
Ancient DNA Shows Genetic Link between Egypt, Mesopotamia
Researchers sequenced whole genomes from the teeth of a remarkably well-preserved skeleton found in a sealed funeral pot in an Egyptian tomb site dating to between roughly 4,500 and 4,800 years ago.Four-fifths of the genome showed links to North Africa and the region around Egypt. But a fifth of the genome showed links to the area in the Middle East between the Tigris and Euphrates Rivers, known as the Fertile Crescent, where Mesopotamian civilization flourished.
'The finding is highly significant' because it 'is the first direct evidence of what has been hinted at' in prior work, said Daniel Antoine, curator of Egypt and Sudan at the British Museum.
Earlier archeological evidence has shown trade links between Egypt and Mesopotamia, as well as similarities in pottery-making techniques and pictorial writing systems. While resemblances in dental structures suggested possible ancestral links, the new study clarifies the genetic ties.
The Nile River is 'likely to have acted as an ancient superhighway, facilitating the movement of not only cultures and ideas, but people,' said Antoine, who was not involved in the study.
The skeleton was found in an Egyptian tomb complex at the archaeological site of Nuwayrat, inside a chamber carved out from a rocky hillside. An analysis of wear and tear on the skeleton — and the presence of arthritis in specific joints — indicates the man was likely in his 60s and may have worked as a potter, said coauthor and bioarchaeologist Joel Irish of Liverpool John Moores University.
The man lived just before or near the start of ancient Egypt's Old Kingdom, when Upper and Lower Egypt were unified as one state, leading to a period of relative political stability and cultural innovation — including the construction of the Giza pyramids.
'This is the time that centralized power allowed the formation of ancient Egypt as we know it,' said coauthor Linus Girdland-Flink, a paleogeneticist at the University of Aberdeen.
At approximately the same time, Sumerian city-states took root in Mesopotamia and cuneiform emerged as a writing system.
Researchers said analysis of other ancient DNA samples is needed to obtain a clearer picture of the extent and timing of movements between the two cultural centers.

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The Mainichi
17 hours ago
- The Mainichi
US aid cuts halt HIV vaccine research in South Africa, with global impact
JOHANNESBURG (AP) -- Just a week had remained before scientists in South Africa were to begin clinical trials of an HIV vaccine, and hopes were high for another step toward limiting one of history's deadliest pandemics. Then the email arrived. Stop all work, it said. The United States under the Trump administration was withdrawing all its funding. The news devastated the researchers, who live and work in a region where more people live with HIV than anywhere else in the world. Their research project, called BRILLIANT, was meant to be the latest to draw on the region's genetic diversity and deep expertise in the hope of benefiting people everywhere. But the $46 million from the U.S. for the project was disappearing, part of the dismantling of foreign aid by the world's biggest donor earlier this year as President Donald Trump announced a focus on priorities at home. South Africa hit hard by aid cuts South Africa has been hit especially hard because of Trump's baseless claims about the targeting of the country's white Afrikaner minority. The country had been receiving about $400 million a year via USAID and the HIV-focused PEPFAR. Now that's gone. Glenda Grey, who heads the Brilliant program, said the African continent has been vital to the development of HIV medication, and the U.S. cuts threaten its capability to do such work in the future. Significant advances have included clinical trials for lenacapavir, the world's only twice-a-year shot to prevent HIV, recently approved for use by the U.S. Food and Drug Administration. One study to show its efficacy involved young South Africans. "We do the trials better, faster and cheaper than anywhere else in the world, and so without South Africa as part of these programs, the world, in my opinion, is much poorer," Gray said. She noted that during the urgency of the COVID-19 pandemic, South Africa played a crucial role by testing the Johnson & Johnson and Novavax vaccines, and South African scientists' genomic surveillance led to the identification of an important variant. Labs empty and thousands are laid off A team of researchers at the University of the Witwatersrand has been part of the unit developing the HIV vaccines for the trials. Inside the Wits