Former MUSC pediatrician announces campaign to oust Lindsey Graham
Annie Andrews, a Mount Pleasant pediatrician, announced she will be running against Lindsey Graham on Thursday, May 29, 2025. (Photo courtesy of Andrews campaign)
A Lowcountry pediatrician is again running for a spot on Capitol Hill, this time aiming for the U.S. Senate seat held by Lindsey Graham, she announced Thursday.
Annie Andrews, who spent 15 years at the Medical University of South Carolina and attempted in 2022 to oust U.S. Rep. Nancy Mace, is the second Democrat to announce a bid to topple Graham next year.
'I believe in South Carolina. I believe in the kids and families that I've served for years, and I'm not afraid to take on the people who've sold them out, and I'm starting with Lindsey Graham,' Andrews told the SC Daily Gazette ahead of her announcement.
Andrews touted her medical experience during her 2022 run and will do so again amid debate in Washington over Republicans' efforts to slash spending in President Donald Trump's second term.
An overhaul of Medicaid in the massive bill passed by the U.S. House last week by a single vote would cut spending on the government-run health insurance program by a projected $625 billion over a decade, according to the nonpartisan Congressional Budget Office.
'I am watching in real time as our health care system is being completely dismantled by conspiracy theorists and drifters who have no business being anywhere near our public health system,' Andrews said. 'I've seen both Republicans and Democrats watch and treat this as normal politics, which is not what this is at all.'
Andrews first ventured into politics for the 2022 election, hoping to flip the coastal 1st District blue again after Mace brought it back to the GOP in 2020, defeating one-term Democrat Joe Cunningham.
But Andrews lost by nearly 14 percentage points as Mace swept every county in the district in the first election following the Legislature's decennial redrawing of congressional voting lines. In a split ruling, the U.S. Supreme Court upheld those lines last year.
In September 2022, weeks before voters cast their ballot, Andrews took a leave of absence from her role at MUSC due to political attacks during the election.
The following June, less than two months after announcing the creation of a political action committee dedicated to supporting children, Andrews announced her departure from MUSC.
Andrews lives in Mount Pleasant but works part time at Children's National Hospital in Washington D.C. And she's active on social media, accruing more than 100,000 followers across Instagram and X, formerly Twitter.
However, that pales in comparison to Graham's 2.2 million followers on X alone, with another 164,000 on Instagram.
Taking on Graham, a fundraising juggernaut with $15.9 million in his campaign account, according to his latest FEC filings and Trump's endorsement, will be no easy task for any Democrat in a state in its biggest red wave in four decades.
But Andrews says it's possible. Despite being the Senate Budget Committee chairman and one of the GOP's most visible faces, he remains divisive.
In Andrews' eyes, that makes him vulnerable.
'Republicans are just as fed up with the corruption in career politicians like Lindsey Graham in Washington D.C. as Democrats are,' she said.
Mark Lynch, a Greenville businessman who invested $5 million of his own money into his campaign as of the end of March, is Graham's lone Republican primary challenger so far.
It's likely that more Republicans will jump into the race. Graham usually draws multiple challengers in elections.
Upstate Democrat announces bid to unseat Lindsey Graham
Graham's re-election campaign is co-chaired by Gov. Henry McMaster and U.S. Sen. Tim Scott.
Before she gets to Graham, Andrews will have to defeat Lee Johnson, a Greenville engineer, for the Democratic nomination.
In a statement, Johnson said he welcomes anybody to the race and wants to find the best candidate to defeat Graham.
'My focus remains squarely on the mission: retiring Lindsey Graham with someone who shows up, listens, and delivers for all of South Carolina,' the statement said.
When asked why she should be the Democratic nominee, Andrews said, 'I'm a doctor. I'm a mom. I'm not a career politician. I've been serving kids and families in South Carolina from every corner of South Carolina for 15 years, and I'm in this fight for those kids and families.'
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