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30 Budget-Friendly Skincare Finds At Walmart

30 Budget-Friendly Skincare Finds At Walmart

Buzz Feed19-05-2025

A bestselling Bioré charcoal face wash because sometimes your face might go straight back to feeling slick mere hours after washing. This cleanser wicks away excess grime while the charcoal inside absorbs oil.
Promising review: "This is the only face wash I use. The others break my face out more or keep it oily and not fresh feeling. This one does the trick for me all day!" —ChealsiePrice: $9.87
ITK brightening vitamin C serum if you want a vitamin C serum that also soothes and moisturizes the skin. While vitamin C does its job brightening the complexion and fading hyperpigmentation, omegas 3 + 6 + 9 fortify the skin's moisture barrier, and peptides help to boost collagen and elastin production. It's basically your entire skincare routine in a tincture that costs less than a fancy salad.
Promising review: "It's the best value vitamin C serum that doesn't tend to make my skin sticky or overly greasy. My skin just drinks it up, and it helps me glow! Would highly recommend if you're ballin' on a budget like me." —AngelaPrice: $14.97
E.l.f. lip exfoliator that does more than just slough off dead skin cells before your lipstick application. A lip exfoliator like this can amp up lip circulation, giving them a fuller, plumper appearance. With moisturizing ingredients like vitamin E, shea butter, avocado, grape, and jojoba oils, your lips will remain smooth and conditioned long after application. Oh, and it tastes like brown sugar! What's sweeter than that?
Promising review: "This is my second time purchasing this product. It lasts for a long time and does a great job of exfoliating. I like it better than an exfoliating cream." —JFreshPrice: $5 (available in two flavors)
A bottle of Garnier micellar water with rose, since there really are few things in this world as luxurious as spreading rose water all over your skin. This micellar water works hard to melt away the daily grime (makeup, sunscreen, pollution — the list goes on), yet is gentle on your skin with soothing rose and hydrating glycerin added inside.
Promising review: "I love how this face cleanser makes my face not only feel completely fresh and clean but also extremely soft as well. I would definitely recommend buying." —VictoriaPrice: $8.97+ (available in two sizes)
Hero Cosmetics Post-Blemish Recovery Cream, which does its job to both cover *and* treat skin redness! This has a green tint to counter any redness in the skin while peptides and antioxidants help to soothe the irritation.
Promising review: "This stuff works amazingly! I'm always searching for products to even out my skin tone and reduce redness, and this one works wonders — plus, it's budget-friendly! I've layered it under a full face of makeup, but it also works great on its own, which I LOVE. I don't always want to wear makeup, but I often do because I feel self-conscious about my facial redness. This gives me an even skin tone without needing any other makeup products. LOVE!" —MJPrice: $12.86
An Olay daily moisturizer that's pretty much made for people with sensitive skin. If you're looking for moisture that soaks in deep and offers SPF protection, this is your new 2-in-1 daily go-to.
Promising review: "When I was 23, I asked my father how he managed to have so few facial wrinkles. He recommended I start using Oil of Olay at night. I did, and at 35, I started twice a day. Now at 70, my skin looks younger than most men my age, and I get lots of comments on how few and small my facial wrinkles are." —CraigPrice: $11.97
A Garnier cleansing balm to melt all your makeup away, including waterproof mascara and intense lip stains! Since this balm has an oily texture, we recommend using it as the first part of your double-cleansing routine.
Promising review: "Cleans ALL makeup off immediately! No traces left AT ALL! I have searched for a product like this for YEARS! I love it and will definitely Buy more! 😍" —SherenaPrice: $11.97
An ice roller that I use several times a day to decrease puffiness, tighten my jowls, and calm down inflammation around my occasional breakouts. Pro tip: This tool is also a godsend for when you need some cooling relief during tension headaches!
Promising review: "This ice roller is something I use daily, and it's soooo soothing and relieves any eye puffiness, etc. After any DIY acid treatments, I also roll this over my face, significantly reducing redness and removing any sting. Super easy. Effective. I store the roller in the freezer, which is the best thing! It's a good-sized, beefy roller that stays cold for a long time. Once I'm finished rolling, if I've left it out on the counter instead of putting it back in the freezer (let's say it's been 20–30 minutes), this thing is still surprisingly COLD. It has surpassed any expectations I initially had. Highly recommend." —AnnieT303Price: $9.95
CeraVe hydrating eye cream so you can go about your day looking like you've had eight hours of sleep (even if that's far from the truth). This eye cream contains essential ceramides, niacinamide, and hyaluronic acid to flood the skin with moisture while helping brighten. And if you wonder about skincare lasting throughout the day, CeraVe's patented MVE ingredient-delivery technology continuously slow-releases ingredients for lasting benefits!
Promising review: "This Cerave eye product is amazing, especially for the price. I've tried MANY eye products, and none moisturize and smooth my delicate eye area like this. I have very dry skin around/under my eyes, which completely fixes that. After one use, I could see it working. I use it in the morning under my face cream and makeup and put it on b4 going to bed. It also helps with under-eye bags, but my main reason for using and loving this product is the moisturizing quality and the way it makes my skin brighter. I highly recommend." —samonePrice: $14.44
