Is MSTR Stock A Buy Or Sell At $370?
CHONGQING, CHINA - APRIL 26: In this photo illustration, the logo of MicroStrategy Incorporated is ... More displayed on a smartphone screen, with the company's branding visible in the background, on April 26, 2025, in Chongqing, China. (Photo illustration by)
Strategy Inc. (NASDAQ: MSTR), a firm previously recognized for its business intelligence, mobile software, and cloud-based services, has evolved into a notable indicator for Bitcoin because of its considerable investments in the cryptocurrency. The company's stock has recorded approximately a 24% increase year-to-date, reflecting Bitcoin's wider upward trend. This increase in Bitcoin's value has been affected by factors including the Trump administration's supportive stance on cryptocurrency.
Aside from the recent gains, MSTR stock has shown impressive long-term growth, rising nearly 500% since the beginning of 2024. This remarkable performance can be mainly ascribed to the following factors:
We will explore the specifics of these factors. While MSTR stock has performed remarkably, if you seek a smoother investment experience than an individual stock, consider the High Quality portfolio, which has surpassed the S&P, achieving over 91% returns since its inception. Separately, see – Nvidia Stock's 1 Big Risk
Strategy's sales have decreased from $496 million in 2023 to $459 million currently. This pattern seems to be a continuation of a wider decline in its core software business, which has been ongoing for some time. This can largely be attributed to the company's redirection of its main strategy from its business intelligence software to becoming a corporate holder of Bitcoin. Even before the intense focus on Bitcoin, Strategy's software business was facing slow or declining growth amid strong competition from other industry players, including Sisense, Domo, and Tibco, among others.
Regarding margins, Strategy's net income margins have shown extreme variability, plunging from 86.5% in 2023 to an astonishing -1161% at present. This dramatic fluctuation is chiefly due to the accounting treatment of Bitcoin in the financial statements. The company recognizes non-cash digital asset impairment charges to reflect changes in the cryptocurrency's value, in compliance with Bitcoin accounting regulations.
Strategy's price-to-sales (P/S) ratio has surged over 700%, skyrocketing from 21x in 2023 to 171x currently. This escalation demonstrates that the company's traditional software sales have become largely inconsequential to its valuation. Instead, investors mainly determine Strategy's value based on its significant Bitcoin holdings. This transition is attributable to several crucial factors:
As of April 28, 2025, Strategy owned 553,555 Bitcoin at an average price of $68,459 per coin, amounting to $37.90 billion. With Bitcoin presently trading around $106,000, this signifies a solid 55% gain on their investment. The company has recently increased its Bitcoin holdings to 580,250.
Currently trading at approximately $370, Strategy's stock has a price-to-sales (P/S) ratio of 171x, which is substantially higher than its three-year average of roughly 48x. However, this elevated P/S ratio is mostly irrelevant since MSTR's valuation is fundamentally driven by its Bitcoin holdings rather than its traditional software revenue. Therefore, if you believe Bitcoin will continue its strong performance, MSTR could represent an appealing investment opportunity. The stock has already seen a correction of over 30% from its 52-week high of around $540.
Several factors indicate potential long-term growth for Bitcoin. Its limited supply naturally enhances its value, and a weakening U.S. dollar makes dollar-denominated assets like Bitcoin more attractive to international investors. Political support from the Trump administration suggests a more favorable regulatory landscape, and the possibility of establishing a U.S. crypto reserve further validates the asset. Increasing interest and investment from large financial institutions are also contributing to heightened demand.
While MSTR provides an appealing avenue for gaining exposure to Bitcoin, it's important to recognize the substantial risks involved. MSTR has a history of significantly underperforming the broader markets during challenging macroeconomic periods. For instance, during the inflation shock of 2022, MSTR's value dropped by nearly 90%, which starkly contrasts with the S&P 500's peak-to-trough decline of 25.4%. Similarly, during the corrections caused by the COVID-19 pandemic, MSTR fell by 65%, compared to a 34% decline in the S&P 500.
Given this historical volatility, investors contemplating MSTR should thoughtfully assess these risks, particularly in the current environment of macroeconomic uncertainty.
