
Paige and NHS Wales Launch PanCancer Pilot to Triage Cases with AI at Betsi Cadwaladr University Health Board
'Through this pilot, we aim to establish the real-world utility of AI to prioritize potentially malignant cases and reduce diagnostic delays,'
The pilot will be the first clinical use of Paige PanCancer Detect and involve the prospective assessment of cases across all tissue types consecutively received for routine evaluation. This will determine whether the use of AI can shorten turnaround times for malignant case assessments and facilitate earlier detection of cancer to get the results to patients faster.
'Through this pilot, we aim to establish the real-world utility of AI to prioritize potentially malignant cases and reduce diagnostic delays,' said Dr. Alistair Heath, Histopathologist at BCUHB. 'By analyzing the impact on turnaround times and diagnostic accuracy, we can begin to understand how to better support quality improvement, more efficient patient management, and ultimately, faster results for patients.'
Each case will be analyzed using Paige PanCancer Detect, developed using more than three million pathology slides, to predict whether a whole slide image (WSI) is benign or suspicious for cancer. Cases flagged as suspicious will be prioritized for pathologist review, while those marked as benign will follow the standard workflow.
'We are committed to exploring how innovative technologies can support our pathology services and ultimately benefit patients across North Wales,' said Dr. Muhammad Aslam, Consultant Pathologist and Clinical Director for North Wales Diagnostic and Specialist Clinical Services. 'This pilot represents an important step toward that vision, and we are pleased to be working on this initiative.'
'We are thrilled to support this pioneering pilot with NHS Wales,' said Dr. Juan Retamero, Medical Vice President at Paige. 'Paige PanCancer Detect was designed to assist pathologists across tissue types, and this project provides a valuable opportunity to see it in action in a clinical setting.'
The pilot builds on the success of Paige being awarded an NHS tender to conduct a larger-scale study and the service improvement project will expand to include additional health boards across Wales.
About Paige
Paige is pushing the boundaries of AI to solve cancer's most critical issues, revolutionizing cancer care with next-generation technology. By leveraging exclusive access to millions of digitized pathology slides, clinical reports, and genomic data, Paige gains a holistic understanding of cancer, encompassing diverse factors such as gender, race, ethnicity, and geographical regions. This comprehensive data enables Paige to create advanced AI solutions that redefine cancer detection, diagnosis, and treatment. With a unique, intricate understanding of tissue, Paige sets new standards in precision diagnostics, earning the distinction of being the first FDA-cleared AI application in pathology. Paige has also developed the first million-slide foundation model for cancer, continuing to lead the way in uncovering novel insights and transforming them into life-changing products. For more information, visit www.paige.ai.
About Betsi Cadwaladr University Health Board (BCUHB)
BCUHB is the largest health organisation in Wales, with a budget of £1.99 billion and a workforce of more than 20,000. The Health Board is responsible for the delivery of health care services to more than 700,000 people across the six counties of North Wales (Anglesey, Gwynedd, Conwy, Denbighshire, Flintshire and Wrexham). This includes the provision of primary, community and mental health, as well as general hospital services. In primary care settings the Health Board delivers NHS care through a combination of independent contractors and directly delivered services across North Wales. This network of primary care services covers 96 medical practices ('GP practices'), 83 dental and orthodontic practices, 69 optometry/optician practices and 147 community pharmacies.