Peach Slices snail mucin facial toner will help balance your skin's pH after cleansing while helping zap zits with its antibacterial benefits! Plus, this toner is pretty hydrating and lightweight — a necessity for your 10-step skincare routine.
Promising review: "I have been spending $50 on toner for the longest time, but a friend recommended this one, and I'm so glad I gave it a shot. I have very sensitive and acne-prone skin, which clears my face and keeps my acne at bay. It's also very inexpensive. Double win!!!" —RebeccaPrice: $13.88
CeraVe hydrating facial cleanser, proving there's no need to use a foaming cleanser to get a deep clean! This cleanser is ideal for whisking away any traces of makeup, sunscreen, or pollution without stripping your moisture barrier.
Promising review: "Can't emphasize how much I love this product! Best quality and best feeling for sensitive or dry skin. I purchased several, one for each bathroom in the house, including the guest bathroom, and they love it as well! TOTALLY RECOMMEND! Super affordable!!" —KarlaPrice: $13.68
A Good Molecules niacinamide serum you should add to your cart ASAP if you find yourself battling acne scars that just won't budge. Niacinamide is a fantastic ingredient that'll help minimize the appearance of pores, brighten dull skin, and diminish uneven skin tone and texture! Plus, since niacinamide is an antioxidant, it'll help fight against free radicals and environmental stressors! Yayyyy.
Promising review: "This serum has made a huge difference in the size of my pores and inflammation , leading to better makeup application and overall less textured skin." —JackiePrice: $5.98
An EOS vanilla cashmere body lotion if you're looking for something that soaks in IMMEDIATELY to lock hydration into dry skin. The mix of whipped vanilla, soft musk, and caramel scents add a cozy, warm and luscious feel that you'll want to wrap yourself in 24/7.
Promising review: "This is the best-smelling vanilla I have ever had the pleasure of smelling. For the first few weeks of using it, it became my personality. I still absolutely love it. This is the first kind of lotion I can put on my body that soaks in and doesn't feel 'icky'. I've tried other scents of eos. They're all fantastic. It's just so soothing. Tl:dr— the best scent and formula." —KikiPrice: $9.97
E.l.f. Skin Suntouchable! Whoa Glow SPF 30 you ought to wear every single day, even if you're spending most of your hours working from home! UV rays travel through your windows indoors, meaning you're still experiencing sun damage while working from your desk. If you don't like spending time rubbing white cast-filled sunscreen into your skin, try this glowy-tinted version instead!
Just remember: a higher SPF doesn't mean prolonged protection. Make sure to reapply every two hours, especially if you're going to be out in the sun!Promising review: "I'm using this as my only face moisturizer and makeup, without any other foundation, etc. It has a nice consistency and is a very good level of moisturizer, not greasy at all. It provides very light coverage, making my skin look brighter and nicer but still a very natural look. I also love that it has SPF 30, so I don't have to apply any extra sunscreen just for a regular day." —SusanPrice: $14 (available in three shades)
A TikTok-viral Tree Hut sugar and shea scrub because I have never tried a body scrub this good at such a low price. It leaves the skin feeling soft (not stripped) and smells gorgeous! It's a great daily alternative to a spa-level body scrub.
Promising review: "So far, love this product. The watermelon scent is amazing in the shower and the exfoliation works well. In addition, can't beat the item for the price. Solid purchase." —JuliePrice: $7.97
Sky Organics vitamin E-infused coconut oil that's perfect if you are a beauty minimalist who wants something that'll moisturize not just your skin but your hair and nails, too!
Promising review: "Best coconut oil there is!! I use this every day after showering. I have super sensitive skin so I love the fact it's all natural. Bonus is the added vitamin E without soy added, love that!" —CrystalPrice: $12.98
B.tan self-tanning mousse because excessive UV exposure can be damaging. If you want the look of a sun-kissed glow, this is one of the best self-tanners to deliver.
Promising review: "Great product, the price makes it even better! I've used all the expensive tanning foams; this one is among the best! Very natural dark color that rarely does that weird hand and feet darkening thing if you put lotion there first." —TemplatePrice: $9.97
A Neutrogena rapid retinol cream is perfect if you're a retinol newbie looking to minimize fine lines, even out your skin tone, and diminish breakouts. This formula has retinol to help kickstart collagen and elastin production, while hyaluronic acid helps to minimize the dryness and irritation associated with most retinol products.
Promising review: "I'm in my '30s, and I've started noticing some fine lines around my eyes and mouth, and just a general dullness to my skin. After using this nightly, my skin looks brighter, smoother, and definitely more even-toned. Those little lines? Way less noticeable. I'm not saying it's a miracle product, but it's pretty darn close. It goes on smoothly, absorbs fast, and doesn't leave my skin feeling greasy. For a drugstore product, it feels way more high-end than I expected. It's affordable, works, and I'll definitely buy it again. If you're on the fence — just try it. Seriously." —katiePrice: $9.97
