in Hemel Hempstead. MEAI can't be tried either, outside of clinical trials, as it is 'not yet approved as a medicine or product in any jurisdiction', says Yael Stav, the head of programme management at Clearmind (and Dr Golan's wife, as it happens). The Home Office has no plans to assess whether Alcarelle or MEAI should be made exempt from the Psychoactive Substances Act, or indeed be covered by it in the first place, a source said. Such legal knots are why there is 'a debate playing out over whether the future of alcohol is synthetic or botanical', says James Jacoby, the co-founder of Sentia, Prof Nutt's plant-based spirit brand. Jacoby's own foray into devising a replacement for alcohol began with an ayahuasca trip in 2002, after which he developed 'a very intense sensitivity to nature', he says. Over 20 years he 'honed that sensitivity and applied it' to the creation of non-alcoholic drinks with an edge. Prof Nutt approached Jacoby and his wife, Vanessa, to collaborate in 2019. The couple's drink blends were then sold as Sentia, Jacoby claims (which Prof Nutt refutes), while Prof Nutt provided his 'worldwide celebrity status'. Raising enough funds to bring Alcarelle to market abroad, and then to try to get it approved here in Britain, 'was the explicit end goal', says Jacoby. Jacoby lost hope in that prospect. He left Sentia and has since set up a new venture, called ON Beer. His new lagers contain ginseng, a berry with energising properties, along with a lot of pepper and liquorice, and a handful of other plants. You can taste them, but that's why 'we're the only company with a clinical trial to support the fact that we provide an alcohol-like effect', Jacoby says. NuWave, meanwhile, an alcohol-free beer made by a former consultant for Sentia called Brendan Williams, has won international awards for its taste but has no proven ability to make you tipsy. (Sentia launched a beer alternative, called GABYR, this summer.) Alcohol with guard rails Jacoby and Prof Nutt face stiff competition from other modern-day apothecarists. In May, the country's first high-end alcohol-free bar opened in London, at a wellness club called Shoreditch &Soul. It's run by 33-year-old Karma Campbell, who, like Jacoby, has created plant blends with a punch through personal experimentation. Campbell grew up as part of the new-age traveller community 'where people use legal plants for their different effects as a part of everyday life', he says. He studied western herbal medicine at the University of Westminster, during which time he began trial-running his own concoctions at festivals. His big break came at Glastonbury in 2024, after the Daily Mail spotted him selling 'vegan cocaine' (a liquid mix including liquorice, damiana, ashwagandha and chilli) to revellers. 'I woke up to hundreds of orders, phone calls and texts,' Campbell says. Its official name is Turbo Tonic, and it's 'meant to get you buzzing, helping you stay up all night', he explains. Campbell's London bar is stocked with Turbo Tonic and three other tinctures, which are mixed into mocktails along with convincing non-alcoholic versions of any spirit or aperitif you could want: vodka, gin and rum, but also mescal, chartreuse and Campari. Customers 'do a lot of socialising', Campbell says. Observers would think they were tipsy. At the bar's launch night, I saw Cambell squirting a syringe of Turbo Tonic into a woman's mouth. I tried all of Campbell's tonics on the night, too, and while they certainly did something – the other guests agreed – I wouldn't say I was drunk. Turbo Tonic, Sentia's spirits, ON Beer and the dozen other products I've tried all have much the same effect, in that they give a hint of familiar fuzzy drunkenness without ever introducing you to the real thing. Alcohol can make you feel happy, sad or angry by turns; it gives plausible deniability for bad behaviour and secrets shared, and a headache to bond over in the morning. These inventors want to give us alcohol with guard rails, where 'every night is a geek's night out that ends at 11pm', as Dr Golan puts it. In that way, the future of drinking is already here. Dr Michael Mascha, an Austrian-born food anthropologist who made his fortune in the dot-com boom, has something for those who are done chasing alcohol's effects entirely. He has spent the past 20 years trying to make water 'a legitimate substitute for alcohol' in high-end restaurants. After becoming rich, Dr Mascha retired early from his post as a university professor, and then spent much of his time in California's finest eateries. He never drank heavily, but when he developed a heart condition in his 50s, his doctor informed him that he could 'either give up wine or give up living'. Dining out became a humiliation. The wines he was accustomed to 'were served in a very fine sommelier glass, with a very beautiful stem' and the first time he ordered water at a restaurant, he 'was given a child's tumbler'. Dr Mascha has since designed a new water flute for use in restaurants, and has set up a training academy for water sommeliers. His collection includes a mist bottled from the air in Tasmania, and a 15,000-year-old water from the last Ice Age, mined in the Czech Republic and flecked with gold. The 'clever' restaurants are now 'realising that alcohol is dying' and are beginning to offer extensive water lists, he says. When he brings a fine water to a party, 'no one is interested in wine anymore'. What does Prof Nutt make of that? 'If you want to go to the pub and drink water, then you can, but it's a different experience,' he says. He acknowledges that alcohol might never go the way of cigarettes, locked up behind counters and stamped with labels warning that it kills. He still enjoys a glass of wine with his wife, and their daughter owns a (traditional) bar in London. He simply wants to 'give people more choice'. His hope is that Alcarelle will replace 25 per cent of all alcohol consumption worldwide by 2050. If that gets people to stop drinking altogether, he would 'save more lives than you would by curing cancer', Prof Nutt believes. 'I want that to be my legacy.'