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Business Wire
29-07-2025
- Business Wire
Paige and Oncoclínicas Strengthen Leadership in AI-Driven Cancer Diagnostics Across Brazil
NEW YORK & SíO PAULO--(BUSINESS WIRE)--Paige, a leader in next-generation AI technology, announced the continued and expanded use of its innovative AI-assisted diagnostic applications by long-time customer, Oncoclínicas&Co (Oncoclínicas), the largest private group of cancer care in Latin America. With a commitment to enhancing diagnostic capabilities and improving patient safety, Oncoclínicas has utilized Paige's technology across prostate and breast cancer diagnosis, supporting its commitment to advancing pathology standards throughout Brazil. Oncoclínicas employs a rigorous approach where all digitized prostate and breast cancer biopsy whole-slide images are analyzed by pathologists using AI as an adjunct diagnostic tool. This process provides extra layers of patient safety, enhancing both sensitivity and efficiency for the pathologists using the technology. Since August 2021, Oncoclínicas has utilized AI to support the review of over 23,000 prostate and breast biopsies. These results demonstrate the scale and commitment of Oncoclínicas to AI integration in their diagnostic workflow, which has led to Oncoclínicas' achieving: Faster second reader sign-out for senior pathologists using FullFocus™ and AI support. 1 Enhanced detection rates, including the identification of approximately .5% of precursor non-obligatory breast lesions that were not initially detected by pathologists. 1 Improved diagnostic consistency and efficiency through the use of Paige Prostate and Paige Breast AI Suites. 1 Dr. Leonard Medeiros da Silva, pathologist at OC Medicina de Precisão, an integrated laboratory of Oncoclínicas&Co dedicated to pathological anatomy, genetic testing and Big Data, reports a positive experience with Paige Prostate. "It aligns with Oncoclínicas published data showing nearly 100% sensitivity and 93% specificity,' he notes. 'The specialist also commends the technology's effectiveness in both cancer detection and accurate Gleason score determination.' 'We are proud to support Oncoclínicas in their mission to offer cutting-edge cancer diagnostic solutions,' said Dr. Juan Retamero, Medical Vice President at Paige. 'Their success in implementing AI technology is a testament to their dedication to clinical excellence and their forward-thinking approach to pathology. Our long-term partnership underscores Paige's commitment to providing access to high-quality AI technology globally, helping pathologists provide better diagnoses for their patients.' 'Over the past few months, I've had the opportunity to witness how the integration of digital pathology, biomarkers, AI, and genomics is accelerating the advancement of precision medicine, and, more importantly, improving patients' quality of life and offering new hope in the fight against cancer,' said Rodrigo Alvarenga, Operations Executive at Oncoclínicas&Co. 'At both the 2025 USCAP in Boston and ASCO in Chicago, it became clear that precision medicine is no longer a distant goal, but a present-day reality that can expand access to advanced technologies and enable more cost-effective care. We've reached an exciting point of no return, the convergence of AI, pathology, and genomics is not only transforming cancer care but is also critical to the long-term sustainability of our healthcare systems.' In Brazil, FullFocus™ and all AI assisted diagnostic applications such as the Paige Prostate Suite and the Paige Breast Suite are for Research Use Only. Not for use in diagnostic procedures. 1 Figures are based on independent clinical research conducted by Oncoclínicas&Co. Finding an average of 12,000 breast biopsies and surgical specimens were analyzed in 2024. The Paige Breast Suite as a second reader detected 55 non-obligatory precursor breast lesions that were not initially detected by pathologists. Additionally, after utilizing FullFocus™ with the Paige Prostate Suite, the average time to read a slide and complete a report reduced to one minute and 10 seconds. About Oncoclínicas&Co Oncoclínicas&Co is the largest group dedicated to cancer treatment in Latin America, with a highly specialized and innovative model focused on the oncology journey. With a medical staff of over 2,900 oncology specialists, the company operates in 40 Brazilian cities, totaling more than 140 units. Focused on research, technology, and innovation, the group has conducted approximately 682,000 treatments in the past 12 months. Oncoclínicas follows international standards of excellence, integrating outpatient clinics with high-complexity cancer centers, enhancing treatment through precision medicine and genomics. As the exclusive partner of the Dana-Farber Cancer Institute in Brazil, affiliated with Harvard Medical School, it has acquired Boston Lighthouse Innovation (USA) and holds a stake in MedSir (Spain). It is also part of the IDIVERSA index of B3, reinforcing its commitment to diversity. With the goal of expanding its global mission to overcome cancer, Oncoclínicas has entered Saudi Arabia through a joint venture with the Al Faisaliah Group, bringing its oncology expertise to a new continent. Learn more at: About Paige Paige