Cetaphil Gentle Foaming Cleanser if you're looking for a no-frills cleanser. This one is gentle enough for sensitive skin types and has a lightweight foaming texture that isn't stripping.
Promising review: "This stuff is so amazing! I have dry, mature skin and haven't been able to use anything without that tight, dry feeling after washing my face. Not this. It removes all my makeup but leaves my skin feeling silky and smooth. Oh my gosh, I'm in love. I've tried several brands, and this is a WINNER. 🏆" —Lynette Price: $8.97
Starface XL Hydro-Star Pimple Patches because pimples are a part of everyone's life, so why not make dealing with them a little fun? These patches aren't just cute — they're made from hydrocolloid, which means they'll help to draw out all the gunk from a breakout while significantly lessening any redness in the skin.
Promising review: "I love these pimple patches. They work amazing for my pimples, and I also love the Star face wash and moisturizer. It works amazing on my acne and is gentle on the skin . Would definitely recommend it. Love these products." —GeanePrice: $12.97 for 32 pimple patches
E.l.f. Holy Hydration! face cream has everything you need for a glow that could make aestheticians jealous. With ingredients like hyaluronic acid and a peptide complex, this moisturizer gets down to the deeper layers of your skin to hydrate and help build new skin cells for a plumping effect.
Promising review: "This cream is great; it's not greasy at all. This is my second jar. When I use it, I don't even have to wear makeup." —RhondaPrice: $12.97
A Neutrogena overnight lip mask so you can wake up with pillowy soft lips each and every morning — all without breaking the bank on more expensive lip masks!
Promising review: "Made my lips pillowy soft. I couldn't stop putting my lips together just to feel how smooth they were, not greasy either, and my lips stayed softer long after. So good!" —DJ Price: $10.87
A refreshing Bliss watermelon toner that'll have you singing your favorite Harry Styles song every morning. This toner rebalances the pH in your skin that might've been altered during cleansing. Plus, it ensures enough hydration on your skin to lock in your favorite moisturizer.
Promising review: "Watermelon lover here! It smells fantastic, fruity watermelon-y! I use it both morning and night, and it fairs well for my melanin-combination skin. I also think the price is adequate for the amount you get because the pump allows you to control how much product you put on your cotton pad to eliminate waste. And even though I use it twice a day, I haven't had to buy it often." —KimPrice: $12
A Dove deodorant, because you wear deodorant, anyway — why not try one that evens skin tone, too?
Promising review: "I love this Dove deodorant! It keeps me dry, smells great, and it visibly lightens my armpits. The scent smells like baby powder. This is probably my favorite deodorant formula." —RebeccaPrice: $10.73
A slab of "the world's best" pumice stone so you can kiss every last callus on your feet goodbye — without having to stop into the salon!
Check out a TikToker adding this to their haul here!Promising review: "This thing is magic and gave me really soft feet. My feet were so soft I almost slipped in the shower. Would definitely buy again." —SsmithPrice: $4.97
Vanicream skin cream people love because it moisturizes without leaving a heavy, greasy film! You can freely use this on your face and body since it's free of dyes, fragrances, parabens, and more!
Promising review: "OMG, this has saved my life. My dermatologist recommended it, and I'm so grateful. Finally, a moisturizing cream that does its job without causing burning, itching, rashes, or no benefit at all. Only six ingredients which are heaven to my sensitive skin." —SharonPrice: $13.56
A Heritage Store Rosewater and Glycerin Hydrating Facial Mist with more uses inside its small bottle than I thought possible. This spray contains rose water and glycerin that works amazingly as a toner, primer, and even a setting spray!
Promising review: "This is my fourth time using this specific product. I use it during my face routine. It leaves your face nice and moisturized. Great for dry skin, I have oily skin and it feels amazing on my face. The ingredients are Glycerin and rose water. Natural fragrance from a rose. I also use it as a setting spray after applying my makeup. Will be buying this for as long as I can." —BrizzyPrice: $6.29
A cherry and chia milk-scented Dove body wash that has lasted me forever (OK, not forever, but about five months). Dove is widely known for being great on sensitive skin, and this scent is fruity yet elevated!
Promising review: "I have been using Dove Body Wash, Cherry and Chia Milk for a long time. It moisturizes the skin very well. And the smell is wonderful. It's great! I will take more! I recommend it to everyone" —IrynaPrice: $7.97
A Bubble Skincare detox mask if you're after one thing and one thing only: clear, even skin. You can use this a few times weekly to soak up excess oil and help combat future breakouts!
Promising review: "The best clay mask there is! Super easy to use and I love how easy it is to wash off. It's extremely gentle but very effective. My skin feels soft, smooth, and fresh after use! It can also be used as a spot treatment, so the price is amazing, especially considering all it can do!" —KiraPrice: $18.98
And a Freeman Dead Sea mineral mask, because algae is a superb ingredient for calming inflammation and helping diminish breakouts over time.
Promising review: "I used this for the first time and I love it, you can feel it tightening on your skin as it dries and your face feels so much smoother and looks so much cleaner when you're done. I would highly recommend this product." —MsSpigner22Price: $10.02

