BioAegis Therapeutics Announces Site Activation and Patient Recruitment Underway in 13 Countries in Phase 2b Clinical Trial of Gelsolin, an Immune Regulator, for the Treatment of Acute Respiratory Dis
BioAegis Therapeutics
600-patient study to assess efficacy of rhu-pGSN, an immune system regulator that interrupts the NLRP3 inflammasome and boosts macrophage clearance of pathogens.
Results from this landmark study expected to inform therapeutic strategies beyond ARDS, positioning rhu-pGSN as a promising intervention across a spectrum of acute and chronic inflammatory diseases.
NORTH BRUNSWICK, N.J., May 06, 2025 (GLOBE NEWSWIRE) -- BioAegis Therapeutics, a pioneering biotech company at the forefront of innovative therapies for acute and chronic inflammatory diseases, announces that patient recruiting is underway across all 13 targeted countries for its Phase 2 study of rhu-pGSN for the treatment of ARDS. (NCT05947955). The Company's portfolio is built around gelsolin (GSN), a highly conserved and critical immune regulatory protein which controls dysfunctional inflammation without suppressing immune function.
Large Global Phase 2 Clinical Trial of rhu-pGSN Underway
The randomized, double-blind, placebo-controlled trial of rhu-pGSN added to standard of care will evaluate the efficacy (survival without organ failure on Day 28) of six doses of rhu-pGSN administered intravenously to hospitalized moderate-to-severe ARDS subjects (P/F ratio ≤150) caused by infection. It will also measure the safety and tolerability of treatment along with secondary outcomes.
Sites are recruiting patients in 13 countries including US, Canada, UK and the EU (Belgium, France, Italy, Germany, Netherlands, Spain, and others). Enrollment is targeted for 600 subjects.
This project has been supported in whole or in part with federal funds from the U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority (BARDA), under contract number 75A50123C00067.
"We are excited with our significant progress in this important study. Focusing this study on the moderate to severe patient who will have severely depleted plasma gelsolin levels promises to address ARDS with a novel approach employing the protein whose role in the body is to balance the inflammation-healing axis,' stated Susan Levinson, Ph.D., Chief Executive Officer of BioAegis.
Effectively Treating ARDS Will Alleviate Massive Healthcare Burden
ARDS is a condition that can develop as a severe complication of sepsis, trauma, pneumonia or other infectious diseases, resulting in life-threatening lung injury with fluid leakage into the lungs. Breathing becomes difficult, and patients require oxygen, mechanical ventilation and extensive critical care resources, placing a significant burden on the healthcare system.
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
4 hours ago
- Yahoo
Global Fashion Agenda Addresses Sustainability's Struggles: Uncertainty Looms Amid Policy Shifts, Economic Pressures and Tariffs
COPENHAGEN — Does sustainability stand a chance in a world where it is being increasingly de-prioritized amid shifting government policies, mounting tariffs and more conservative political climates? That was the question attendees grappled with at this year's Global Fashion Agenda conference in Copenhagen. Organizers acknowledged the mood was 'somber,' reflecting rising uncertainty. Attendance was lighter, as brands cut budgets and pivoted toward contingency planning in response to legislative delays and economic headwinds. More from WWD Miley Cyrus Puts Her Own Twist on a '80s Rockstar Hairstyle at the Chanel and Tribeca Film Festival Luncheon in NYC Miley Cyrus, Parker Posey, Riley Keough & More Celebrate 'Through Her Lens' With Chanel and Tribeca Lucy Liu Anchors Chanel Textured Midi Dress With Pearl-heeled Pumps at TriBeCa Through Her Lens Luncheon In Europe, the European Commission's conservative pivot has led to a rollback of key legislation, most notably the Corporate Sustainability Due Diligence Directive. The directive, which required large companies to identify and address human rights and environmental impacts across their supply chains, is now partially on hold, leaving many companies in limbo. 'The EU has given the world a political signal that we, too, are going to do things differently, and I would even call it a sort of 'Trump lite,'' said European Parliament member Lara Wolters. Though the EU's upcoming changes are being framed as simplifications, 'it's far too soon…to make a harsh policy move like this. And yet that's been done and everybody is now scrambling to try to do damage control,' said Wolters. The likely outcome will be more paperwork on imports and burdens on small businesses, with less scrutiny at the source of production. In the U.S., new tariffs under the Trump administration have further complicated sustainability strategies. Companies investing in decarbonizing their supply chains now face uncertainty around future production costs and sourcing locations. 