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Harvard scientists may soon prevent malaria from spreading

Harvard scientists may soon prevent malaria from spreading

Eyewitness News4 days ago

CAPE TOWN - A discovery by scientists at Harvard could soon stop the spread of malaria.
Researchers at the Ivy League University have found two substances that, when absorbed through the legs of a mosquito, kill the malaria parasite.
Malaria claims nearly 600,000 lives each year, with the majority of the victims being children.
Malaria Researcher at the H3D Centre for the University of Cape Town, Dr Dale Taylor, said mosquitoes sometimes become resistant to the current insecticides used to kill them
'So what this drug does, it goes up through the feet, gets into the mosquito's circulatory system and it can kill the egg before it matures, and the beauty of this, when you're trying to treat a patient with malaria you're looking at trying to treat a billion parasites the mosquito probably only has two or three eggs so it is a really clever way to really focus and target what you're trying to do," said Taylor.
Taylor added that bed nets are not scarce in sub–Saharan Africa
'So in an ideal world we'd be able to use this as a tablet and also in spray form on bed nets, I imagine they would still need to do some testing to see whether or not it will work well enough in a human to become a tablet but certainly the bed net is probably less than five years away from a practical solution.'

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Harvard scientists may soon prevent malaria from spreading
Harvard scientists may soon prevent malaria from spreading

Eyewitness News

time4 days ago

  • Eyewitness News

Harvard scientists may soon prevent malaria from spreading

CAPE TOWN - A discovery by scientists at Harvard could soon stop the spread of malaria. Researchers at the Ivy League University have found two substances that, when absorbed through the legs of a mosquito, kill the malaria parasite. Malaria claims nearly 600,000 lives each year, with the majority of the victims being children. Malaria Researcher at the H3D Centre for the University of Cape Town, Dr Dale Taylor, said mosquitoes sometimes become resistant to the current insecticides used to kill them 'So what this drug does, it goes up through the feet, gets into the mosquito's circulatory system and it can kill the egg before it matures, and the beauty of this, when you're trying to treat a patient with malaria you're looking at trying to treat a billion parasites the mosquito probably only has two or three eggs so it is a really clever way to really focus and target what you're trying to do," said Taylor. Taylor added that bed nets are not scarce in sub–Saharan Africa 'So in an ideal world we'd be able to use this as a tablet and also in spray form on bed nets, I imagine they would still need to do some testing to see whether or not it will work well enough in a human to become a tablet but certainly the bed net is probably less than five years away from a practical solution.'

AI tool uses selfies to predict biological age and cancer survival
AI tool uses selfies to predict biological age and cancer survival

eNCA

time09-05-2025

  • eNCA

AI tool uses selfies to predict biological age and cancer survival

NEW YORK - Doctors often start exams with the so-called "eyeball test" -- a snap judgment about whether the patient appears older or younger than their age, which can influence key medical decisions. That intuitive assessment may soon get an AI upgrade. FaceAge, a deep learning algorithm described in The Lancet Digital Health, converts a simple headshot into a number that more accurately reflects a person's biological age rather than the birthday on their chart. Trained on tens of thousands of photographs, it pegged cancer patients on average as biologically five years older than healthy peers. The study's authors say it could help doctors decide who can safely tolerate punishing treatments, and who might fare better with a gentler approach. "We hypothesise that FaceAge could be used as a biomarker in cancer care to quantify a patient's biological age and help a doctor make these tough decisions," said co-senior author Raymond Mak, an oncologist at Mass Brigham Health, a Harvard-affiliated health system in Boston. Consider two hypothetical patients: a spry 75‑year‑old whose biological age clocks in at 65, and a frail 60‑year‑old whose biology reads 70. Aggressive radiation might be appropriate for the former but risky for the latter. The same logic could help guide decisions about heart surgery, hip replacements or end-of-life care. - Sharper lens on frailty - Growing evidence shows humans age at different rates, shaped by genes, stress, exercise, and habits like smoking or drinking. While pricey genetic tests can reveal how DNA wears over time, FaceAge promises insight using only a selfie. The model was trained on 58,851 portraits of presumed-healthy adults over 60, culled from public datasets. It was then tested on 6,196 cancer patients treated in the United States and the Netherlands, using photos snapped just before radiotherapy. Patients with malignancies looked on average 4.79 years older biologically than their chronological age. Among cancer patients, a higher FaceAge score strongly predicted worse survival -- even after accounting for actual age, sex, and tumour type -- and the hazard rose steeply for anyone whose biological reading tipped past 85. Intriguingly, FaceAge appears to weigh the signs of aging differently than humans do. For example, being gray-haired or balding matters less than subtle changes in facial muscle tone. FaceAge boosted doctors' accuracy, too. Eight physicians were asked to examine headshots of terminal cancer patients and guess who would die within six months. Their success rate barely beat chance; with FaceAge data in hand, predictions improved sharply. The model even affirmed a favourite internet meme, estimating actor Paul Rudd's biological age as 43 in a photo taken when he was 50. - Bias and ethics guardrails - AI tools have faced scrutiny for under‑serving non-white people. Mak said preliminary checks revealed no significant racial bias in FaceAge's predictions, but the group is training a second‑generation model on 20,000 patients. They're also probing how factors like makeup, cosmetic surgery or room lighting variations could fool the system. Ethics debates loom large. An AI that can read biological age from a selfie could prove a boon for clinicians, but also tempting for life insurers or employers seeking to gauge risk. "It is for sure something that needs attention, to assure that these technologies are used only in the benefit for the patient," said Hugo Aerts, the study's co-lead who directs MGB's AI in medicine program. Another dilemma: What happens when the mirror talks back? Learning that your body is biologically older than you thought may spur healthy changes -- or sow anxiety. The researchers are planning to open a public-facing FaceAge portal where people can upload their own pictures to enroll in a research study to further validate the algorithm. Commercial versions aimed at clinicians may follow, but only after more validation.

EU's Von der Leyen announces 500 mln euro package to lure top researchers to Europe
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Daily Maverick

time05-05-2025

  • Daily Maverick

EU's Von der Leyen announces 500 mln euro package to lure top researchers to Europe

'Science is an investment – and we need to offer the right incentives. This is why I can announce that we will put forward a new 500 million euros package for 2025-2027 to make Europe a magnet for researchers,' she said at a speech in Paris alongside French President Emmanuel Macron. 'We are choosing to put research and innovation, science and technology, at the heart of our economy. We are choosing to be the continent where universities are pillars of our societies and our way of life,' she added. She also said she wanted EU-member states to invest 3% of gross domestic product in research and development by 2030. Last month, Macron and Von der Leyen said they would be looking to invite scientists and researchers from the world over to Europe, at a time when Trump's administration is threatening to cut federal funding for Harvard and other U.S. universities. In April, France also launched the 'Choose France for Science' platform, operated by the French National Research Agency (ANR), which enables universities, schools, and research organisations to apply for co-funding from the government to host researchers. ($1 = 0.8825 euros)

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