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Corvus Pharmaceuticals to Present at the 2025 Jefferies Global Healthcare Conference

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30 Budget-Friendly Skincare Finds At Walmart
30 Budget-Friendly Skincare Finds At Walmart

Buzz Feed

time19-05-2025

  • Buzz Feed

30 Budget-Friendly Skincare Finds At Walmart

A bestselling Bioré charcoal face wash because sometimes your face might go straight back to feeling slick mere hours after washing. This cleanser wicks away excess grime while the charcoal inside absorbs oil. Promising review: "This is the only face wash I use. The others break my face out more or keep it oily and not fresh feeling. This one does the trick for me all day!" —ChealsiePrice: $9.87 ITK brightening vitamin C serum if you want a vitamin C serum that also soothes and moisturizes the skin. While vitamin C does its job brightening the complexion and fading hyperpigmentation, omegas 3 + 6 + 9 fortify the skin's moisture barrier, and peptides help to boost collagen and elastin production. It's basically your entire skincare routine in a tincture that costs less than a fancy salad. Promising review: "It's the best value vitamin C serum that doesn't tend to make my skin sticky or overly greasy. My skin just drinks it up, and it helps me glow! Would highly recommend if you're ballin' on a budget like me." —AngelaPrice: $14.97 E.l.f. lip exfoliator that does more than just slough off dead skin cells before your lipstick application. A lip exfoliator like this can amp up lip circulation, giving them a fuller, plumper appearance. With moisturizing ingredients like vitamin E, shea butter, avocado, grape, and jojoba oils, your lips will remain smooth and conditioned long after application. Oh, and it tastes like brown sugar! What's sweeter than that? Promising review: "This is my second time purchasing this product. It lasts for a long time and does a great job of exfoliating. I like it better than an exfoliating cream." —JFreshPrice: $5 (available in two flavors) A bottle of Garnier micellar water with rose, since there really are few things in this world as luxurious as spreading rose water all over your skin. This micellar water works hard to melt away the daily grime (makeup, sunscreen, pollution — the list goes on), yet is gentle on your skin with soothing rose and hydrating glycerin added inside. Promising review: "I love how this face cleanser makes my face not only feel completely fresh and clean but also extremely soft as well. I would definitely recommend buying." —VictoriaPrice: $8.97+ (available in two sizes) Hero Cosmetics Post-Blemish Recovery Cream, which does its job to both cover *and* treat skin redness! This has a green tint to counter any redness in the skin while peptides and antioxidants help to soothe the irritation. Promising review: "This stuff works amazingly! I'm always searching for products to even out my skin tone and reduce redness, and this one works wonders — plus, it's budget-friendly! I've layered it under a full face of makeup, but it also works great on its own, which I LOVE. I don't always want to wear makeup, but I often do because I feel self-conscious about my facial redness. This gives me an even skin tone without needing any other makeup products. LOVE!" —MJPrice: $12.86 An Olay daily moisturizer that's pretty much made for people with sensitive skin. If you're looking for moisture that soaks in deep and offers SPF protection, this is your new 2-in-1 daily go-to. Promising review: "When I was 23, I asked my father how he managed to have so few facial wrinkles. He recommended I start using Oil of Olay at night. I did, and at 35, I started twice a day. Now at 70, my skin looks younger than most men my age, and I get lots of comments on how few and small my facial wrinkles are." —CraigPrice: $11.97 A Garnier cleansing balm to melt all your makeup away, including waterproof mascara and intense lip stains! Since this balm has an oily texture, we recommend using it as the first part of your double-cleansing routine. Promising review: "Cleans ALL makeup off immediately! No traces left AT ALL! I have searched for a product like this for YEARS! I love it and will definitely Buy more! 😍" —SherenaPrice: $11.97 An ice roller that I use several times a day to decrease puffiness, tighten my jowls, and calm down inflammation around my occasional breakouts. Pro tip: This tool is also a godsend for when you need some cooling relief during tension headaches! Promising review: "This ice roller is something I use daily, and it's soooo soothing and relieves any eye puffiness, etc. After any DIY acid treatments, I also roll this over my face, significantly reducing redness and removing any sting. Super easy. Effective. I store the roller in the freezer, which is the best thing! It's a good-sized, beefy roller that stays cold for a long time. Once I'm finished rolling, if I've left it out on the counter instead of putting it back in the freezer (let's say it's been 20–30 minutes), this thing is still surprisingly COLD. It has surpassed any expectations I initially had. Highly recommend." —AnnieT303Price: $9.95 CeraVe hydrating eye cream so you can go about your day looking like you've had eight hours of sleep (even if that's far from the truth). This eye cream contains essential ceramides, niacinamide, and hyaluronic acid to flood the skin with moisture while helping brighten. And if you wonder about skincare lasting throughout the day, CeraVe's patented MVE ingredient-delivery technology continuously slow-releases ingredients for lasting benefits! Promising review: "This Cerave eye product is amazing, especially for the price. I've tried MANY eye products, and none moisturize and smooth my delicate eye area like this. I have very dry skin around/under my eyes, which completely fixes that. After one use, I could see it working. I use it in the morning under my face cream and makeup and put it on b4 going to bed. It also helps with under-eye bags, but my main reason for using and loving this product is the moisturizing quality and the way it makes my skin brighter. I highly recommend." —samonePrice: $14.44 Peach Slices snail mucin facial toner will help balance your skin's pH after cleansing while helping zap zits with its antibacterial benefits! Plus, this toner is pretty hydrating and lightweight — a necessity for your 10-step skincare routine. Promising review: "I have been spending $50 on toner for the longest time, but a friend recommended this one, and I'm so glad I gave it a shot. I have very sensitive and acne-prone skin, which clears my face and keeps my acne at bay. It's also very inexpensive. Double win!!!" —RebeccaPrice: $13.88 CeraVe hydrating facial cleanser, proving there's no need to use a foaming cleanser to get a deep clean! This cleanser is ideal for whisking away any traces of makeup, sunscreen, or pollution without stripping your moisture barrier. Promising review: "Can't emphasize how much I love this product! Best quality and best feeling for sensitive or dry skin. I purchased several, one for each bathroom in the house, including the guest bathroom, and they love it as well! TOTALLY RECOMMEND! Super