'It's hard to convince your CFO to make that decision,' said Chelsea Murtha, senior director of sustainability at the American Apparel and Footwear Association. '[Companies are] operating in confusion.' Meanwhile, states that once led on climate action are facing rising costs and cross-border partnerships, such as U.S.-Canadian collaborations on recycling and sorting systems, are now under threat due to the new fees and increased shipping complexity. USAID had long funded many NGOs and programs that U.S. brands relied on to monitor human rights and labor conditions in sourcing countries. That support is now cut, and brands are being asked to fill the gap. 'As much as the brands would like to, they're also getting squeezed by the tariffs,' said Murtha. 'So there's this sort of paralysis happening right now where everyone's trying to figure out what on earth can we continue to hold on to?' Claus Teilmann Petersen, Bestseller's head of sustainability and human rights, urged brands to channel this uncertainty into 'productive paranoia.' He believes that while the EU battle 'is kind of lost,' legislators should regroup to implement simplified due diligence based on global OECD guidelines. GFA's vice president of public affairs María Luisa Martínez Díez added that geopolitical instability is adding to the uncertainty. 'Wars and conflicts [are] also disrupting the industry, with brands having to reassess production locations and loans due to the risky conflict zones.' Financing is also impacted, with banks less inclined to fund factory upgrades that set out to reduce carbon emissions or water use. 'The focus on sustainability has been left behind, fading into the background, to the favor of competitors,' she noted. Adding to the challenge is the compliance burden of data collection and upcoming circular economy regulations. Brands are navigating varying rules from the U.S., EU, China and pending new laws in India, South America and Mexico. Amid the gloom, some companies see a silver lining in artificial intelligence. One promising use case is to modernize the outdated wholesale model. 'The system relies on the traditional system of bulk ordering,' said MannyAI cofounder and chief executive officer Shruti Grover. AI, she suggested, could optimize inventory, reduce overstock, and cut costs. The system relies on the traditional method of bulk ordering. Brands have to front the stock then absorb the cost of any items that are returned. Revamping the system could be especially beneficial for small brands, but this would break longstanding business practices and is resisted by existing players in the industry. 'So brands need to take a really brave decision for this,' she said. But while AI has potential, so far it has not paid out, according to research from BCG. Arti Zeighami, partner and director at the consulting group's tech design division BCGX, shared that only 4 percent of CEOs implementing AI have seen measurable return on investment, highlighting a gap between hype and tangible value. Still, smaller brands see opportunity. Mudd Jeans CEO Jolanda Brink said AI could enable her 12-person team to compete at scale. 'Everybody's talking like people are scared about AI, but I'm actually thinking this can tremendously help me,' she told WWD. 'It used to be large team, large results. So now this can be small team, large results.' Brink hopes to build a product lifecycle management system and launch targeted paid ads built with AI tools, especially to reach 'light green' consumers who value style but consider sustainability a bonus. She sees this possibility as a win-win. 'That is really good for retailers also, because that means they don't have to invest a lot in us, because they can see if it sells, and then they can order from us,' she said. StyleDNA cofounder and CEO Elena Volkova echoed the hype vs. value gap in AI, this time from the consumer perspective. Her research found that while 82 percent of users want AI-assisted shopping, many haven't acted on its suggestions. It will take time for consumers to develop trust in a new system and to see any personal value in using it, she said. This disconnect between intention and action was a recurring theme. Visa Europe's vice president of impact and sustainability Katherine Brown said their Behavioral Insights Lab found 87 percent of consumers want to shop sustainably, but only 27 percent follow through. The lab partners with retailers such as Selfridges, Cos, and John Lewis to test messaging and to nudge strategies that drive more sustainable choices. For Gen Z, framing sustainability as community-driven behavior raised sales at Cos by 22 percent. Pre-purchase nudges promoting refillables were also successful in a Charlotte Tilbury case study, she told WWD. These 'nudges' are less about hard-hitting sustainability messaging and more about a few key words that appeal to style or make economic sense to consumers in a softer way. Visa is also exploring 'agentic AI,' which autonomously searches and shops for products based on a consumer's personalized preferences. Yet trust and fraud prevention remain critical, especially in resale. 