is pushing the boundaries of AI to solve cancer's most critical issues, revolutionizing cancer care with next-generation technology. By leveraging exclusive access to millions of digitized pathology slides, clinical reports, and genomic data, Paige gains a holistic understanding of cancer, encompassing diverse factors such as gender, race, ethnicity, and geographical regions. This comprehensive data enables Paige to create advanced AI solutions that redefine cancer detection, diagnosis, and treatment. With a unique, intricate understanding of tissue, Paige sets new standards in precision diagnostics, earning the distinction of being the first FDA-cleared AI application in pathology. Paige has also developed the first million-slide foundation model for cancer, continuing to lead the way in uncovering novel insights and transforming them into life-changing products. For more information, visit


Newsweek
15-07-2025
- Newsweek
AI Impact Awards 2025: Financial Services Need Efficient, Reliable Solutions
Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. In the world of finance, efficiency and accuracy are paramount for institutions managing billions in assets around the world. The three winners of Newsweek's AI Impact Awards in the Finance category are pioneering AI technology to help streamline operations, save time and money, boost employee well-being and protect against fraud. Principal Financial Group Executive Vice President and Chief Information Officer Kathy Kay told Newsweek that the future of AI in financial services is both exciting and transformative. "I see it driving smarter decision-making, hyper-personalized customer experiences and stronger risk management," she said over email. "We will see problems being solved in ways we never thought possible so our people can continue to do their best work. But to realize that future responsibly, we need to invest just as much in data literacy, ethical frameworks and cross-functional collaboration as we do in the technology itself. It's not just about what AI can do — it's about how we guide it to create real, sustainable value." Principal Financial Group is a Fortune 500 investment management and insurance company with $712 billion in total assets under management around the world. In response to facing critical operation challenges and inefficiencies internally, the company created the Principal Artificial Intelligence Generative Experience (PAIGE) – an AI-powered assistant that automates content generation, training materials and marketing content through advanced analytics. "Like many growing organizations, we saw opportunities where smarter tools could make a real difference," Kay said. "More specifically, we knew that using technology in the right way could free up our employees' time and allow them to prioritize the most important things – like solving complex customer problems." Kay said teams were spending too much time on things like managing documents and onboarding new employees and there was a "persistent" challenge with explaining complex financial topics in clear, accessible ways. "We knew these hurdles were affecting both our internal teams and our ability to communicate consistently with customers," she said. PAIGE's main functions include creating compliant and efficient documents and training materials, breaking down complicated financial concepts into clear, approachable language and handling routine tasks to improve productivity and allow employees to "focus on what really matters," Kay said. The company is already seeing measurable results as PAIGE's growth has exceeded expectations, "expanding from initial pilot users to over 800 active users by year-end," according to the company. There is a 50 percent reduction in task completion time across diverse functions, including client inquiries, while maintaining accuracy metrics with a query acceptance rate exceeding 95 percent and negative feedback remained below 1 percent. Newsweek Illustration Customer onboarding time also decreased by 90 percent, down from over 20 days to just three days. This efficiency has enabled the company to service 40 percent more members over five years. Kay said that PAIGE helps break down barriers to make financial planning more accessible for everyone, exemplifying Principal's core value that everyone deserves a clear path to financial security. "Simply put, it's here to help us fulfill our promise: making financial security achievable for all," she said. "Whether it's helping our employees work more efficiently or making financial concepts less intimidating, it supports our vision of a world where everyone has the tools and understanding they need to pursue their financial dreams." ABBYY, a global tech company specializing in AI-powered document processing and automation, also understands the need for efficiency and accuracy when working internally and for clients and partners. The company has been around for over 30 years and serves over 10,000 customers, including several Fortune 500 companies, McDonald's, Volkswagen, Deloitte, DHL and the National Library of Latvia. CFO Brian Unruh told Newsweek in an interview that the company has "product superiority," but is hoping to improve its "operational excellence," which is key to really reduce the friction not only how