Paige and NHS Wales Launch PanCancer Pilot to Triage Cases with AI at Betsi Cadwaladr University Health Board
NEW YORK--(BUSINESS WIRE)--Paige, a leader in next-generation AI technology, together with NHS Wales, has announced the launch of a new pilot project at Betsi Cadwaladr University Health Board (BCUHB). The project will evaluate how Paige's AI-assisted diagnostic application, Paige PanCancer Detect, can streamline pathology workflows and enhance patient care by triaging routine clinical cases.
'Through this pilot, we aim to establish the real-world utility of AI to prioritize potentially malignant cases and reduce diagnostic delays,'
The pilot will be the first clinical use of Paige PanCancer Detect and involve the prospective assessment of cases across all tissue types consecutively received for routine evaluation. This will determine whether the use of AI can shorten turnaround times for malignant case assessments and facilitate earlier detection of cancer to get the results to patients faster.
'Through this pilot, we aim to establish the real-world utility of AI to prioritize potentially malignant cases and reduce diagnostic delays,' said Dr. Alistair Heath, Histopathologist at BCUHB. 'By analyzing the impact on turnaround times and diagnostic accuracy, we can begin to understand how to better support quality improvement, more efficient patient management, and ultimately, faster results for patients.'
Each case will be analyzed using Paige PanCancer Detect, developed using more than three million pathology slides, to predict whether a whole slide image (WSI) is benign or suspicious for cancer. Cases flagged as suspicious will be prioritized for pathologist review, while those marked as benign will follow the standard workflow.
'We are committed to exploring how innovative technologies can support our pathology services and ultimately benefit patients across North Wales,' said Dr. Muhammad Aslam, Consultant Pathologist and Clinical Director for North Wales Diagnostic and Specialist Clinical Services. 'This pilot represents an important step toward that vision, and we are pleased to be working on this initiative.'
'We are thrilled to support this pioneering pilot with NHS Wales,' said Dr. Juan Retamero, Medical Vice President at Paige. 'Paige PanCancer Detect was designed to assist pathologists across tissue types, and this project provides a valuable opportunity to see it in action in a clinical setting.'
The pilot builds on the success of Paige being awarded an NHS tender to conduct a larger-scale study and the service improvement project will expand to include additional health boards across Wales.
About Paige
Paige is pushing the boundaries of AI to solve cancer's most critical issues, revolutionizing cancer care with next-generation technology. By leveraging exclusive access to millions of digitized pathology slides, clinical reports, and genomic data, Paige gains a holistic understanding of cancer, encompassing diverse factors such as gender, race, ethnicity, and geographical regions. This comprehensive data enables Paige to create advanced AI solutions that redefine cancer detection, diagnosis, and treatment. With a unique, intricate understanding of tissue, Paige sets new standards in precision diagnostics, earning the distinction of being the first FDA-cleared AI application in pathology. Paige has also developed the first million-slide foundation model for cancer, continuing to lead the way in uncovering novel insights and transforming them into life-changing products. For more information, visit www.paige.ai.
About Betsi Cadwaladr University Health Board (BCUHB)
BCUHB is the largest health organisation in Wales, with a budget of £1.99 billion and a workforce of more than 20,000. The Health Board is responsible for the delivery of health care services to more than 700,000 people across the six counties of North Wales (Anglesey, Gwynedd, Conwy, Denbighshire, Flintshire and Wrexham). This includes the provision of primary, community and mental health, as well as general hospital services. In primary care settings the Health Board delivers NHS care through a combination of independent contractors and directly delivered services across North Wales. This network of primary care services covers 96 medical practices ('GP practices'), 83 dental and orthodontic practices, 69 optometry/optician practices and 147 community pharmacies.
