
Seven Questions for Miruna Sasu, Cancer Data and Research Guru
Data is more important than ever before for health care organizations. In today's techy environment, hospitals and clinics can derive insights from vast patient records to deliver care more safely, effectively and efficiently.
But patient data is often unstructured, and insights aren't always easy to glean—especially in specialties like oncology, where care records are particularly long and complex. That's where COTA Healthcare comes in. Its platform pulls data from electronic medical records at hospitals and clinics, cleans and adjudicates the clinical notes and then returns them to the health care organizations for cancer research and drug development purposes.
That work has enormous potential, as the American Cancer Society estimates that more than 2 million new cancer cases will be diagnosed in 2025 alone. Despite the wide-ranging impacts, this mission is deeply personal for Miruna Sasu, the president and CEO of COTA Healthcare.
Ahead of Newsweek's Women's Global Impact forum, Sasu told Newsweek how her work intertwines with her identity.
Miruna Sasu is the president and CEO of COTA Healthcare and will be speaking at Newsweek's Women's Global Impact forum on August 5 in New York City.
Miruna Sasu is the president and CEO of COTA Healthcare and will be speaking at Newsweek's Women's Global Impact forum on August 5 in New York City.
Newsweek Illustration/Canva
Newsweek: Walk me through your career trajectory. What sparked your interest in science / health care? Do you recall any formative experiences or mentors?
Sasu: "The fight against cancer is personal for me. When I first moved to the U.S., my grandfather was diagnosed with Stage 4 lung cancer. Enrolling him in a clinical trial saved his life and gave us 35 more years with him. That time changed the course of my life. It allowed me to pursue my education and career, and it's a big part of why I do this work.
The path to my current role has taken a few turns. I started in food safety with the federal government, then moved into life sciences at Bristol Myers Squibb, where I first worked with real-world data. I continued that work at Johnson & Johnson, focusing on making clinical trials more efficient. Eventually, I felt a strong pull to work entirely in cancer, which brought me to COTA.
Along the way, I have been fortunate to have mentors who offered their time, insight and belief in me. Some of them recognized my leadership potential before I was ready to see it in myself. That kind of support shaped who I am and how I lead. It taught me to stay curious, to act with courage and to lead with empathy and purpose."
What challenges did you face along the way, and what accomplishments are you most proud of?
"There have been plenty of challenges. Change is hard, especially in health care. Most people care deeply about making a meaningful impact on patient outcomes, but org structures don't always make it easy. A lot of my work has focused on getting people aligned across departments and functions and on building trust so we can move forward together."
What problems do you aim to solve in your current role? How do you measure progress toward your goals?
"We are trying to solve a core problem in health care: how to use data to improve outcomes for patients. It's about making data not just available but actionable. We want to help pharma find the right patients for trials faster, support providers with better insights and ultimately help people get the care they need sooner."
What are some recent projects or advancements that you're particularly excited about?
"One of the most exciting developments at COTA is the launch of CAILIN, a new suite of AI-powered cancer data tools. For a long time, working with real-world data has required deep technical expertise and significant time to extract insights. CAILIN changes that by allowing users to ask complex research questions in plain language and receive answers within seconds. It also supports our medical abstractors by guiding them through the data curation process more efficiently, which helps improve both speed and quality.
We are already seeing the impact of CAILIN across our work. Researchers, clinicians and life sciences teams can now access the insights they need without relying solely on data scientists. This kind of access accelerates decision-making and makes it easier for more people to work directly with high-quality oncology data. CAILIN is not a replacement for human expertise, but it is a powerful tool that helps us do more, faster. It is a meaningful step forward in cancer research, and I am incredibly proud of the team that made it possible."
What are you most passionate about? Does your current role enable you to explore this passion?
"I care deeply about using data to solve real-world problems. My passion lies in making health care more equitable, more effective and more humane. I'm also passionate about people. Building a healthy, inclusive team culture where people feel valued and motivated is something I work on just as intentionally as product or strategy. The two go hand in hand."
Has being a woman shaped your leadership style and/or the way that you think about your work in the health care industry?
"It has. Being a woman in leadership has taught me how to lead with both strength and empathy. I've had to work harder at times to prove myself, and that has made me more aware of how I show up and how I support others. I've learned to listen more, to trust my instincts and to lead with clarity. And I've made it a point to open doors for others wherever I can."
Women make up 70% of the global health care workforce but hold just 25% of the industry's leadership positions. What do you make of this gender gap? How might we begin to close it?
"It's a real gap, and it reflects long-standing structural issues, not a lack of qualified women. We need to be more intentional about creating pathways to leadership. That includes mentorship, sponsorship, fair hiring practices and making sure women have real opportunities to grow and lead.
Representation also matters. When women see others leading at the highest levels, it expands what feels possible. I take that responsibility seriously and try to be the kind of leader I would have looked up to earlier in my own journey and to carve out paths for others to have an opportunity to do the same."