we work team of teams, but how we engage with our customers." ABBYY is the winner of Newsweek's AI Impact Award for Best Outcomes, Accounting for its work helping Asia-Pacific vehicle part provider Bapcor and Australian dairy cooperative Norco with its advanced Document AI. According to the company's application, ABBYY was able to reduce the need for manual entry and matching, cut down on overtime and excessive labor costs related to invoice processing, and free up accounts payable employees' time for more fulfilling and value-generating tasks. ABBYY IDP was able to streamline Norco's invoices for shipping goods to various locations and reduce labor costs by about half, Unruh said. It also helped Bapcor move away from printed invoices and manual data entry to improve efficiency and eliminate overtime – both saving costs and boosting employee satisfaction. "These aren't edge cases, this is typical," Unruh said, "We find customers that benefit, especially in finance and banking, because they have fiduciary responsibilities for accuracy. And so we come in and we can cut their error rate, and that's hard savings for them." When adopting AI for business operations, Unruh said it's important to "walk the walk" and demonstrate how the AI solution addresses actual problems or opportunities. It is also important for that solution to be rooted in ethical and responsible practices. "It's really important that this isn't something that they are recklessly deploying, or it's not long term," he said. "It's one thing about going live, it's another thing [to have] maintenance and make sure that you continue driving the success that you intend." In the financial world, AI tools are not only helping financial institutions work better, more efficiently, but they are also helping protect against fraud. Instnt, a venture-backed insurance technology business, uses AI to mitigate fraud risks for businesses and transfers residual losses to the insurance market, saving businesses millions in operational and treasury costs. It is also the winner of Newsweek's award for Best Outcomes, Mitigating Fraud in the AI Finance category. "Globally, fraud is set to account for something like 4 to 5 percent of global GDP loss," Instnt founder and CEO Sunil Madhu told Newsweek. "If that fraud loss was a country, it'd be the third or fourth largest country in the world." When he started his previous company, a platform for digital identity verification called Socure, Madhu saw a larger problem around how fraud was being managed in the financial industry and decided to start a new company to address that. With the Instnt Fraud Loss Insurance Solution, the company helps customers detect fraud with AI-driven models. "Instnt is the first company that has managed to make fraud insurable," he said. "We are an AI for fraud loss insurance, so we built a machine learning and artificial intelligence system that allows us to uniquely price risk and shift that risk off their balance sheets onto the insurance market." By making fraud insurable, Madhu said these institutions can use insurance to offset losses, which improves their margins and allows them to grow faster because they aren't sacrificing growth to keep fraud under control. Current fraud solutions aren't doing enough, Instnt said. The existing solutions that do detect fraud don't eliminate the financial liability for businesses and risk management and the fragmentation of risk management forces businesses to rely on multiple, disconnected tools for fraud detection, compliance and insurance coverage. Additionally, banks often limit customer approvals due to fraud concerns, reducing revenue potential. "Our viewpoint is not so much that we have to try to stop fraud; our viewpoint is that no two types of fraud losses are created equal, and there's this difference in that paradigm where most fraud prevention tools would strive to stop the fraud binary, good or bad," Madhu said. "So we can make a more qualitative decision based on expected losses and that allows the businesses do some optimizations they weren't able to before in terms of how many customers they let in through the front door." Instnt's solution integrates machine learning-driven risk assessment with access to insurance-backed financial protection, according to the application. This allows businesses to offload fraud loss liability while approving more legitimate customers. The tool analyzes an organization's historical fraud patterns and creates a custom policy for fraud loss coverage. It can identify fraud signals in real time to prevent unauthorized transactions before they happen. If fraud does occur, businesses can file claims through Instant's platform and receive payouts within 30 days. By allowing Instant to absorb the financial impact of fraud, banks can focus on growth, customer acquisition and financial resilience, Instnt said. "One of the largest digital banks in the world. We can't name them because it's not public yet, but the one of the largest digital banks in the world is losing nearly $45 million in just one type of fraud loss, which is first-party fraud in the loan products that they provide to their customers. And we were able to show them that for $8 million they could take that $45 million of exposure off the books," Madhu said.