Even with its 500% increase since early 2024, and factoring in the associated risks, MSTR might still attract long-term investors. However, those wary of the short-term volatility and high risks tied to crypto-related investments could explore alternative strategies. For example, the Trefis High Quality (HQ) Portfolio, a selection of 30 stocks, has consistently surpassed the S&P 500 over the past four years. This outperformance stems from HQ Portfolio stocks historically providing better returns with lower risk, offering a less volatile investment experience than the broader market, as evidenced in HQ Portfolio performance metrics.
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Business Wire
26 minutes ago
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Zai Lab and Novocure Announce Results From the Phase 3 PANOVA-3 Trial of Tumor Treating Fields (TTFields) Therapy for Pancreatic Cancer to be Presented at 2025 ASCO Annual Meeting
SHANGHAI & CAMBRIDGE, Mass. & BAAR, Switzerland--(BUSINESS WIRE)--Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) and Novocure (NASDAQ: NVCR) announced that results from the Phase 3 PANOVA-3 trial of Tumor Treating Fields (TTFields) therapy for pancreatic cancer will be presented today at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago and simultaneously published in the Journal of Clinical Oncology. 'The data presented today from the PANOVA-3 trial of Tumor Treating Fields show a clinically meaningful and statistically significant improvement in overall survival for people with locally advanced pancreatic cancer,' said Vincent Picozzi, MD, MMM, medical oncologist and investigator in the PANOVA-3 trial. 'Importantly, we also saw an extension in the duration of time before pain progressed. Pain is a hallmark of this disease, and as a clinician, the potential of this therapy to address this aspect of pancreatic cancer is very encouraging. These results illustrate the potential of Tumor Treating Fields therapy concomitant with gemcitabine and nab-paclitaxel to become a standard of care for unresectable, locally advanced pancreatic cancer.' The Phase 3 PANOVA-3 trial evaluated the use of TTFields therapy concomitantly with gemcitabine and nab-paclitaxel as a first-line treatment for unresectable, locally advanced pancreatic adenocarcinoma compared to gemcitabine and nab-paclitaxel alone. The trial met its primary endpoint, demonstrating a statistically significant improvement in median overall survival (mOS) for patients treated with TTFields. 'The encouraging data from the Phase 3 PANOVA-3 study demonstrate a meaningful improvement in outcomes for patients with unresectable, locally advanced pancreatic cancer—including pain reduction and a statistically significant improvement in overall survival,' said Rafael Amado, M.D., President, Head of Global Research and Development at Zai Lab. 'Pancreatic cancer remains one of the most challenging cancers to treat globally, with approximately 134,000 new cases diagnosed annually in China alone. Zai Lab participated in this trial and looks forward to continuing our collaboration with Novocure to bring this innovative therapy to patients in China as quickly as possible.' 'Most people with pancreatic cancer are diagnosed with advanced disease, which is very difficult to treat and only about 1 in 10 people are alive five years after diagnosis,' said Nicolas Leupin, MD, PhD, Chief Medical Officer, Novocure. 'The results shared today at ASCO and in the Journal of Clinical Oncology demonstrate that Tumor Treating Fields therapy improved overall survival and pain-free survival in unresectable, locally advanced pancreatic cancer. We plan to submit these data to the FDA in the second half of 2025 to support a premarket approval for Tumor Treating Fields therapy.' Results from PANOVA-3 In the intent-to-treat population, patients treated with TTFields therapy concomitantly with gemcitabine and nab-paclitaxel had an mOS of 16.2 months compared to 14.2 months for patients treated with gemcitabine and nab-paclitaxel alone, a statistically significant 2.0-month improvement [hazard ratio (HR) 0.82; p=0.039 (N=571)]. TTFields therapy concomitant with gemcitabine and nab-paclitaxel demonstrated improvement in several secondary endpoints including the one-year survival rate and pain-free survival. Pancreatic cancer can cause significant pain as the disease progresses and managing pain is a key clinical challenge. The one-year survival rate showed a statistically significant improvement in the TTFields concomitant with gemcitabine and nab-paclitaxel treated group with 68.1% [95% CI: 62.0–73.5] compared to those who received gemcitabine and nab-paclitaxel alone, 60.2% [95% CI: 54.2–65.7], p=0.029. Patients treated with TTFields concomitant with gemcitabine and nab-paclitaxel had a median pain-free survival of 15.2 months [95% CI: 10.3–22.8] compared to a median 9.1 