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WIRED
3 days ago
- WIRED
What Really Happened in the Aftermath of the Lizard Squad Hacks
Jun 5, 2025 6:00 AM On Christmas Day in 2014 hackers knocked out the Xbox and PlayStation gaming networks, impacting how video game companies handled cybersecurity for years. Photo-Illustration:The Andersons are Christmas traditionalists. Dan says it's more his wife Paige than him, but secretly he also loves all the fuss. So, there they were on the sofa in their pajamas in front of the twinkling Christmas tree before the sun had risen over a chilly morning in Buffalo, New York. Thirty-two-year-old Dan was proud and smug as he handed over his gift to Paige—a 'fancy new Kindle Voyage.' She loved it. Then it was his turn, and he excitedly ripped into the wrapping paper watched over by his confused dogs—one of which was tellingly named after Dan's favorite computer-game character (Vivi from Final Fantasy ). As the present revealed itself, the avid gamer saw the instantly recognizable and much-loved logo—it was a brand-new PlayStation 4. Straight away he unpacked it, rigged it up to the TV, and switched it on. The plan was to get it fired up and download LittleBigPlanet 3 to play for a few hours before meeting up with family. Paige had been looking forward to it since she bought the new console. However, it wasn't to be. 'We didn't even make it as far as starting to download the game, because it wouldn't let me log in to PlayStation Network,' Dan said. 'Nothing was online at all, so we couldn't even try and download games.' Disappointedly they headed out for the day's events and couldn't try again until that evening, when they discovered that the network was still down. A $400 gift they couldn't play. Dan had to work the next day too, so he couldn't even try it then. He was gutted. Courtesy of Elliott and Thompson Buy This Book At: If you buy something using links in our stories, we may earn a commission. This helps support our journalism. Learn more. Five hundred and fifty miles north, in Toronto, 16-year-old Mustafa Aijaz was pumped. Christmas Day—particularly the evening—was the best game time of the year. It's always been a bit of a holiday within the holiday for serious players. The tradition revolves around a phenomenon called 'Christmas Noobs.' At Christmas, so many new players receive new games and consoles that online games are flooded with a tidal wave of gamers who often fumble their way through the top games and act like cannon fodder for the waiting legions of seasoned veterans. Mustafa and his mates were skilled at Call of Duty: Advanced Warfare . 'We were all ready for a night of easy wins, quick XP [experience points] farming, and were looking forward to leveling up like crazy.' So, they waited like crocodiles anticipating herds of migrating buffalo to enter the river. But just as the bullets started flying they were all unceremoniously chucked out of their matches and knocked offline. 'None of us could log back in, and party chat was down too, so we couldn't even talk to each other to figure out what was happening,' Mustafa said. It was all over social media: A group of hackers called Lizard Squad were bragging about their massive DDoS attack on Xbox Live and PlayStation Network—the crucial services that linked tens of millions of gamers to the Microsoft and Sony servers. Mustafa had seen that the group had already carried out smaller-scale attacks and had for weeks been taunting and threatening a big attack. Apparently it was all linked to some silly and incomprehensible spat with a rival but minor hacking group. Mustafa was angry but also fascinated by the attack and the incredible reaction online. 'The fallout was instantaneous. People were furious,' he said. PlayStation Network at the time had about 110 million subscribers, and Xbox Live had roughly 48 million. Xbox was back to normal within 24 hours—on Boxing Day. But PlayStation struggled for longer. It didn't just affect existing subscribers. Before you can use any new games, consoles, or vouchers, you need to register them via the gaming company's servers. It was a catastrophe for the games industry, especially Sony, which had already been having a tough time after a different cyberattack the previous month. Services were down around the world. Error messages in dozens of languages were being posted as screenshots on YouTube and Twitter. There was nothing anyone could do until the engineers at Sony and Microsoft figured it out or Lizard Squad stopped the attack. Late in the evening on Boxing Day, BBC Radio 5 Live aired an interview with two members of the group. They showed zero remorse for the impact they'd had on people around the world. Twelve hours later I walked into the newsroom and was given the seemingly impossible task of 'getting a Lizard' on the evening TV bulletin at Sky News. It took hours of trawling Twitter and speaking to dozens of wannabes and fakes, but I eventually succeeded in finding contact details for a British man called Vinnie Omari. Incredibly, he lived a few miles from our newsroom in west London. He agreed to come to us for the interview and was pale, skinny, wore all black and talked fast. He was at pains to distance himself from the gang but left the studios promising that a Lizard Squad hacker called 'Ryan' would be in touch. I had no idea at the time of course that this 'Ryan' was Julius Kivimäki—an already infamous teenage hacker and delinquent from Finland. It was later that afternoon—at around 3 pm —that 'Ryan' called through on Skype. Just in time for us to edit our conversation with him into our news piece. The 17-year-old looked very young and pale and had a shaved head and soft features. In spite of everything, he was polite and seemed in no rush. But he was also utterly unremorseful and arrogant, struggling to stifle a smirk throughout the interview. When I started by asking him why he wanted to ruin Christmas for tens of millions of people, he gave me the same boilerplate answer about the boys doing it to amuse themselves and embarrass these tech mega corps. 