affordable!!" —KarlaPrice: $13.68 A Good Molecules niacinamide serum you should add to your cart ASAP if you find yourself battling acne scars that just won't budge. Niacinamide is a fantastic ingredient that'll help minimize the appearance of pores, brighten dull skin, and diminish uneven skin tone and texture! Plus, since niacinamide is an antioxidant, it'll help fight against free radicals and environmental stressors! Yayyyy. Promising review: "This serum has made a huge difference in the size of my pores and inflammation , leading to better makeup application and overall less textured skin." —JackiePrice: $5.98 An EOS vanilla cashmere body lotion if you're looking for something that soaks in IMMEDIATELY to lock hydration into dry skin. The mix of whipped vanilla, soft musk, and caramel scents add a cozy, warm and luscious feel that you'll want to wrap yourself in 24/7. Promising review: "This is the best-smelling vanilla I have ever had the pleasure of smelling. For the first few weeks of using it, it became my personality. I still absolutely love it. This is the first kind of lotion I can put on my body that soaks in and doesn't feel 'icky'. I've tried other scents of eos. They're all fantastic. It's just so soothing. Tl:dr— the best scent and formula." —KikiPrice: $9.97 E.l.f. Skin Suntouchable! Whoa Glow SPF 30 you ought to wear every single day, even if you're spending most of your hours working from home! UV rays travel through your windows indoors, meaning you're still experiencing sun damage while working from your desk. If you don't like spending time rubbing white cast-filled sunscreen into your skin, try this glowy-tinted version instead! Just remember: a higher SPF doesn't mean prolonged protection. Make sure to reapply every two hours, especially if you're going to be out in the sun!Promising review: "I'm using this as my only face moisturizer and makeup, without any other foundation, etc. It has a nice consistency and is a very good level of moisturizer, not greasy at all. It provides very light coverage, making my skin look brighter and nicer but still a very natural look. I also love that it has SPF 30, so I don't have to apply any extra sunscreen just for a regular day." —SusanPrice: $14 (available in three shades) A TikTok-viral Tree Hut sugar and shea scrub because I have never tried a body scrub this good at such a low price. It leaves the skin feeling soft (not stripped) and smells gorgeous! It's a great daily alternative to a spa-level body scrub. Promising review: "So far, love this product. The watermelon scent is amazing in the shower and the exfoliation works well. In addition, can't beat the item for the price. Solid purchase." —JuliePrice: $7.97 Sky Organics vitamin E-infused coconut oil that's perfect if you are a beauty minimalist who wants something that'll moisturize not just your skin but your hair and nails, too! Promising review: "Best coconut oil there is!! I use this every day after showering. I have super sensitive skin so I love the fact it's all natural. Bonus is the added vitamin E without soy added, love that!" —CrystalPrice: $12.98 self-tanning mousse because excessive UV exposure can be damaging. If you want the look of a sun-kissed glow, this is one of the best self-tanners to deliver. Promising review: "Great product, the price makes it even better! I've used all the expensive tanning foams; this one is among the best! Very natural dark color that rarely does that weird hand and feet darkening thing if you put lotion there first." —TemplatePrice: $9.97 A Neutrogena rapid retinol cream is perfect if you're a retinol newbie looking to minimize fine lines, even out your skin tone, and diminish breakouts. This formula has retinol to help kickstart collagen and elastin production, while hyaluronic acid helps to minimize the dryness and irritation associated with most retinol products. Promising review: "I'm in my '30s, and I've started noticing some fine lines around my eyes and mouth, and just a general dullness to my skin. After using this nightly, my skin looks brighter, smoother, and definitely more even-toned. Those little lines? Way less noticeable. I'm not saying it's a miracle product, but it's pretty darn close. It goes on smoothly, absorbs fast, and doesn't leave my skin feeling greasy. For a drugstore product, it feels way more high-end than I expected. It's affordable, works, and I'll definitely buy it again. If you're on the fence — just try it. Seriously." —katiePrice: $9.97 Cetaphil Gentle Foaming Cleanser if you're looking for a no-frills cleanser. This one is gentle enough for sensitive skin types and has a lightweight foaming texture that isn't stripping. Promising review: "This stuff is so amazing! I have dry, mature skin and haven't been able to use anything without that tight, dry feeling after washing my face. Not this. It removes all my makeup but leaves my skin feeling silky and smooth. Oh my gosh, I'm in love. I've tried several brands, and this is a WINNER. 🏆" —Lynette Price: $8.97 Starface XL Hydro-Star Pimple Patches because pimples are a part of everyone's life, so why not make dealing with them a little fun? These patches aren't just cute — they're made from hydrocolloid, which means they'll help to draw out all the gunk from a breakout while significantly lessening any redness in the skin. Promising review: "I love these pimple patches. They work amazing for my pimples, and I also love the Star face wash and moisturizer. It works amazing on my acne and is gentle on the skin . Would definitely recommend it. Love these products." —GeanePrice: $12.97 for 32 pimple patches E.l.f. Holy Hydration! face cream has everything you need for a glow that could make aestheticians jealous. With ingredients like hyaluronic acid and a peptide complex, this moisturizer gets down to the deeper layers of your skin to hydrate and help build new skin cells for a plumping effect. Promising review: "This cream is great; it's not greasy at all. This is my second jar. When I use it, I don't even have to wear makeup." —RhondaPrice: $12.97 A Neutrogena overnight lip mask so you can wake up with pillowy soft lips each and every morning — all without breaking the bank on more expensive lip masks! Promising review: "Made my lips pillowy soft. I couldn't stop putting my lips together just to feel how smooth they were, not greasy either, and my lips stayed softer long after. So good!" —DJ Price: $10.87 A refreshing Bliss watermelon toner that'll have you singing your favorite Harry Styles song every morning. This toner rebalances the pH in your skin that might've been altered during cleansing. Plus, it ensures enough hydration on your skin to lock in your favorite moisturizer. Promising review: "Watermelon lover here! It smells fantastic, fruity watermelon-y! I use it both morning and night, and it fairs well for my melanin-combination skin. 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Corvus Pharmaceuticals Announces Interim Data from Placebo-Controlled Phase 1 Clinical Trial of Soquelitinib for Atopic Dermatitis
Corvus Pharmaceuticals Announces Interim Data from Placebo-Controlled Phase 1 Clinical Trial of Soquelitinib for Atopic Dermatitis