Sasu will join Newsweek at this year's inaugural Women's Global Impact forum. The August 5 event, hosted at Newsweek's headquarters in New York City, will bring together some of the world's top female executives and connect them with rising stars across industries and job functions.
For more information on the event, please visit the Women's Global Impact homepage.

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UPI
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Newsweek
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While genetic and environmental factors play a role, scientists also haven't been able to suggest why some people with the same risk factors might develop it and others don't—until now. The scientists unearthed that lithium loss in the human brain is one of the earliest changes leading to Alzheimer's. In mice, meanwhile, similar lithium depletion accelerated brain pathology (disease or abnormality) and memory decline. They also found reduced lithium levels stemmed from binding to amyloid plaques (misfolded proteins found between nerve cells found in the brains of people with Alzheimer's) and impaired uptake in the brain. One pair of boxes shows fewer green amyloid clusters on the left and more on the right. Another pair of boxes shows a dim arc of purple and red tau on the left and a... One pair of boxes shows fewer green amyloid clusters on the left and more on the right. Another pair of boxes shows a dim arc of purple and red tau on the left and a brighter arc on the right. More Yankner Lab In their final set of experiments, they found a new lithium compound that avoids "capture" by amyloid plaques restored memory in mice. "In people that start experiencing memory loss, the so-called mild cognitive impairment, lithium gets trapped by amyloid plaques—reducing its availability just when it's most needed to protect against inflammation and neurodegeneration," Yankner and Aron explained. "This creates a self-perpetuating feedback loop of worsening pathology and accelerating disease progression and memory loss." This all ties together decades-long observations in patients and provides a new theory of the disease and strategy for early diagnosis, prevention and treatment, according to the researchers. Recently developed treatments that target amyloid beta (a key component of the amyloid plaques) typically don't reverse memory loss and only modestly reduce the rate of decline. "The idea that lithium deficiency could be a cause of Alzheimer's disease is new and suggests a different therapeutic approach," said Yankner in a statement. Researchers had previously found lithium to be the only metal that had markedly different levels across people with and without Alzheimer's at different stages. But Yankner added in a statement, "Lithium turns out to be like other nutrients we get from the environment, such as iron and vitamin C. "It's the first time anyone's shown that lithium exists at a natural level that's biologically meaningful without giving it as a drug." Previous population studies have shown that higher lithium levels in the environment, including in drinking water, tracked with lower rates of dementia. Woman hugging her elderly mother. Woman hugging her elderly mother. PIKSEL/Getty Images Yankner's team demonstrated in mice that lithium depletion isn't just linked to Alzheimer's, it actually helps drive it. This raises hope that one day lithium could be used to treat the disease in its entirety rather than focusing on a single factor like amyloid beta or tau (another Alzheimer's-associated protein), Yankner said. Crucially, the researchers discovered that as amyloid beta begins to form deposits in the early stages of dementia in both humans and mouse models, it binds to lithium, reducing lithium's function in the brain. The reduced levels of lithium affect all major brain cell types and, in mice, lead to changes similar to those seen in Alzheimer's disease, including memory loss. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer's pathology, prevented brain cell damage and restored memory. While the findings need to be confirmed in humans through clinical trials, they suggest that measuring lithium levels could help screen for early Alzheimer's. They also highlight the importance of testing amyloid-evading lithium compounds for treatment or prevention. While other lithium compounds are already used to treat bipolar disorder and clinical depression, they are given at much higher concentrations that can be toxic to some people, the researchers flag. Yankner's team discovered lithium orotate is effective at one-thousandth that dose— enough to mimic the natural level of lithium in the brain. Mice treated for nearly their entire adult lives showed no evidence of toxicity, the study found. If further studies confirm these findings, the researchers say lithium screening through routine blood tests may one day offer a way to identify individuals at risk for Alzheimer's who would benefit from treatment to prevent or delay disease onset. "Our study adds to growing evidence that Alzheimer's may be preventable—with something as simple as keeping brain lithium at healthy levels as we age," said Yankner and Aron. "Clinical trials [on humans] could test the impact of low-dose supplementation on cognitive health and dementia risk." Before lithium is proved to be safe and effective in protecting against neurodegeneration in humans, Yankner emphasized that people should not take lithium compounds on their own. Do you have a health story to share with Newsweek? Do you have a question about Alzheimer's? Let us know via health@ Reference Aron, L., Ngian, Z. K., Qiu, C., Choi, J., Liang, M., Drake, D. M., Hamplova, S. E., Lacey, E. K., Roche, P., Yuan, M., Hazaveh, S. S., Lee, E. A., Bennett, D. A., & Yankner, B. A. (2025). Lithium deficiency and the onset of Alzheimer's disease. Nature.