Yahoo
12-06-2025
- Yahoo
Charlotte Figi Was a Face of the Medical Marijuana Movement. 5 Years After Her Death, Her Mom Is Still Fighting (Exclusive)
Young Charlotte Figi captured the attention of the world after high-CBD, low-THC hemp helped tame the seizures that had taken over her life Charlotte's quality of life was improved by the combination, dubbed Charlotte's Web, but she died in March 2020 from complications of an upper respiratory illness Charlotte's mother, Paige, opens up for the first time as she tells PEOPLE about grieving Charlotte, caring for her family in the aftermath of the COVID-19 pandemic and moving forward in a way that honors Charlotte's legacyFor 13 years, Paige Figi's primary concern was the wellbeing of her daughter, Charlotte Figi. Charlotte was born as one-half of a set of twin girls, "healthy and on time," her mom shares. "Everything was great. Then at 3 months old, she started having a very severe seizure," Paige tells PEOPLE. Seizures would be the primary symptom Charlotte faced in the years that followed, with medical professionals trying different interventions to no avail. "When it first happens, and something's wrong with your newborn child, it's that tragic, helpless feeling. Charlotte wasn't diagnosed with an actual name for her disorder — which is considered one of the world's worst kinds of epilepsies — until she was about 2½." Charlotte was diagnosed with Dravet syndrome after "time waiting and very expensive testing." The diagnosis brought forth difficult realities: children with Dravet's typically do not survive into adulthood. "There was a loss of innocence in finding out there's really nothing we can do. We just tried to enjoy her. The first four years of her life were just a medical tragedy with all of these medications and sadness and intense medical interventions," Paige says. The family, as well as medical professionals, continued to search for other options. Paige learned about a "high-CBD, low-THC hemp," now called full-spectrum hemp extract, a non-intoxicating plant extract that had shown some promise with seizures. "It felt like another hopeless situation, like, 'Of course this isn't going to work. She's failed every drug she's had,' " Paige says. "Many of her seizures were longer than 20 minutes. Those first four years, she would stop breathing. Her heart would stop. We had to do life support to CPR while we waited for a doctor, an ambulance. At 4, she was put into hospice — end of life care." At the same time as she was balancing Charlotte's care, Paige was still raising two other children, Charlotte's twin Chase and oldest child Maxwell. Her then-husband, their father Matt, was overseas in Iraq and Afghanistan. "We were just always in the hospital. I ... turned the hospital room, the ICU into, like, homeschool. I raised my kids in a hospital and made it fun and made it interesting. We figured out a way to sort of thrive under the situation," she recalls. Despite everything on her plate, she kept researching possible interventions that could help Charlotte. "I called Israel. I called France and Brazil. I hired translators to see what they were learning from this hemp plant on rodents. It was stopping their seizures. I thought, 'I live in Colorado. Certainly someone must know something about this.' " "Before kids, I was a rescue diver for the fire department, so I used to dive for dead bodies. I'm a first responder, which is to say I'm good in a crisis. It was very difficult, but I did my best. But when the kids were all asleep, I'd have my moment of, 'This is not a normal family lifestyle,' " Paige recalls. Living in Colorado gave the family the option to explore the hemp, at the time defined as marijuana and a schedule I substance that couldn't be studied or accessed by a layperson. When she was able to get her hands on it, it changed everything. Never miss a story — sign up for to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. "For Charlotte, we gave it to her, and it worked. Her seizures stopped — her 50 seizures a day, her 50 status seizures a day stopped. So, the first thing that happened was she started breathing room air. We took her off oxygen. She just opened her eyes. Slowly, one thing at a time, just one little life thing at a time started coming back as the seizures stopped," Paige recalls. "I'm watching this, alone here with three kids, watching this happen like, 'This is insane.' It's kind of mad to see that this worked, that I had to figure this out and that this was efficacious when the stuff we were giving her was not." It was then that Charlotte's story went public, entering the larger conversation around marijuana. At the same time, she was enjoying her best quality of life she'd had to that point. "I turned 99% of the media down at the time. They wanted a pot mom story and it wasn't a pot mom story," Paige says. "This is my life. This is my little tragedy. It's my family. This wasn't provocative. I wasn't just giving my dying kid marijuana." One year later, CNN and Dr. Sanjay Gupta reached out about a documentary. "I was very uncomfortable looking into his views on this because I had Child Protective Services and law enforcement involved and while I was following the letter of the law, she was the first that had done this," Paige says. They ultimately appeared in his 2013 docuseries, WEED. As