laboratory, technician Nozipho Mlotshwa was among the young people in white gowns working on samples, but she may soon be out of a job. Her position is grant-funded. She uses her salary to support her family and fund her studies in a country where youth unemployment hovers around 46%. "It's very sad and devastating, honestly," she said of the U.S. cuts and overall uncertainty. "We'll also miss out collaborating with other scientists across the continent." Professor Abdullah Ely leads the team of researchers. He said the work had promising results indicating that the vaccines were producing an immune response. But now that momentum, he said, has "all kind of had to come to a halt." The BRILLIANT program is scrambling to find money to save the project. The purchase of key equipment has stopped. South Africa's health department says about 100 researchers for that program and others related to HIV have been laid off. Funding for postdoctoral students involved in experiments for the projects is at risk. South Africa's government has estimated that universities and science councils could lose about $107 million in U.S. research funding over the next five years due to the aid cuts, which affect not only work on HIV but also tuberculosis -- another disease with a high number of cases in the country. Less money, and less data on what's affected South Africa's government has said it will be very difficult to find funding to replace the U.S. support. And now the number of HIV infections will grow. Medication is more difficult to obtain. At least 8,000 health workers in South Africa's HIV program have already been laid off, the government has said. Also gone are the data collectors who tracked patients and their care, as well as HIV counselors who could reach vulnerable patients in rural communities. For researchers, Universities South Africa, an umbrella body, has applied to the national treasury for over $110 million for projects at some of the largest schools. During a visit to South Africa in June, UNAIDS executive director Winnie Byanyima was well aware of the stakes, and the lives at risk, as research and health care struggle in South Africa and across Africa at large. Other countries that were highly dependent on U.S. funding including Zambia, Nigeria, Burundi and Ivory Coast are already increasing their own resources, she said. "But let's be clear, what they are putting down will not be funding in the same way that the American resources were funding," Byanyima said. ___


Japan Today
2 days ago
- Japan Today
Dark series 'The Institute' adaptation gets author Stephen King's thumbs up
This image released by MGM+ shows Joe Freeman in a scene from "The Institute." (Chris Reardon/MGM+ via AP) By MARK KENNEDY Stephen King has a rule for anyone wanting to adapt one of his books for the big or small screen. It's basically the Hippocratic oath for intellectual property — first, do no harm. 'When you deviate from the story that I wrote, you do so at your own risk,' he said in a recent interview from his home in Maine. 'I know what I'm doing and I'm not sure that screenwriters always do or that producers and directors always do.' Not everyone has listened to King, who has enjoyed hit adaptations — 'The Shawshank Redemption,' 'Stand By Me,' 'Misery,' 'It' and 'The Shining' — as well as flops — 'Salem's Lot,' 'Graveyard Shift' and 'The Lawnmower Man.' The industrious novelist has lately watched as a wave of adaptations are crafted for theaters or streaming platforms, a list that includes 'The Life of Chuck' and the upcoming 'The Long Walk,' 'The Running Man' and 'It: Welcome to Derry.' It also includes the eight-episode series 'The Institute,' which debuts on MGM+ on Sunday. It's about a secret government facility where kids with special talents — telekinesis and telepathy — are imprisoned and put to dark geopolitical uses. Their bedrooms are faithfully re-created and creepy posters — 'Your Gift Is Important' and 'I Choose to be Happy' — line the halls. Does this small-screen adaptation of his 2019 book get King's approval? 'I'm talking to you which is a pretty good sign,' he says, laughing. He even signed on as executive producer. 'When I write a book, it's a single-person sport and when these people do a TV show or a movie it becomes a team sport. So you expect some changes and, sometimes, man, they're really good.' 'The Institute' stars Mary-Louise Parker as a sinister scientist and Ben Barnes as a small-town cop on opposite sides as the group of children are kidnapped and exploited. The series is faithful to the book, but includes some changes, like setting it entirely in Maine and aging the hero up so as not to appear too sadistic. That hero — 14-year-old Luke Ellis, played winningly by Joe Freeman — is the latest youngster with special powers that King has manifested, a line that stretches back to the heroine of 'Carrie,' Danny Torrance in 'The Shining' and Charlie McGee in 'Firestarter.' 