'These companies make tens of millions every month from just their subscriber fees, and they should have more than enough funding to be able to protect against these attacks.' We went back and forth for about 15 minutes without him giving any hint of regret or awareness for how many people had been affected by his stunt. 'I'd be worried if those people didn't have anything better to do than play games on their consoles at Christmas Eve and Christmas Day,' he said. 'I mean, I can't really say I feel bad. I might have forced a couple of kids to spend their time with their families instead of playing games.' The interview blew up online, with more than a million views on YouTube and thousands of comments on Twitter, where many four-letter words were hurled at the Lizards. PlayStation and Xbox also received a torrent of abuse. Later they would offer a five-day extension to players' subscription periods and 10 percent off as compensation. The resulting bill for the company must easily have been in the millions. Kivimäki went on to speak to other reporters, sometimes calling himself Ryan Cleary (a reference to another hacker he had vague and likely acrimonious link to from a previous teen hacker gang called LulzSec). In one interview and debate on YouTube channel DramaAlert he is implored by Kim Dotcom to stop the silly hacker rivalries that were impacting so many innocent people. 'Hackers used to be respected; they used to have a magic about them,' Kim said, accusing Lizard Squad of harming the image of hackers around the world with their actions. Kivimäki's response is fascinating: He laughed it off as old-fashioned thinking. 'It's wrong to connect groups like Lizard Squad with, for example, L0pht from a couple of decades back,' he said. 'There's really no connection with the hacking groups of today and the hacking groups of two decades ago. The meaning is totally different now.' Although many security experts angrily railed against the media's portrayal of Lizard Squad as 'sophisticated,' people grudgingly came to accept that the Christmas attack did have a big impact on cybersecurity and the gaming industry. There's little doubt that this was not the group's motive—despite their clumsy attempts to claim so in interviews. But it was a wake-up call. Security website SecurityAffairs wrote a 'lessons learned' piece by dissecting my interview with Kivimäki. Many people considered Lizard Squad script kiddies, they wrote, adding, 'This approach is totally wrong.' The size of the attack unleashed on that day would be shrugged off by most modern sites, but DDoS attacks are still commonplace and are getting more powerful. Expensive protection services are now a must-have for any organization that needs to stay online. The attacks also started something of a cybercrime trend. In 2024 Europol unveiled an international law enforcement operation to take DDoS services down in December: 'The festive season has long been a peak period for hackers to carry out some of their most disruptive DDoS attacks, causing severe financial loss, reputational damage, and operational chaos for their victims,' the organization said in a statement. At the time of Lizard Squad's attacks, the general public was stunned. Despite Lizard Squad being on the tail end of a wave of teenage hacking groups in the 2010s, there was little awareness of the power that could be wielded by these otherwise amateur attackers. There might have been a vague feeling in the zeitgeist that 'hackers in hoodies in their bedrooms' were increasingly causing problems, but this attack was immediate, unmissable, and easy to understand. It was of course also easy to get angry about. Over the next couple of days I came back to the story with follow-ups about the fallout as other Lizard Squad members spoke to YouTubers about the so-called 'drama.' But the big thing the newsroom kept asking me was, When would these kids be arrested? Vinnie Omari was the first. On New Year's Eve he was raided by the South East Regional Organized Crime Unit, which collared him on suspicion of cyber fraud offenses committed in 2013 and 2014. It looked like the raid was for other alleged offenses involving PayPal fraud, but the search warrant, which later surfaced online, also referenced the Christmas DDoS attacks. 