Yahoo

time18-12-2024

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Corvus Pharmaceuticals Announces Interim Data from Placebo-Controlled Phase 1 Clinical Trial of Soquelitinib for Atopic Dermatitis

Data from lowest dose level cohorts demonstrate a favorable safety and efficacy profile Data includes complete results from cohort 1 and initial results from cohort 2 Early exercise of common stock warrants from stockholder generates cash proceeds of approximately $12.7 million Company to host conference call and webcast today at 8:00 a.m. ET / 5:00 a.m. PT BURLINGAME, Calif., Dec. 18, 2024 (GLOBE NEWSWIRE) -- Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS), a clinical-stage biopharmaceutical company, today announced interim data from the randomized, double-blind, placebo-controlled Phase 1 clinical trial evaluating soquelitinib in patients with moderate to severe atopic dermatitis. The data demonstrated a favorable safety profile and efficacy profile, supporting the ongoing development of soquelitinib for atopic dermatitis and the potential of ITK inhibition as a novel mechanism of action for other immune diseases. 'We are pleased with the early results of our soquelitinib Phase 1 atopic dermatitis clinical trial, which show an attractive potential product profile at the lowest dose we are studying,' said Richard A. Miller, M.D., co-founder, president and chief executive officer of Corvus. 'The data show consistent signs of efficacy, combined with a novel mechanism of action, a convenient oral route of administration and a favorable safety profile. This is also supported by an analysis of serum cytokine levels, which show a possible relationship between clinical response and reductions in IL-5, IL-17, IL-31, IL-33 and TSLP, along with a trend for TARC. We believe the data highlights soquelitinib's potential as a new treatment option for atopic dermatitis and the broader opportunity for ITK inhibition for other immune related diseases. In addition to blocking the production of multiple inflammatory cytokines, soquelitinib may have persistent direct effects on immune cell function that act to regulate aberrant immune responses. We look forward to completing the Phase 1 trial and initiating other trials with soquelitinib for immune diseases.' Soquelitinib Atopic Dermatitis Phase 1 Clinical Trial DesignThe randomized, double-blind, placebo-controlled Phase 1 clinical trial is planned to enroll 64 patients with moderate to severe atopic dermatitis that previously failed one prior topical or systemic therapy. Patients are enrolled into one of four dosing cohorts in a 3:1 ratio (12 active and 4 placebo) to receive either soquelitinib or placebo. The cohorts are sequentially enrolled and will examine 100 mg oral twice per day, 200 mg oral once per day, 200 mg oral twice per day and 400 mg oral once per day. Patients are treated for 28 days and are then followed for an additional 30 days with no therapy. These doses were selected based on the Company's prior experience evaluating soquelitinib in T cell lymphoma patients. The doses in the atopic dermatitis trial bracket the 200 mg oral twice a day dosing regimen, which is the level that has been shown to provide complete ITK occupancy and that is being evaluated in the Company's ongoing registrational Phase 3 clinical trial of soquelitinib in peripheral T cell lymphoma. The primary endpoints include safety and tolerability, and efficacy, measured by improvement in Eczema Area and Severity Index (EASI) score, Investigator Global Assessment (IGA), reduction in itch and various cytokine biomarkers. EASI scores are also evaluated by the percent of patients that achieve a specified percent reduction in EASI score – EASI 50 for patients that achieved a 50% reduction; EASI 75 for a 75% reduction; and EASI 90 for a 90% reduction. Corvus and a data monitoring committee will be able to monitor the data from the trial as the trial progresses. Soquelitinib Interim Data from the Atopic Dermatitis Phase 1 Clinical TrialThe Company is reporting complete results from Cohort 1 of the trial, which includes 16 patients (12 that received soquelitinib 100 mg oral twice per day and four that received placebo) with follow up at 28 days and at 58 days. At 58 days, two patients in the soquelitinib group were not available for follow up. The soquelitinib and placebo patients were well matched; see Table 1 below for patient characteristics. Table 1: Cohort 1 Patient Characteristics Soquelitinib Placebo (N=12) (N=4) Age, mean (range), yrs 46.3 (30–66) 50.5 (32–62) Gender, male n (%) 7 (58.3) 4 (100) Race/ethnicity, n (%) Asian 2 (16.7) 0 (0) Black or African American 6 (50) 4 (100) White 3 (25) 0 (0) Hispanic or Latino 1 (8.3) 0 (0) Baseline EASI, mean (range) 20.4 (15.0–46.6) 18.5 (14.9–24.8) Baseline IGA, mean (range) 3.0 (2–4) 3.3 (3–4) Prior AD therapies, n (%) Topical Corticosteroids 11 (91.7) 4 (100) Systemic therapies 3 (25) 2 (50) Concomitant topical steroids 0 (0) 1 (25) The mean baseline EASI and IGA scores for soquelitinib patients were 20.4 and 3.0, respectively, compared to an EASI score of 18.5 and an IGA score of 3.3 for placebo patients. All soquelitinib patients discontinued topical corticosteroids prior to enrollment, while one placebo patient continued topical corticosteroid treatment. All patients, except the one placebo, discontinued topical corticosteroids for at least 27 days prior to enrolling in the study. Cohort 1 included a