After Biden's diagnosis: Prostate cancer facts every man should know
It's not particularly pleasant, but a digital rectal exam can save a man's life.
Its purpose is to screen for cancer of the prostate gland, the second most frequent malignancy (after lung cancer) in men worldwide in 2020, and the leading one in more than half of the world's countries, according to the International Agency for Research on Cancer (IARC).
"Cancer touches us all," former US president Joe Biden wrote in a post on the online platform X on Monday, after it became known he has prostate cancer. Biden's office says it is an aggressive and advanced form of the disease that has spread to the bones, but that the condition can be managed.
From warning signs to treatment options, here is some essential information for anyone with an ageing prostate.
Who's especially at risk?
"Prostate cancer is a disease of older men," says Dr Anno Graser, a Munich-based radiologist and prostate specialist. A 35-year-old man has a 0.1% risk of developing prostate cancer within the next 10 years, he notes, while a 75-year-old's risk is 5%. Joe Biden is 82.
There were more than 1.41 million cases of prostate cancer worldwide in 2020, or 7.3% of total cancer cases, estimates the IARC, part of the World Health Organization (WHO).
What are the warning signs?
Usually there aren't any. "The body doesn't recognize that abnormal cells are multiplying uncontrollably, so there are typically no symptoms in the early stages," explains Dr Olaf Reichelt, chief physician in the Department of Urology and Paediatric Urology at the Helios Clinic in Aue, Germany. This is why screening is so important, he says.
At an advanced stage, bone pain in the lower back, hips and ribs, or difficulty urinating, can occur. By this time, however, the cancer is likely to have metastasized, or spread, to nearby areas such as the spine or lymph nodes in the groin.
How can prostate cancer be detected early?
As mentioned above, one screening method is prostate palpation. Many early cancers are still too small to be felt though. Another method is a prostate-specific antigen (PSA) test. PSA is protein produced by cells of the prostate gland, and men with prostate cancer often have an elevated level of PSA in their blood. However, some non-cancerous conditions can also cause a man's PSA level to rise.
Men can lower the risk of having prostate cancer overlooked by getting both a digital rectal exam and a PSA test. But cancer specialists say this also increases the chances of false-positive results for cancer.
A further screening method is multiparametric magnetic resonance imaging (mpMRI), regarded as the most sensitive and specific imaging technique for the detection and evaluation of prostate cancer.
Is a rectal exam painful?
While the procedure isn't particularly pleasant and may make you feel helpless, having your prostate palpated by a doctor is normally painless.
During the exam, a doctor inserts a gloved, lubricated finger into the rectum and palpates, or feels, the prostate for any hard, lumpy or abnormal areas. It takes just a few minutes, after which you can feel good about having had a perhaps life-saving check-up.
How dangerous is prostate cancer compared with other cancers?
Prostate cancer is among the somewhat less aggressive cancers and curable if it hasn't reached an advanced stage. It's accountable for 3.8% of all mortality caused by cancer in men - more than 375,000 deaths annually - and estimated to be the fifth leading cause of cancer death in men globally, according to the IARC.
Compared with cancer types that affect fewer men but kill a higher percentage of them, prostate cancer is curable about 90% of the time, Graser says. The earlier it's detected, the better the patient's prognosis.
What are the treatment options?
The type of treatment depends on several factors, including the patient's age, PSA level, biopsy result and any accompanying illnesses, points out Reichelt. If the patient is between 50 and 75 years of age and his cancer isn't at an advanced stage, the treatment is usually surgical removal of the prostate or radiation.
While advanced prostate cancer is rarely curable, Reichelt says, in many cases it can be kept under control for several years with hormone, chemo- and immunotherapy.
"Many men don't die of, but rather with, cancer carcinoma," he remarks. Doctors may recommend, for example, that an 80-year-old patient with a tumour that's not very aggressive not be treated at all.
Will prostate surgery impact my pelvic floor?
Most people don't give their pelvic floor a thought until it acts up. For women, this often happens during pregnancy and after childbirth, when coughing, sneezing or laughing can cause urine to leak - a sign of weakened pelvic floor muscles due to overstretching.
But men, too, especially those impacted by prostate cancer, would do well to give some love to their pelvic floor, a dome-shaped sheet of muscles and connective tissue forming the base of the abdomen in both men and women.
"An integral pelvic floor organ in men is the prostate," says urologist and andrologist Dr Wolfgang Bühmann.
The prostate, a walnut-sized organ that sits below the bladder very close to the pelvic floor, plays a key role for the muscle sheet, explains Bühmann: "If it has to be removed due to cancer, the pelvic floor loses an essential buttress that's important for urinary continence."
A weak pelvic floor can cause back pain as well as lead to abnormal curvature of the spine and herniated spinal discs - not to mention erectile dysfunction. Your doctor will be able to suggest certain exercises to strengthen your pelvic floor as needed.
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