'There is just so much financial fraud at this moment in time, so people really do want to know that if I'm buying something, I want to know that it's from a real source,' she said. 'Trust and security is not yet robust in the resale market.' Visa is supporting digital passports to ensure the authenticity of goods as well as ensure the payments systems behind secondhand transactions. The lab, focused on Europe, plans to expand into global markets and new sectors, including travel and home goods. 'The fashion industry has been a brilliant starting point because the industry just so vastly needs to understand how to move people away from fast fashion,' said Brown. Devon Leahy, global head of sustainability at L Catterton, stressed the business case for bridging the gap. 'Closing the consumer gap is tangible financial value,' she said, urging brands to present sustainability as a co-benefit, not the primary purchase driver. Florence Bulté, chief sustainability officer at Chalhoub Group, discussed efforts to shift secondhand perceptions in the Middle East, where the group operates. When the group launched a jewelry rental program, she knew it would appeal to expats in the region. But to her surprise, it performed better than expected with local communities. The group is working to extend this kind of change with handbags and shoes as well. GFA CEO Federica Marchionni acknowledged the global moment. 'This time was a very different feeling…we were anxious of the time and the situation we are living in, and it's hard to tackle all of these barriers that are growing every day,' she said, highlighting the event's theme of 'Barriers and Bridges.' 'I always say that sustainability can really be the uniting bond,' she said. Many attendees noted that this year's conference felt smaller, whether due to overlapping events, tighter travel budgets, or broader fatigue. SXSW London was scheduled at the same time, where one attendee was due to be a panelist before she realized the dates conflicted, and the Textiles Recycling Expo was happening in Brussels. As a result, 'all the recyclers are there and the brands are here,' the attendee said. Though fewer CEOs were visible, C-level sustainability leaders from brands like Chanel and Kering participated in closed-door roundtables. Kering even brought along its first 'sustainability futurist,' who is focused on studying long-range transformation a decade out. One returning attendee, attending for the sixth time, said they had hoped for more 'actionable' content given how 'people have backed down on messaging.' Nonetheless, the networking was strong. 'It's good to meet people we only see on Zoom,' one attendee said. 'In that aspect, it is doing its job.' A standout moment of the week was the debut of Lycra EcoMade with Qira — a corn-based stretch fiber containing 70 percent renewable content. The drop-in replacement for petroleum-based Lycra delivers the same performance, making it possible for activewear such as yoga pants to go bio-based. There's no difference in appearance or feel. Both CEOs were on hand to unveil the fiber at the event, Lycra's Gary Smith and Qira's Jon Veldhouse. The fiber has been in development for seven years, and already piloted by brands like A-Golde. The material is being produced at a factory in Iowa and will scale to 65 tons a year, with the first large-scale shipments expected this fall for inclusion in spring collections. Leather alternative pioneer Modern Meadow also revealed its newly rebranded material, Innovera, with CEO David Williamson on hand to discuss the future of bio-designed material innovations. To close the week, Refibered was awarded the GFA Trailblazer prize. The startup uses AI to identify textile compositions, helping recyclers and boosting resale authentication and traceability. Best of WWD Walmart Calls California Waste Dumping Lawsuit 'Unjustified' Year in Review: Sustainability's Biggest Controversies of 2021 Year in Review: Sustainability's New Strides
Business Upturn
5 hours ago
- Business Upturn
Miningcoop announced that it will comprehensively increase the interest rate of cloud mining contracts, and the daily return on investment for mining Bitcoin & Dogecoin can reach 6.8%.