months in the group treated with gemcitabine and nab-paclitaxel alone [95% CI: 7.4–12.7]; HR 0.74 [95% CI: 0.56–0.97], p=0.027. This is a statistically significant 6.1-month extension in pain-free survival. Pain-free survival was defined as the time from baseline until an increase of 20 or more points was reported by patients on a visual scale for pain or until death. Quality of life was also measured as a secondary endpoint. Analyses were performed for all patients using the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) with the pancreatic cancer specific PAN26 addendum. Deterioration-free survival in global health status, pain and digestive problems were significantly improved in patients receiving TTFields therapy concomitant with gemcitabine and nab-paclitaxel compared to the gemcitabine and nab-paclitaxel alone group. Full analysis of the quality of life results in PANOVA-3 will be shared at a future scientific conference. There was no statistically significant difference in additional secondary outcome measures of progression-free survival, local progression-free survival, objective response rate, puncture-free survival or tumor resectability rate between the TTFields with gemcitabine and nab-paclitaxel and the gemcitabine and nab-paclitaxel arms. TTFields therapy was well-tolerated, no new safety signals were observed, and safety was consistent with prior clinical studies. Mild to moderate skin adverse events (AEs) were the most common device-related AEs. Data Presentation & Publication Details The PANOVA-3 data, (LBA 3500) Phase 3 study of Tumor Treating Fields (TTFields) with gemcitabine and nab-paclitaxel for locally advanced pancreatic ductal adenocarcinoma (LA-PAC), will be presented today by Dr. Picozzi in Hall D1 during the 3:00 – 6:00 p.m. Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary oral session. The Phase 3 PANOVA-3 publication in the Journal of Clinical Oncology, Tumor Treating Fields with gemcitabine and nab-paclitaxel for locally advanced pancreatic adenocarcinoma: randomized, open-label, pivotal phase 3 PANOVA-3 study, will be available online at Novocure Investor Event Novocure will host an investor event featuring Dr. Picozzi and Novocure leadership after the oral presentation. Event details and a link to a live webcast of the event are available on the investor relations page of For more information or to request in-person attendance, please contact Novocure investor relations at investorinfo@ Regulatory & Ongoing Clinical Study of TTFields for Pancreatic Cancer Novocure plans to file for regulatory approval for use of TTFields therapy in unresectable, locally advanced pancreatic adenocarcinoma based on PANOVA-3 in the U.S. in the second half of 2025. The company also plans to file for regulatory approval in EU, Japan and other key markets. Novocure continues to follow patients in its Phase 2 PANOVA-4 trial exploring the use of TTFields therapy together with atezolizumab, gemcitabine and nab-paclitaxel for the treatment of metastatic pancreatic cancer. PANOVA-4 has completed enrollment with data anticipated in the first half of 2026. About PANOVA-3 PANOVA-3 is an international prospective, randomized, open-label, controlled Phase 3 clinical trial designed to test the efficacy and safety of Tumor Treating Fields (TTFields) therapy used concomitantly with gemcitabine and nab-paclitaxel, as a first-line treatment for locally advanced pancreatic adenocarcinoma. Patients were randomized to receive either TTFields therapy concomitant with gemcitabine and nab-paclitaxel or gemcitabine and nab-paclitaxel alone. The primary endpoint is overall survival. Secondary endpoints include progression-free survival, local progression-free survival, objective response rate, one-year survival rate, quality of life, pain-free survival, puncture-free survival, resectability rate, and toxicity. The PANOVA-3 trial enrolled 571 patients who were randomized 1:1 and followed for a minimum of 18 months. About PANOVA-4 PANOVA-4 is an international, multi-center, Phase 2 clinical trial designed to test the safety and efficacy of Tumor Treating Fields (TTFields) therapy together with atezolizumab, gemcitabine and nab-paclitaxel for the treatment of metastatic pancreatic cancer. The primary endpoint is disease control rate. Secondary endpoints include overall survival, progression-free survival, one-year survival rate, objective response rate, progression-free survival at six months, duration of response, and toxicity. The study is designed to enroll 76 patients and enrollment is complete. About Pancreatic Cancer in China Pancreatic cancer is one of the most common and deadliest cancers globally. In China, there were an estimated 134,374 new cases in 2022, and it is now the eighth most common cancer type 1. The current median survival of patients with locally advanced, unresectable pancreatic cancer is nine to twelve months, and the five-year survival rate was 7.2% 2, making it the malignancy with the lowest survival rate in China. 