the story got out there, Paige heard from other families who were desperate for options. "I had no idea how many other people were in the same boat — back against the wall, no pharmaceutical options left," she says. Families desperate for treatment packed up and moved to Colorado. "You couldn't travel with a schedule I substance over state lines, so I opened my house to them. They lived with me. I gave them 48 hours. I said, 'You have two days, and then another family's going come.' I had a soft landing. A lot of these families came in a medical ambulance type of situation, and they had to stay in Colorado to access this." Asked how she found it in herself to give when spread so thin, she says, "I think I was just the person in the place at the time. I don't even know how to describe it, but there was no chance that I wouldn't have said yes. It was an honor to be a part of that." "It was a very interesting time for us all. We created this movement together, and we were cheering each other on," she continues. In the better years, the family did everything they could to enjoy their time with Charlotte. That continued even after Paige and Matt made the decision to divorce and later, each remarried. "With the divorce, Matt was in Special Forces. The divorce rate is pretty high there and then with Dravet syndrome, it's even higher. We didn't have a chance. It just breaks you. It breaks you as a human. It breaks your relationship," she says. "To go through a divorce on top if everything else ... and so many of the families I met had gone through a divorce as well. It's a true test of motherhood, not just raising a sick child, but knowing my healthy children are watching me, they're helping out, they're seeing how to be a human and a mother and how sometimes, you have to just do it and not let it break you. For me, the whole thing made me stronger." Paige also remembers the period as "ethically and morally, a very heavy time," during which she did enter the advocacy space, going to the federal government to ensure this treatment wasn't lumped in with marijuana and could be legalized for the people who needed it. "I didn't have any help, no nursing care. And I'd get on a red-eye and fly to their state and help pass the bill, go to the capital and then fly home on a red-eye to feed my family," she recalls. "It was like the essence of community. It was mothers sorting this out for their kids and helping themselves together, and it was really powerful." "It was very emotional time. My house kind of became this gathering place. These families don't have social life. They don't have a job, they're taken out of productive society to care for a sick loved one. At the same time, how much suffering you can watch a child go through and and not let it break you?" She continues, "You had to be a resident of the state see multiple doctors, get a marijuana card, and then you couldn't leave the state. And we changed all of that through legislation." Paige focused on making the most of life with Charlotte while continuing to share the impact of hemp on her life. "She wasn't sickly. She didn't see herself as a person to be labeled with a medical disease. She was very strong. She was a tough little kid," she says. That changed in 2020. In February, the whole family was suffering from an upper respiratory illness, unaware of what was around the corner. The rest of them would be on the mend by March, but as the world started learning about COVID-19 and hospital protocols started rapidly changing, Charlotte's condition did not improve. On April 7, 2020, Charlotte Figi died at the age of 13, of an upper respiratory illness. There was never an official COVID diagnosis. "She died in the COVID wing of the hospital, with a COVID doctor, in quarantine, but there were no tests. So officially, she died of a respiratory illness, after we were all very sick for a month." "It was tragic. I lived here, 13 years of her life, knowing she was going to die. You could say nobody was more prepared than I was, but she was so healthy before that, that it was ... that was the tragedy of it," Paige says. The bereaved mother had not just her own grief to grapple with, but that of the rest of her family. "Watching them fall in love with her and then watching them watch her suffer ... you want to take that away from the siblings. You want to take that away from Charlotte, but you can't. You had to just kind of dive into the deep and then let them feel these things and let it transform them into good, kind, caring people that always care for others," the mom of three says. "I think for Chase, losing her twin sister was just absolutely devastating. There's a thing that happens with with twins. The twin loss syndrome is very tough." The loss was even tougher on the family because lockdown protocols made it so a funeral was impossible. "We couldn't bury her. We had to have her cremated," Paige says. Their community rallied around them, organizing 'Rock the Rock,' a concert-like virtual celebration of Charlotte with musicians sending in songs written for her. As for how this journey has impacted Chase and Maxwell, Paige says the two "became caretakers." "They became very empathetic and sympathetic people. They were very good with with special needs kids. All of our friends had a sibling with a special needs kids, so they became