high proportion of African American patients: 50% of the soquelitinib group and 100% of the placebo group. African Americans with atopic dermatitis are known to have a less favorable prognosis compared to other patient populations. Cohort 1 Efficacy DataThe cohort 1 EASI and IGA scores are shown in Table 2 below. EASI scores at 28-day and 58-day follow-up demonstrate a favorable effect of soquelitinib treatment compared to placebo. The soquelitinib mean EASI score reduction was 55.9% at 28 days (n=12) compared to mean EASI reduction of 27.0% in placebo. At day 58, continued improvement in the soquelitinib group was seen with mean EASI reduction of 69.1% (n=10) compared to mean EASI reduction of 19.1% for the placebo group. At day 28, in the soquelitinib group, nine of 12 patients achieved EASI 50; three of 12 achieved EASI 75 and one of 12 achieved EASI 90. Three of 12 patients achieved IGA 0 or 1. In the placebo group, two of four patients achieved EASI 50 and no patients achieved EASI 75, EASI 90 or IGA 0 or 1. At day 58, in the soquelitinib group, nine of 10 patients achieved EASI 50, four of 10 achieved EASI 75 and one of 10 achieved EASI 90. Three of 10 patients achieved IGA 0 or 1. In the placebo group, one in four patients achieved EASI 50 and no patients achieved EASI 75, EASI 90 or IGA 0 or 1. The timing of EASI improvement in the soquelitinib group indicates that a treatment effect begins early, at eight days, and continues for the remainder of the study. (See Figures 1 and 2 below). All soquelitinib treated patients showed improvement in EASI scores. The small number of placebo patients demonstrates a variable course over the treatment period with no substantial change over the 58-day period. Table 2: Cohort 1 Efficacy Results 4 week (Day 28) 8 week (Day 58) Placebo Soquelitinib Placebo Soquelitinib (N=4) (N=12) (N=4) (N=10) Change EASI Mean % Reduction 27.0 55.9 19.1 69.1 EASI 50 (%pts) 50 75 25 90 EASI 75 (%pts) 0 25 0 40 EASI 90 (%pts) 0 8 0 10 IGA 0 or 1 (%pts) 0 25 0 30 Figure 1: Mean EASI Score Change from Baseline (%) for Soquelitinib Treatment Group (N=12 at day 28 and N=10 at day 58)Figure 2: Mean EASI Score Change from Baseline (%) for Placebo Group (N=4)Cohort 1 Safety DataNo significant safety issues were observed. All the patients completed 28 days of dosing. One patient reported Grade 1 nausea that did not interfere with the subject receiving the full treatment course, and one patient developed COVID-19 on day 28 of treatment; that patient had an uneventful recovery. No clinically significant laboratory abnormalities were seen. See Table 3 below. Table 3: Cohort 1 Safety Soquelitinib Placebo (N=12) (N=4) Subjects with adverse events 2* 0 Serious adverse events 0 0 Adverse events leading to study drug discontinuation 0 0 Adverse events leading to death 0 0 Treatment-related adverse events: Nausea (Grade 1) 1 0 *Reported adverse events: Nausea (N=1) and Covid-19 (N=1); both resolved without any dose modification. Serum Cytokine ChangesRelationships between reductions in certain cytokines with improvement in EASI scores were observed. Significant cytokines changes were seen for IL-5, IL-17, IL-31, IL-33, TSLP and a trend for TARC in EASI 50 responders (N=9) compared to non-responders (N=3). No such relationships were seen in the placebo group. Cohort 2 Initial Efficacy and Safety DataAs of December 16, the Company has enrolled 12 patients in Cohort 2 of the trial (soquelitinib 200 mg oral once per day). As of December 7, Day 28 follow up data is available for three patients with efficacy results consistent with that seen in Cohort 1. No clinically significant laboratory abnormalities or treatment related adverse events have been reported in any of the patients enrolled in Cohort 2. Early Exercise of Common Stock WarrantsThe Company also announced that Samlyn Capital, a holder of warrants to purchase 3,633,978 shares of common stock, has delivered exercise notices with respect to all of its warrants in advance of the June 30, 2025 expiration date, which will result in cash proceeds to the Company of approximately $12.7 million. Conference Call, Webcast and Presentation SlidesCorvus will host a conference call and webcast today, Wednesday, December 18, 2024 from 8:00 – 9:00 a.m. ET to provide an overview of the soquelitinib atopic dermatitis Phase 1 clinical data. The conference call can be accessed by dialing 1-800-717-1738 (toll-free domestic) or 1-646-307-1865 (international) or by clicking on this link for instant telephone access to the event. The live webcast, which will include presentation slides, may be accessed via the investor relations section of the Corvus website. A replay of the webcast will be available on Corvus' website for 60 days. About Atopic DermatitisAtopic dermatitis, also called eczema, is a chronic disease that can cause inflammation, redness, scaly patches, blisters and irritation of the skin. It affects up to 20% of children and up to 10% of adults, and treatments include topical therapies, oral therapies and systemic injectable biologic therapies. It is frequently associated with other allergic disorders such as food allergies and asthma. Atopic dermatitis, like asthma and allergy, involves the participation of Th2 lymphocytes which secrete cytokines that result in inflammation. Soquelitinib has been shown in preclinical studies to inhibit cytokine production from Th2 lymphocytes. About SoquelitinibSoquelitinib (formerly CPI-818) is