'They took everything: Xbox One, phones, laptops, computer USBs, etc.,' Omari told reporter William Turton from the Daily Dot. He was later cleared of any involvement. After Omari's arrest, other Lizards were taken out too. On January 16, 2015, police announced that they had arrested an 18-year-old in Southport, near Liverpool. They didn't give a name, but reporters at the Daily Mail identified him: 'The 'quiet' teenager, named locally as Jordan Lee-Bevan, was arrested during a raid at his semi-detached home in Southport, Merseyside, today, with officers seizing computers as he was taken away in a police car.' In 2016 teenager Zachary Buchta from Maryland was also arrested for his role in Lizard Squad and another group called PoodleCorp. As a boy he had been warned in 2014 about his criminal path by police who had caught him carrying out minor cybercrime activity. But he was undeterred and even changed his Twitter profile at one stage to @fbiarelosers to taunt the cops. At the same time that Buchta was arrested, Dutch police raided and arrested another 19-year-old. Bradley van Rooy, who used the names 'Uchiha' or 'UchihaLS,' was accused of conspiring with other members of Lizard Squad to operate websites that provided cyberattack-for-hire services, facilitating thousands of DDoS attacks and trafficking stolen payment card account information for thousands of victims. Bradley was put on bail for two years and eventually given a two-year suspended sentence and 180 hours of community service. The vast majority of charges against him were dropped as they had taken place when he was a minor. He ended up being convicted of the DDoS-for-hire operation and handling stolen credit cards. I tracked him down, and he openly talked about that period of his life, which he had put behind him a long time ago. 'I'm now 27, and I see the damage that I did and understand that there could have been a higher punishment,' he says. 'But then I also see that I was just a kid, and I had a troubled time at school and just fell into the hacking life after meeting the wrong people when I was playing the game RuneScape .' Bradley's journey and words track so perfectly to the experiences of almost every hacker I have met or interviewed. It's as though there is a universal constant, whereby a subset of gamers in every generation is pulled into cybercrime in exactly the same way. There are literally billions of gamers in the world, so these people represent only a tiny fraction. But it seems to be inevitable and cyclical as hacker groups rise and fall. The differentiating and more important aspect, though, is how these boys and young men react when they cross the line and are caught. So what of Julius Kivimäki, aka 'Ryan,' aka 'Ryan Cleary' and many other aliases including the by now infamous 'Zeekill'? Surely, after appearing on TV and radio admitting that he was part of the gang, he too would be rearrested sharpish? Officers did indeed visit Kivimäki to interview him, but they did not arrest him—contrary to reports in the international media. It's not clear why they took no further action, but perhaps when the teenager confidently said that police would find nothing on his computer he was right. 'They'd have to let me go,' he had cockily asserted in our interview. If so, maybe his run-in with police years earlier had taught him to cover his tracks more effectively. Or maybe he hadn't taken as much of a leading role in the DDoS attacks as he had claimed. For Finnish cybercrime cop Antti Kurittu, seeing Kivimäki on TV was especially galling. Antti had raided and arrested Kivimaki two years earlier for other cyberattacks carried out with a different teenage cyber gang called HTP. 'I remember watching your Sky News interview and just thinking 'wow, this guy is not even trying to cover up his crimes. He's just a different sort of person,'' Antti recalls. It wasn't until July 2015 that Kivimäki received his first criminal conviction. He was found guilty of the rather preposterous total of 50,700 instances of aggravated computer break-ins—one for every computer enslaved into HTPs botnet. He was also convicted of other offenses including data breach, money laundering, and being in possession of, and using, stolen credit cards. For all of these offenses, he was handed a two-year suspended sentence. If he had been an adult he could have got years behind bars, but as a minor and first-time offender he served no time in prison. So Kivimäki, just a few weeks from his 18th birthday, remained free. He began calling himself the 'Untouchable Hacker God' on Twitter. A year after Kivimäki's sentencing, in a bizarre coincidence, Antti bumped into Kivimäki in Amsterdam. It was April 2016 and Antti was walking through the departures lounge of Schiphol Airport when he passed the by-then 18-year-old. Antti did a double take, gobsmacked to see him. It was so surreal that they both found it amusing and took a selfie. After a short chat, Antti asked Kivimäki if he was now 'staying out of trouble.' Kivimäki replied, 'Of course.' But when Antti asked him for a contact email address, he made one up with '@ at the end. They laughed and went their separate ways. But, as Antti predicted, the Untouchable Hacker God would be back. Four years later he was. And this time he was linked to the cruelest cyberattack in history and had a new alias: ransom_man. Excerpt adapted from Ctrl+Alt+Chaos: How Teenage Hackers Hijack the Internet by Joe Tidy. Published by arrangement with Elliott & Thompson. Copyright © 2025 by Joe Tidy.