very caring people in a lot of ways. We've all been through a lot of therapy because they got to see somebody that you care so much about, this big, blue-eyed girl who had a huge personality, and it wasn't pity that we had for her, but it's such a difficult feeling to watch them suffer." She continues, "It's a difficult sentence to have a special needs or a high-medical person in your family. I think if you're open to understanding it a different way, it can be the greatest thing that can ever happen to you because it changes you. So, I'm hoping that that's what they take from it." In the years since Charlotte's death, her memory has remained very present with the family. "My kids, they're 18 and 21 now, so they can do whatever they want, but we still grieve together. We share her. We share stories of her together. We share online on social media with other families. We just share her out loud. And while it's painful to do, I think it's the healthiest way is to grieve together," she says."We do a little bonfire, and that reminds us of the gathering of all of these families in our yard, so we do a lot of bonfires. We trying to do some live music concerts. We always light candles in her name. We remember her constantly. We talk about her constantly." Paige in particular has also been dedicated to carrying on Charlotte's legacy. She continues to speak on behalf of Charlotte's Web, the high-CBD, low-THC hemp that gave Charlotte relief for so many years and is now named in her memory. "I still continue my work in Coalition for Access Now to further make sure people have access to this. This isn't going to work for everybody, obviously, but this is very worthwhile and valuable. And I have a deep empathy, a first-hand experience of what it's like to have nothing and no one helping you and that the experts have no idea what to tell you," she says. "I love what I do. I'm very good at what I do, it's very necessary, and because I've been so consistent, and it's so sensible, it's become apolitical. There's no opposition, it's bipartisan. We're not doing anything outrageous, or on the fringe of what is ethical or moral. This is just like a no-brainer, and so it's been fun to win." "It's way bigger than kids with epilepsy," she adds. "They're now the smallest population that use this, but the most necessary and urgent still." There's also Charlotte's Ranch, a ranch Paige purchased in Hahn's Peak, Colo., that she has a special vision for. "I look at it like her life was shared and so public — that's what I want for this beautiful horse ranch. We have sheep and cattle here, and it's to be shared. The intent is to have an open-door policy. I'm not sure how I'm gonna offer this to people or families or non-profits to come and have respite, a place that they can come to. They're welcome to be here. They can be handicapped, and it can be in wheelchairs, but it'll be accessible and available," she shares. She's hoping to offer something to other families that she and Charlotte never got to enjoy: a break from their home environment, a getaway that presents minimal medical complications. "Nothing was ever offered to us. We qualified for Make-a-Wish, but when you get the list of ideas and she's too sick for any of them, there's nothing there. I just want to pay it back a little bit, so they can just have a moment of knowing there's people out there who who are thinking of you and want to do something. I feel very driven to do this for people who've never been offered anything," Paige explains. With an empty nest and a heart full of love to give — and a mind for change — Paige wants the ranch to be "the essence of Charlotte, very magical." "These things that carry her name, they represent the life and meaning of this child, and that's very meaningful to me," Paige says. "I think it's one of the hardest things you can go through is losing a kid. There's not even a name for it. I'm not a widow. I don't know what you call a mother who's lost a daughter, but we need a name for that," she says. "It's the most horrible thing. I can't imagine that there's something more horrible than that." At the same time, it's been "really incredible" to see how Charlotte's story has impacted the world as we know it. "To see how impactful one little wide-eyed, innocent kid can be, this special needs kid ... We weren't really welcomed in society. We didn't go anywhere. We didn't take her out to eat because no one wants to see a sick kid in a wheelchair. People are a------- and to think of a kid whose life was meant to be nothing ... I mean, I was told I should put her in an institution and live my life. To see an unsightly special needs epileptic child be celebrated and lifted up and have meaning in someone's life ... I don't even have words for it. It still hits me every day in the work I do," Paige says. "I think what we've done is probably the most meaningful thing I'll ever do. What we're still doing today is the most meaningful thing I'll ever do in my entire life, and it's an honor to be involved with this," Paige continues. "It's been fun and frustrating, very gratifying work, but at the end, it's something that I feel driven to do because I know too much. I've seen too much, I know things, and I can't unsee them and unknow them. And so I can't stop until it's complete." Read the original article on People