an investigational small molecule drug given orally designed to selectively inhibit ITK (interleukin-2-inducible T cell kinase), an enzyme that is expressed predominantly in T cells and plays a role in T cell and natural killer (NK) cell immune function. Soquelitinib has been shown to affect T cell differentiation and induce the generation of Th1 helper cells while blocking the development of both Th2 and Th17 cells and production of their secreted cytokines. Th1 T cells are required for immunity to tumors, viral infections and other infectious diseases. Th2 and Th17 helper T cells are involved in the pathogenesis of many autoimmune and allergic diseases. The Company believes the inhibition of specific molecular targets in T cells may be of therapeutic benefit for patients with cancers, including solid tumors, and in patients with autoimmune and allergic diseases. Recent studies have demonstrated that ITK controls a switch between the differentiation of Th17 proinflammatory cells and T regulatory suppressor cells. Inhibition of ITK leads to a shift toward T regulatory cell differentiation which has the potential to suppress autoimmune and inflammatory reactions. Based on interim results from a Phase 1/1b clinical trial in patients with refractory T cell lymphomas, which demonstrated tumor responses in very advanced, refractory, difficult to treat T cell malignancies, the Company has initiated a registrational Phase 3 clinical trial (NCT06561048) of soquelitinib in patients with relapsed PTCL. Soquelitinib is also now being investigated in a randomized placebo-controlled phase 1 clinical trial in patients with atopic dermatitis. A recent publication describing the chemistry, enzymology and biology of soquelitinib appeared in npj Drug Discovery in December 2024 and is available online at the Nature website and on the Publications and Presentations page of the Corvus website. About Corvus PharmaceuticalsCorvus Pharmaceuticals is a clinical-stage biopharmaceutical company pioneering the development of ITK inhibition as a new approach to immunotherapy for a broad range of cancer and immune diseases. The Company's lead product candidate is soquelitinib, an investigational, oral, small molecule drug that selectively inhibits ITK. Its other clinical-stage candidates are being developed for a variety of cancer indications. For more information, visit Forward-Looking StatementsThis press release contains forward-looking statements, including statements related to the potential safety and efficacy of the Company's product candidates including soquelitinib; the potential use of soquelitinib to treat atopic dermatitis and the potential of ITK inhibition as a novel mechanism of action for other immune diseases; and the Company's conduct of, enrollment in and timing of clinical trials, including the Company's Phase 3 clinical trial in PTCL and Phase 1 clinical trial in atopic dermatitis. All statements other than statements of historical fact contained in this press release are forward-looking statements. These statements often include words such as 'believe,' 'expect,' 'anticipate,' 'intend,' 'plan,' 'estimate,' 'seek,' 'will,' 'may' or similar expressions. Forward-looking statements are subject to a number of risks and uncertainties, many of which involve factors or circumstances that are beyond the Company's control. The Company's actual results could differ materially from those stated or implied in forward-looking statements due to a number of factors, including but not limited to, risks detailed in the Company's Quarterly Report on Form 10-Q for the three months ended September 30, 2024, filed with the Securities and Exchange Commission on November 12, 2024, as well as other documents that may be filed by the Company from time to time with the Securities and Exchange Commission. In particular, the following factors, among others, could cause results to differ materially from those expressed or implied by such forward-looking statements: the Company's ability to demonstrate sufficient evidence of efficacy and safety in its clinical trials of its product candidates; the accuracy of the Company's estimates relating to its ability to initiate and/or complete preclinical studies and clinical trials and release data from such studies and clinical trials; the results of preclinical studies and interim data from clinical trials not being predictive of future results; the Company's ability to enroll sufficient numbers of patients in its clinical trials; the unpredictability of the regulatory process; regulatory developments in the United States and other foreign countries; the costs of clinical trials may exceed expectations; and the Company's ability to raise additional capital. Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee that the events and circumstances reflected in the forward-looking statements will be achieved or occur, and the timing of events and circumstances and actual results could differ materially from those projected in the forward-looking statements. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and the Company undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise. INVESTOR CONTACT:Leiv LeaChief Financial OfficerCorvus Pharmaceuticals, Inc.+1-650-900-4522llea@ MEDIA CONTACT:Sheryl SeapyReal Chemistry+1-949-903-4750sseapy@ Photos accompanying this announcement are available at in to access your portfolio

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