'I thought to myself, what would happen if a bunch of kids that had psychic powers could see enough of the future to tell when certain moments were going to come along,' he says. 'But the kids would be wrecked by this process and they would be kept in a place where they could serve the greater good. It was a moral problem that I really liked.' King has a special respect for young adults, who he says can be brave and behave nobly under pressure but who can also be mean and petty. He says he was inspired by William Golding, who wrote the iconic 'Lord of the Flies,' a dystopian novel about a group of schoolboys who while trying to survive on a remote island unlock their own barbarism. 'He was talking to his wife before he wrote the book and he said, 'What would it be like if I wrote a story about boys and the way that boys really acted?' And so I tried to write a book about kids the way that kids really act,' says King. Executive producer and co-writer Benjamin Cavell says King resists the impulse to be overly involved in the process, instead identifying people he trusts to do right by the material. 'So much of the pleasure of King's writing is the access he gives his reader to the deepest, darkest, most private thoughts and dreams and desires of his characters; the adaptor's task is to make all that external and cinematic,' says Cavell. Jack Bender has become something of a King whisperer, helping adapt both King's 'Mr. Mercedes' and 'The Outsider' to the screen. This time, he helped direct and executive produce 'The Institute.' 'I count my blessings to be in the position of someone he creatively trusts,' says Bender. 'He is a genius at tapping into the fears we all share of what's hiding under our beds. For me, both 'Mr. Mercedes' and 'The Institute' deal with those fears by focusing on the monsters inside of us human beings, not just outside in the world around us.' The first thing Bender and Cavell had to figure out was what form 'The Institute' would take — a standalone film or a series. 'In the case of 'The Institute,' which was a 576-page novel packed with rich, fascinating characters that would need time to connect and be with each other, I didn't want to shrink it into a 110 minute movie that would've become the 'X-Kids,'' says Bender. King says that while Hollywood has a seemingly insatiable appetite for his books, he hasn't gotten more cinematic as a writer — he always has been. 'I am one of the first writers that was actually influenced by television as well as movies. 'I grew up with the idea that things should be cinematic and that you should look at things in a visual way, a very sensory way.' King was also pleased that the adapters of 'The Institute' made sure not to change the name of Barnes' small-town cop, Tim. "I named him Tim because I read somewhere that no great thing was ever done by a man named Tim. And so I thought to myself, 'Yeah, well, OK, I'll call him Tim and he can do great things.'' © Copyright 2025 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.


Yomiuri Shimbun
5 days ago
- Yomiuri Shimbun
U.S. Plans to Begin Breeding Billions of Flies to Fight Pest
TOPEKA, Kan. (AP) — The U.S. government is preparing to breed billions of flies and dump them out of airplanes over Mexico and southern Texas to fight a flesh-eating maggot. That sounds like the plot of a horror movie, but it is part of the government's plans for protecting the U.S. from a bug that could devastate its beef industry, decimate wildlife and even kill household pets. This weird science has worked well before. 'It's an exceptionally good technology,' said Edwin Burgess, an assistant professor at the University of Florida who studies parasites in animals, particularly livestock. 'It's an all-time great in terms of translating science to solve some kind of large problem.' The targeted pest is the flesh-eating larva of the New World Screwworm fly. The U.S. Department of Agriculture plans to ramp up the breeding and distribution of adult male flies — sterilizing them with radiation before releasing them — so they can mate ineffectively with females and over time cause the population to die out. It is more effective and environmentally friendly than spraying the pest into oblivion, and it is how the U.S. and other nations north of Panama eradicated the same pest decades ago. Sterile flies from a factory in Panama kept the flies contained there for years, but the pest appeared in southern Mexico late last year. The USDA expects a new screwworm fly factory to be up and running in southern Mexico by July 2026. It plans to open a fly distribution center in southern Texas by the end of the year so that it can import and distribute flies from Panama if necessary. Fly feeds on live flesh Most fly larvae feed on dead flesh, making the New World screwworm fly and its Old World counterpart in Asia and Africa outliers — and for the American beef industry, a serious threat. Females lay their eggs in wounds and, sometimes, exposed mucus. 