By GlobeNewswire Published on June 8, 2025, 19:00 IST London, United Kingdom , June 08, 2025 (GLOBE NEWSWIRE) — As global demand for passive cryptocurrency income continues to surge in 2025, cloud mining has quickly become the preferred strategy for a growing number of investors. Amid rising financial uncertainty worldwide, investor interest in decentralized assets like Bitcoin (BTC) has soared, driving unprecedented demand for legal, secure, convenient, and high-return crypto investment platforms. Leading this transformation is Miningcoop—widely recognized as the most profitable and trusted Bitcoin and Dogecoin cloud mining platform of 2025. Unlike traditional mining setups, Miningcoop requires no expensive hardware or complex installations. With just a few clicks, users can begin earning stable daily returns through cloud-based crypto mining. Miningcoop: Delivering the Most Trusted Daily Crypto ROI Solutions in 2025 (Awarded Best Cloud Mining Platform) A key advantage of Miningcoop lies in its AI-powered, transparent, and quantifiable income model. Users can flexibly select from a variety of short- and medium-term mining contracts based on their budgets and profit goals. Contracts pay daily and automatically return the principal upon maturity—with no hidden fees or costs. Miningcoop's most popular mining contracts feature: · Contract durations starting from just 1 day · Daily earnings of up to $4,400, based on real mining pool output · Multi-currency support for deposits and withdrawals (BTC, ETH, DOGE, USDT) · Zero hardware costs, no maintenance required � Visit now to claim your free $100 bonus Example Earnings Table: The following chart illustrates the potential profit you can achieve. Mining Model Contract Price ($) Daily Rate (%) Daily Earnings ($) Duration (Days) Total Earnings ($) iPollo V1 Ultra 200 4.00% 8.00 1 8.00 Goldshell Mini-DOGE III 500 3.20% 16.00 2 32.00 Antminer L7 3,800 4.15% 157.70 5 788.50 Antminer S21 XP+ Hyd 30,000 6.80% 2,040.00 3 6,120.00 Withdrawals are supported in BTC, ETH, DOGE, or USDT. The minimum withdrawal amount is $200. Earnings are calculated and distributed automatically each day. Beginners Welcome: Start Your Crypto Passive Income with Zero Experience 1. Fast Account Registration: Visit and register with your email in just one minute. and register with your email in just one minute. 2. Claim Your $100 Free Mining Bonus: All new users receive a free 1-day contract worth $100, with estimated earnings up to $1.35. All new users receive a free 1-day contract worth $100, with estimated earnings up to $1.35. 3. Choose a High-Yield Plan: Select from a wide variety of BTC and DOGE mining contracts with flexible durations and stable daily returns. Select from a wide variety of BTC and DOGE mining contracts with flexible durations and stable daily returns. 4. Multi-Currency Payment, Instant Start: Pay using BTC, USDT, ETH, or DOGE—mining begins automatically after payment, no manual setup needed. Pay using BTC, USDT, ETH, or DOGE—mining begins automatically after payment, no manual setup needed. 5. Track Your Earnings in Real-Time: The user dashboard provides transparent insights into daily profits, balances, contract progress, and withdrawal history. The user dashboard provides transparent insights into daily profits, balances, contract progress, and withdrawal history. 6. Withdraw or Reinvest: Once your account reaches $200, withdraw at any time or reinvest into a new plan to enjoy compound growth. If you're searching for 'how to mine Bitcoin without hardware' or 'best Bitcoin cloud mining app for beginners,' Miningcoop is the ideal starting point. It offers a simple, secure, and beginner-friendly gateway into the world of crypto passive income. Trusted by Millions Worldwide: Miningcoop Ranked Among the Safest Cloud Mining Platforms of 2025 As of 2025, Miningcoop boasts over 1 million active users across 150+ countries and regions, making it one of the most widely adopted and trusted Bitcoin and Dogecoin cloud mining platforms globally. With consistent 4.6+ star ratings on Trustpilot , Reddit, and Google Reviews, Miningcoop ranks at the top in categories such as 'legal, verifiable, and