Associated Press
5 days ago
- Associated Press
Lumea and Paige Partner to Advance AI-Powered Digital Pathology
Lumea and Paige partner to integrate AI-powered workflows, enhancing diagnostic efficiency and accessibility in cancer care. LEHI, UT, UNITED STATES, June 3, 2025 / / -- Lumea, the U.S. leader in primary clinical digital pathology, today announced a partnership with Paige, a leader in next-generation AI technology, to expand the integration and impact of AI-powered workflows across pathology practices. This collaboration brings together Lumea's FDA-cleared digital pathology platform with Paige's advanced AI-assisted applications to enhance diagnostic efficiency and accessibility in cancer care. Through this partnership, Lumea will integrate Paige's AI-assisted diagnostic and biomarker AI software-applications* into its end-to-end digital pathology ecosystem. The combined solution intends to support pathologists in streamlining workflows and enhancing confidence in diagnoses across high-volume clinical settings. By embedding Paige's AI applications within Lumea's high-efficiency infrastructure, the partnership aims to help pathologists deliver faster insights while scaling access to advanced diagnostics. 'Lumea is the proven, secure platform trusted by leading labs to streamline pathology workflows and improve patient outcomes,' said James Thackeray, Lumea CEO. 'Our collaboration with Paige enhances our ability to deliver faster, more precise diagnoses—helping labs boost efficiency, improve outcomes, and maximize ROI.' Lumea's digital pathology system supports the highest volume of digital cases in the U.S., with significant adoption in urology, dermatology, and gastroenterology. Paige contributes regulatory expertise with the first FDA-cleared AI application in digital pathology*, two additional FDA-breakthrough device designations and state-of-the-art foundation model trained on over a million whole slide images, offering one of the most extensive AI datasets. 'Partnerships like the one we've formed with Lumea are essential to accelerating the adoption of digital pathology and making it a seamless part of routine clinical practice,' said Razik Yousfi, CEO and CTO of Paige. 'By integrating Paige's AI-assisted diagnostic applications into Lumea's platform, we're reducing the friction pathologists often face with new technologies and delivering scalable, real-world solutions that enhance care across diverse clinical settings.' About Lumea Lumea is powering efficient, affordable, and accessible digital pathology through simplified, workflow-driven innovation with both tissue-handling technology and a best-in-class viewer with AI-driven workflows. As the U.S. leader in primary clinical digital pathology, processing the highest volume of digital cases nationwide. With over a decade of expertise, Lumea has set the standard for efficiency, quality, and premium cancer diagnostics. With a global presence spanning five continents, Lumea supports over half of the U.S. urology market and top dermatology and gastroenterology groups, optimizing tissue integrity, boosting detection rates, and delivering measurable ROI. By placing patients at the core, Lumea is transforming pathology for a more precise and efficient future. Learn more at About Paige Paige is pushing the boundaries of AI to solve cancer's most critical issues, revolutionizing cancer care with next-generation technology. By leveraging exclusive access to millions of digitized pathology slides, clinical reports, and genomic data, Paige gains a holistic understanding of cancer, encompassing diverse factors such as gender, race, ethnicity, and geographical regions. This comprehensive data enables Paige to create advanced AI solutions that redefine cancer detection, diagnosis, and treatment. With a unique, intricate understanding of tissue, Paige sets new standards in precision diagnostics, earning the distinction of being the first FDA-cleared AI application in pathology. Paige has also developed the first million-slide foundation model for cancer, continuing to lead the way in uncovering novel insights and transforming them into life-changing products. For more information, visit * Refer to the product-specific labeling for the regulatory status of each Paige AI-assisted diagnostic application. When Research Use Only (RUO) products are used with regulated products (e.g., FDA-cleared/approved, CE-IVDD, or CE-IVDD), the integrated workflow will be for Research Use Only (RUO) and not for use in diagnostic procedures. Bianca Collings Lumea email us here Visit us on social media: LinkedIn Instagram YouTube X Legal Disclaimer: EIN Presswire provides this news content 'as is' without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.
Yahoo
28-05-2025
- Yahoo
VSP issues CODI alert for 15-year-old girl in Frederick County last seen Memorial Day
FREDERICK COUNTY, Va. () — Virginia State Police (VSP) issued a CODI alert Tuesday for a 15-year-old girl who disappeared in Frederick County on Memorial Day. State police said Paige Elizabeth Littman, 15, was last seen around 11:30 p.m. on May 26, in the 100 block of Ward Avenue in Winchester. DC community frustrated over recent deadly shootings The Frederick County Sheriff's Office said she may have left the area on foot or in a vehicle. Authorities described Paige as around 5 feet and 4 inches with strawberry blonde hair and hazel eyes. A description of her clothing is currently unknown. VSP noted that Paige's disappearance poses a credible threat to her health and safety. Anyone who sees her is asked to call the Frederick County Sheriff's Office at 540-662-6162 immediately. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