1 Xia C, Dong X, Li H et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl) 2022; 135: 584-590. 2 Hu JX, Zhao CF, Chen WB et al. Pancreatic cancer: A review of epidemiology, trend, and risk factors. World J Gastroenterol 2021; 27: 4298-4321. About Tumor Treating Fields Tumor Treating Fields (TTFields) are electric fields that exert physical forces to kill cancer cells via a variety of mechanisms. TTFields do not significantly affect healthy cells because they have different properties (including division rate, morphology, and electrical properties) than cancer cells. These multiple, distinct mechanisms work together to target and kill cancer cells. Due to these multimechanistic actions, TTFields therapy can be added to cancer treatment modalities in approved indications and demonstrates enhanced effects across solid tumor types when used with chemotherapy, radiotherapy, immune checkpoint inhibition, or targeted therapies in preclinical models. TTFields therapy provides clinical versatility that has the potential to help address treatment challenges across a range of solid tumors. To learn more about TTFields therapy and its multifaceted effect on cancer cells, visit About Zai Lab Zai Lab is an innovative, research-based, commercial-stage biopharmaceutical company based in China and the United States. We are focused on discovering, developing, and commercializing innovative products that address medical conditions with significant unmet needs in the areas of oncology, immunology, neuroscience and infectious disease. Our goal is to leverage our competencies and resources to positively impact human health worldwide. For additional information about Zai Lab, please visit or follow us at About Novocure Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure's commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma, non-small cell lung cancer, malignant pleural mesothelioma and pleural mesothelioma. Novocure has several additional ongoing or completed clinical trials exploring the use of Tumor Treating Fields therapy in the treatment of glioblastoma, non-small cell lung cancer and pancreatic cancer. Novocure's global headquarters is located in Baar, Switzerland, with U.S. headquarters located in Portsmouth, New Hampshire and research and development facilities located in Haifa, Israel. For additional information about the company, please visit and follow @Novocure on LinkedIn and Twitter. Zai Lab Forward-Looking Statements This press release contains forward-looking statements about future expectations, plans, and prospects for Zai Lab, including, without limitation, statements regarding the prospects of and plans for developing and commercializing TTFields therapy, the potential benefits of TTFields therapy, and the potential treatment of pancreatic cancer. These forward-looking statements may contain words such as 'aim,' 'anticipate,' 'believe,' 'could,' 'estimate,' 'expect,' 'forecast,' 'goal,' 'intend,' 'may,' 'plan,' 'possible,' 'potential,' 'will,' 'would,' and other similar expressions. Such statements constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are not statements of historical fact or guarantees or assurances of future performance. Forward-looking statements are based on our expectations and assumptions as of the date of this press release and are subject to inherent uncertainties, risks, and changes in circumstances that may differ materially from those contemplated by the forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including but not limited to (1) our ability to successfully commercialize and generate revenue from our approved products, (2) our ability to obtain funding for our operations and business initiatives, (3) the results of clinical and pre-clinical development of our product candidates, (4) the content and timing of decisions made by the relevant regulatory authorities regarding regulatory approvals of our product candidates, (5) risks related to doing business in China, and (6) other factors identified in our most recent annual and quarterly reports and in other reports we have filed with the U.S. Securities and Exchange Commission (SEC). We anticipate that subsequent events and developments will cause our expectations and assumptions to change, and we undertake no obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, except as may be required by law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release. Our SEC filings can be found on our website at and the SEC's website at
Yahoo
28 minutes ago
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Tempus AI hits back at scathing short report
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The Hill
33 minutes ago
- The Hill
Puerto Rico is Trump's perfect partner in reshoring