high-yield cloud mining sites.' On the security front, Miningcoop has implemented cold wallet-based multi-layered encryption systems, AI-driven fraud detection, tiered firewalls, and behavior analysis technologies to effectively prevent hacking and fraudulent activity. The platform is also deeply integrated with world-leading mining pools to ensure 99.9% uptime and globally balanced load distribution. Conclusion: The Most Trusted Bitcoin Cloud Mining Platform of 2025 Offering Leading Investment Solutions As cloud mining enters a new era of compliance and intelligent efficiency, choosing a platform that is legal, secure, and high-yield is more important than ever. Backed by AI-powered hash rate scheduling, fully transparent profit mechanisms, and a world-class user experience, Miningcoop has earned its place as one of the most recommended crypto investment platforms of 2025. Start mining smarter today — visit and explore the leading Bitcoin and Dogecoin cloud mining solution of 2025. Begin your automated passive crypto income journey with confidence. Disclaimer: The information provided in this press release is not a solicitation for investment, nor is it intended as investment advice, financial advice, or trading advice. Cryptocurrency mining and staking involves risk. There is potential for loss of funds. It is strongly recommended you practice due diligence, including consultation with a professional financial advisor, before investing in or trading cryptocurrency and securities. Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. GlobeNewswire provides press release distribution services globally, with substantial operations in North America and Europe.
Yahoo
6 hours ago
- Yahoo
Slovakia will veto Russian sanctions if they harm national interests, Fico says
Slovak Prime Minister Robert Fico said on June 8 that Slovakia will block EU sanctions against Russia if they are deemed to harm the country's national interests. "If there is a sanction that would harm us, I will never vote for it," Fico told reporters. Fico's comments come as Slovakia's parliament passed a resolution on June 5 urging the government to oppose any new international sanctions or trade restrictions against Russia, citing alleged negative economic impacts. The non-binding resolution argues that the sanctions imposed in response to Russia's full-scale invasion of Ukraine have driven up energy prices, disrupted supply chains, and harmed Slovak industry. The resolution calls on government ministers to 'defend national economic interests' in international forums and resist further punitive measures targeting Moscow. Since taking office in 2023, Fico has reversed Slovakia's previous pro-Ukraine policy, ending military aid to Kyiv and questioning the value of EU sanctions on Russia. EU foreign policy decisions, including sanctions, require unanimous approval by all member states. A Slovak veto could force concessions or delay enforcement in future rounds. Unlike Ukraine-skeptic Hungarian Prime Minister Viktor Orban who has repeatedly obstructed and delayed the bloc's sanctions against Russia and military aid for Ukraine, Slovakia has not previously attempted to block EU sanctions. "I am interested in being a constructive player in the European Union, but not at the expense of Slovakia," Fico said, without elaborating on how he will vote on any upcoming EU sanctions packages. Fico added that he would not support any measure that halts Russian fuel imports that are used to power Slovakia's nuclear power plants. Discussions are underway as the EU is preparing an 18th sanctions package against Russia. EU ambassadors on May 14 agreed on the bloc's 17th package of sanctions against Russia, primarily targeting its shadow fleet of oil tankers. Ukraine's European allies are tightening sanctions against Russia as Moscow refuses to cease fire. Despite Russia's refusal, no new U.S. sanctions have been imposed so far. Read also: After 3 years of full-scale war in Ukraine, Europe announces plan to ban all Russian gas imports We've been working hard to bring you independent, locally-sourced news from Ukraine. Consider supporting the Kyiv Independent.