'A thousand-pound bovine can be dead from this in two weeks,' said Michael Bailey, president elect of the American Veterinary Medicine Association. Veterinarians have effective treatments for infested animals, but an infestation can still be unpleasant — and cripple an animal with pain. Don Hineman, a retired western Kansas rancher, recalled infected cattle as a youngster on his family's farm. 'It smelled nasty,' he said. 'Like rotting meat.' Using the fly's biology against it The New World screwworm fly is a tropical species, unable to survive Midwestern or Great Plains winters, so it was a seasonal scourge. Still, the U.S. and Mexico bred and released more than 94 billion sterile flies from 1962 through 1975 to eradicate the pest, according to the USDA. The numbers need to be large enough that females in the wild can't help but hook up with sterile males for mating. One biological trait gives fly fighters a crucial wing up: Females mate only once in their weekslong adult lives. Why U.S. wants to breed more flies Alarmed about the fly's migration north, the U.S. temporarily closed its southern border in May to imports of live cattle, horses and bison and it won't be fully open again at least until mid-September. But female flies can lay their eggs in wounds on any warm-blooded animal, and that includes humans. Decades ago, the U.S. had fly factories in Florida and Texas, but they closed as the pest was eradicated. The Panama fly factory can breed up to 117 million a week, but the USDA wants the capacity to breed at least 400 million a week. It plans to spend $8.5 million on the Texas site and $21 million to convert a facility in southern Mexico for breeding sterile fruit flies into one for screwworm flies. Raising hundreds of millions of flies In one sense, raising a large colony of flies is relatively easy, said Cassandra Olds, an assistant professor of entomology at Kansas State University. But, she added, 'You've got to give the female the cues that she needs to lay her eggs, and then the larvae have to have enough nutrients.' Fly factories once fed larvae horse meat and honey and then moved to a mix of dried eggs and either honey or molasses, according to past USDA research. Later, the Panama factory used a mix that included egg powder and red blood cells and plasma from cattle. In the wild, larvae ready for the equivalent of a butterfly's cocoon stage drop off their hosts and onto the ground, burrow just below the surface and grow to adulthood inside a protective casing making them resemble a dark brown Tic Tac mint. In the Panama factory, workers drop them into trays of sawdust. Security is an issue. Sonja Swiger, an entomologist with Texas A&M University's Extension Service, said a breeding facility must prevent any fertile adults kept for breeding stock from escaping. How to drop flies from airplane Dropping flies from the air can be dangerous. Last month, a plane freeing sterile flies crashed near Mexico's border with Guatemala, killing three people. In test runs in the 1950s, according to the USDA, scientists put the flies in paper cups and then dropped the cups out of planes using special chutes. Later, they loaded them into boxes with a machine known as a 'Whiz Packer.' The method is still much the same: Light planes with crates of flies drop those crates. Burgess called the development of sterile fly breeding and distribution in the 1950s and 1960s one of the USDA's 'crowning achievements.' Some agriculture officials argue now that new factories shouldn't be shuttered after another successful fight. 'Something we think we have complete control over — and we have declared a triumph and victory over — can always rear its ugly head again,' Burgess said. Mexico to open sterile fly plant MEXICO CITY (Reuters) — Mexico's government said on Monday that it has started to build a $51 million facility in the country's south as part of an effort to combat screwworm, a pest that has disrupted Mexican exports of cattle to the United States. Mexico's agriculture ministry said in a statement that the plant, a joint project with the U.S., will produce 100 million sterile screwworm flies per week once completed in the first half of 2026.