President Trump recently signed an executive order to bring pharmaceutical manufacturing back to the U.S. by streamlining the process for the Food and Drug Administration to approve pharmaceutical manufacturing plants. This is the latest in the Trump administration's agenda to protect national security and create American jobs by promoting the reshoring of critical supply chains that Americans rely on every day. These efforts are coupled with international tariffs to encourage domestic manufacturing. Reshoring pharmaceutical manufacturing is not only dire for American national security, but it could have resounding economic impacts across the country. One U.S. jurisdiction that is ready and in a perfect position to partner in this effort is Puerto Rico, where pharmaceutical manufacturing is already a more than $50 billion industry. With complementary efforts underway in Congress and on the island, the White House should look to Puerto Rico as America's pharmaceutical powerhouse while not trapping the island in its current territory status by hindering a future transition to statehood that would further boost the island's manufacturing ability. As a territory, the island is part of the U.S. customs zone and is not subject to U.S. tariffs, and everything that is made in Puerto Rico is 'Made in the USA.' Yet, that same territory status has limited Puerto Rico's economic development by creating persistent uncertainty, underinvestment and an unequal playing field for economic competition. The territory status is unpopular on the island, and Puerto Rican voters have voted in favor of statehood four consecutive times, most recently last November. Trump and Congress have the opportunity of a generation to leverage the pharmaceutical infrastructure and workforce in Puerto Rico to achieve their agenda while also turbocharging the economy on the island, and they have the perfect ally in Puerto Rico to do it with — the island's Republican Gov. Jenniffer González-Colón. González-Colón is leading an ambitious agenda to reshape the national narrative about the island and its people — and ultimately achieve statehood for Puerto Rico. Aligning with the Trump administration's vision to reshore advanced manufacturing of critical products, she issued an executive order in late March and reached out to top White House officials to offer Puerto Rico's well-established, yet currently underutilized, manufacturing capacity as an economic engine to help grow American prosperity. González-Colón's executive order promotes the relocation of overseas manufacturing of pharmaceuticals and other products to Puerto Rico. Much like Trump's executive order, it eliminates barriers and streamlines the process for businesses to move to the island. This action is complementary to the Medical Manufacturing, Economic Development and Sustainability Act, which was recently reintroduced and incentivizes pharmaceutical manufacturing on the island and throughout economically distressed zones across the United States. The bill is designed to attract business to the island in a way that invests in the people of Puerto Rico. It does this by providing an incentive for medical manufacturing facilities to relocate to economically distressed zones, with an incentive dependent on the number of jobs created to ensure money is flowing back into communities. The incentive itself is based on economic factors and applies to communities throughout the United States — an appropriately wide scope that comports with Trump's strong desire to reshore large amounts of production in a short time frame. By tethering the tax credits to what manufacturers invest directly into wages, salaries and real middle-class benefits, the proposal creates good-paying, quality American jobs. Reshoring to Puerto Rico would mean that critical pharmaceuticals and medical devices, as well as other products that are currently manufactured overseas in China and other nations, would now be produced in America. This would create thousands of well-paying manufacturing jobs that Puerto Rico needs to turbocharge the modest economic progress it's made in recent years. The increased consumer demand on the island would help boost the approximately $70 billion in annual interstate commerce, resulting in more jobs and profits stateside. Puerto Rico is a natural partner in reshoring the medical and pharmaceutical manufacturing industry within U.S. borders. The island's leaders share in the White House's vision of a more prosperous pharmaceutical manufacturing industry and are working to ensure reshoring efforts do not trap Puerto Rico in its current territory status but instead enable it to reach its full potential as an engine of economic growth and prosperity as a future state of our Union. Manufacturing makes America stronger, especially when it lifts up communities and the hard-working American citizens that make 'Made in the USA' a possibility, including those in Puerto Rico.
